Clinical correlates of patients with rapid-cycling bipolar disorder and a recent history of substance use disorder: a subtype comparison from baseline data of 2 randomized, placebo-controlled trialsKeming Gao
Department of Psychiatry, Bipolar Disorder Research Center at the Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
J Clin Psychiatry 69:1057-63. 2008
..To compare clinical variables in patients with rapid-cycling bipolar I or II disorder and a recent history of substance use disorder (SUD)...
Treatment-emergent mania/hypomania during antidepressant monotherapy in patients with rapid cycling bipolar disorderKeming Gao
Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, 10524 Euclid Avenue, Cleveland, OH 44106, USA
Bipolar Disord 10:907-15. 2008
..To study treatment-emergent mania/hypomania (TEM) associated with second-generation antidepressant monotherapy in patients with rapid cycling bipolar disorder (RCBD)...
- Investigation into the long-term metabolic effects of aripiprazole adjunctive to lithium, valproate, or lamotrigine
David E Kemp
University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA Electronic address
J Affect Disord 148:84-91. 2013
..Bipolar I disorder (BPD) patients are often overweight or obese, and likely to have metabolic syndrome. Several medications used to treat BPD are associated with increased body weight and/or worsening metabolic parameters...
Lamotrigine as add-on treatment to lithium and divalproex: lessons learned from a double-blind, placebo-controlled trial in rapid-cycling bipolar disorderDavid E Kemp
Department of Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
Bipolar Disord 14:780-9. 2012
..This study assessed the antidepressant effects of lamotrigine as compared with placebo when used as add-on therapy for rapid-cycling bipolar depression non-responsive to the combination of lithium plus divalproex...
- Use of insulin sensitizers for the treatment of major depressive disorder: a pilot study of pioglitazone for major depression accompanied by abdominal obesity
David E Kemp
Case Western Reserve University, University Hospitals Case Medical Center, Department of Psychiatry, Cleveland, OH 44106, USA
J Affect Disord 136:1164-73. 2012
..This study was conducted to examine the safety and efficacy of pioglitazone, a thiazolidinedione insulin sensitizer, in adult outpatients with major depressive disorder...
- Predictive value of early improvement in bipolar depression trials: a post-hoc pooled analysis of two 8-week aripiprazole studies
D E Kemp
Case Western Reserve University, Cleveland, OH, USA
Psychopharmacol Bull 43:5-27. 2010
..To evaluate the value of early improvement to predict treatment outcome in patients with bipolar depression...
- Ziprasidone with adjunctive mood stabilizer in the maintenance treatment of bipolar I disorder: long-term changes in weight and metabolic profiles
David E Kemp
Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA
Eur Neuropsychopharmacol 22:123-31. 2012
..Our findings suggest that MetS is highly prevalent in patients with bipolar disorder, may be associated with greater manic symptom severity, and may predict treatment outcomes...
- Clinical value of early partial symptomatic improvement in the prediction of response and remission during short-term treatment trials in 3369 subjects with bipolar I or II depression
David E Kemp
Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA
J Affect Disord 130:171-9. 2011
..To evaluate the clinical value of early partial symptomatic improvement in predicting the probability of response during the short-term treatment of bipolar depression...
- A 6-month, double-blind, maintenance trial of lithium monotherapy versus the combination of lithium and divalproex for rapid-cycling bipolar disorder and Co-occurring substance abuse or dependence
David E Kemp
Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio, USA
J Clin Psychiatry 70:113-21. 2009
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- Medical and substance use comorbidity in bipolar disorder
David E Kemp
Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA
J Affect Disord 116:64-9. 2009
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- Bipolar depression: trial-based insights to guide patient care
David E Kemp
Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio, USA
Dialogues Clin Neurosci 10:181-92. 2008
..A pragmatic clinical approach is presented for management of the depressed phase of bipolar disorder...
- Long-acting risperidone: a review of its role in the treatment of bipolar disorder
David E Kemp
Mood and Metabolic Clinic, Case Western Reserve University, University Hospitals Case Medical Center, 10524 Euclid Avenue, 12th Floor, Cleveland, OH 44106, USA
Adv Ther 26:588-99. 2009
..The specific role of LAR in comparison to other atypical antipsychotics, and the limitations of available studies will be discussed from the perspectives of efficacy, tolerability, and sequential positioning in treatment guidelines...
- Metabolic syndrome in patients enrolled in a clinical trial of aripiprazole in the maintenance treatment of bipolar I disorder: a post hoc analysis of a randomized, double-blind, placebo-controlled trial
David E Kemp
Case Western Reserve University School of Medicine, 10524 Euclid Ave, 12th Floor, Cleveland, OH 44106, USA
J Clin Psychiatry 71:1138-44. 2010
..To compare the effects of maintenance treatment with aripiprazole or placebo on the incidence of metabolic syndrome in bipolar disorder...
