L Lavreys

Summary

Country: Kenya

Publications

  1. pmc Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected women
    Paul K Drain
    Department of Medicine, University of Washington, 1959 NE Pacific, A 300 Health Sciences, Box 356340, Seattle, WA 98105, USA
    BMC Infect Dis 6:85. 2006
  2. ncbi request reprint Human herpesvirus 8: seroprevalence and correlates in prostitutes in Mombasa, Kenya
    Ludo Lavreys
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    J Infect Dis 187:359-63. 2003
  3. ncbi request reprint Hormonal contraception and risk of cervical infections among HIV-1-seropositive Kenyan women
    Ludo Lavreys
    Departments of Epidemiology and Medicine, University of Washington, Seattle 98104 2499, USA
    AIDS 18:2179-84. 2004
  4. ncbi request reprint Effect of circumcision on incidence of human immunodeficiency virus type 1 and other sexually transmitted diseases: a prospective cohort study of trucking company employees in Kenya
    L Lavreys
    Departments of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle 98104 2499, USA
    J Infect Dis 180:330-6. 1999
  5. ncbi request reprint Trends in HIV-1 incidence in a cohort of prostitutes in Kenya: implications for HIV-1 vaccine efficacy trials
    J M Baeten
    Departments of Epidemiology, Biostatistics, and Medicine, University of Washington, Seattle, Washington, USA
    J Acquir Immune Defic Syndr 24:458-64. 2000
  6. ncbi request reprint Hormonal contraception and risk of sexually transmitted disease acquisition: results from a prospective study
    J M Baeten
    Department of Epidemiology, University of Washington, Seattle, WA 98104 2499, USA
    Am J Obstet Gynecol 185:380-5. 2001
  7. ncbi request reprint Treatment of cervicitis is associated with decreased cervical shedding of HIV-1
    R S McClelland
    Department of Medicine, University of Washington, Seattle 98104, USA
    AIDS 15:105-10. 2001
  8. ncbi request reprint Evaluation of a low-dose nonoxynol-9 gel for the prevention of sexually transmitted diseases: a randomized clinical trial
    B A Richardson
    Departments of Biostatistics, Epidemiology, and Medicine, University of Washington, Seattle WA 98104-2499, USA
    Sex Transm Dis 28:394-400. 2001
  9. ncbi request reprint Contribution of HIV-1 infection to acquisition of sexually transmitted disease: a 10-year prospective study
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    J Infect Dis 191:333-8. 2005
  10. ncbi request reprint Correlates of human herpesvirus 8 seropositivity among heterosexual men in Kenya
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle 98104 2499, USA
    AIDS 16:2073-8. 2002

Collaborators

Detail Information

Publications49

  1. pmc Low serum albumin and the acute phase response predict low serum selenium in HIV-1 infected women
    Paul K Drain
    Department of Medicine, University of Washington, 1959 NE Pacific, A 300 Health Sciences, Box 356340, Seattle, WA 98105, USA
    BMC Infect Dis 6:85. 2006
    ..Low serum selenium has been associated with lower CD4 counts and greater mortality among HIV-1-seropositive individuals, but most studies have not controlled for serum albumin and the presence of an acute phase response...
  2. ncbi request reprint Human herpesvirus 8: seroprevalence and correlates in prostitutes in Mombasa, Kenya
    Ludo Lavreys
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    J Infect Dis 187:359-63. 2003
    ..These results suggest that heterosexual transmission may contribute to acquisition of HHV-8 infections in this African population of prostitutes...
  3. ncbi request reprint Hormonal contraception and risk of cervical infections among HIV-1-seropositive Kenyan women
    Ludo Lavreys
    Departments of Epidemiology and Medicine, University of Washington, Seattle 98104 2499, USA
    AIDS 18:2179-84. 2004
    ..To evaluate the relationship between hormonal contraceptive use and the acquisition of cervical sexually transmitted infections (STI) among HIV-1-infected women...
  4. ncbi request reprint Effect of circumcision on incidence of human immunodeficiency virus type 1 and other sexually transmitted diseases: a prospective cohort study of trucking company employees in Kenya
    L Lavreys
    Departments of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle 98104 2499, USA
    J Infect Dis 180:330-6. 1999
    ..In this prospective cohort of trucking company employees, uncircumcised status was associated with increased risk of HIV-1 infection and genital ulcer disease, and these effects remained after controlling for potential confounders...
