D James Nokes

Summary

Affiliation: Kenya Medical Research Institute
Country: Kenya

Publications

  1. ncbi Respiratory syncytial virus epidemiology in a birth cohort from Kilifi district, Kenya: infection during the first year of life
    D James Nokes
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    J Infect Dis 190:1828-32. 2004
  2. pmc Incidence and severity of respiratory syncytial virus pneumonia in rural Kenyan children identified through hospital surveillance
    D James Nokes
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Clin Infect Dis 49:1341-9. 2009
  3. pmc Respiratory syncytial virus infection and disease in infants and young children observed from birth in Kilifi District, Kenya
    D James Nokes
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Clin Infect Dis 46:50-7. 2008
  4. pmc Genetic relatedness of infecting and reinfecting respiratory syncytial virus strains identified in a birth cohort from rural Kenya
    Charles N Agoti
    Kenya Medical Research Institute, Centre for Geographic Medicine Research, Coast, Kenya
    J Infect Dis 206:1532-41. 2012
  5. pmc The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya
    Rachel Ochola
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS ONE 4:e8088. 2009
  6. pmc Sensitivity of hospital-based surveillance for severe disease: a geographic information system analysis of access to care in Kilifi district, Kenya
    Jennifer C Moïsi
    KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    Bull World Health Organ 89:102-11. 2011
  7. pmc Influenza surveillance among children with pneumonia admitted to a district hospital in coastal Kenya, 2007-2010
    Clayton O Onyango
    KEMRI Wellcome Trust Research Programme, Kilifi District Hospital, Kilifi, Kenya
    J Infect Dis 206:S61-7. 2012
  8. pmc Severe lower respiratory tract infection in early infancy and pneumonia hospitalizations among children, Kenya
    Patrick Kiio Munywoki
    KEMRI Wellcome Trust Research Programme Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Emerg Infect Dis 19:223-9. 2013
  9. pmc Duration of shedding of respiratory syncytial virus in a community study of Kenyan children
    Emelda A Okiro
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Nairobi, Kenya
    BMC Infect Dis 10:15. 2010
  10. pmc Viral etiology of severe pneumonia among Kenyan infants and children
    James A Berkley
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    JAMA 303:2051-7. 2010

