K Maitland

Summary

Affiliation: Kenya Medical Research Institute
Country: Kenya

Publications

  1. ncbi request reprint Acidosis of severe falciparum malaria: heading for a shock?
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kenya, PO Box 230, Kilifi, Kenya
    Trends Parasitol 21:11-6. 2005
  2. pmc Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malaria
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research, Kenya
    Malar J 4:57. 2005
  3. ncbi request reprint Perturbations in electrolyte levels in kenyan children with severe malaria complicated by acidosis
    Kathryn Maitland
    Centre for Geographic Medicine Research, Coast, Kenyan Medical Research Unit, Kilifi, Kenya
    Clin Infect Dis 40:9-16. 2005
  4. ncbi request reprint HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia
    K Maitland
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK
    Tissue Antigens 64:678-86. 2004
  5. ncbi request reprint Pre-transfusion management of children with severe malarial anaemia: a randomised controlled trial of intravascular volume expansion
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kenya
    Br J Haematol 128:393-400. 2005
  6. ncbi request reprint Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Clin Infect Dis 40:538-45. 2005
  7. ncbi request reprint Falciparum malaria: current therapeutic challenges
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kilifi, Kenya
    Curr Opin Infect Dis 17:405-12. 2004
  8. ncbi request reprint Pathophysiology of severe malaria in children
    Kathryn Maitland
    The Centre for Geographic Medicine Research Coast, KEMRI, Kenya, P O Box 230, Kilifi, Kenya
    Acta Trop 90:131-40. 2004
  9. pmc Management of severe malaria in children: proposed guidelines for the United Kingdom
    Kathryn Maitland
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi, Kenya
    BMJ 331:337-43. 2005
  10. ncbi request reprint Malaria
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kilifi, Kenya
    Curr Opin Infect Dis 16:389-95. 2003

Detail Information

Publications57

  1. ncbi request reprint Acidosis of severe falciparum malaria: heading for a shock?
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kenya, PO Box 230, Kilifi, Kenya
    Trends Parasitol 21:11-6. 2005
    ..We summarize the results of recent clinical trials examining the safety and efficacy of volume expansion in children with 'cerebral malaria' complicated by acidosis...
  2. pmc Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malaria
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research, Kenya
    Malar J 4:57. 2005
    ..Abnormal motor posturing is often observed in children with cerebral malaria, but the aetiology and pathogenesis is poorly understood. This study examined the risk factors and outcome of posturing in Kenyan children with cerebral malaria...
  3. ncbi request reprint Perturbations in electrolyte levels in kenyan children with severe malaria complicated by acidosis
    Kathryn Maitland
    Centre for Geographic Medicine Research, Coast, Kenyan Medical Research Unit, Kilifi, Kenya
    Clin Infect Dis 40:9-16. 2005
    ..To date, information about the frequency of electrolyte disturbances among children with severe falciparum malaria is limited...
  4. ncbi request reprint HLA class-I and class-II allele frequencies and two-locus haplotypes in Melanesians of Vanuatu and New Caledonia
    K Maitland
    MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine, Oxford, UK
    Tissue Antigens 64:678-86. 2004
    ..No consistent pattern was demonstrated for any HLA locus in relation to malaria endemicity...
  5. ncbi request reprint Pre-transfusion management of children with severe malarial anaemia: a randomised controlled trial of intravascular volume expansion
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kenya
    Br J Haematol 128:393-400. 2005
    ..The impact on mortality should be assessed where blood transfusion services are unable to supply emergency transfusions...
  6. ncbi request reprint Randomized trial of volume expansion with albumin or saline in children with severe malaria: preliminary evidence of albumin benefit
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Clin Infect Dis 40:538-45. 2005
    ..In an open-label, randomized, controlled trial, we compared the safety of resuscitation with albumin to saline in Kenyan children with severe malaria...
  7. ncbi request reprint Falciparum malaria: current therapeutic challenges
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kilifi, Kenya
    Curr Opin Infect Dis 17:405-12. 2004
    ..We then review some recent literature regarding the pathological processes involved in the aetiology of severe malaria that may lead to improvements in the management of children with severe disease...