  5. ncbi request reprint Trends in HIV-1 incidence in a cohort of prostitutes in Kenya: implications for HIV-1 vaccine efficacy trials
    J M Baeten
    Departments of Epidemiology, Biostatistics, and Medicine, University of Washington, Seattle, Washington, USA
    J Acquir Immune Defic Syndr 24:458-64. 2000
    ..Little information is available on the estimated incidence of HIV-1 in such populations, especially information on incidence over time and incidence while participating in risk-reduction programs...
  6. ncbi request reprint Hormonal contraception and risk of sexually transmitted disease acquisition: results from a prospective study
    J M Baeten
    Department of Epidemiology, University of Washington, Seattle, WA 98104 2499, USA
    Am J Obstet Gynecol 185:380-5. 2001
    ..To examine the relationship between use of oral contraceptive pills or depot medroxyprogesterone acetate and sexually transmitted disease acquisition...
  7. ncbi request reprint Treatment of cervicitis is associated with decreased cervical shedding of HIV-1
    R S McClelland
    Department of Medicine, University of Washington, Seattle 98104, USA
    AIDS 15:105-10. 2001
    ..Treatment of sexually transmitted diseases may be an important means of decreasing the infectivity of HIV-1 seropositive women by reducing exposure to HIV-1 in genital secretions...
  8. ncbi request reprint Evaluation of a low-dose nonoxynol-9 gel for the prevention of sexually transmitted diseases: a randomized clinical trial
    B A Richardson
    Departments of Biostatistics, Epidemiology, and Medicine, University of Washington, Seattle WA 98104-2499, USA
    Sex Transm Dis 28:394-400. 2001
    ....
  9. ncbi request reprint Contribution of HIV-1 infection to acquisition of sexually transmitted disease: a 10-year prospective study
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    J Infect Dis 191:333-8. 2005
    ..Sexually transmitted diseases (STDs) enhance human immunodeficiency virus (HIV)-1 susceptibility, but few studies have examined the reciprocal effect of HIV-1 on STD acquisition...
  10. ncbi request reprint Correlates of human herpesvirus 8 seropositivity among heterosexual men in Kenya
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle 98104 2499, USA
    AIDS 16:2073-8. 2002
    ..However, few studies have examined heterosexual HHV-8 transmission, especially among African populations in which HHV-8 is endemic...
  11. ncbi request reprint Studies of human immunodeficiency virus type 1 mucosal viral shedding and transmission in Kenya
    J Overbaugh
    Program in Molecular Medicine, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 1024, USA
    J Infect Dis 179:S401-4. 1999
    ..Of interest, our data suggest that the complexity of the virus that is transmitted may be different in female and male sexual exposures...
  12. ncbi request reprint Infection with Trichomonas vaginalis increases the risk of HIV-1 acquisition
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Infect Dis 195:698-702. 2007
    ..52-fold (95% confidence interval, 1.04-2.24-fold) increased risk of HIV-1 acquisition after adjustment for potential confounding factors. Treatment and prevention of T. vaginalis infection could reduce HIV-1 risk in women...
  13. doi request reprint A prospective study of risk factors for bacterial vaginosis in HIV-1-seronegative African women
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Sex Transm Dis 35:617-23. 2008
    ..Bacterial vaginosis (BV) is common and has been associated with increased HIV-1 susceptibility. The objective of this study was to identify risk factors for BV in African women at high risk for acquiring HIV-1...
  14. ncbi request reprint Shedding of human herpesvirus 8 in oral and genital secretions from HIV-1-seropositive and -seronegative Kenyan women
    Melanie M Taylor
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Infect Dis 190:484-8. 2004
    ..1 [95% confidence interval, 1.1-4.0]). In HIV-1-seropositive women, there was no association between detection of HHV8 and either CD4 count or HIV-1 viral load...
  15. doi request reprint Improvement of vaginal health for Kenyan women at risk for acquisition of human immunodeficiency virus type 1: results of a randomized trial
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, USA
    J Infect Dis 197:1361-8. 2008
    ..Vaginal infections are common and have been associated with increased risk for acquisition of human immunodeficiency virus type 1 (HIV-1)...
