A first report of radioembolization for hepatic metastases from ocular melanomaAndrew S Kennedy
Wake Radiology Oncology, Cary, North Carolina 27518, USA
Cancer Invest 27:682-90. 2009
..Yttrium-90 microspheres (radioembolization) delivered via the hepatic artery is an established and effective approach for primary and metastatic hepatic tumors, although (90)Y use in OM has not been reported previously...
- Computer modeling of yttrium-90-microsphere transport in the hepatic arterial tree to improve clinical outcomes
Andrew S Kennedy
Wake Radiology Oncology, Cary, NC 27518, USA
Int J Radiat Oncol Biol Phys 76:631-7. 2010
..However, no data are available regarding the impact of local blood flow dynamics on (90)Y-microsphere transport and distribution in the human hepatic arterial system...
- Radioembolization (yttrium-90 microspheres) for primary and metastatic hepatic malignancies
Andrew S Kennedy
Wake Radiology Oncology, Cary, NC 27518, USA
Cancer J 16:163-75. 2010
..Patients with hepatocellular cancer, neuroendocrine tumors, and other primary sites, including breast and lung, have also shown promising response and survival increases in multi-institutional experiences...
- Integrating radioembolization into the treatment paradigm for metastatic neuroendocrine tumors in the liver
Andrew Kennedy
Wake Radiology Oncology, Cary, North Carolina 27518, USA
Am J Clin Oncol 35:393-8. 2012
..Benefits of this intervention seem to extend from use in early lines of treatment to salvage of refractory disease. Radioembolization also offers a potential somatostatin analog-sparing effect in symptomatic disease...
Radioembolization for the treatment of liver tumors general principlesAndrew Kennedy
Wake Radiology Oncology, Cary, NC 27518, USA
Am J Clin Oncol 35:91-9. 2012
..The expanding literature on radioembolization shows that this is an effective treatment for the management of both primary and metastatic tumors...
- Integrating radioembolization ((90)Y microspheres) into current treatment options for liver tumors: introduction to the international working group report
Andrew Kennedy
Wake Radiology Oncology, Cary, NC 27518, USA
Am J Clin Oncol 35:81-90. 2012
..This task has been undertaken by a group of the most experienced clinicians in radioembolization from multiple disciplines involved in this therapy...
- Treatment parameters and outcome in 680 treatments of internal radiation with resin 90Y-microspheres for unresectable hepatic tumors
Andrew S Kennedy
Wake Radiology Oncology, Cary, NC 27518, USA
Int J Radiat Oncol Biol Phys 74:1494-500. 2009
..Radiation-induced liver disease (RILD) is rare after RE; however, greater understanding of radiation-related factors leading to serious liver toxicity is needed...
- Resin 90Y-microsphere brachytherapy for unresectable colorectal liver metastases: modern USA experience
Andrew S Kennedy
Wake Radiology Oncology, Cary, NC 27511, USA
Int J Radiat Oncol Biol Phys 65:412-25. 2006
..High doses of radiation were delivered to tumors from permanently implanted 90Y microspheres, delivered through the hepatic arterial vessels...
- Pathologic response and microdosimetry of (90)Y microspheres in man: review of four explanted whole livers
Andrew S Kennedy
Wake Radiology Oncology, Cary, NC 27511, USA
Int J Radiat Oncol Biol Phys 60:1552-63. 2004
..We present an analysis of 4 explanted livers previously treated with (90)Y microsphere agents (glass or resin). One tumor nodule was analyzed with submillimeter three-dimensional microdosimetry...
- Radioembolization for unresectable neuroendocrine hepatic metastases using resin 90Y-microspheres: early results in 148 patients
Andrew S Kennedy
Wake Radiology Oncology, Cary, NC 27511, USA
Am J Clin Oncol 31:271-9. 2008
..The use of 90Y-microspheres to treat unresectable liver metastases originating from a variety of neuroendocrine tumors was reviewed...
