Janet K Kern

Summary

Publications

  1. ncbi request reprint Evidence of parallels between mercury intoxication and the brain pathology in autism
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Acta Neurobiol Exp (Wars) 72:113-53. 2012
  2. doi request reprint Handgrip strength in autism spectrum disorder compared with controls
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    J Strength Cond Res 27:2277-81. 2013
  3. pmc Thimerosal exposure and the role of sulfation chemistry and thiol availability in autism
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, MD 20905, USA
    Int J Environ Res Public Health 10:3771-800. 2013
  4. doi request reprint A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorder
    Janet K Kern
    Autism Treatment Center, Dallas, TX, USA
    Biometals 23:1043-51. 2010
  5. doi request reprint Toxicity biomarkers in autism spectrum disorder: a blinded study of urinary porphyrins
    Janet K Kern
    Research Department, Genetics Consultants of Dallas ASD Centers, LLC, 408 N Allen Dr, Allen, TX 75013, USA
    Pediatr Int 53:147-53. 2011
  6. ncbi request reprint Sensory correlations in autism
    Janet K Kern
    University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA
    Autism 11:123-34. 2007
  7. doi request reprint A prospective study of transsulfuration biomarkers in autistic disorders
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Neurochem Res 34:386-93. 2009
  8. doi request reprint Biomarkers of environmental toxicity and susceptibility in autism
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    J Neurol Sci 280:101-8. 2009
  9. ncbi request reprint Sulfhydryl-reactive metals in autism
    Janet K Kern
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9119, USA
    J Toxicol Environ Health A 70:715-21. 2007
  10. pmc Hair toxic metal concentrations and autism spectrum disorder severity in young children
    David A Geier
    Institute of Chronic Illnesses, Silver Spring, MD 20905, USA
    Int J Environ Res Public Health 9:4486-97. 2012