  16. ncbi request reprint Impact of an alarm device on medication compliance in women in Mombasa, Kenya
    P A Frick
    Departments of Epidemiology and Medicine, University of Washington, Seattle, Washington, USA
    Int J STD AIDS 12:329-33. 2001
    ..In conclusion, the alarm device was found to significantly improve medication adherence rates and may be particularly beneficial for improving adherence to antiretroviral therapy among HIV-1 infected persons in developing countries...
  17. ncbi request reprint Effect of contraceptive methods on natural history of HIV: studies from the Mombasa cohort
    Jared M Baeten
    University of Washington, Seattle, WA, USA
    J Acquir Immune Defic Syndr 38:S18-21. 2005
  18. ncbi request reprint Vaginal washing and increased risk of HIV-1 acquisition among African women: a 10-year prospective study
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    AIDS 20:269-73. 2006
    ..No prospective study has examined the risk of HIV-1 acquisition associated with vaginal washing, although intravaginal practices have been identified as potentially important contributors to HIV-1 susceptibility...
  19. ncbi request reprint Virus load during primary Human Immunodeficiency Virus (HIV) type 1 infection is related to the severity of acute HIV illness in Kenyan women
    Ludo Lavreys
    University of Washington, Seattle, WA, 98104, USA
    Clin Infect Dis 35:77-81. 2002
    ..4 log(10) copies/mL...
  20. ncbi request reprint Associations between intravaginal practices and bacterial vaginosis in Kenyan female sex workers without symptoms of vaginal infections
    Wisal M Hassan
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Sex Transm Dis 34:384-8. 2007
    ..Bacterial vaginosis (BV) is highly prevalent among African women and has been associated with adverse pregnancy outcomes, sexually transmitted diseases, and HIV-1...
  21. ncbi request reprint A comparison of genital HIV-1 shedding and sexual risk behavior among Kenyan women based on eligibility for initiation of HAART according to WHO guidelines
    R Scott McClelland
    Departments of Medicine, University of Washington, Box 359909, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 41:611-5. 2006
    ..Guidelines for initiating antiretrovirals are based on markers of advanced disease and are not directly linked to markers of HIV-1 transmission such as viral shedding...
  22. ncbi request reprint The effect of hormonal contraception on genital tract shedding of HIV-1
    Chia C Wang
    Department of Medicine, University of Washington, Seattle, Washington 98104 2499, USA
    AIDS 18:205-9. 2004
    ..We conducted a prospective study to determine if cervical shedding of HIV-1 increased after initiating hormonal contraception...
  23. ncbi request reprint HIV-1 acquisition and disease progression are associated with decreased high-risk sexual behaviour among Kenyan female sex workers
    R Scott McClelland
    Departments of Medicine, University of Washington, 325 Ninth Avenue, Seattle, WA 98104, USA
    AIDS 20:1969-73. 2006
    ..Changes in sexual risk behaviour may occur following HIV-1 infection...
  24. ncbi request reprint Identification of modifiable factors that affect the genetic diversity of the transmitted HIV-1 population
    Manish Sagar
    Division of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, 1100 Fairview Avenue, Seattle, WA 98109, USA
    AIDS 18:615-9. 2004
    ..Infection with multiple viral variants was associated with higher plasma HIV-1 RNA levels and faster CD4 T-cell decline...
  25. ncbi request reprint A decrease in albumin in early HIV type 1 infection predicts subsequent disease progression
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington 98104, USA
    AIDS Res Hum Retroviruses 23:1197-200. 2007
    ..0, p = 0.008). Trends for an increased risk of mortality were also seen. A greater decrease in albumin levels accompanying HIV-1 acquisition may be a marker for changes in early infection associated with more rapid disease progression...
  26. ncbi request reprint Hormonal contraceptive use, herpes simplex virus infection, and risk of HIV-1 acquisition among Kenyan women
    Jared M Baeten
    Seattle HIV Prevention Trials Unit, Department of Medicine, University of Washington, 9012 Boren Avenue, Seattle, WA 98104, USA
    AIDS 21:1771-7. 2007
    ..A recent study from Uganda and Zimbabwe found that women using hormonal contraception were at increased risk for HIV-1 if they were seronegative for herpes simplex virus type 2 (HSV-2), but not if they were HSV-2 seropositive...