- Resin 90Y microsphere activity measurements for liver brachytherapy
William A Dezarn
Wake Radiology Oncology, Cary, North Carolina 27518, USA
Med Phys 34:1896-900. 2007
..Careful characterization of the local activity measurement standard is recommended instead of simply accepting the calibration value of the dose calibrator manufacturer...
- Incidence of radiation pneumonitis after hepatic intra-arterial radiotherapy with yttrium-90 microspheres assuming uniform lung distribution
Riad Salem
Department of Radiology, Section of Interventional Radiology, Northwestern Memorial Hospital, Chicago, IL 60611, USA
Am J Clin Oncol 31:431-8. 2008
..To assess the incidence of clinical and imaging radiation pneumonitis (RP) in a cohort of patients treated with >30 Gy cumulative lung dose (CLD) using Y90 microspheres...
- 90Y Radioembolization for metastatic neuroendocrine liver tumors: preliminary results from a multi-institutional experience
Thomas K Rhee
Department of Radiology, Northwestern University, Chicago, IL, USA
Ann Surg 247:1029-35. 2008
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- Use of yttrium-90 microspheres in the treatment of unresectable hepatic metastases from breast cancer
Douglas M Coldwell
Department of Radiology, University of Mississippi Medical Center, Jackson, MS, USA
Int J Radiat Oncol Biol Phys 69:800-4. 2007
..High doses of radiation were delivered to tumors from these permanently implanted yttrium-90 ((90)Y) microspheres, delivered through the hepatic arterial vessels...
- Radioembolization with 90Y microspheres: angiographic and technical considerations
Robert J Lewandowski
Department of Radiology, Section of Interventional Radiology, Northwestern Memorial Hospital, Robert H Lurie Comprehensive Cancer Center, Chicago, IL, USA
Cardiovasc Intervent Radiol 30:571-92. 2007
..Furthermore, the principles described here apply to all liver-directed transarterial therapies...
- Selective Internal Radiation Therapy (SIRT) for liver metastases secondary to colorectal adenocarcinoma
James S Welsh
Department of Human Oncology, University of Wisconsin Madison, Madison, WI, USA
Int J Radiat Oncol Biol Phys 66:S62-73. 2006
..It is FDA approved for liver metastases secondary to colorectal carcinoma and is under investigation for treatment of other liver malignancies, such as hepatocellular carcinoma and neuroendocrine malignancies...
- Yttrium-90 microsphere therapy for hepatic malignancy: devices, indications, technical considerations, and potential complications
Ravi Murthy
Interventional Radiology Section, Division of Diagnostic Imaging, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 325, Houston, TX 77030, USA
Radiographics 25:S41-55. 2005
..Effective use of these devices requires knowledge of the accumulated clinical experience and a dedicated multidisciplinary effort to ensure optimal outcomes and avoid therapy-specific life-threatening complications...
- Radiation absorbed dose distribution in a patient treated with yttrium-90 microspheres for hepatocellular carcinoma
Mehrdad Sarfaraz
Radiation Oncology Department, University of Maryland Medical System, Baltimore, Maryland 21201, USA
Med Phys 31:2449-53. 2004
..The mean tumor and liver doses were 163 and 58 Gy, respectively...
- Physical aspects of yttrium-90 microsphere therapy for nonresectable hepatic tumors
Mehrdad Sarfaraz
University of Maryland Medical System, 22 S Greene Street, Baltimore, Maryland 21201, USA
Med Phys 30:199-203. 2003
..The average exposure rates at 1 m from the patients and on contact just anterior to the liver were 6 and 135 uSv/h, respectively. The special physics and dosimetry protocol developed for this procedure is presented...
- Cytotoxicity of docetaxel (Taxotere) used as a single agent and in combination with radiation in human gastric, cervical and pancreatic cancer cells
Elizabeth K Balcer-Kubiczek
Department of Radiation Oncology, University of Maryland School of Medicine and Greenebaum Cancer Center, Baltimore, 21201, USA
Chemotherapy 52:231-40. 2006
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