Ally Olotu

Summary

Affiliation: Kenya Medical Research Institute
Country: Kenya

Publications

  1. pmc Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age
    Philip Bejon
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    N Engl J Med 359:2521-32. 2008
  2. pmc Estimating individual exposure to malaria using local prevalence of malaria infection in the field
    Ally Olotu
    Kenya Medical Research Institute, Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Kilifi, Kenya
    PLoS ONE 7:e32929. 2012
  3. pmc Haemolytic uraemic syndrome in children admitted to a rural district hospital in Kenya
    Ally Ibrahim Olotu
    Centre for Geographic Medicine Research, Coast KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    Trop Doct 38:165-7. 2008
  4. pmc Characteristics and outcome of cardiopulmonary resuscitation in hospitalised African children
    A Olotu
    KEMRI Welcome Trust Collaborative Research, Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    Resuscitation 80:69-72. 2009
  5. pmc Defining clinical malaria: the specificity and incidence of endpoints from active and passive surveillance of children in rural Kenya
    Ally Olotu
    Kenya Medical Research Institute Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Kilifi, Kenya
    PLoS ONE 5:e15569. 2010
  6. pmc Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial
    Ally Olotu
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
    Lancet Infect Dis 11:102-9. 2011
  7. pmc A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E
    Francis M Ndungu
    Kenya Medical Research Institute, Centre for Geographical Medical Research Coast, Kilifi, Kenya
    PLoS ONE 7:e52870. 2012
  8. doi request reprint Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure
    Ally Olotu
    Centre for Geographic Medicine Research, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    N Engl J Med 368:1111-20. 2013
  9. pmc Effect of the pre-erythrocytic candidate malaria vaccine RTS,S/AS01E on blood stage immunity in young children
    Philip Bejon
    Kenya Medical Research Institute, Centre for Geographic Medicine Research, Kilifi, Kenya
    J Infect Dis 204:9-18. 2011
  10. pmc Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya
    Philip Bejon
    Kilifi KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 7:e1000304. 2010