  27. ncbi request reprint Vitamin A deficiency and the acute phase response among HIV-1-infected and -uninfected women in Kenya
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle 98104 2499, USA
    J Acquir Immune Defic Syndr 31:243-9. 2002
    ..These results provide possible explanations for the disparity between observational studies and randomized trials of vitamin A for HIV-1 infection...
  28. ncbi request reprint Hormonal contraception and risk of HIV-1 acquisition: results of a 10-year prospective study
    Ludo Lavreys
    Departments of Epidemiology and Medicine, University of Washington, Seattle, WA, USA
    AIDS 18:695-7. 2004
  29. ncbi request reprint HIV type 1 variants transmitted to women in Kenya require the CCR5 coreceptor for entry, regardless of the genetic complexity of the infecting virus
    E Michelle Long
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    AIDS Res Hum Retroviruses 18:567-76. 2002
    ....
  30. ncbi request reprint Relationship between markers of HIV-1 disease progression and serum beta-carotene concentrations in Kenyan women
    Jared M Baeten
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Int J STD AIDS 18:202-6. 2007
    ....
  31. ncbi request reprint HIV-1 subtype D infection is associated with faster disease progression than subtype A in spite of similar plasma HIV-1 loads
    Jared M Baeten
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Infect Dis 195:1177-80. 2007
    ..There were no differences in plasma viral load by HIV-1 subtype during follow-up. HIV-1 subtype D infection is associated with a >2-fold higher risk of death than subtype A infection, in spite of similar plasma HIV-1 loads...
  32. pmc Comparison of human immunodeficiency virus type 1 viral loads in Kenyan women, men, and infants during primary and early infection
    Barbra A Richardson
    Department of Biostatistics, University of Washington and Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, 98104, USA
    J Virol 77:7120-3. 2003
    ....
  33. pmc Higher pre-infection vitamin E levels are associated with higher mortality in HIV-1-infected Kenyan women: a prospective study
    Susan M Graham
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    BMC Infect Dis 7:63. 2007
    ..However, vitamin E supplementation has also been reported to increase CCR5 expression, which could increase HIV-1 replication. We hypothesized that vitamin E levels at HIV-1 acquisition may influence disease progression...
  34. ncbi request reprint Injectable contraceptive use and genital ulcer disease during the early phase of HIV-1 infection increase plasma virus load in women
    Ludo Lavreys
    Department of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 189:303-11. 2004
    ..These findings suggest that, in women, the use of DMPA and the presence of GUD during the early phase of HIV-1 infection may influence the natural course of infection...
  35. ncbi request reprint High levels of cervical HIV-1 RNA during early HIV-1 infection
    Ludo Lavreys
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    AIDS 20:2389-90. 2006
    ..43 versus 2.85 log10 copies/swab, P < 0.001). After adjusting for HIV-1-plasma RNA, cervical HIV-1 RNA from 30 days or less after infection was increased by 0.45 log10 copies/swab (P = 0.006)...
  36. ncbi request reprint The influence of hormonal contraceptive use on HIV-1 transmission and disease progression
    Jared M Baeten
    Department of Medicine, University of Washington, Seattle, WA, USA
    Clin Infect Dis 45:360-9. 2007
    ..Safe and effective contraceptive choices are essential for women with and at risk for HIV-1 infection. Thus, understanding the effect, if any, of hormonal contraception on HIV-1 disease among women is a public health priority...
  37. ncbi request reprint Vitamin A supplementation and human immunodeficiency virus type 1 shedding in women: results of a randomized clinical trial
    Jared M Baeten
    Department of Epidemiology, University of Washington, 325 Ninth Avenue, Seattle, WA 98104 2499, USA
    J Infect Dis 185:1187-91. 2002
    ..Vitamin A supplementation is unlikely to decrease the infectivity of women infected with HIV-1...
  38. pmc Quantification of genital human immunodeficiency virus type 1 (HIV-1) DNA in specimens from women with low plasma HIV-1 RNA levels typical of HIV-1 nontransmitters
    Sarah Benki
    Department of Microbiology, University of Washington, Seattle, WA 98109, USA, and Coast Provincial General Hospital, Mombasa, Kenya
    J Clin Microbiol 44:4357-62. 2006
    ..The assay described here can be utilized in future efforts to examine the role of cell-associated HIV-1 in transmission...
