C R Newton

Summary

Affiliation: Kenya Medical Research Institute
Country: Kenya

Publications

  1. pmc Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malaria
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research, Kenya
    Malar J 4:57. 2005
  2. pmc The prognostic value of measures of acid/base balance in pediatric falciparum malaria, compared with other clinical and laboratory parameters
    Charles R J C Newton
    Institute of Child Health, St George s Hospital Medical School, London, United Kingdom
    Clin Infect Dis 41:948-57. 2005
  3. ncbi request reprint Interaction between Plasmodium falciparum and human immunodeficiency virus type 1 on the central nervous system of African children
    Charles R J C Newton
    Neurosciences Unit, Institute of Child Health, London, United Kingdom
    J Neurovirol 11:45-51. 2005
  4. pmc Cerebral malaria
    C R Newton
    Neurosciences Unit, Institute of Child Health, London, United Kingdom
    J Neurol Neurosurg Psychiatry 69:433-41. 2000
  5. ncbi request reprint Diagnosis of acute bacterial meningitis in children at a district hospital in sub-Saharan Africa
    J A Berkley
    Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi, Kenya
    Lancet 357:1753-7. 2001
  6. ncbi request reprint High-performance liquid chromatographic determination of diazepam in plasma of children with severe malaria
    S N Muchoh
    Kenya Medical Research Institute Wellcome Trust Collaborative Research Programme, Nairobi
    J Chromatogr B Biomed Sci Appl 761:255-9. 2001
  7. ncbi request reprint Determination of lorazepam in plasma from children by high-performance liquid chromatography with UV detection
    Simon N Muchohi
    Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, P O Box 43640, 00100 GPO, Nairobi, Kenya
    J Chromatogr B Analyt Technol Biomed Life Sci 824:333-40. 2005
  8. pmc Management of severe malaria in children: proposed guidelines for the United Kingdom
    Kathryn Maitland
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi, Kenya
    BMJ 331:337-43. 2005
  9. ncbi request reprint Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children
    Simon N Muchohi
    Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, PO Box 43640, 00100 GPO, Nairobi
    J Chromatogr B Analyt Technol Biomed Life Sci 821:1-7. 2005
  10. ncbi request reprint Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya
    Thomas N Williams
    Wellcome Trust Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research, Kilifi, Kenya
    Blood 106:368-71. 2005

Detail Information

Publications58

  1. pmc Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malaria
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research, Kenya
    Malar J 4:57. 2005
    ..Abnormal motor posturing is often observed in children with cerebral malaria, but the aetiology and pathogenesis is poorly understood. This study examined the risk factors and outcome of posturing in Kenyan children with cerebral malaria...
  2. pmc The prognostic value of measures of acid/base balance in pediatric falciparum malaria, compared with other clinical and laboratory parameters
    Charles R J C Newton
    Institute of Child Health, St George s Hospital Medical School, London, United Kingdom
    Clin Infect Dis 41:948-57. 2005
    ..In this large, prospective study, we examined the prognostic value of acidosis and hyperlactatemia and compared these markers to clinically assessed variables...
  3. ncbi request reprint Interaction between Plasmodium falciparum and human immunodeficiency virus type 1 on the central nervous system of African children
    Charles R J C Newton
    Neurosciences Unit, Institute of Child Health, London, United Kingdom
    J Neurovirol 11:45-51. 2005
    ..The coinfection of malaria and HIV-1 may aggravate the neurodevelopmental impairments documented in these children. However, to date there are little published data, although it may have a profound effect of children living in SSA...
  4. pmc Cerebral malaria
    C R Newton
    Neurosciences Unit, Institute of Child Health, London, United Kingdom
    J Neurol Neurosurg Psychiatry 69:433-41. 2000
    ..Neurological sequelae are increasingly recognised, but further research on the pathogenesis of coma and neurological damage is required to develop other ancillary treatments...
