James A Berkley

Summary

Affiliation: Kenya Medical Research Institute
Country: Kenya

Publications

  1. ncbi request reprint Bacteremia among children admitted to a rural hospital in Kenya
    James A Berkley
    Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    N Engl J Med 352:39-47. 2005
  2. pmc Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity
    Emelda A Okiro
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, KEMRI Wellcome Trust Collaborative Programme, Kenyatta National Hospital Grounds PO Box 43640 00100, Nairobi, Kenya
    Malar J 8:4. 2009
  3. pmc Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Crit Care 14:R227. 2010
  4. pmc Homozygosity and risk of childhood death due to invasive bacterial disease
    Emily J Lyons
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    BMC Med Genet 10:55. 2009
  5. pmc Neonatal seizures in a rural Kenyan District Hospital: aetiology, incidence and outcome of hospitalization
    Michael Mwaniki
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    BMC Med 8:16. 2010
  6. pmc HIV infection, malnutrition, and invasive bacterial infection among children with severe malaria
    James A Berkley
    Centre for Geographic Medicine Research, Kilifi, Kenya
    Clin Infect Dis 49:336-43. 2009
  7. pmc Viral etiology of severe pneumonia among Kenyan infants and children
    James A Berkley
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    JAMA 303:2051-7. 2010
  8. pmc Defining childhood severe falciparum malaria for intervention studies
    Philip Bejon
    Kenya Medical Research Institute KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 4:e251. 2007
  9. pmc Progressive increase in antimicrobial resistance among invasive isolates of Haemophilus influenzae obtained from children admitted to a hospital in Kilifi, Kenya, from 1994 to 2002
    J Anthony G Scott
    Wellcome Trust Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, P O Box 230, Kilifi, Kenya
    Antimicrob Agents Chemother 49:3021-4. 2005
  10. pmc Diarrhoea complicating severe acute malnutrition in Kenyan children: a prospective descriptive study of risk factors and outcome
    Alison Talbert
    Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
    PLoS ONE 7:e38321. 2012

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Bacteremia among children admitted to a rural hospital in Kenya
    James A Berkley
    Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    N Engl J Med 352:39-47. 2005
    ..We studied every acute pediatric admission to a rural district hospital in Kenya to examine the prevalence, incidence, types, and outcome of community-acquired bacteremia...
  2. pmc Age patterns of severe paediatric malaria and their relationship to Plasmodium falciparum transmission intensity
    Emelda A Okiro
    Malaria Public Health and Epidemiology Group, Centre for Geographic Medicine, KEMRI Wellcome Trust Collaborative Programme, Kenyatta National Hospital Grounds PO Box 43640 00100, Nairobi, Kenya
    Malar J 8:4. 2009
    ....
  3. pmc Common NFKBIL2 polymorphisms and susceptibility to pneumococcal disease: a genetic association study
    Stephen J Chapman
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    Crit Care 14:R227. 2010
    ..The possible role of genetic variation in the atypical NF-κB inhibitor IκB-R, encoded by NFKBIL2, in susceptibility to invasive pneumococcal disease has not, to our knowledge, previously been reported upon...
  4. pmc Homozygosity and risk of childhood death due to invasive bacterial disease
    Emily J Lyons
    The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Oxford OX3 7BN, UK
    BMC Med Genet 10:55. 2009
    ..Consequently, we performed a case-control study of fatal invasive bacterial disease in Kenyan children using a genome-wide screen with microsatellite markers...
  5. pmc Neonatal seizures in a rural Kenyan District Hospital: aetiology, incidence and outcome of hospitalization
    Michael Mwaniki
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    BMC Med 8:16. 2010
    ..We determined the minimum incidence, aetiology and immediate outcome of seizures among neonates admitted to a rural district hospital in Kenya...
  6. pmc HIV infection, malnutrition, and invasive bacterial infection among children with severe malaria
    James A Berkley
    Centre for Geographic Medicine Research, Kilifi, Kenya
    Clin Infect Dis 49:336-43. 2009
    ..However, it is unclear whether their cooccurrence with falciparum parasitization and severe disease happens by chance or by association among children in areas where malaria is endemic...