  8. ncbi request reprint Pathophysiology of severe malaria in children
    Kathryn Maitland
    The Centre for Geographic Medicine Research Coast, KEMRI, Kenya, P O Box 230, Kilifi, Kenya
    Acta Trop 90:131-40. 2004
    ..Current therapeutic challenges are discussed and research priorities are highlighted...
  9. pmc Management of severe malaria in children: proposed guidelines for the United Kingdom
    Kathryn Maitland
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi, Kenya
    BMJ 331:337-43. 2005
  10. ncbi request reprint Malaria
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kilifi, Kenya
    Curr Opin Infect Dis 16:389-95. 2003
    ..This review addresses recent developments that relate to the pathogenesis of severe malaria and its treatment, and also highlights the increase in the global burden of malaria and provides a summary of clinical trials of malaria vaccines...
  11. ncbi request reprint Severe P. falciparum malaria in Kenyan children: evidence for hypovolaemia
    K Maitland
    Centre for Geographic Medicine Research, Coast, KEMRI Wellcome Trust Unit, P O Box 230, Kilifi, Kenya
    QJM 96:427-34. 2003
    ..The role of volume resuscitation in severe Plasmodium falciparum malaria is controversial...
  12. pmc Fraction of all hospital admissions and deaths attributable to malnutrition among children in rural Kenya
    Philip Bejon
    Kenyan Medical Research Institute Centre for Geographic Medicine Research, Kilifi, Kenya
    Am J Clin Nutr 88:1626-31. 2008
    ....
  13. pmc Defining childhood severe falciparum malaria for intervention studies
    Philip Bejon
    Kenya Medical Research Institute KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 4:e251. 2007
    ....
  14. doi request reprint Phase II trial on the use of Dextran 70 or starch for supportive therapy in Kenyan children with severe malaria
    Samuel O Akech
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Crit Care Med 38:1630-6. 2010
    ..Human albumin solution is expensive and not readily available in Africa. We examined the safety and efficacy of the fluid resuscitation with two synthetic colloids, Dextran 70 and hydroxyethyl starch, to inform future trial design...
  15. ncbi request reprint Research priorities in the management of severe Plasmodium falciparum malaria in children
    R Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Laboratories, P O Box 230, Kilifi, Kenya
    Ann Trop Med Parasitol 100:95-108. 2006
    ..This review covers the priority areas for research in the care of children with severe malaria, addressing each of the main risk factors associated with death, in a bid to reduce the inpatient mortality...
  16. ncbi request reprint Genetic restriction of Plasmodium falciparum in an area of stable transmission: an example of island evolution?
    K Maitland
    Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford, UK
    Parasitology 120:335-43. 2000
    ..The simplicity of the Vanuatu P. falciparum population may facilitate the use and interpretation of sequence level analyses to address the mechanisms by which genetic diversity is generated and maintained in natural populations...
  17. pmc Burden, features, and outcome of neurological involvement in acute falciparum malaria in Kenyan children
    Richard Idro
    Centre for Geographic Medicine Research, Kenya Medical Research Institute Wellcome Trust Research Labs, Kilifi, Kenya
    JAMA 297:2232-40. 2007
    ..Plasmodium falciparum appears to have a particular propensity to involve the brain but the burden, risk factors, and full extent of neurological involvement have not been systematically described...
  18. ncbi request reprint Severe malaria: lessons learned from the management of critical illness in children
    Kathryn Maitland
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kenya, PO Box 230, Kilifi, Kenya
    Trends Parasitol 22:457-62. 2006
    ....
  19. pmc Progressive increase in antimicrobial resistance among invasive isolates of Haemophilus influenzae obtained from children admitted to a hospital in Kilifi, Kenya, from 1994 to 2002
    J Anthony G Scott
    Wellcome Trust Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, P O Box 230, Kilifi, Kenya
    Antimicrob Agents Chemother 49:3021-4. 2005
    ..In Africa, the increasing cost of treating resistant infections supports economic arguments for prevention through conjugate H. influenzae type b immunization...