- Medical comorbidity in bipolar disorder: relationship between illnesses of the endocrine/metabolic system and treatment outcome
David E Kemp
Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
Bipolar Disord 12:404-13. 2010
..It was hypothesized that illnesses of the endocrine/metabolic system would be associated with greater psychiatric symptom burden and would impact the response to treatment with lithium and valproate...
- Clinical utility of early improvement to predict response or remission in acute mania: focus on olanzapine and risperidone
David E Kemp
Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
J Clin Psychiatry 72:1236-41. 2011
..To evaluate early improvement associated with atypical antipsychotic treatment as a predictor of later response or remission among patients experiencing an acute manic or mixed episode without psychotic features...
- Screening for bipolar disorder in a county jail at the time of criminal arrest
David E Kemp
Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA
J Psychiatr Res 42:778-86. 2008
..This study assessed the operating characteristics of the mood disorder questionnaire (MDQ) among offenders arrested and detained at a county jail...
- An association of intrusive, repetitive phrases with lamotrigine treatment in bipolar II disorder
David E Kemp
Bipolar Disorder Research Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
CNS Spectr 12:106-11. 2007
..Bipolar disorder is frequently associated with obsessional symptoms. However, no reports have identified a pattern of obsessionality that is associated with a specific mood stabilizer treatment...
- Aripiprazole augmentation in treatment-resistant bipolar depression: early response and development of akathisia
David E Kemp
University Hospitals Case Medical Center, Case Western Reserve University, USA
Prog Neuropsychopharmacol Biol Psychiatry 31:574-7. 2007
..This report, though limited by its small sample size and naturalistic design, suggests that the usefulness of aripiprazole in the treatment of bipolar depression may be limited by akathisia...
- Lamotrigine adjunctive therapy to lithium and divalproex in depressed patients with rapid cycling bipolar disorder and a recent substance use disorder: a 12-week, double-blind, placebo-controlled pilot study
Zuowei Wang
Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA
Psychopharmacol Bull 43:5-21. 2010
..To pilot the efficacy and safety data of lamotrigine adjunctive therapy to lithium and divalproex in patients with rapid-cycling bipolar disorder (RCBD) and a recent substance use disorder (SUD)...
- Correlates of historical suicide attempt in rapid-cycling bipolar disorder: a cross-sectional assessment
Keming Gao
Department of Psychiatry, Case Western University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
J Clin Psychiatry 70:1032-40. 2009
..A rapid-cycling course in bipolar disorder has previously been identified as a risk factor for attempted suicide. This study investigated factors associated with suicide attempts in patients with rapid-cycling bipolar I or II disorder...
- A review of sensitivity and tolerability of antipsychotics in patients with bipolar disorder or schizophrenia: focus on somnolence
Keming Gao
Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, University Hospitals Case Medical Center Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
J Clin Psychiatry 69:302-9. 2008
..This study compared the sensitivity and tolerability of antipsychotics in patients with bipolar disorder or schizophrenia...
- Differential interactions between comorbid anxiety disorders and substance use disorder in rapid cycling bipolar I or II disorder
Keming Gao
Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
J Affect Disord 110:167-73. 2008
..Anxiety disorders (AD) and substance use disorders (SUD) commonly co-occur with bipolar disorder. This study was undertaken to assess AD-SUD-bipolar subtype interactions...
- Predictors of non-stabilization during the combination therapy of lithium and divalproex in rapid cycling bipolar disorder: a post-hoc analysis of two studies
Keming Gao
Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
Psychopharmacol Bull 43:23-38. 2010
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- Independent predictors for lifetime and recent substance use disorders in patients with rapid-cycling bipolar disorder: focus on anxiety disorders
Keming Gao
Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
Am J Addict 19:440-9. 2010
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- Number needed to treat to harm for discontinuation due to adverse events in the treatment of bipolar depression, major depressive disorder, and generalized anxiety disorder with atypical antipsychotics
Keming Gao
Department of Psychiatry, Mood and Anxiety Clinic in the Mood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
J Clin Psychiatry 72:1063-71. 2011
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- Acute efficacy of divalproex sodium versus placebo in mood stabilizer-naive bipolar I or II depression: a double-blind, randomized, placebo-controlled trial
David J Muzina
Department of Psychiatry and Psychology, Neurological Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
J Clin Psychiatry 72:813-9. 2011
..To conduct an exploratory evaluation of the acute efficacy of extended-release divalproex sodium compared to placebo in patients with bipolar I or II depression...
