Affiliation: Kenya Medical Research Institute
- Decorticate, decerebrate and opisthotonic posturing and seizures in Kenyan children with cerebral malariaRichard Idro
Centre for Geographic Medicine Research Coast, Kenya Medical Research, Kenya
Malar J 4:57. 2005..Abnormal motor posturing is often observed in children with cerebral malaria, but the aetiology and pathogenesis is poorly understood. This study examined the risk factors and outcome of posturing in Kenyan children with cerebral malaria...
- Research priorities in the management of severe Plasmodium falciparum malaria in childrenR Idro
Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Laboratories, P O Box 230, Kilifi, Kenya
Ann Trop Med Parasitol 100:95-108. 2006..This review covers the priority areas for research in the care of children with severe malaria, addressing each of the main risk factors associated with death, in a bid to reduce the inpatient mortality...
- Pathogenesis, clinical features, and neurological outcome of cerebral malariaRichard Idro
Centre for Geographic Medicine Research Coast, Kenya Medical Research Insitute, Kilifi, Kenya
Lancet Neurol 4:827-40. 2005..We also summarise recent studies of persisting neurocognitive impairments in children who survive cerebral malaria and suggest areas for further research...
- Risk factors for persisting neurological and cognitive impairments following cerebral malariaR Idro
Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute Wellcome Trust Research Labs, Kilifi, Kenya
Arch Dis Child 91:142-8. 2006..Persisting neurological and cognitive impairments are common after cerebral malaria. Although risk factors for gross deficits on discharge have been described, few studies have examined those associated with persistent impairments...
- Axonal and astrocyte injury markers in the cerebrospinal fluid of Kenyan children with severe malariaIsabelle M Medana
Nuffield Department of Clinical Laboratory Sciences, Academic Block, Level 4, The John Radcliffe Hospital, Oxford, OX3 9DU, United Kingdom
J Neurol Sci 258:93-8. 2007..This study provides evidence that axonal injury is associated with malaria coma and identifies the potential role of severe anaemia, acidosis and hyperparasitaemia to causing brain parenchymal damage in children with malaria...
- Severe anaemia in childhood cerebral malaria is associated with profound comaRichard Idro
Department of Paediatrics and Child Health, Mulago Hospital, P O Box 7051, Kampala, Uganda
Afr Health Sci 3:15-8. 2003..The ensuing metabolic derangement may further depress the level of consciousness culminating in presentation with profound coma. This association has poorly been studied...
- Manifestations, quality of emergency care and outcome of severe malaria in Mulago Hospital, UgandaRichard Idro
Department of Paediatrics and Child Health, Mulago Hospital Makerere University Faculty of Medicine, PO Box 7051 Kampala, Uganda
Afr Health Sci 4:50-7. 2004..Most of these deaths are associated with poor resuscitation systems, delays within the units by health workers and lack of essential drugs and supplies...
- Immediate outcome and prognostic factors for cerebral malaria among children admitted to Mulago Hospital, UgandaRichard Idro
Department of Paediatrics and Child Health, Makerere University Medical School, Kampala, Uganda
Ann Trop Paediatr 24:17-24. 2004..In primary health units, health workers may use a combination of cold peripheries, hypothermia and dehydration to predict circulatory failure...
- Burden, features, and outcome of neurological involvement in acute falciparum malaria in Kenyan childrenRichard Idro
Centre for Geographic Medicine Research, Kenya Medical Research Institute Wellcome Trust Research Labs, Kilifi, Kenya
JAMA 297:2232-40. 2007..Plasmodium falciparum appears to have a particular propensity to involve the brain but the burden, risk factors, and full extent of neurological involvement have not been systematically described...
- High levels of erythropoietin are associated with protection against neurological sequelae in African children with cerebral malariaCliment Casals-Pascual
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, and National Blood Service, John Radcliffe Hospital, Headington, Oxford OX3 9BQ, United Kingdom
Proc Natl Acad Sci U S A 105:2634-9. 2008..The age-dependent Epo response to anemia and the age-dependent protective effect may influence the clinical epidemiology of CM. These data support further study of Epo as an adjuvant therapy in CM...
- The incidence, aetiology and outcome of acute seizures in children admitted to a rural Kenyan district hospitalRichard Idro
Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
BMC Pediatr 8:5. 2008..We determined the incidence, aetiological factors and the immediate outcome of seizures in a rural malaria endemic area in coastal Kenya...
- Cerebrospinal fluid cytokine levels and cognitive impairment in cerebral malariaChandy C John
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Am J Trop Med Hyg 78:198-205. 2008..34, P = 0.04) and working memory (Spearman rho, -0.32, P = 0.06) 6 months later. In children with cerebral malaria, central nervous system TNF-alpha production is associated with subsequent neurologic and cognitive morbidity...
- Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort studyManish Sadarangani
Centre for Geographic Medicine Research Coast CGMRC, Kenya Medical Research Institute KEMRI, Kilifi, Kenya
Lancet Neurol 7:145-50. 2008..In sub-Saharan Africa, the high incidence of febrile illnesses might influence the incidence and outcome of CSE. We aimed to provide data on the incidence, causes, and outcomes of childhood CSE in this region...
- Cognitive impairment after cerebral malaria in children: a prospective studyMichael J Boivin
International Neurologic and Psychiatric Epidemiology Program, College of Osteopathic Medicine, Michigan State University, East Lansing, Michigan, USA
Pediatrics 119:e360-6. 2007..This study was conducted to assess prospectively the frequency of cognitive deficits in children with cerebral malaria...
- Low levels of RANTES are associated with mortality in children with cerebral malariaChandy C John
University of Minnesota Medical School, Minneapolis, MN 55455, USA
J Infect Dis 194:837-45. 2006..In children with cerebral malaria (CM), serum chemokine levels and associated morbidity and mortality have not been characterized...
- Rehabilitation for cognitive impairments after cerebral malaria in African children: strategies and limitationsPaul Bangirana
Department of Mental Health and Community Psychology, Makerere University Institute of Psychology, Kampala, Uganda
Trop Med Int Health 11:1341-9. 2006..The limitations of implementing these interventions and solutions are discussed in light of the limited human resources and infrastructure of the developing countries that are malaria endemic...
- Clinical manifestations of severe malaria in the highlands of southwestern UgandaRichard Idro
Department of Pediatrics and Child Health, Makerere University Medical School/Mulago Hospital, Kampala, Uganda
Am J Trop Med Hyg 72:561-7. 2005..quot;Typical" signs like splenomegaly are frequently absent, prostration is the major manifestation, and other manifestations vary in frequency according to age...
- Cerebral malaria in children is associated with long-term cognitive impairmentChandy C John
Department of Pediatrics, University of Minnesota Medical School, Minneapolis, Minnesota, USA
Pediatrics 122:e92-9. 2008..This study was conducted to determine the long-term effects of cerebral malaria on the cognitive function of these children...