Research Topics
| Douglas S WalshSummaryAffiliation: The US Army Medical Research Unit Country: Kenya Publications
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Detail Information
Publications
Antimicrobial resistance surveillance in the AFHSC-GEIS networkWilliam G Meyer
Armed Forces Health Surveillance Center, 11800 Tech Rd, Silver Spring, MD 20904, USA
BMC Public Health 11:S8. 2011..This section documents the accomplishments and activities of the network through AFHSC-GEIS partners in 2009...
Buruli ulcer (Mycobacterium ulcerans infection)Douglas S Walsh
United States Army Medical Research Unit Kenya, Walter Reed Project, PO Box 54, Kisumu, 10400, Kenya
Trans R Soc Trop Med Hyg 102:969-78. 2008..The first cultivation of M. ulcerans from nature was reported in 2008...
Clinical and histologic features of skin lesions in a cynomolgus monkey experimentally infected with mycobacterium ulcerans (Buruli ulcer) by intradermal inoculationDouglas S Walsh
Department of Immunology and Medicine, US Army Medical Component, Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
Am J Trop Med Hyg 76:132-4. 2007..This report, the first to describe a non-human primate experimentally infected with M. ulcerans, suggests that cynomolgus monkeys are modestly susceptible and develop some of the clinical and histologic features of Buruli ulcer...- Clinical and histological features of inoculation site skin lesions in cynomolgus monkeys experimentally infected with Orientia tsutsugamushiDouglas S Walsh
Department of Immunology and Medicine, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
Vector Borne Zoonotic Dis 7:547-54. 2007..This pilot study shows that cynomolgus intradermally inoculated with O. tsutsugamushi replicate the localized cutaneous pathogenesis of human scrub typhus infections, strengthening the value of this animal model... - Optimizing the HRP-2 in vitro malaria drug susceptibility assay using a reference clone to improve comparisons of Plasmodium falciparum field isolatesWiriya Rutvisuttinunt
Department of Immunology and Medicine, US Army Medical Corps, Armed Forces Research Institute of Medical Sciences USAMC AFRIMS, Bangkok, Thailand
Malar J 11:325. 2012..Although in vitro anti-malarial susceptibility tests are widely used, uncertainties remain regarding interpretation of P. falciparum field isolate values... - Ex vivo drug sensitivity profiles of Plasmodium falciparum field isolates from Cambodia and Thailand, 2005 to 2010, determined by a histidine-rich protein-2 assayStuart D Tyner
Department of Immunology and Medicine, US Army Medical Corps, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Malar J 11:198. 2012.... - Limited susceptibility of cynomolgus monkeys (Macaca fascicularis) to leprosy after experimental administration of Mycobacterium lepraeGerald P Walsh
Leonard Wood Memorial, Cebu Leprosy and Tuberculosis Research Foundation, Cebu, Philippines
Am J Trop Med Hyg 87:327-36. 2012..Overall, however, cynomolgus monkeys seem minimally susceptible to leprosy after experimental M. leprae administration... - Recent advances in leprosy and Buruli ulcer (Mycobacterium ulcerans infection)Douglas S Walsh
Department of Immunology and Medicine, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Curr Opin Infect Dis 23:445-55. 2010..After tuberculosis, leprosy (Mycobacterium leprae) and Buruli ulcer (M. ulcerans infection) are the second and third most common mycobacterial infections in humankind, respectively. Recent advances in both diseases are summarized... - Buruli ulcer: Advances in understanding Mycobacterium ulcerans infectionDouglas S Walsh
Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Dermatol Clin 29:1-8. 2011..First-line therapy for BU is rifampin plus streptomycin, sometimes with surgery. New insights into the pathogenesis of BU should improve control strategies... - Short report: Clinical and molecular evidence for a case of Buruli ulcer (Mycobacterium ulcerans infection) in KenyaDouglas S Walsh
Kenya Medical Research Institute Walter Reed Project, United States Army Medical Research Unit Kenya, Kisumu, Kenya
