Geoffrey M Lairumbi

..This study explores practical experiences of stakeholders involved in global health research in Kenya, over what benefits are fair within a developing world context...

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..Our findings suggest ongoing training, external supportive supervision, open feedback, and local facilitation may be valuable additions to more typical in-service training approaches, and may be feasible...

..At an individual level, lack of interest in the evidence supporting guidelines, feelings that they erode professionalism, and expectations that people should be paid to change practice threaten successful implementation...

..International and local research ethics guidelines are reviewed here to delineate the guidance they provide...

..We examine this awareness among stakeholders involved in health related research in Kenya...

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..In Africa, the increasing cost of treating resistant infections supports economic arguments for prevention through conjugate H. influenzae type b immunization...

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..To assess the availability of resources that support the provision of basic neonatal care in eight first-referral level (district) hospitals in Kenya...

..However, strategies to change multiple paediatric care practices in rural hospitals have rarely been evaluated...

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..To determine how well antibiotic treatment is targeted by simple clinical syndromes and to what extent drug resistance threatens affordable antibiotics...

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..This article reviews recent evidence on clinical assessment and severity classification of pneumonia and reported results on the effectiveness of currently recommended treatments...

..Although necessary for developing a rationale for vaccination, the burden of severe respiratory syncytial virus (RSV) disease in children in resource-poor settings remains poorly defined...

..We have demonstrated how dynamic such contexts are, and therefore the need to consider context when interpreting an intervention's effectiveness...

..5°C or <35.5°C, change in level of activity, fast breathing/respiratory rate ≥60 breaths per minute, severe chest indrawing, grunting and cyanosis...

..Emerging evidence suggests that sublingual sugar is a feasible and effective therapy for correction of hypoglycaemia, and should be considered where intravenous glucose is delayed or impossible...

..Improved country level data on pattern of microorganisms, resistance and antibiotic use are required to help reduce mortality through development of local, evidence-based clinical guidelines...

..Using video records of clinical signs we assessed agreement among experts and assessed whether Kenyan health workers could identify signs defined by expert consensus...

..To evaluate final year medical students' access to new medical information...

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..Indicators of quality of care for children in hospitals in low-income countries have been proposed, but information on their perceived validity and acceptability is lacking...

..However, it is unclear whether their cooccurrence with falciparum parasitization and severe disease happens by chance or by association among children in areas where malaria is endemic...

..We aimed to describe and evaluate the potential of simple clinical features to identify severe illness among young infants who present to rural district hospitals in Kenya...

..Our aim was to determine if a simple one day newborn resuscitation training (NRT) alters health worker resuscitation practices in a public hospital setting in Kenya...

..To optimise appropriate policy decisions, studies should aim to collect data on resource use and costs of training implementation...

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..We aimed to identify indicators of bacterial meningitis in young infants in Kenya, and compared their performance to the WHO guidelines. We also examined the feasibility of developing a scoring system for meningitis...

..Countries such as Kenya need better bacterial disease surveillance systems allied to better information for healthcare providers to promote appropriate decision-making on prevention and treatment strategies...

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..Basic, effective resuscitation should therefore be available at all health facilities and potentially in the community...

..We studied every acute pediatric admission to a rural district hospital in Kenya to examine the prevalence, incidence, types, and outcome of community-acquired bacteremia...

..CONCLUSION: The 10-item score developed may be useful to monitor changes in motivation over time within our study or be used for more extensive rapid assessments of health worker motivation in Kenya...

..Some factors influencing motivation may themselves be influenced by the processes chosen to implement change...

..Assessing the cost effectiveness of the latter, particularly for very specific interventions such as further maternal vaccination, will require very large trials...