  7. pmc Viral etiology of severe pneumonia among Kenyan infants and children
    James A Berkley
    Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    JAMA 303:2051-7. 2010
    ..Pneumonia is the leading cause of childhood death in sub-Saharan Africa. Comparative estimates of the contribution of causative pathogens to the burden of disease are essential for targeted vaccine development...
  8. pmc Defining childhood severe falciparum malaria for intervention studies
    Philip Bejon
    Kenya Medical Research Institute KEMRI Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    PLoS Med 4:e251. 2007
    ....
  9. pmc Progressive increase in antimicrobial resistance among invasive isolates of Haemophilus influenzae obtained from children admitted to a hospital in Kilifi, Kenya, from 1994 to 2002
    J Anthony G Scott
    Wellcome Trust Kenya Medical Research Institute, Centre for Geographic Medicine Research Coast, P O Box 230, Kilifi, Kenya
    Antimicrob Agents Chemother 49:3021-4. 2005
    ..In Africa, the increasing cost of treating resistant infections supports economic arguments for prevention through conjugate H. influenzae type b immunization...
  10. pmc Diarrhoea complicating severe acute malnutrition in Kenyan children: a prospective descriptive study of risk factors and outcome
    Alison Talbert
    Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
    PLoS ONE 7:e38321. 2012
    ..We examined the clinical and laboratory features on admission and outcome of children with SAM and diarrhoea at a Kenyan district hospital...
  11. pmc Congenital and neonatal malaria in a rural Kenyan district hospital: an eight-year analysis
    Michael K Mwaniki
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Box 230, Kilifi, Kenya
    Malar J 9:313. 2010
    ..Using prospectively collected data on neonatal admissions to a rural district hospital in a region of stable malaria endemicity in Kenya, the prevalence of congenital and neonatal malaria was described...
  12. ncbi request reprint Invasive Gram-negative bacilli are frequently resistant to standard antibiotics for children admitted to hospital in Kilifi, Kenya
    Philip Bejon
    Wellcome Trust Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    J Antimicrob Chemother 56:232-5. 2005
    ....
  13. pmc Treatment failure among Kenyan children with severe pneumonia--a cohort study
    Clare Webb
    Kenya Medical Research Institute KEMRI, Centre for Geographic Medicine Research, Kilifi, Kenya
    Pediatr Infect Dis J 31:e152-7. 2012
    ..Pneumonia is the leading cause of childhood mortality worldwide. The World Health Organization recommends presumptive treatment based on clinical syndromes. Recent studies raise concerns over the frequency of treatment failure in Africa...
  14. pmc Bacteraemia in Kenyan children with sickle-cell anaemia: a retrospective cohort and case-control study
    Thomas N Williams
    Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Lancet 374:1364-70. 2009
    ..The causes of death are poorly documented, but bacterial sepsis is probably important. We examined the risk of invasive bacterial diseases in children with sickle-cell anaemia...
  15. pmc Risk and causes of paediatric hospital-acquired bacteraemia in Kilifi District Hospital, Kenya: a prospective cohort study
    Alexander M Aiken
    Kenya Medical Research Institute Wellcome Trust Research Programme, Kilifi, Kenya
    Lancet 378:2021-7. 2011
    ..In sub-Saharan Africa, community-acquired bacteraemia is an important cause of illness and death in children. Our aim was to establish the magnitude and causes of hospital-acquired (nosocomial) bacteraemia in African children...
  16. pmc Fraction of all hospital admissions and deaths attributable to malnutrition among children in rural Kenya
    Philip Bejon
    Kenyan Medical Research Institute Centre for Geographic Medicine Research, Kilifi, Kenya
    Am J Clin Nutr 88:1626-31. 2008
    ....
  17. pmc Diagnostic performance of visible severe wasting for identifying severe acute malnutrition in children admitted to hospital in Kenya
    Polycarp Mogeni
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medical Research Coast, Kilifi, Kenya
    Bull World Health Organ 89:900-6. 2011
    ..To determine the diagnostic value of visible severe wasting in identifying severe acute malnutrition at two public hospitals in Kenya...