  5. ncbi request reprint Diagnosis of acute bacterial meningitis in children at a district hospital in sub-Saharan Africa
    J A Berkley
    Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi, Kenya
    Lancet 357:1753-7. 2001
    ..We have assessed the value of non-laboratory tests and incomplete laboratory data in diagnosing childhood acute bacterial meningitis in this setting...
  6. ncbi request reprint High-performance liquid chromatographic determination of diazepam in plasma of children with severe malaria
    S N Muchoh
    Kenya Medical Research Institute Wellcome Trust Collaborative Research Programme, Nairobi
    J Chromatogr B Biomed Sci Appl 761:255-9. 2001
    ..This method has been used for monitoring plasma diazepam concentrations in children with seizures associated with severe malaria...
  7. ncbi request reprint Determination of lorazepam in plasma from children by high-performance liquid chromatography with UV detection
    Simon N Muchohi
    Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, P O Box 43640, 00100 GPO, Nairobi, Kenya
    J Chromatogr B Analyt Technol Biomed Life Sci 824:333-40. 2005
    ..The method has been successfully applied to a pharmacokinetic study of LZP in children with severe malaria and convulsions following administration of a single intravenous dose (0.1 mg/kg body weight) of LZP...
  8. pmc Management of severe malaria in children: proposed guidelines for the United Kingdom
    Kathryn Maitland
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi, Kenya
    BMJ 331:337-43. 2005
  9. ncbi request reprint Determination of midazolam and its major metabolite 1'-hydroxymidazolam by high-performance liquid chromatography-electrospray mass spectrometry in plasma from children
    Simon N Muchohi
    Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, PO Box 43640, 00100 GPO, Nairobi
    J Chromatogr B Analyt Technol Biomed Life Sci 821:1-7. 2005
    ..The method was successfully applied to a pharmacokinetic study of MDZ and 1'-OHM in children with severe malaria and convulsions following administration of MDZ either intravenously (i.v.) or intramuscularly (i.m.)...
  10. ncbi request reprint Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya
    Thomas N Williams
    Wellcome Trust Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research, Kilifi, Kenya
    Blood 106:368-71. 2005
    ..Our study supports the conclusion that both heterozygotes and homozygotes enjoy a selective advantage against death from Plasmodium falciparum malaria...
  11. ncbi request reprint The burden of the neurocognitive impairment associated with Plasmodium falciparum malaria in sub-saharan Africa
    Victor Mung'ala-Odera
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Am J Trop Med Hyg 71:64-70. 2004
    ..The figure is likely to be considerably higher, since these estimates do not include neurocognitive impairment following non-cerebral malaria in children or adults in stable endemic areas, or populations in low stable or epidemic areas...
  12. ncbi request reprint Indicators of acute bacterial meningitis in children at a rural Kenyan district hospital
    James A Berkley
    Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Pediatrics 114:e713-9. 2004
    ....
  13. pmc Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study
    James A Berkley
    Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi, Kenya
    BMJ 330:995. 2005
    ..To determine how well antibiotic treatment is targeted by simple clinical syndromes and to what extent drug resistance threatens affordable antibiotics...
  14. ncbi request reprint Perturbations in electrolyte levels in kenyan children with severe malaria complicated by acidosis
    Kathryn Maitland
    Centre for Geographic Medicine Research, Coast, Kenyan Medical Research Unit, Kilifi, Kenya
    Clin Infect Dis 40:9-16. 2005
    ..To date, information about the frequency of electrolyte disturbances among children with severe falciparum malaria is limited...
  15. ncbi request reprint Acidosis of severe falciparum malaria: heading for a shock?
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kenya, PO Box 230, Kilifi, Kenya
    Trends Parasitol 21:11-6. 2005
    ..We summarize the results of recent clinical trials examining the safety and efficacy of volume expansion in children with 'cerebral malaria' complicated by acidosis...