Am J Trop Med Hyg 81:1110-3. 2009..Buruli ulcer is named after Buruli County in Uganda (east Africa), where an epidemic occurred in the 1960s. Today, BU is most common in central and west Africa. We describe clinical and molecular evidence for a case of BU in Kenya... - Inhibitory activity of ferroquine, versus chloroquine, against western Kenya Plasmodium falciparum field isolates determined by a SYBR Green I in vitro assayFredrick L Eyase
Department of Emerging Infectious Diseases Program, U S Army Medical Research Unit Kenya, Kenya Medical Research Institute Walter Reed Project, Kisumu, Kenya
Am J Trop Med Hyg 85:984-8. 2011..FQ is more potent than CQ against CQ-resistant P. falciparum field isolates and the W2 clone, and is less affected by Pfcrt 76T. These findings support the notion that FQ could be useful in treating persons with P. falciparum malaria... - Impact of RTS,S/AS02(A) and RTS,S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trialJohn N Waitumbi
Walter Reed Project, Kenya Medical Research Institute, Kisumu, Kenya
PLoS ONE 4:e7849. 2009..Parasite isolates from this study were used to determine the molecular impact of RTS,S/AS02(A) and RTS,S/AS01(B) on the multiplicity of infection (MOI) and the csp allelic characteristics of subsequent parasitemias... - Heterologous prime-boost immunization in rhesus macaques by two, optimally spaced particle-mediated epidermal deliveries of Plasmodium falciparum circumsporozoite protein-encoding DNA, followed by intramuscular RTS,S/AS02ADouglas S Walsh
Department of Immunology and Medicine, US Army Medical Component, Armed Forces Research Institute of Medical Sciences AFRIMS, Bangkok, Thailand
Vaccine 24:4167-78. 2006..In field studies, RTS,S/AS02A reduced malaria infection, clinical episodes, and disease severity. Heterologous prime-boost immunization regimens, optimally spaced, might improve the protective immunity of RTS,S/AS02A... - Pre-clinical evaluation of the malaria vaccine candidate P. falciparum MSP1(42) formulated with novel adjuvants or with alumSathit Pichyangkul
Department of Immunology and Medicine, Armed Forces Research Institute of Medical Science AFRIMS, Bangkok, Thailand
Vaccine 22:3831-40. 2004..The notable difference in Th1/Th2 polarization induced by the AS02A and AS01B formulations warrants comparative clinical testing... - Effective treatment of uncomplicated Plasmodium falciparum malaria with azithromycin-quinine combinations: a randomized, dose-ranging studyR Scott Miller
Department of Immunology and Medicine, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 74:401-6. 2006..Three- and five-day azithromycin-quinine combination therapy appears safe, well tolerated, and effective in curing drug-resistant P. falciparum malaria. Further evaluation, especially in pediatric and obstetric populations, is warranted... - Efficacy of monthly tafenoquine for prophylaxis of Plasmodium vivax and multidrug-resistant P. falciparum malariaDouglas S Walsh
Department of Immunology and Medicine, United States Army Medical Component, Bangkok, Thailand
J Infect Dis 190:1456-63. 2004..falciparum malaria (95% CI, 60%-100%). Monthly tafenoquine was safe, well tolerated, and highly effective in preventing P. vivax and multidrug-resistant P. falciparum malaria in Thai soldiers during 6 months of prophylaxis... - Safety and immunogenicity of rts,s+trap malaria vaccine, formulated in the as02a adjuvant system, in infant rhesus monkeysDouglas S Walsh
Department of Immunology and Medicine, U S Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
Am J Trop Med Hyg 70:499-509. 2004..RTS,S+TRAP/AS02A was safe and well tolerated. Vigorous antibody production and modest, selective cell-mediated immune responses suggest that RTS,S+TRAP/AS02A may be immunogenic in human infants... - Robust in vitro replication of Plasmodium falciparum in glycosyl-phosphatidylinositol-anchored membrane glycoprotein-deficient red blood cellsKovit Pattanapanyasat
Center of Excellence for Flow Cytometry, Office for Research and Development, Department of Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand
Am J Trop Med Hyg 69:360-5. 2003..4 +/- 4.8%). Expression of DAF in 12 (63%) of 19 infected PNH samples was reduced. Thus, P. falciparum does not selectively avoid RBCs with fewer GPI proteins and parasite replication in PNH cells is at least as robust as in normal RBCs...