Thomas Neil Williams

Summary

Affiliation: Kenya Medical Research Institute
Country: Kenya

Publications

  1. ncbi request reprint The membrane characteristics of Plasmodium falciparum-infected and -uninfected heterozygous alpha(0)thalassaemic erythrocytes
    Thomas Neil Williams
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Br J Haematol 118:663-70. 2002
  2. ncbi request reprint Reevaluation of flow cytometry for investigating antibody binding to the surface of Plasmodium falciparum trophozoite-infected red blood cells
    T N Williams
    Wellcome Trust Research Laboratories, Kilifi, Kenya
    Cytometry A 56:96-103. 2003
  3. ncbi request reprint Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya
    Thomas N Williams
    Wellcome Trust Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research, Kilifi, Kenya
    Blood 106:368-71. 2005
  4. pmc An immune basis for malaria protection by the sickle cell trait
    Thomas N Williams
    Kenya Medical Research Institute, Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya
    PLoS Med 2:e128. 2005
  5. pmc Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases
    Thomas N Williams
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya
    J Infect Dis 192:178-86. 2005
  6. pmc Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait
    Thomas N Williams
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, PO Box 230, Kilifi District Hospital, Kilifi, Kenya
    Nat Genet 37:1253-7. 2005
  7. ncbi request reprint Red blood cell defects and malaria
    Thomas N Williams
    KEMRI Wellcome Trust Collaborative Programme, P O Box 230, Kilifi, Kenya
    Mol Biochem Parasitol 149:121-7. 2006
  8. ncbi request reprint Human red blood cell polymorphisms and malaria
    Thomas N Williams
    KEMRI Wellcome Trust Collaborative Programme, Kilifi, Kenya
    Curr Opin Microbiol 9:388-94. 2006
  9. pmc Evidence for over-dispersion in the distribution of clinical malaria episodes in children
    Tabitha Wanja Mwangi
    Kenya Medical Research Institute, Centre for Geographic Medicine Research, Coast Wellcome Trust Collaborative Program, Kilifi, Kenya
    PLoS ONE 3:e2196. 2008

Detail Information

Publications9

  1. ncbi request reprint The membrane characteristics of Plasmodium falciparum-infected and -uninfected heterozygous alpha(0)thalassaemic erythrocytes
    Thomas Neil Williams
    Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    Br J Haematol 118:663-70. 2002
    ..We hypothesize that altered red-cell membrane band 3 protein may be a target for enhanced antibody binding to alpha-thalassaemic IRBCs and could be involved in the mechanism of malaria protection...
  2. ncbi request reprint Reevaluation of flow cytometry for investigating antibody binding to the surface of Plasmodium falciparum trophozoite-infected red blood cells
    T N Williams
    Wellcome Trust Research Laboratories, Kilifi, Kenya
    Cytometry A 56:96-103. 2003
    ..In recent years, flow cytometry has been used increasingly to investigate these responses, but few systematic assessments of this method are available in the published literature...
  3. ncbi request reprint Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya
    Thomas N Williams
    Wellcome Trust Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research, Kilifi, Kenya
    Blood 106:368-71. 2005
    ..Our study supports the conclusion that both heterozygotes and homozygotes enjoy a selective advantage against death from Plasmodium falciparum malaria...
  4. pmc An immune basis for malaria protection by the sickle cell trait
    Thomas N Williams
    Kenya Medical Research Institute, Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya
    PLoS Med 2:e128. 2005
    ....
  5. pmc Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseases
    Thomas N Williams
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya
    J Infect Dis 192:178-86. 2005
    ..Nevertheless, >50 years after this hypothesis was first proposed, the epidemiological description of the relationships between HbAS, malaria, and other common causes of child mortality remains incomplete...
  6. pmc Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell trait
    Thomas N Williams
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, PO Box 230, Kilifi District Hospital, Kilifi, Kenya
    Nat Genet 37:1253-7. 2005
    ..Negative epistasis could explain the failure of alpha(+)-thalassemia to reach fixation in any population in sub-Saharan Africa...
  7. ncbi request reprint Red blood cell defects and malaria
    Thomas N Williams
    KEMRI Wellcome Trust Collaborative Programme, P O Box 230, Kilifi, Kenya
    Mol Biochem Parasitol 149:121-7. 2006
    ..The challenge for the future must be to convert these advances into fresh approaches to the prevention and treatment of malaria...
  8. ncbi request reprint Human red blood cell polymorphisms and malaria
    Thomas N Williams
    KEMRI Wellcome Trust Collaborative Programme, Kilifi, Kenya
    Curr Opin Microbiol 9:388-94. 2006
    ..The challenge for the future must be to translate such advances into fresh approaches to the prevention and treatment of malaria...
  9. pmc Evidence for over-dispersion in the distribution of clinical malaria episodes in children
    Tabitha Wanja Mwangi
    Kenya Medical Research Institute, Centre for Geographic Medicine Research, Coast Wellcome Trust Collaborative Program, Kilifi, Kenya
    PLoS ONE 3:e2196. 2008
    ..The aim of this study was to identify this group of children and investigate possible causes for this increased susceptibility...