  16. ncbi request reprint Developmental impairments following severe falciparum malaria in children
    Julie A Carter
    Neurosciences Unit, Institute of Child Health, London, UK
    Trop Med Int Health 10:3-10. 2005
    ..Thus, our objective was to investigate the long-term developmental outcome of CM and malaria with complicated seizures (M/S)...
  17. ncbi request reprint Chloramphenicol pharmacokinetics in African children with severe malaria
    Gilbert O Kokwaro
    Department of Pharmaceutics and Pharmacy Practice, Faculty of Pharmacy, University of Nairobi, Nairobi, Kenya
    J Trop Pediatr 52:239-43. 2006
    ..The current dosage regimen for CAP needs to include a loading dose of 40 mg/kg CAPS to rapidly achieve plasma CAP concentrations within the reported therapeutic range...
  18. ncbi request reprint Increased prevalence of epilepsy associated with severe falciparum malaria in children
    Julie A Carter
    Neurosciences Unit, Institute of Child Health, The Wolfson Centre, London, United Kingdom
    Epilepsia 45:978-81. 2004
    ..The relation between falciparum malaria and epilepsy is undetermined; thus we measured the prevalence and characteristics of epilepsy in children with a history of severe malaria...
  19. ncbi request reprint Pathogenesis, clinical features, and neurological outcome of cerebral malaria
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Insitute, Kilifi, Kenya
    Lancet Neurol 4:827-40. 2005
    ..We also summarise recent studies of persisting neurocognitive impairments in children who survive cerebral malaria and suggest areas for further research...
  20. ncbi request reprint Malaria: pathogenicity and disease
    Mike English
    Center for Geographic Medicine Research, Kenya Medical Research Institute, Wellcome Trust Research Laboratories, PO Box 230, Kilifi, Kenya
    Chem Immunol 80:50-69. 2002
  21. ncbi request reprint The effect of Plasmodium falciparum on cognition: a systematic review
    Michael Kihara
    The Centre for Geographical Medicine Research Coast, KEMRI, Kilifi, Kenya
    Trop Med Int Health 11:386-97. 2006
    ..Systematic review to investigate the relationship between Plasmodium falciparum infection and cognitive function...
  22. ncbi request reprint Pre-transfusion management of children with severe malarial anaemia: a randomised controlled trial of intravascular volume expansion
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kenya
    Br J Haematol 128:393-400. 2005
    ..The impact on mortality should be assessed where blood transfusion services are unable to supply emergency transfusions...
  23. pmc Phenytoin pharmacokinetics and clinical effects in African children following fosphenytoin and chloramphenicol coadministration
    Bernhards R Ogutu
    Kenya Medical Research Institute KEMRI Wellcome Trust Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Br J Clin Pharmacol 54:635-42. 2002
    ..Since chloramphenicol inhibits the metabolism of phenytoin in vivo, we studied the effects of chloramphenicol on phenytoin pharmacokinetics in children with malaria...
  24. pmc Hypothetical performance of syndrome-based management of acute paediatric admissions of children aged more than 60 days in a Kenyan district hospital
    Mike English
    Centre for Geographic Medicine Research, Kenya Medical Research Institute Wellcome Trust Research Laboratories, Kilifi, Kenya
    Bull World Health Organ 81:166-73. 2003
    ....
  25. pmc Pharmacokinetics and clinical effects of phenytoin and fosphenytoin in children with severe malaria and status epilepticus
    Bernhards R Ogutu
    Kenya Medical Research Institute Centre for Geographic Medicine Research Coast Wellcome Trust Collaborative Research Programme, Kilifi, Kenya
    Br J Clin Pharmacol 56:112-9. 2003
    ..We studied the pharmacokinetics and clinical effects of phenytoin and fosphenytoin sodium in children with severe falciparum malaria and status epilepticus...