  18. pmc Clinical indicators of bacterial meningitis among neonates and young infants in rural Kenya
    Michael K Mwaniki
    Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
    BMC Infect Dis 11:301. 2011
    ..We aimed to identify indicators of bacterial meningitis in young infants in Kenya, and compared their performance to the WHO guidelines. We also examined the feasibility of developing a scoring system for meningitis...
  19. pmc Use of clinical syndromes to target antibiotic prescribing in seriously ill children in malaria endemic area: observational study
    James A Berkley
    Centre for Geographic Medicine Research Coast, PO Box 230, Kilifi, Kenya
    BMJ 330:995. 2005
    ..To determine how well antibiotic treatment is targeted by simple clinical syndromes and to what extent drug resistance threatens affordable antibiotics...
  20. pmc Low prevalence of transmitted HIV type 1 drug resistance among antiretroviral-naive adults in a rural HIV clinic in Kenya
    Amin S Hassan
    KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    AIDS Res Hum Retroviruses 29:129-35. 2013
    ..Continued broader surveillance is needed to monitor the extent of TDR in sSA...
  21. doi request reprint Reliability and accuracy of anthropometry performed by community health workers among infants under 6 months in rural Kenya
    Martha K Mwangome
    KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    Trop Med Int Health 17:622-9. 2012
    ..To assess the inter-observer variability and accuracy of Mid Upper Arm Circumference (MUAC) and weight-for-length Z score (WFLz) among infants aged <6 months performed by community health workers (CHWs) in Kilifi District, Kenya...
  22. pmc Acute seizures attributable to falciparum malaria in an endemic area on the Kenyan coast
    Symon M Kariuki
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya, PO Box 230 Kilifi 80108, Kenya
    Brain 134:1519-28. 2011
    ..The reduction in malaria has decreased the burden of seizures that are attributable to malaria and this could lead to reduced neurological disabilities and epilepsy in the area...
  23. pmc Malaria as a cause of morbidity and mortality in children with homozygous sickle cell disease on the coast of Kenya
    Albert N Komba
    Kenya Medical Research Institute Wellcome Trust Programme, Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Clin Infect Dis 49:216-22. 2009
    ..Nevertheless, few data are available that support this practice...
  24. pmc Invasive bacterial infections in neonates and young infants born outside hospital admitted to a rural hospital in Kenya
    Alison W A Talbert
    Kenya Medical Research Institute KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
    Pediatr Infect Dis J 29:945-9. 2010
    ..We studied invasive bacterial infections (IBIs) in young infants, born at home or in first-level health units ("outborn") who were admitted to a Kenyan rural district hospital during an 8-year period...
  25. doi request reprint Early loss to follow-up of recently diagnosed HIV-infected adults from routine pre-ART care in a rural district hospital in Kenya: a cohort study
    Amin S Hassan
    KEMRI Wellcome Trust Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Trop Med Int Health 17:82-93. 2012
    ..To determine the rate and predictors of early loss to follow-up (LTFU) for recently diagnosed HIV-infected, antiretroviral therapy (ART)-ineligible adults in rural Kenya...
  26. pmc An increase in the burden of neonatal admissions to a rural district hospital in Kenya over 19 years
    Michael K Mwaniki
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, PO Box 230, Kilifi, Kenya
    BMC Public Health 10:591. 2010
    ....
  27. ncbi request reprint Salmonella bacteremia in Kenyan children
    Andrew J Brent
    Wellcome Trust KEMRI Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Pediatr Infect Dis J 25:230-6. 2006
    ..Nontyphoidal Salmonella spp. are among the leading causes of childhood bacteremia in sub-Saharan Africa, yet there are few published clinical series, and the risk factors for acquiring infection are not fully understood...
  28. pmc Children with severe malnutrition: can those at highest risk of death be identified with the WHO protocol?
    Kathryn Maitland
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    PLoS Med 3:e500. 2006
    ....