Detail Information

Publications24

  1. ncbi Respiratory syncytial virus epidemiology in a birth cohort from Kilifi district, Kenya: infection during the first year of life
    D James Nokes
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    J Infect Dis 190:1828-32. 2004
    ..RSV contributed significantly to total LRTI disease in this vaccine-target group...
  2. pmc Incidence and severity of respiratory syncytial virus pneumonia in rural Kenyan children identified through hospital surveillance
    D James Nokes
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Clin Infect Dis 49:1341-9. 2009
    ..Although necessary for developing a rationale for vaccination, the burden of severe respiratory syncytial virus (RSV) disease in children in resource-poor settings remains poorly defined...
  3. pmc Respiratory syncytial virus infection and disease in infants and young children observed from birth in Kilifi District, Kenya
    D James Nokes
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Clin Infect Dis 46:50-7. 2008
    ..In developing countries, there are few data that characterize the disease burden attributable to respiratory syncytial virus (RSV) and clearly define which age group to target for vaccine intervention...
  4. pmc Genetic relatedness of infecting and reinfecting respiratory syncytial virus strains identified in a birth cohort from rural Kenya
    Charles N Agoti
    Kenya Medical Research Institute, Centre for Geographic Medicine Research, Coast, Kenya
    J Infect Dis 206:1532-41. 2012
    ..Respiratory syncytial virus (RSV) reinfects individuals repeatedly. The extent to which this is a consequence of RSV antigenic diversity is unclear...
  5. pmc The level and duration of RSV-specific maternal IgG in infants in Kilifi Kenya
    Rachel Ochola
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS ONE 4:e8088. 2009
    ..The rate of decay of RSV-specific maternal antibodies (RSV-matAb), the factors affecting cord blood levels, and the relationship between these levels and protection from infection are poorly defined...
  6. pmc Sensitivity of hospital-based surveillance for severe disease: a geographic information system analysis of access to care in Kilifi district, Kenya
    Jennifer C Moïsi
    KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    Bull World Health Organ 89:102-11. 2011
    ..To explore the relationship between homestead distance to hospital and access to care and to estimate the sensitivity of hospital-based surveillance in Kilifi district, Kenya...
  7. pmc Influenza surveillance among children with pneumonia admitted to a district hospital in coastal Kenya, 2007-2010
    Clayton O Onyango
    KEMRI Wellcome Trust Research Programme, Kilifi District Hospital, Kilifi, Kenya
    J Infect Dis 206:S61-7. 2012
    ..Influenza data gaps in sub-Saharan Africa include incidence, case fatality, seasonal patterns, and associations with prevalent disorders...
  8. pmc Severe lower respiratory tract infection in early infancy and pneumonia hospitalizations among children, Kenya
    Patrick Kiio Munywoki
    KEMRI Wellcome Trust Research Programme Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Emerg Infect Dis 19:223-9. 2013
    ..Excess pneumonia risk persisted for 2 years after the initial hospitalization. Close postdischarge follow-up of infants with LRTI, with or without RSV, could help prevent severe pneumonia later in childhood...
  9. pmc Duration of shedding of respiratory syncytial virus in a community study of Kenyan children
    Emelda A Okiro
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Nairobi, Kenya
    BMC Infect Dis 10:15. 2010
    ..Our understanding of the transmission dynamics of respiratory syncytial virus (RSV) infection will be better informed with improved data on the patterns of shedding in cases not limited only to hospital admissions...
  10. pmc Viral etiology of severe pneumonia among Kenyan infants and children
    James A Berkley
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    JAMA 303:2051-7. 2010
    ..Pneumonia is the leading cause of childhood death in sub-Saharan Africa. Comparative estimates of the contribution of causative pathogens to the burden of disease are essential for targeted vaccine development...
  11. pmc Improved detection of respiratory viruses in pediatric outpatients with acute respiratory illness by real-time PCR using nasopharyngeal flocked swabs
    Patrick Kiio Munywoki
    KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    J Clin Microbiol 49:3365-7. 2011
    ..6% versus 79.2%; P = 0.0043). NFS collection was noninferior to NW collection in the detection of RSV by IF...
  12. pmc Group- and genotype-specific neutralizing antibody responses against respiratory syncytial virus in infants and young children with severe pneumonia
    Charles J Sande
    KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    J Infect Dis 207:489-92. 2013
    ..4) or BA virus (50% vs 65%; P = .4). The RSV neutralizing response is group specific. The BA-associated genetic change did not confer an ability to escape neutralizing responses to previous non-BA viruses...
  13. pmc Rotavirus genetic diversity, disease association, and temporal change in hospitalized rural Kenyan children
    D James Nokes
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    J Infect Dis 202:S180-6. 2010
    ..Longitudinal surveillance of disease-causing strains is a prerequisite to intervention...
  14. pmc Identification of group B respiratory syncytial viruses that lack the 60-nucleotide duplication after six consecutive epidemics of total BA dominance at coastal Kenya
    Charles N Agoti
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute KEMRI, Kilifi, Kenya
    Influenza Other Respir Viruses 7:1008-12. 2013
    ..These results are of relevance to an understanding of RSV persistence. ..
  15. pmc Treatment failure among Kenyan children with severe pneumonia--a cohort study
    Clare Webb
    Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research, Kilifi, Kenya
    Pediatr Infect Dis J 31:e152-7. 2012
    ..Pneumonia is the leading cause of childhood mortality worldwide. The World Health Organization recommends presumptive treatment based on clinical syndromes. Recent studies raise concerns over the frequency of treatment failure in Africa...
  16. pmc Identifying infections with respiratory syncytial virus by using specific immunoglobulin G (IgG) and IgA enzyme-linked immunosorbent assays with oral-fluid samples
    Emelda A Okiro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
    J Clin Microbiol 46:1659-62. 2008
    ..Our data show significant promise for the use of oral fluid alone in RSV infection surveillance. The observed rapid dynamics of the antibody responses are informative in defining study sampling intervals...
  17. pmc Added value of an oropharyngeal swab in detection of viruses in children hospitalized with lower respiratory tract infection
    Laura L Hammitt
    KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    J Clin Microbiol 49:2318-20. 2011
    ..Oropharyngeal swabs increased the number of viral infections detected by 15%, compared to collection of a nasopharyngeal swab alone. This advantage was most pronounced for detection of influenza, parainfluenza, and adenovirus...
  18. pmc Intrapatient variation of the respiratory syncytial virus attachment protein gene
    Charles N Agoti
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    J Virol 84:10425-8. 2010
    ..Of particular note, the deletion of the exact portion of the gene which had been duplicated in some isolates was observed in viral RNAs from two patients...
  19. pmc Emergency triage assessment for hypoxaemia in neonates and young children in a Kenyan hospital: an observational study
    Michael K Mwaniki
    Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
    Bull World Health Organ 87:263-70. 2009
    ....
  20. pmc Seroprevalence, predictors and estimated incidence of maternal and neonatal Herpes Simplex Virus type 2 infection in semi-urban women in Kilifi, Kenya
    Joyce U Nyiro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    BMC Infect Dis 11:155. 2011
    ..Little is known of its epidemiology and burden in Coastal Kenya...
  21. pmc Incidence and clinical characteristics of group A rotavirus infections among children admitted to hospital in Kilifi, Kenya
    D James Nokes
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 5:e153. 2008
    ..The study objective was to accurately define the incidence and severity of group A rotavirus disease in a resource-poor setting necessary to make informed decisions on the need for vaccine prevention...
  22. ncbi Molecular epidemiology of respiratory syncytial virus in Kilifi district, Kenya
    Paul D Scott
    Division of Immunity and Infection, University of Birmingham, Birmingham, United Kingdom
    J Med Virol 74:344-54. 2004
    ..Samples from different sources, clearly differing in disease severity, did not differ in genotype characteristics, suggesting that disease causing variants are a general reflection of infections within this community...
  23. ncbi Comparison of strain-specific antibody responses during primary and secondary infections with respiratory syncytial virus
    Paul D Scott
    Department of Biological Sciences, University of Warwick, Coventry, UK
    J Med Virol 79:1943-50. 2007
    ..In conclusion, the strain-specific nature of the serum antibody response to the variable regions of the G protein of RSV observed in primary infections can become cross-reactive in subsequent reinfections...
  24. pmc On the determinants of population structure in antigenically diverse pathogens
    M Gabriela M Gomes
    Ecology and Epidemiology Group, Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    Proc Biol Sci 269:227-33. 2002
    ..Results are robust to strain number, but sensitive to the mechanism of cumulative immunity...