  26. pmc Pharmacokinetics and clinical effect of phenobarbital in children with severe falciparum malaria and convulsions
    Gilbert O Kokwaro
    Kenya Medical Research Institute Centre for Geographic Medicine Research Coast Wellcome Trust Collaborative Research Programme, Kilifi, Kenya
    Br J Clin Pharmacol 56:453-7. 2003
    ..We evaluated a 15-mg kg(-1) intravenous (i.v.) dose of phenobarbital to determine its pharmacokinetics and clinical effects in children with severe falciparum malaria and status epilepticus...
  27. ncbi request reprint Malaria
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kilifi, Kenya
    Curr Opin Infect Dis 16:389-95. 2003
    ..This review addresses recent developments that relate to the pathogenesis of severe malaria and its treatment, and also highlights the increase in the global burden of malaria and provides a summary of clinical trials of malaria vaccines...
  28. ncbi request reprint Severe falciparum malaria and acquired childhood language disorder
    Julie A Carter
    Neurosciences Unit, Institute of Child Health, The Wolfson Centre, London, UK
    Dev Med Child Neurol 48:51-7. 2006
    ..04) was associated with significantly increased odds of an impairment-level score relative to the unexposed group. The results suggest that falciparum malaria is one of the most common causes of acquired language disorders in the tropics...
  29. ncbi request reprint Neuro-cognitive impairment following acquired central nervous system infections in childhood: a systematic review
    Julie A Carter
    Neurosciences Unit, Institute of Child Health, The Wolfson Centre, Mecklenburgh Square, WC1N 2AP, London, UK
    Brain Res Brain Res Rev 43:57-69. 2003
    ..Higher morbidity for similar mortality in acute bacterial meningitis compared with cerebral malaria in the epidemiological data may suggest future research directions for clinical research to devise more effective interventions...
  30. ncbi request reprint Oxidative stress and erythrocyte damage in Kenyan children with severe Plasmodium falciparum malaria
    M J Griffiths
    Institute of Child Health, University College London, London, UK
    Br J Haematol 113:486-91. 2001
    ..Erythrocyte membrane alpha-tocopherol appeared a better indicator of ROS exposure than plasma...
  31. ncbi request reprint Neurological manifestations of falciparum malaria
    C R Newton
    Neuroscience s Unit, Institute of Child Health, London, United Kingdom
    Ann Neurol 43:695-702. 1998
    ..In addition, new antimalarial agents have been examined worldwide and initial studies on supportive studies conducted. This paper reviews these new advances, putting them into the perspective of the more established knowledge...
  32. pmc Using community/researcher partnerships to develop a culturally relevant intervention for children with communication disabilities in Kenya
    Sally Hartley
    Centre for International Health and Development, Institute of Child Health, London, UK
    Disabil Rehabil 31:490-9. 2009
    ..The resulting intervention is for use in a randomized control trial which will be reported at a later stage...
  33. doi request reprint Paediatric coma scales
    Fenella J Kirkham
    Neurosciences Unit, Institute of Child Health, University College London, London, UK
    Dev Med Child Neurol 50:267-74. 2008
    ..This review looks at the recent history of the development of coma scales and the rationale for recommending the CGCS...
  34. pmc Pharmacokinetics and clinical efficacy of lorazepam in children with severe malaria and convulsions
    Simon N Muchohi
    Kenya Medical Research Institute Wellcome Trust Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Br J Clin Pharmacol 65:12-21. 2008
    ..To investigate the pharmacokinetics and clinical efficacy of intravenous (i.v.) and intramuscular (i.m.) lorazepam (LZP) in children with severe malaria and convulsions...
  35. ncbi request reprint Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo
    Climent Casals-Pascual
    Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford OX3 9BQ, United Kingdom
    Blood 108:2569-77. 2006
    ..Taken together, these observations provide compelling evidence for inhibition of erythropoiesis by Hz...
  36. ncbi request reprint Role of viruses in Kenyan children presenting with acute encephalopathy in a malaria-endemic area
    Christian D Schubart
    Academical Medical Centre, University of Amsterdam, Department of Medical Microbiology, Laboratory of Clinical Virology, Amsterdam, The Netherlands
    Am J Trop Med Hyg 75:1148-50. 2006
    ..A significant proportion of children who fulfil the WHO clinical definition of CM may have viral encephalitis...
