Matcheri S Keshavan

Summary

Publications

  1. doi request reprint Reimagining psychoses: an agnostic approach to diagnosis
    Matcheri S Keshavan
    Beth Israel Deaconess Hospital, Harvard Medical School, Boston, MA, United States
    Schizophr Res 146:10-6. 2013
  2. pmc A dimensional approach to the psychosis spectrum between bipolar disorder and schizophrenia: the Schizo-Bipolar Scale
    Matcheri S Keshavan
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, United States
    Schizophr Res 133:250-4. 2011
  3. pmc Multivariate prediction of emerging psychosis in adolescents at high risk for schizophrenia
    Jai Shah
    Beth Israel Deaconess Medical Center, Boston, MA 02115, United States
    Schizophr Res 141:189-96. 2012
  4. pmc Are structural brain abnormalities associated with suicidal behavior in patients with psychotic disorders?
    Christoforos I Giakoumatos
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Psychiatr Res 47:1389-95. 2013
  5. pmc Progressive alterations of the auditory association areas in young non-psychotic offspring of schizophrenia patients
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Psychiatr Res 45:205-12. 2011
  6. pmc Gray matter loss in young relatives at risk for schizophrenia: relation with prodromal psychopathology
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA, USA
    Neuroimage 54:S272-9. 2011
  7. pmc Alterations in the cerebral white matter of genetic high risk offspring of patients with schizophrenia spectrum disorder
    Alan N Francis
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 40:187-92. 2013
  8. pmc Longitudinal alterations of executive function in non-psychotic adolescents at familial risk for schizophrenia
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:469-74. 2010
  9. pmc A broad cortical reserve accelerates response to cognitive enhancement therapy in early course schizophrenia
    Matcheri S Keshavan
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 130:123-9. 2011
  10. pmc Abnormalities of the corpus callosum in non-psychotic high-risk offspring of schizophrenia patients
    Alan N Francis
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Psychiatry Res 191:9-15. 2011