Detail Information

Publications17

  1. pmc Efficacy of RTS,S/AS01E vaccine against malaria in children 5 to 17 months of age
    Philip Bejon
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    N Engl J Med 359:2521-32. 2008
    ..We evaluated the efficacy of RTS,S given with a more immunogenic adjuvant system (AS01E) in children 5 to 17 months of age, a target population for vaccine licensure...
  2. pmc Estimating individual exposure to malaria using local prevalence of malaria infection in the field
    Ally Olotu
    Kenya Medical Research Institute, Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Kilifi, Kenya
    PLoS ONE 7:e32929. 2012
    ..Analysis may be facilitated by taking into account the variability in individual exposure levels, but it is unclear how exposure can be estimated at an individual level...
  3. pmc Haemolytic uraemic syndrome in children admitted to a rural district hospital in Kenya
    Ally Ibrahim Olotu
    Centre for Geographic Medicine Research, Coast KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    Trop Doct 38:165-7. 2008
    ..Shigella dysenteriae was the most common isolated organism in the stool and Escherichia coli and S. dysenteriae were the most common blood isolates. HUS carries a high mortality rate and D-HUS is as common as D + HUS...
  4. pmc Characteristics and outcome of cardiopulmonary resuscitation in hospitalised African children
    A Olotu
    KEMRI Welcome Trust Collaborative Research, Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    Resuscitation 80:69-72. 2009
    ..To review the characteristics and outcome of cardiopulmonary resuscitation in children at a rural hospital in Kenya...
  5. pmc Defining clinical malaria: the specificity and incidence of endpoints from active and passive surveillance of children in rural Kenya
    Ally Olotu
    Kenya Medical Research Institute Wellcome Trust Research Programme, Centre for Geographic Medicine Research, Kilifi, Kenya
    PLoS ONE 5:e15569. 2010
    ..Subjective and objective fevers are both used to define the endpoint, but have not been carefully compared, and the relative incidence of clinical malaria by active and passive case detection is unknown...
  6. pmc Efficacy of RTS,S/AS01E malaria vaccine and exploratory analysis on anti-circumsporozoite antibody titres and protection in children aged 5-17 months in Kenya and Tanzania: a randomised controlled trial
    Ally Olotu
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
    Lancet Infect Dis 11:102-9. 2011
    ..We recently showed efficacy against clinical falciparum malaria in 5-17 month old children, during an average of 8 months follow-up. We aimed to assess the efficacy of RTS,S/AS01E during 15 months of follow-up...
  7. pmc A statistical interaction between circumsporozoite protein-specific T cell and antibody responses and risk of clinical malaria episodes following vaccination with RTS,S/AS01E
    Francis M Ndungu
    Kenya Medical Research Institute, Centre for Geographical Medical Research Coast, Kilifi, Kenya
    PLoS ONE 7:e52870. 2012
    ..002). Vaccination strategies that combine potent cellular and antibody responses may enhance protection against malaria...
  8. doi request reprint Four-year efficacy of RTS,S/AS01E and its interaction with malaria exposure
    Ally Olotu
    Centre for Geographic Medicine Research, Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    N Engl J Med 368:1111-20. 2013
    ..The candidate malaria vaccine RTS,S/AS01E has entered phase 3 trials, but data on long-term outcomes are limited...
  9. pmc Effect of the pre-erythrocytic candidate malaria vaccine RTS,S/AS01E on blood stage immunity in young children
    Philip Bejon
    Kenya Medical Research Institute, Centre for Geographic Medicine Research, Kilifi, Kenya
    J Infect Dis 204:9-18. 2011
    ..RTS,S/AS01(E) is the lead candidate malaria vaccine and confers pre-erythrocytic immunity. Vaccination may therefore impact acquired immunity to blood-stage malaria parasites after natural infection...
  10. pmc Stable and unstable malaria hotspots in longitudinal cohort studies in Kenya
    Philip Bejon
    Kilifi KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 7:e1000304. 2010
    ..This heterogeneity reduces the efficacy of control strategies, but also implies that focusing control strategies on "hotspots" of transmission could be highly effective...
  11. pmc Circumsporozoite-specific T cell responses in children vaccinated with RTS,S/AS01E and protection against P falciparum clinical malaria
    Ally Olotu
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    PLoS ONE 6:e25786. 2011
    ..falciparum. We studied CS-specific T cell responses in order to identify correlates of protection...
  12. pmc Lack of avidity maturation of merozoite antigen-specific antibodies with increasing exposure to Plasmodium falciparum amongst children and adults exposed to endemic malaria in Kenya
    Frances Ibison
    Kenya Medical Research Institute, Centre for Geographical Medicine Research Coast, Kilifi, Kenya
    PLoS ONE 7:e52939. 2012
    ....
  13. pmc Serological evidence of discrete spatial clusters of Plasmodium falciparum parasites
    Philip Bejon
    Centre for Geographic Medicine Research, Kenya Medical Research Institute Wellcome Trust Programme, Coast, Kilifi, Kenya
    PLoS ONE 6:e21711. 2011
    ..Since the Plasmodium falciparum Erythrocyte Membrane Protein 1 (PfEMP1) is highly polymorphic, the host's serological responses may be used to infer exposure to parasite sub-populations...
  14. pmc Efficacy of RTS,S malaria vaccines: individual-participant pooled analysis of phase 2 data
    Philip Bejon
    KEMRI Wellcome Trust Research Programme, Kenya Medical Research Institute, Kilifi, Kenya
    Lancet Infect Dis 13:319-27. 2013
    ..To ascertain variations in vaccine efficacy according to covariates such as transmission intensity, choice of adjuvant, age at vaccination, and bednet use, we did an individual-participant pooled analysis of phase 2 clinical data...
  15. pmc Feedback of research findings for vaccine trials: experiences from two malaria vaccine trials involving healthy children on the Kenyan Coast
    Caroline Gikonyo
    KEMRI Wellcome Trust Research Programme, 230, Kilifi, Coast 80108, Kenya
    Dev World Bioeth 13:48-56. 2013
    ....
  16. pmc Memory B cells are a more reliable archive for historical antimalarial responses than plasma antibodies in no-longer exposed children
    Francis Maina Ndungu
    Kenya Medical Research Institute, Centre for Geographical Medical Research Coast, Box 230, 80108 Kilifi, Kenya
    Proc Natl Acad Sci U S A 109:8247-52. 2012
    ..We conclude that serological analysis by itself would greatly underestimate the true memory of Pf-specific Ab responses in previously exposed children living in areas where Pf transmission has been reduced or eliminated...
  17. pmc Acute seizures attributable to falciparum malaria in an endemic area on the Kenyan coast
    Symon M Kariuki
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya, PO Box 230 Kilifi 80108, Kenya
    Brain 134:1519-28. 2011
    ..The reduction in malaria has decreased the burden of seizures that are attributable to malaria and this could lead to reduced neurological disabilities and epilepsy in the area...