  37. ncbi request reprint Axonal and astrocyte injury markers in the cerebrospinal fluid of Kenyan children with severe malaria
    Isabelle M Medana
    Nuffield Department of Clinical Laboratory Sciences, Academic Block, Level 4, The John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
    J Neurol Sci 258:93-8. 2007
    ..This study provides evidence that axonal injury is associated with malaria coma and identifies the potential role of severe anaemia, acidosis and hyperparasitaemia to causing brain parenchymal damage in children with malaria...
  38. pmc Defining childhood severe falciparum malaria for intervention studies
    Philip Bejon
    Kenya Medical Research Institute KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 4:e251. 2007
    ....
  39. doi request reprint Paediatric HIV and neurodevelopment in sub-Saharan Africa: a systematic review
    Amina Abubakar
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Trop Med Int Health 13:880-7. 2008
    ..To determine the degree of motor, cognitive, language and social-emotional impairment related to HIV infection in children living in sub-Saharan Africa (SSA)...
  40. ncbi request reprint Cerebral malaria: optimising management
    Neema Mturi
    Kenya Medical Research Institute Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    CNS Drugs 17:153-65. 2003
    ..Other adjuncts have not been adequately tested. Further research is required on drugs that interfere with the pathophysiological processes to prevent neurological complications and death...
  41. ncbi request reprint Plasmodium falciparum malaria in a hypoendemic region in Senegal
    Shamez Ladhani
    Am J Trop Med Hyg 68:379-80; author reply 380-1. 2003
  42. ncbi request reprint Acute bacterial meningitis in children admitted to a rural Kenyan hospital: increasing antibiotic resistance and outcome
    Isaiah Mwangi
    Kenya Medical Research Institute, Center for Geographic Medicine Research Coast, Kilifi, Kenya
    Pediatr Infect Dis J 21:1042-8. 2002
    ..Acute bacterial meningitis (ABM) is an important cause of mortality in Africa, but most studies are based in urban referral hospitals. Poor laboratory facilities make diagnosis difficult, and treatment is limited to inexpensive antibiotics...
  43. ncbi request reprint Antibodies to voltage-gated calcium channels in children with falciparum malaria
    Bethan Lang
    Neurosciences, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK
    J Infect Dis 191:117-21. 2005
    ..Here, we show that, in a cohort of Kenyan children, levels of antibodies to the voltage-gated calcium channels, but not to other ion channels, increased with the severity of malaria infection...
  44. ncbi request reprint Carboxyhemoglobin levels in Kenyan children with Plasmodium falciparum malaria
    Aubrey J Cunnington
    Department of Paediatrics, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom
    Am J Trop Med Hyg 71:43-7. 2004
    ..These results do not support a systemic increase in HO activity in malaria compared with other infectious diseases, but the roles of HO and CO in malaria require further study...
  45. ncbi request reprint Management of severe falciparum malaria in African children
    Charles R J C Newton
    Trop Doct 34:65. 2004
  46. ncbi request reprint Traumatic lumbar punctures
    James A Berkley
    Pediatrics 113:172; author reply 172. 2004
  47. ncbi request reprint Hypokalemia in children with severe falciparum malaria
    Kathryn Maitland
    Centre for Geographic Medicine Research, Coast, KEMRI, Kenya
    Pediatr Crit Care Med 5:81-5. 2004
    ..Alterations in plasma potassium concentrations are commonly associated with acidosis. To date, there is little information about the changes in potassium in severe malaria...
  48. ncbi request reprint Response to volume resuscitation in children with severe malaria
    Kathryn Maitland
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Pediatr Crit Care Med 4:426-31. 2003
    ..To examine whether hypovolemia is an important cause of the acidosis in children with severe malaria...