Collaborators

Detail Information

Publications26

  1. doi request reprint Reimagining psychoses: an agnostic approach to diagnosis
    Matcheri S Keshavan
    Beth Israel Deaconess Hospital, Harvard Medical School, Boston, MA, United States
    Schizophr Res 146:10-6. 2013
    ....
  2. pmc A dimensional approach to the psychosis spectrum between bipolar disorder and schizophrenia: the Schizo-Bipolar Scale
    Matcheri S Keshavan
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, United States
    Schizophr Res 133:250-4. 2011
    ..Neurobiological models linked to dimensional clinical data may provide a better foundation to represent diagnostic variation in neuropsychiatric disorders...
  3. pmc Multivariate prediction of emerging psychosis in adolescents at high risk for schizophrenia
    Jai Shah
    Beth Israel Deaconess Medical Center, Boston, MA 02115, United States
    Schizophr Res 141:189-96. 2012
    ....
  4. pmc Are structural brain abnormalities associated with suicidal behavior in patients with psychotic disorders?
    Christoforos I Giakoumatos
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA
    J Psychiatr Res 47:1389-95. 2013
    ..Regions in which differences were observed are part of neural circuitries that mediate inhibition, impulsivity and emotion, visceral, visual and auditory perception. ..
  5. pmc Progressive alterations of the auditory association areas in young non-psychotic offspring of schizophrenia patients
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Psychiatr Res 45:205-12. 2011
    ..These alterations may be greater in male patients. It is unclear if these deficits are state-dependent or whether they predate illness onset and reflect familial diathesis...
  6. pmc Gray matter loss in young relatives at risk for schizophrenia: relation with prodromal psychopathology
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA, USA
    Neuroimage 54:S272-9. 2011
    ....
  7. pmc Alterations in the cerebral white matter of genetic high risk offspring of patients with schizophrenia spectrum disorder
    Alan N Francis
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Prog Neuropsychopharmacol Biol Psychiatry 40:187-92. 2013
    ..05) and age as covariates. High Risk offspring had significant reductions in total WM, hemispheric WM and WM within left parietal and left cingulate cortices. Male offspring had more pronounced right hemisphere WM reductions than females...
  8. pmc Longitudinal alterations of executive function in non-psychotic adolescents at familial risk for schizophrenia
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, Massachusetts, USA
    Prog Neuropsychopharmacol Biol Psychiatry 34:469-74. 2010
    ..Our results suggest an altered maturational trajectory of executive function during adolescence in individuals at familial risk for schizophrenia...
  9. pmc A broad cortical reserve accelerates response to cognitive enhancement therapy in early course schizophrenia
    Matcheri S Keshavan
    Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 130:123-9. 2011
    ..We investigated this question in early course schizophrenia patients treated with Cognitive Enhancement Therapy (CET)...
  10. pmc Abnormalities of the corpus callosum in non-psychotic high-risk offspring of schizophrenia patients
    Alan N Francis
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Psychiatry Res 191:9-15. 2011
    ..The absence of an age-related volume increase suggests an abnormal developmental trajectory that may underlie susceptibility to schizophrenia...
  11. pmc Do inter-regional gray-matter volumetric correlations reflect altered functional connectivity in high-risk offspring of schizophrenia patients?
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 118:62-8. 2010
    ..Gray-matter volumetric alterations may be related to these functional connectivity deficits. Also, gray-matter volume inter-regional correlations may reflect altered inter-regional functional connectivity...
  12. pmc Gray matter alterations in schizophrenia high-risk youth and early-onset schizophrenia: a review of structural MRI findings
    Benjamin K Brent
    Harvard Medical School, Boston, MA 02115, USA Division of Public Psychiatry, Massachusetts Mental Health Center, 75 Fenwood Road, Boston, MA 02115, USA Department of Psychiatry, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA Electronic address
    Child Adolesc Psychiatr Clin N Am 22:689-714. 2013
    ....
  13. pmc Early prodromal symptoms can predict future psychosis in familial high-risk youth
    Neeraj Tandon
    Beth Israel Deaconess Medical Center, Harvard Medical School, 401 Park Dr, 2E Psychiatry, Boston, MA 02215, USA
    J Psychiatr Res 46:105-10. 2012
    ..We sought to evaluate the relative utility of "psychosis-proneness" measures for prospective prediction of psychotic disorders in a group of young relatives at familial risk for schizophrenia...
  14. doi request reprint Brain metabolite alterations in young adults at familial high risk for schizophrenia using proton magnetic resonance spectroscopy
    Neeraj Tandon
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA, USA
    Schizophr Res 148:59-66. 2013
    ..While individuals at high familial risk for schizophrenia (HR) exhibit some neurobiological findings observed in the disorder, (1)H MRS findings and their clinical correlates are not well characterized in this population...
  15. ncbi request reprint Psychosis prediction and clinical utility in familial high-risk studies: selective review, synthesis, and implications for early detection and intervention
    Jai L Shah
    Massachusetts Mental Health Center, Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA Connecticut Mental Health Center, New Haven, Connecticut, USA Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
    Early Interv Psychiatry 7:345-60. 2013
    ..We sought to review investigations of prospective psychosis prediction based on markers and variables examined in longitudinal familial high-risk (FHR) studies...
  16. ncbi request reprint Medial Temporal Lobe Structures and Hippocampal Subfields in Psychotic Disorders: Findings From the Bipolar-Schizophrenia Network on Intermediate Phenotypes (B-SNIP) Study
    Ian Mathew
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts
    JAMA Psychiatry 71:769-77. 2014
    ..Structural alterations in the hippocampus and other medial temporal lobe regions have been observed in schizophrenia. How these alterations and hippocampal subfields might differ across the psychosis spectrum remains unclear...
  17. doi request reprint Reduced subicular subdivisions of the hippocampal formation and verbal declarative memory impairments in young relatives at risk for schizophrenia
    Alan N Francis
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States MGH MIT HMS Martinos Center for Biomedical Imaging Boston, MA, United States
    Schizophr Res 151:154-7. 2013
    ..In this study, subdivisions of the hippocampal formation and their association with verbal and visual learning and memory were assessed in persons at familial high risk (FHR) for SZ...
  18. pmc Early and broadly defined psychosis risk mental states
    Matcheri S Keshavan
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Schizophr Res 126:1-10. 2011
    ..The disadvantages as well as the potential benefits of this approach are discussed...
  19. pmc Grey matter and cognitive deficits in young relatives of schizophrenia patients
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA, USA
    Neuroimage 54:S287-92. 2011
    ..Overlapping structural and cognitive deficits may define a hyper vulnerable sub-sample among individuals at familial predisposition to schizophrenia...
  20. ncbi request reprint Mentalization-based treatment for psychosis: linking an attachment-based model to the psychotherapy for impaired mental state understanding in people with psychotic disorders
    Benjamin K Brent
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Boston, Mass, U S A Harvard Medical School, Boston, Mass, U S A
    Isr J Psychiatry Relat Sci 51:17-24. 2014
    ..this is followed by an illustration of some of the core mBt techniques for the rehabilitation of the capacity to mentalize as applied to the treatment of a patient with a psychotic disorder. ..
  21. pmc Self-disturbances as a possible premorbid indicator of schizophrenia risk: a neurodevelopmental perspective
    Benjamin K Brent
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA, USA Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA Massachusetts Mental Health Center Division of Public Psychiatry, Boston, MA, USA Harvard Medical School, Boston, MA, USA Electronic address
    Schizophr Res 152:73-80. 2014
    ..Our goal is that the ideas presented here might provide future directions for research into the neurobiology of SDs during the pre-psychosis development of youth at risk for schizophrenia. ..
  22. doi request reprint Prevention and recovery in early psychosis (PREP(®)): building a public-academic partnership program in Massachusetts, United States
    Brina Caplan
    Private Practice, Boston, MA, USA
    Asian J Psychiatr 6:171-7. 2013
    ..This account offers one possible blueprint for the development of EI programs despite the lack in the U.S. of a national mandate for EI or prevention-based mental health programs...
  23. doi request reprint Insight into illness in patients and caregivers during early psychosis: a pilot study
    Benjamin K Brent
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 127:100-6. 2011
    ....
  24. doi request reprint Verbal fluency deficits and altered lateralization of language brain areas in individuals genetically predisposed to schizophrenia
    Tejas S Bhojraj
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 115:202-8. 2009
    ..Volumetric deficits and altered asymmetry in inferior parietal and Heschl's gyrii may accompany genetic liability to schizophrenia...
  25. ncbi request reprint A review and new report of medial temporal lobe dysfunction as a vulnerability indicator for schizophrenia: a magnetic resonance imaging morphometric family study of the parahippocampal gyrus
    Larry J Seidman
    Commonwealth Research Center, Harvard Medical School, Department of Psychiatry, Massachusetts Mental Health Center, Boston, MA, USA
    Schizophr Bull 29:803-30. 2003
    ..Implications of genetic risk studies for prodromal research are discussed...
  26. pmc Schizophrenia, "Just the Facts" 6. Moving ahead with the schizophrenia concept: from the elephant to the mouse
    Matcheri S Keshavan
    Department of Psychiatry, Beth Israel Deaconess Medical Center and Massachusetts Mental Health Center, Harvard Medical School, Boston, MA 02215, USA
    Schizophr Res 127:3-13. 2011
    ..The mouse may be the way to rescue the trapped elephant!..