  20. pmc HIV infection, malnutrition, and invasive bacterial infection among children with severe malaria
    James A Berkley
    Centre for Geographic Medicine Research, Kilifi, Kenya
    Clin Infect Dis 49:336-43. 2009
    ..However, it is unclear whether their cooccurrence with falciparum parasitization and severe disease happens by chance or by association among children in areas where malaria is endemic...
  21. ncbi request reprint Response to volume resuscitation in children with severe malaria
    Kathryn Maitland
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Pediatr Crit Care Med 4:426-31. 2003
    ..To examine whether hypovolemia is an important cause of the acidosis in children with severe malaria...
  22. pmc Characteristics and outcome of cardiopulmonary resuscitation in hospitalised African children
    A Olotu
    KEMRI Welcome Trust Collaborative Research, Centre for Geographic Medicine Research, Coast, Kilifi, Kenya
    Resuscitation 80:69-72. 2009
    ..To review the characteristics and outcome of cardiopulmonary resuscitation in children at a rural hospital in Kenya...
  23. ncbi request reprint Plasmodium vivax: a cause of malnutrition in young children
    T N Williams
    Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK
    QJM 90:751-7. 1997
    ..falciparum was not. Wasting neither predisposed to nor protected against malaria of either species. Although P. vivax malaria is generally regarded as benign, it may produce considerable global mortality through malnutrition...
  24. ncbi request reprint Both heterozygous and homozygous alpha+ thalassemias protect against severe and fatal Plasmodium falciparum malaria on the coast of Kenya
    Thomas N Williams
    Wellcome Trust Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research, Kilifi, Kenya
    Blood 106:368-71. 2005
    ..Our study supports the conclusion that both heterozygotes and homozygotes enjoy a selective advantage against death from Plasmodium falciparum malaria...
  25. pmc Haptoglobin HP2-2 genotype, alpha-thalassaemia and acute seizures in children living in a malaria-endemic area
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Epilepsy Res 81:114-8. 2008
    ..We conclude that the HP2-2 polymorphism and deletions in alpha-globin gene are not risk factors for acute seizures in children. Future studies should examine other susceptibility genes...
  26. ncbi request reprint Assessment of severe malnutrition among hospitalized children in rural Kenya: comparison of weight for height and mid upper arm circumference
    James Berkley
    Kenya Medical Institute Centre for Geographic Medicine Research, Kilifi, Kenya
    JAMA 294:591-7. 2005
    ..Mid upper arm circumference (MUAC) and the clinical sign "visible severe wasting" are simple and inexpensive methods but have not been evaluated in this setting...
  27. ncbi request reprint Malaria
    Kathryn Maitland
    The Center for Geographic Medicine Research, Coast, KEMRI, Kilifi, Kenya
    Adv Exp Med Biol 549:125-34. 2004
  28. pmc Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study
    James A Berkley
    Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi, Kenya
    BMJ 330:995. 2005
    ..To determine how well antibiotic treatment is targeted by simple clinical syndromes and to what extent drug resistance threatens affordable antibiotics...
  29. ncbi request reprint Fluid management of severe falciparum malaria in African children
    Allan Pamba
    The Centre for Geographic Medicine Research, Coast, Kenya Medical Research Institute KEMRI WellcomeTrust Unit, Kenya, PO Box 230, Kilifi, Kenya
    Trop Doct 34:67-70. 2004
    ..Early recognition and prompt treatment may lead to improvements in outcome. We discuss the new evidence supporting the role of hypovolaemia in severe malaria and potential treatment options whilst awaiting the results of clinical trials...
  30. ncbi request reprint Bacteremia among children admitted to a rural hospital in Kenya
    James A Berkley
    Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    N Engl J Med 352:39-47. 2005
    ..We studied every acute pediatric admission to a rural district hospital in Kenya to examine the prevalence, incidence, types, and outcome of community-acquired bacteremia...
  31. pmc The acceptability to women in Mombasa, Kenya, of the donation and transfusion of umbilical cord blood for severe anaemia in young children
    O Hassall
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
    Vox Sang 94:125-31. 2008
    ....