  49. ncbi request reprint Thrombocytopenia in falciparum malaria is associated with high concentrations of IL-10
    Climent Casals-Pascual
    Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford, United Kingdom
    Am J Trop Med Hyg 75:434-6. 2006
    ..Taken together, these data suggest why thrombocytopenia has a complex relationship with severe disease and suggest one mechanism whereby IL-10 may modify the outcome of severe disease...
  50. ncbi request reprint Changes in white blood cells and platelets in children with falciparum malaria: relationship to disease outcome
    Shamez Ladhani
    Centre for Geographical Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Br J Haematol 119:839-47. 2002
    ..Thus, leucocytosis was associated with both severity and mortality in children with falciparum malaria, irrespective of bacteraemia, whereas thrombocytopenia, although very common, was not associated with adverse outcome...
  51. ncbi request reprint Determination of paraldehyde by gas chromatography in whole blood from children
    Isaiah M Githiga
    Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme Centre for Geographic Medicine Research Coast, 80108 Kilifi
    J Chromatogr B Analyt Technol Biomed Life Sci 805:365-9. 2004
    ..The method was successfully applied for pharmacokinetic studies of paraldehyde in children with convulsions associated with severe malaria...
  52. pmc High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malaria
    Climent Casals-Pascual
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, and National Blood Service, John Radcliffe Hospital, Headington, Oxford OX3 9BQ, United Kingdom
    Proc Natl Acad Sci U S A 105:2634-9. 2008
    ..The age-dependent Epo response to anemia and the age-dependent protective effect may influence the clinical epidemiology of CM. These data support further study of Epo as an adjuvant therapy in CM...
  53. pmc Over-diagnosis and co-morbidity of severe malaria in African children: a guide for clinicians
    Samson Gwer
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Am J Trop Med Hyg 77:6-13. 2007
    ..Published data on co-morbidity with HIV infection and malnutrition are reviewed. A structured approach to assessment and care is essential, and is largely independent of underlying etiology...
  54. ncbi request reprint Neurological and developmental outcome of neonatal jaundice and sepsis in rural Kenya
    Anne L Gordon
    Centre for Geographic Medicine Research Coast, KEMRI Wellcome Trust Research Laboratories, Kilifi, Kenya
    Trop Med Int Health 10:1114-20. 2005
    ..Since NS is common in resource poor countries, this may be an important cause of neuro-developmental impairment in children living in this setting...
  55. pmc Immunization coverage and risk factors for failure to immunize within the Expanded Programme on Immunization in Kenya after introduction of new Haemophilus influenzae type b and hepatitis b virus antigens
    Moses Ndiritu
    Wellcome Trust Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    BMC Public Health 6:132. 2006
    ..We estimated immunization coverage before and after introduction, timeliness of vaccination and risk factors for failure to immunize in Kilifi district, Kenya...
  56. pmc Effectiveness of Haemophilus influenzae type b Conjugate vaccine introduction into routine childhood immunization in Kenya
    Karen D Cowgill
    Epidemic Intelligence Service, Epidemiology Program Office, Division of Applied Public Health Training, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA
    JAMA 296:671-8. 2006
    ..Haemophilus influenzae type b (Hib) conjugate vaccine is not perceived as a public health priority in Africa because data on Hib disease burden and vaccine effectiveness are scarce. Hib immunization was introduced in Kenyan infants in 2001...
  57. pmc Children with severe malnutrition: can those at highest risk of death be identified with the WHO protocol?
    Kathryn Maitland
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    PLoS Med 3:e500. 2006
    ....
  58. pmc Effect of a fall in malaria transmission on morbidity and mortality in Kilifi, Kenya
    Wendy P O'Meara
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Wellcome Trust Collaborative Program, Kilifi, Kenya Fogarty International Center, National Institutes of Health, Bethesda, MD, USA
    Lancet 372:1555-62. 2008
    ..We aimed to assess the epidemiological characteristics of malaria in Kilifi, Kenya, during a period of decreasing transmission intensity...