Thomas Neil Williams
Affiliation: Kenya Medical Research Institute
- The membrane characteristics of Plasmodium falciparum-infected and -uninfected heterozygous alpha(0)thalassaemic erythrocytesThomas Neil Williams
Molecular Parasitology Group, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
Br J Haematol 118:663-70. 2002..We hypothesize that altered red-cell membrane band 3 protein may be a target for enhanced antibody binding to alpha-thalassaemic IRBCs and could be involved in the mechanism of malaria protection...
- Reevaluation of flow cytometry for investigating antibody binding to the surface of Plasmodium falciparum trophozoite-infected red blood cellsT N Williams
Wellcome Trust Research Laboratories, Kilifi, Kenya
Cytometry A 56:96-103. 2003..In recent years, flow cytometry has been used increasingly to investigate these responses, but few systematic assessments of this method are available in the published literature...
- Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of KenyaThomas N Williams
Wellcome Trust Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research, Kilifi, Kenya
Blood 106:368-71. 2005..Our study supports the conclusion that both heterozygotes and homozygotes enjoy a selective advantage against death from Plasmodium falciparum malaria...
- An immune basis for malaria protection by the sickle cell traitThomas N Williams
Kenya Medical Research Institute, Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya
PLoS Med 2:e128. 2005....
- Sickle cell trait and the risk of Plasmodium falciparum malaria and other childhood diseasesThomas N Williams
Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi District Hospital, Kilifi, Kenya
J Infect Dis 192:178-86. 2005..Nevertheless, >50 years after this hypothesis was first proposed, the epidemiological description of the relationships between HbAS, malaria, and other common causes of child mortality remains incomplete...
- Negative epistasis between the malaria-protective effects of alpha+-thalassemia and the sickle cell traitThomas N Williams
Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, PO Box 230, Kilifi District Hospital, Kilifi, Kenya
Nat Genet 37:1253-7. 2005..Negative epistasis could explain the failure of alpha(+)-thalassemia to reach fixation in any population in sub-Saharan Africa...
- Red blood cell defects and malariaThomas N Williams
KEMRI Wellcome Trust Collaborative Programme, P O Box 230, Kilifi, Kenya
Mol Biochem Parasitol 149:121-7. 2006..The challenge for the future must be to convert these advances into fresh approaches to the prevention and treatment of malaria...
- Human red blood cell polymorphisms and malariaThomas N Williams
KEMRI Wellcome Trust Collaborative Programme, Kilifi, Kenya
Curr Opin Microbiol 9:388-94. 2006..The challenge for the future must be to translate such advances into fresh approaches to the prevention and treatment of malaria...
- Evidence for over-dispersion in the distribution of clinical malaria episodes in childrenTabitha Wanja Mwangi
Kenya Medical Research Institute, Centre for Geographic Medicine Research, Coast Wellcome Trust Collaborative Program, Kilifi, Kenya
PLoS ONE 3:e2196. 2008..The aim of this study was to identify this group of children and investigate possible causes for this increased susceptibility...