Evidence of parallels between mercury intoxication and the brain pathology in autismJanet K Kern
Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
Acta Neurobiol Exp (Wars) 72:113-53. 2012
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A biomarker of mercury body-burden correlated with diagnostic domain specific clinical symptoms of autism spectrum disorderJanet K Kern
Autism Treatment Center, Dallas, TX, USA
Biometals 23:1043-51. 2010
..The results show an association between the apparent level of mercury toxicity as measured by recognized urinary porphyrin biomarkers of mercury toxicity and the magnitude of the specific hallmark features of autism as assessed by ATEC...
- Toxicity biomarkers in autism spectrum disorder: a blinded study of urinary porphyrins
Janet K Kern
Research Department, Genetics Consultants of Dallas ASD Centers, LLC, 408 N Allen Dr, Allen, TX 75013, USA
Pediatr Int 53:147-53. 2011
..However, these initial studies were criticized because the controls were not age- and gender-matched to the children diagnosed with an ASD...
- Sensory correlations in autism
Janet K Kern
University of Texas, Southwestern Medical Center, Dallas, TX 75390, USA
Autism 11:123-34. 2007
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- A prospective study of transsulfuration biomarkers in autistic disorders
David A Geier
Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
Neurochem Res 34:386-93. 2009
..Patients diagnosed with ASDs should be routinely tested to evaluate transsulfuration metabolites, and potential treatment protocols should be evaluated to potentially correct the transsulfuration abnormalities observed...
- Biomarkers of environmental toxicity and susceptibility in autism
David A Geier
Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
J Neurol Sci 280:101-8. 2009
..The transsulfuration abnormalities observed among study participants indicate that mercury intoxication was associated with increased oxidative stress and decreased detoxification capacity...
- A prospective blinded evaluation of urinary porphyrins verses the clinical severity of autism spectrum disorders
David A Geier
Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
J Toxicol Environ Health A 72:1585-91. 2009
..Since urinary porphyrin testing is clinically available, relatively inexpensive, and noninvasive, it may be used to help suggest whether heavy metal toxicity is associated with ASD...
- A clinical trial of glutathione supplementation in autism spectrum disorders
Janet K Kern
Genetic Consultants of Dallas, Allen, TX, USA
Med Sci Monit 17:CR677-82. 2011
..The purpose of this study was to examine the use of two commonly used glutathione supplements in subjects diagnosed with an ASD to determine their efficacy in increasing blood glutathione levels in subjects diagnosed with an ASD...
- Sulfhydryl-reactive metals in autism
Janet K Kern
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9119, USA
J Toxicol Environ Health A 70:715-21. 2007
..The evidence from our study supports the notion that children with autism may have trouble excreting these metals, resulting in a higher body burden that may contribute to symptoms of autism...
- A significant relationship between mercury exposure from dental amalgams and urinary porphyrins: a further assessment of the Casa Pia children's dental amalgam trial
David A Geier
Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
Biometals 24:215-24. 2011
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Barriers to implementation of a computerized decision support system for depression: an observational report on lessons learned in "real world" clinical settingsMadhukar H Trivedi
Mood Disorders Research Program and Clinic, Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, TX, USA
BMC Med Inform Decis Mak 9:6. 2009
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- An evaluation of the role and treatment of elevated male hormones in autism spectrum disorders
David A Geier
The Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
Acta Neurobiol Exp (Wars) 72:1-17. 2012
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- The biological basis of autism spectrum disorders: Understanding causation and treatment by clinical geneticists
David A Geier
The Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
Acta Neurobiol Exp (Wars) 70:209-26. 2010
..Finally, the clinical geneticist has a wealth of biomarkers to evaluate and treat patients diagnosed with an ASD...
- Blood mercury levels in autism spectrum disorder: Is there a threshold level?
David A Geier
Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
Acta Neurobiol Exp (Wars) 70:177-86. 2010
..4). The weight of scientific evidence supports Hg as a causal factor in subjects diagnosed with an ASD...
- A prospective double-blind, randomized clinical trial of levocarnitine to treat autism spectrum disorders
David A Geier
The Institute of Chronic Illnesses, Inc, Silver Spring, MD, USA
Med Sci Monit 17:PI15-23. 2011
..L-carnitine was proposed as a potential treatment for patients diagnosed with an autism spectrum disorder to improve mitochondrial dysfunction, but no prior randomized controlled trials have been conducted...
- Prospective trial of equine-assisted activities in autism spectrum disorder
Janet K Kern
Research Department, Autism Treatment Center, Dallas, Texas, USA
Altern Ther Health Med 17:14-20. 2011
..Anecdotal reports and some studies suggest that equine-assisted activities may be beneficial in autism spectrum disorders (ASD)...
- Hair toxic metal concentrations and autism spectrum disorder severity in young children
David A Geier
Institute of Chronic Illnesses, Silver Spring, MD 20905, USA
Int J Environ Res Public Health 9:4486-97. 2012
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- A prospective study of prenatal mercury exposure from maternal dental amalgams and autism severity
David A Geier
Institute of Chronic Illnesses, Inc, Silver Spring, Maryland, USA
Acta Neurobiol Exp (Wars) 69:189-97. 2009
..Dental amalgam policies should consider Hg exposure in women before and during the child-bearing age and the possibility of subsequent fetal exposure and adverse outcomes...
- Evidence of toxicity, oxidative stress, and neuronal insult in autism
Janet K Kern
Department of Psychiatry, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9119, USA
J Toxicol Environ Health B Crit Rev 9:485-99. 2006
..Finally, the article discusses what may be happening over the course of development and the multiple factors that may interplay and make these children more vulnerable to toxicity, oxidative stress, and neuronal insult...
- The pattern of sensory processing abnormalities in autism
Janet K Kern
Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9119, USA
Autism 10:480-94. 2006
..These results suggest that sensory abnormalities in autism are global in nature (involving several modalities) but have the potential to improve with age...
- Assessing physicians' use of treatment algorithms: Project IMPACTS study design and rationale
Madhukar H Trivedi
Department of Psychiatry, The University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9119, USA
Contemp Clin Trials 28:192-212. 2007
..These new procedures and data points will also allow a more refined assessment of algorithm-driven treatment in the future...