  29. pmc Are diagnostic criteria for acute malnutrition affected by hydration status in hospitalized children? A repeated measures study
    Martha K Mwangome
    KEMRI Wellcome Trust Research Programme, Centre for Geographic Medical Research Coast, Kilifi, Kenya
    Nutr J 10:92. 2011
    ..Changes in weight observed during this period were considered to be due to changes in hydration status...
  30. pmc Incidence and outcome of convulsive status epilepticus in Kenyan children: a cohort study
    Manish Sadarangani
    Centre for Geographic Medicine Research Coast CGMRC, Kenya Medical Research Institute KEMRI, Kilifi, Kenya
    Lancet Neurol 7:145-50. 2008
    ..In sub-Saharan Africa, the high incidence of febrile illnesses might influence the incidence and outcome of CSE. We aimed to provide data on the incidence, causes, and outcomes of childhood CSE in this region...
  31. pmc Emergency triage assessment for hypoxaemia in neonates and young children in a Kenyan hospital: an observational study
    Michael K Mwaniki
    Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
    Bull World Health Organ 87:263-70. 2009
    ....
  32. pmc Influenza surveillance among children with pneumonia admitted to a district hospital in coastal Kenya, 2007-2010
    Clayton O Onyango
    KEMRI Wellcome Trust Research Programme, Kilifi District Hospital, Kilifi, Kenya
    J Infect Dis 206:S61-7. 2012
    ..Influenza data gaps in sub-Saharan Africa include incidence, case fatality, seasonal patterns, and associations with prevalent disorders...
  33. pmc Mid-upper arm circumference at age of routine infant vaccination to identify infants at elevated risk of death: a retrospective cohort study in the Gambia
    Martha K Mwangome
    Kenya Medical Research Institute Wellcome Trust Research Programme, PO Box 230, Kilifi, 80108, Kenya
    Bull World Health Organ 90:887-94. 2012
    ..To determine the predictive value for death before 12 months of age of mid-upper arm circumference (MUAC) and weight-for-length Z score (WFLz)...
  34. pmc Over-diagnosis and co-morbidity of severe malaria in African children: a guide for clinicians
    Samson Gwer
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Am J Trop Med Hyg 77:6-13. 2007
    ..Published data on co-morbidity with HIV infection and malnutrition are reviewed. A structured approach to assessment and care is essential, and is largely independent of underlying etiology...
  35. pmc Dynamics and constraints of early infant diagnosis of HIV infection in Rural Kenya
    Amin S Hassan
    Centre for Geographic Medicine Research, Kenya Medical Research Institute, Kilifi, Kenya
    AIDS Behav 16:5-12. 2012
    ..EID should be more closely aligned within PMTCT services, integrated with routine mother and child health (MCH) activities and its implementation more closely monitored...
  36. doi request reprint The prognostic value of dipstick urinalysis in children admitted to hospital with severe malnutrition
    Nahashon Thuo
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Arch Dis Child 95:422-6. 2010
    ..UTIs are common in SAM and can lead to secondary invasive bacterial sepsis. Very few studies have examined the usefulness of dipstick screening of urine specimens in SAM and none has explored its prognostic value...
  37. pmc Effect of HIV infection on the acute antibody response to malaria antigens in children: an observational study
    Daniel K M Muema
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, PO Box 230, Kilifi, 80108, Kenya
    Malar J 10:55. 2011
    ..To test this hypothesis, levels of anti-merozoite and schizont extract antibodies were compared between HIV-infected and uninfected children who participated in the original study...
  38. pmc Maternal and early onset neonatal bacterial sepsis: burden and strategies for prevention in sub-Saharan Africa
    Anna C Seale
    Centre for Geographic Medicine Research Coast, Kenya Medical Research Institute, Kilifi, Kenya
    Lancet Infect Dis 9:428-38. 2009
    ....
  39. ncbi request reprint Indicators of acute bacterial meningitis in children at a rural Kenyan district hospital
    James A Berkley
    Centre for Geographic Medicine Research Coast, Kilifi, Kenya
    Pediatrics 114:e713-9. 2004
    ....