  32. pmc Positive replication and linkage disequilibrium mapping of the chromosome 21q22.1 malaria susceptibility locus
    C C Khor
    Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Genes Immun 8:570-6. 2007
    ....
  33. pmc Children with severe malnutrition: can those at highest risk of death be identified with the WHO protocol?
    Kathryn Maitland
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    PLoS Med 3:e500. 2006
    ....
  34. pmc The incidence, aetiology and outcome of acute seizures in children admitted to a rural Kenyan district hospital
    Richard Idro
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    BMC Pediatr 8:5. 2008
    ..We determined the incidence, aetiological factors and the immediate outcome of seizures in a rural malaria endemic area in coastal Kenya...
  35. pmc Changing trends in blood transfusion in children and neonates admitted in Kilifi District Hospital, Kenya
    Rosalon Pedro
    Kenya Medical Research Institute Wellcome Trust Programme, PO Box 230, Kilifi, Kenya
    Malar J 9:307. 2010
    ..This study aimed to investigate whether this trend affected clinical burden, clinical severity of anaemia and requirements for paediatric transfusion...
  36. pmc Survival and haematological recovery of children with severe malaria transfused in accordance to WHO guidelines in Kilifi, Kenya
    Samuel O Akech
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Malar J 7:256. 2008
    ..Few studies have reported outcome and haematological recovery of children with severe malaria where transfusion practice complies with WHO recommendations...
  37. pmc Capillary refill: prognostic value in Kenyan children
    A Pamba
    Centre for Geographic Medicine Research, Coast, KEMRI Wellcome Trust Unit, PO Box 230, Kilifi, Kenya
    Arch Dis Child 89:950-5. 2004
    ..To determine whether delayed capillary refill time (>3 seconds) is a useful prognostic indicator in Kenyan children admitted to hospital...
  38. pmc Are bedside features of shock reproducible between different observers?
    H Otieno
    The Centre for Geographic Medicine Research, Coast, KEMRI, Kenya, PO Box 230, Kilifi, Kenya
    Arch Dis Child 89:977-9. 2004
    ..55). Capillary refill times and assessment of pulse volume recommended by the recent American consensus guidelines achieved only a "low" moderate to poor interrater agreement, questioning the reliability of such parameters...
  39. doi request reprint Joint BAPEN and Nutrition Society Symposium on 'Feeding size 0: the science of starvation'. Severe malnutrition: therapeutic challenges and treatment of hypovolaemic shock
    Kathryn Maitland
    KEMRI Wellcome Trust Programme, Kilifi, Kenya
    Proc Nutr Soc 68:274-80. 2009
    ..The present paper focuses on the identification of children with sepsis and on fluid management strategies...
  40. doi request reprint Hypothermia in children with severe malnutrition: low prevalence on the tropical coast of Kenya
    Alison Talbert
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, PO Box 230, Kilifi, Kenya
    J Trop Pediatr 55:413-6. 2009
    ..Hypothermia was a rare marker of severity in our setting. We recommend that other observations be highlighted to identify high risk groups and that routine temperature observations be reduced wherever staff are few...
  41. pmc Bacterial contamination of pediatric whole blood transfusions in a Kenyan hospital
    Oliver Hassall
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
    Transfusion 49:2594-8. 2009
    ..The risk from bacterial contamination of blood for transfusion in sub-Saharan Africa is not known. This study assessed the frequency of bacterial contamination of pediatric whole blood transfusions at a referral hospital in Kenya...
  42. pmc Lactate levels in severe malarial anaemia are associated with haemozoin-containing neutrophils and low levels of IL-12
    Climent Casals-Pascual
    Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, Oxford, OX3 9DU, UK
    Malar J 5:101. 2006
    ....
  43. ncbi request reprint Hypokalemia in children with severe falciparum malaria
    Kathryn Maitland
    Centre for Geographic Medicine Research, Coast, KEMRI, Kenya
    Pediatr Crit Care Med 5:81-5. 2004
    ..Alterations in plasma potassium concentrations are commonly associated with acidosis. To date, there is little information about the changes in potassium in severe malaria...