  39. ncbi request reprint Diversity in HIV-1 envelope V1-V3 sequences early in infection reflects sequence diversity throughout the HIV-1 genome but does not predict the extent of sequence diversity during chronic infection
    Manish Sagar
    Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    AIDS Res Hum Retroviruses 22:430-7. 2006
    ..Analysis of HIV-1 sequences from about 3 years after infection revealed that the level of diversity and diversification was similar between the women in the two groups...
  40. ncbi request reprint Use of serum retinol-binding protein for prediction of vitamin A deficiency: effects of HIV-1 infection, protein malnutrition, and the acute phase response
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, WA 98104, USA
    Am J Clin Nutr 79:218-25. 2004
    ..The performance of RBP in the context of infection or protein malnutrition, however, has not been evaluated...
  41. ncbi request reprint Micronutrient supplementation increases genital tract shedding of HIV-1 in women: results of a randomized trial
    R Scott McClelland
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    J Acquir Immune Defic Syndr 37:1657-63. 2004
    ..The potential benefit of micronutrient supplementation in HIV-1-seropositive women should be considered in relation to the potential for increased infectivity...
  42. pmc Infection with multiple human immunodeficiency virus type 1 variants is associated with faster disease progression
    Manish Sagar
    Divisions of Human Biology, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington 98109, USA
    J Virol 77:12921-6. 2003
    ..01) 4 to 24 months after infection compared to women who were infected with a single viral genotype. These studies suggest that early HIV-1 genetic diversity is linked to faster disease progression...
  43. ncbi request reprint Female-to-male infectivity of HIV-1 among circumcised and uncircumcised Kenyan men
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 191:546-53. 2005
    ..e., infectivity) for circumcised and uncircumcised men, by use of detailed accounts of sexual behavior in a population with multiple partnerships...
  44. pmc Evidence for frequent reinfection with human immunodeficiency virus type 1 of a different subtype
    Bhavna Chohan
    Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave N, C3 168, Seattle, WA 98109 1024, USA
    J Virol 79:10701-8. 2005
    ..Our findings indicate an urgent need for studies of larger cohorts to determine the incidence and timing of both intersubtype and intrasubtype reinfection...
  45. ncbi request reprint Higher set point plasma viral load and more-severe acute HIV type 1 (HIV-1) illness predict mortality among high-risk HIV-1-infected African women
    Ludo Lavreys
    Department of Epidemiology, Medicine, and Biostatistics, University of Washington, Seattle, WA 98104 2499, USA
    Clin Infect Dis 42:1333-9. 2006
    ..We used data from a prospective cohort study of female sex workers in Mombasa, Kenya, who were followed up monthly from before the date of HIV-1 infection...
  46. ncbi request reprint HIV-1 infection alters the retinol-binding protein:transthyretin ratio even in the absence of the acute phase response
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, WA, USA
    J Nutr 136:1624-9. 2006
    ..Our results raise questions about the utility of this measurement given the high prevalence of HIV-1 infection in areas where vitamin A deficiency is common...
  47. ncbi request reprint Vitamin A supplementation and genital shedding of herpes simplex virus among HIV-1-infected women: a randomized clinical trial
    Jared M Baeten
    Department of Epidemiology, University of Washington, Seattle, Washington 98104 2499, USA
    J Infect Dis 189:1466-71. 2004
    ..Vitamin A supplementation is unlikely to decrease HSV shedding and infectivity...
  48. ncbi request reprint Human herpesvirus 8 seroconversion in Kenyan women by enzyme-linked immunosorbent assay and immunofluorescence assay
    Bhavna H Chohan
    Department of Medical Microbiology, University of Nairobi, Nairobi, Kenya
    J Clin Virol 30:137-44. 2004
    ..Human herpesvirus 8 (HHV-8) antibody tests vary in reported sensitivity and specificity, depending on the population tested and the assay...
  49. pmc Selection for human immunodeficiency virus type 1 envelope glycosylation variants with shorter V1-V2 loop sequences occurs during transmission of certain genetic subtypes and may impact viral RNA levels
    Bhavna Chohan
    Division of Human Biology, Fred Hutchinson Cancer Center, 1100 Fairview Ave N, C3 168 Seattle, WA 98109 1024, USA
    J Virol 79:6528-31. 2005
    ..Thus, our study also suggests that the extent of glycosylation in the infecting virus could impact disease progression...