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Evidence of parallels between mercury intoxication and the brain pathology in autism
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Acta Neurobiol Exp (Wars) 72:113-53. 2012
    ....
  2. doi request reprint Handgrip strength in autism spectrum disorder compared with controls
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    J Strength Cond Res 27:2277-81. 2013
    ..The present study provides support for the use of handgrip strength as a tool for the assessment of targeted treatment in ASD...
  3. pmc Thimerosal exposure and the role of sulfation chemistry and thiol availability in autism
    Janet K Kern
    Institute of Chronic Illnesses, Inc, Silver Spring, MD 20905, USA
    Int J Environ Res Public Health 10:3771-800. 2013
    ....
  4. doi request reprint A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorder
    Janet K Kern
    Autism Treatment Center, Dallas, TX, USA
    Biometals 23:1043-51. 2010
    ..The results show an association between the apparent level of mercury toxicity as measured by recognized urinary porphyrin biomarkers of mercury toxicity and the magnitude of the specific hallmark features of autism as assessed by ATEC...
  5. doi request reprint Toxicity biomarkers in autism spectrum disorder: a blinded study of urinary porphyrins
    Janet K Kern
    Research Department, Genetics Consultants of Dallas ASD Centers, LLC, 408 N Allen Dr, Allen, TX 75013, USA
    Pediatr Int 53:147-53. 2011
    ..However, these initial studies were criticized because the controls were not age- and gender-matched to the children diagnosed with an ASD...
  6. ncbi request reprint Sensory correlations in autism
    Janet K Kern
    University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA
    Autism 11:123-34. 2007
    ....
  7. doi request reprint A prospective study of transsulfuration biomarkers in autistic disorders
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Neurochem Res 34:386-93. 2009
    ..Patients diagnosed with ASDs should be routinely tested to evaluate transsulfuration metabolites, and potential treatment protocols should be evaluated to potentially correct the transsulfuration abnormalities observed...
  8. doi request reprint Biomarkers of environmental toxicity and susceptibility in autism
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    J Neurol Sci 280:101-8. 2009
    ..The transsulfuration abnormalities observed among study participants indicate that mercury intoxication was associated with increased oxidative stress and decreased detoxification capacity...
  9. ncbi request reprint Sulfhydryl-reactive metals in autism
    Janet K Kern
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9119, USA
    J Toxicol Environ Health A 70:715-21. 2007
    ..The evidence from our study supports the notion that children with autism may have trouble excreting these metals, resulting in a higher body burden that may contribute to symptoms of autism...
  10. pmc Hair toxic metal concentrations and autism spectrum disorder severity in young children
    David A Geier
    Institute of Chronic Illnesses, Silver Spring, MD 20905, USA
    Int J Environ Res Public Health 9:4486-97. 2012
    ....
  11. doi request reprint A prospective blinded evaluation of urinary porphyrins verses the clinical severity of autism spectrum disorders
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    J Toxicol Environ Health A 72:1585-91. 2009
    ..Since urinary porphyrin testing is clinically available, relatively inexpensive, and noninvasive, it may be used to help suggest whether heavy metal toxicity is associated with ASD...
  12. pmc A clinical trial of glutathione supplementation in autism spectrum disorders
    Janet K Kern
    Genetic Consultants of Dallas, Allen, TX, USA
    Med Sci Monit 17:CR677-82. 2011
    ..The purpose of this study was to examine the use of two commonly used glutathione supplements in subjects diagnosed with an ASD to determine their efficacy in increasing blood glutathione levels in subjects diagnosed with an ASD...
  13. ncbi request reprint The biological basis of autism spectrum disorders: Understanding causation and treatment by clinical geneticists
    David A Geier
    The Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    Acta Neurobiol Exp (Wars) 70:209-26. 2010
    ..Finally, the clinical geneticist has a wealth of biomarkers to evaluate and treat patients diagnosed with an ASD...
  14. doi request reprint A significant relationship between mercury exposure from dental amalgams and urinary porphyrins: a further assessment of the Casa Pia children's dental amalgam trial
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Biometals 24:215-24. 2011
    ....
  15. pmc Barriers to implementation of a computerized decision support system for depression: an observational report on lessons learned in "real world" clinical settings
    Madhukar H Trivedi
    Mood Disorders Research Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX, USA
    BMC Med Inform Decis Mak 9:6. 2009
    ....
  16. ncbi request reprint An evaluation of the role and treatment of elevated male hormones in autism spectrum disorders
    David A Geier
    The Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Acta Neurobiol Exp (Wars) 72:1-17. 2012
    ....
  17. ncbi request reprint Blood mercury levels in autism spectrum disorder: Is there a threshold level?
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Acta Neurobiol Exp (Wars) 70:177-86. 2010
    ..4). The weight of scientific evidence supports Hg as a causal factor in subjects diagnosed with an ASD...
  18. pmc A prospective double-blind, randomized clinical trial of levocarnitine to treat autism spectrum disorders
    David A Geier
    The Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
    Med Sci Monit 17:PI15-23. 2011
    ..L-carnitine was proposed as a potential treatment for patients diagnosed with an autism spectrum disorder to improve mitochondrial dysfunction, but no prior randomized controlled trials have been conducted...
  19. ncbi request reprint Prospective trial of equine-assisted activities in autism spectrum disorder
    Janet K Kern
    Research Department, Autism Treatment Center, Dallas, Texas, USA
    Altern Ther Health Med 17:14-20. 2011
    ..Anecdotal reports and some studies suggest that equine-assisted activities may be beneficial in autism spectrum disorders (ASD)...
  20. ncbi request reprint Evidence of toxicity, oxidative stress, and neuronal insult in autism
    Janet K Kern
    Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9119, USA
    J Toxicol Environ Health B Crit Rev 9:485-99. 2006
    ..Finally, the article discusses what may be happening over the course of development and the multiple factors that may interplay and make these children more vulnerable to toxicity, oxidative stress, and neuronal insult...
  21. ncbi request reprint A prospective study of prenatal mercury exposure from maternal dental amalgams and autism severity
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
    Acta Neurobiol Exp (Wars) 69:189-97. 2009
    ..Dental amalgam policies should consider Hg exposure in women before and during the child-bearing age and the possibility of subsequent fetal exposure and adverse outcomes...
  22. pmc Prospective, blinded exploratory evaluation of the PlayWisely program in children with autism spectrum disorder
    Janet K Kern
    Autism Treatment Center, Research Department, Dallas, Texas 75243, USA
    Yale J Biol Med 86:157-67. 2013
    ..Future studies are needed to see if this intervention can mitigate autism symptoms in very young children with ASD...
  23. pmc Evidence of microglial activation in autism and its possible role in brain underconnectivity
    Juan I Rodriguez
    Stop Calling It Autism, Fort Worth, TX, USA
    Neuron Glia Biol 7:205-13. 2011
    ..Future studies that examine treatments that may reduce microglial activation and neuroinflammation, and ultimately help to mitigate symptoms in ASD, are warranted...
  24. pmc A prospective Cross-sectional Cohort Assessment of Health, Physical, and Behavioral Problems in Autism Spectrum Disorders
    David A Geier
    Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA CoMeD, Inc, Silver Spring, MD, USA
    Maedica (Buchar) 7:193-200. 2012
    ..The present findings also suggest the ATEC provides an economical means for healthcare providers to identify health, physical, and behavioral problems in subjects diagnosed with an ASD...
  25. ncbi request reprint The pattern of sensory processing abnormalities in autism
    Janet K Kern
    Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9119, USA
    Autism 10:480-94. 2006
    ..These results suggest that sensory abnormalities in autism are global in nature (involving several modalities) but have the potential to improve with age...
  26. pmc Assessing physicians' use of treatment algorithms: Project IMPACTS study design and rationale
    Madhukar H Trivedi
    Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
    Contemp Clin Trials 28:192-212. 2007
    ..These new procedures and data points will also allow a more refined assessment of algorithm-driven treatment in the future...