  44. pmc Choice of fluids for resuscitation in children with severe infection and shock: systematic review
    Samuel Akech
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Programme, PO Box 230, Kilifi, Kenya
    BMJ 341:c4416. 2010
    ..To systemically review the evidence from clinical trials comparing the use of crystalloids and colloids for fluid resuscitation in children with severe infection...
  45. ncbi request reprint Invasive Gram-negative bacilli are frequently resistant to standard antibiotics for children admitted to hospital in Kilifi, Kenya
    Philip Bejon
    Wellcome Trust Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    J Antimicrob Chemother 56:232-5. 2005
    ....
  46. pmc Maternal perceptions of factors contributing to severe under-nutrition among children in a rural African setting
    A Abubakar
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Rural Remote Health 11:1423. 2011
    ..The current study aimed to elicit maternal perceptions of factors that contribute to severe undernutrition among children in a rural Kenyan community in order to identify appropriate and acceptable targeted interventions...
  47. ncbi request reprint Population pharmacokinetics of a single daily intramuscular dose of gentamicin in children with severe malnutrition
    Claire Seaton
    KEMRI Wellcome Research Programme, Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, PO Box 230, Kilifi, Kenya
    J Antimicrob Chemother 59:681-9. 2007
    ..5 mg/kg) in children with severe malnutrition and to evaluate clinical factors affecting pharmacokinetic parameters...
  48. pmc Emergency triage assessment for hypoxaemia in neonates and young children in a Kenyan hospital: an observational study
    Michael K Mwaniki
    Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
    Bull World Health Organ 87:263-70. 2009
    ....
  49. doi request reprint The prognostic value of dipstick urinalysis in children admitted to hospital with severe malnutrition
    Nahashon Thuo
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Arch Dis Child 95:422-6. 2010
    ..UTIs are common in SAM and can lead to secondary invasive bacterial sepsis. Very few studies have examined the usefulness of dipstick screening of urine specimens in SAM and none has explored its prognostic value...
  50. pmc Incidence and clinical characteristics of group A rotavirus infections among children admitted to hospital in Kilifi, Kenya
    D James Nokes
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 5:e153. 2008
    ..The study objective was to accurately define the incidence and severity of group A rotavirus disease in a resource-poor setting necessary to make informed decisions on the need for vaccine prevention...
  51. ncbi request reprint How do we treat children with severe malaria?
    Kathryn Maitland
    The Centre for Geographic Medicine Research, KEMRI, Kenya
    Adv Exp Med Biol 582:9-21. 2006
  52. pmc Volume status in severe malaria: no evidence provided for the degree of filling of the intravascular compartment
    Kathryn Maitland
    PLoS Med 2:e27; author reply e32. 2005
  53. ncbi request reprint Suppression of erythropoiesis in malarial anemia is associated with hemozoin in vitro and in vivo
    Climent Casals-Pascual
    Nuffield Department of Clinical Laboratory Sciences and National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford OX3 9BQ, United Kingdom
    Blood 108:2569-77. 2006
    ..Taken together, these observations provide compelling evidence for inhibition of erythropoiesis by Hz...
  54. pmc A Mal functional variant is associated with protection against invasive pneumococcal disease, bacteremia, malaria and tuberculosis
    Chiea C Khor
    The Wellcome Trust Centre for Human Genetics, University of Oxford, UK
    Nat Genet 39:523-8. 2007
    ..6 x 10(-8)). We found that the Mal S180L variant attenuated TLR2 signal transduction...
  55. ncbi request reprint Intravenous fluids for seriously ill children
    Kathryn Maitland
    Lancet 363:242-3. 2004
  56. ncbi request reprint Mortality among Kenyan children admitted to a rural district hospital on weekends as compared with weekdays
    James A Berkley
    Pediatrics 114:1737-8; author reply 1738. 2004
  57. doi request reprint Case management of HIV-infected severely malnourished children: challenges in the area of highest prevalence
    Geert Tom Heikens
    Department of Paediatrics, College of Medicine, University of Malawi, Blantyre, Malawi
    Lancet 371:1305-7. 2008