- Should an assessment of Axis I comorbidity be included in the initial diagnostic assessment of mood disorders? Role of QIDS-16-SR total score in predicting number of Axis I comorbidity
Keming Gao
Mood and Anxiety Clinic in the Mood Disorders Program of the Department of Psychiatry, Case Western Reserve University School of Medicine University Hospitals Case Medical Center, 10524 Euclid Avenue, 12th Floor, Cleveland, OH 44016, USA Electronic address
J Affect Disord 148:256-64. 2013
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- Treatment-emergent mania in unipolar and bipolar depression: focus on repetitive transcranial magnetic stimulation
Guohua Xia
Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA
Int J Neuropsychopharmacol 11:119-30. 2008
..More systematic studies are needed to better understand TEM associated with rTMS. Special precautions and measures should be adopted to prevent, monitor, and manage TEM in research and practice...
- Safety and efficacy of olanzapine monotherapy in treatment-resistant bipolar mania: a 12-week open-label study
Jun Chen
Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
Hum Psychopharmacol 26:588-95. 2011
..To examine the safety and efficacy of olanzapine monotherapy in treatment-resistant bipolar mania...
- Antipsychotic-induced extrapyramidal side effects in bipolar disorder and schizophrenia: a systematic review
Keming Gao
Department of Psychiatry, Bipolar Disorder Research Center at the Mood Disorders Program, University Hospitals Case Medical Center Case Western Reserve University, School of Medicine, Cleveland, OH, USA
J Clin Psychopharmacol 28:203-9. 2008
..This review is to compare antipsychotic-induced EPS relative to placebo in bipolar disorder (BPD) and schizophrenia...
- Acute treatment of mania: an update on new medications
Prashant Gajwani
Case School of Medicine, Mood Disorders Program, University Hospitals Case Medical Center, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
Curr Psychiatry Rep 8:504-9. 2006
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- Communication of potential benefits and harm to patients and payers in psychiatry: a review and commentary
Renrong Wu
Department of Psychiatry, Mood and Anxiety Clinic in Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
Clin Ther 33:B62-76. 2011
..Communicating potential benefits and harm to patients and payers is essential for high-quality care. However, there are no published guidelines or consensuses on how to communicate potential benefits and harm to patients and payers...
- Predictors of bipolar disorder risk among patients currently treated for major depression
Joseph R Calabrese
Mood Disorders Program, Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
MedGenMed 8:38. 2006
..PATIENTS, DESIGN, AND SETTING: Psychiatrists from community and private practice settings sequentially selected patients with unipolar depression who exhibited nonresponse to at least 1 antidepressant (AD) trial...
- Differentiating bipolar disorders from major depressive disorders: treatment implications
David J Muzina
Cleveland Clinic Neurological Institute, Psychiatry and Psychology, Cleveland, OH 44195, USA
Ann Clin Psychiatry 19:305-12. 2007
..Bipolar disorder is a highly prevalent mood disorder, frequently misdiagnosed as unipolar major depressive disorder...
- Switching to hypomania and mania: differential neurochemical, neuropsychological, and pharmacologic triggers and their mechanisms
Jun Chen
Department of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
Curr Psychiatry Rep 12:512-21. 2010
..Venlafaxine was shown to have an increased risk of TEM compared with bupropion and sertraline. The evolving literature continues to support the role of mood stabilizers in preventing future mood episodes of BPD...
- A double-blind, placebo-controlled pilot study of galantamine to improve cognitive dysfunction in minimally symptomatic bipolar disorder
S Nassir Ghaemi
Department of Psychiatry, Mood Disorders Program, Tufts Medical Center, Boston, MA, USA
J Clin Psychopharmacol 29:291-5. 2009
..In addition, the effect of galantamine on clinical measures of functioning and psychopathology was assessed...
- Bipolar disorder and suicide: research synthesis and clinical translation
Roger S McIntyre
Department of Psychiatry and Pharmacology, University of Toronto, Mood Disorders Psychopharmacology Unit, University Health Network, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
Curr Psychiatry Rep 10:66-72. 2008
..A nascent database suggests that adjunctive psychosocial interventions may further reduce suicide risk in bipolar individuals...
- Bipolar drug development: are we getting closer to the real world?
Joseph R Calabrese
Am J Psychiatry 165:1234-6. 2008
- Aripiprazole augmentation for treatment-resistant bipolar depression: sustained remission after 36 months
David E Kemp
J Clin Psychopharmacol 27:304-5. 2007
- Divalproex in the treatment of acute bipolar depression: a preliminary double-blind, randomized, placebo-controlled pilot study
S Nassir Ghaemi
Bipolar Disorder Research Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
J Clin Psychiatry 68:1840-4. 2007
..To determine the efficacy of divalproex (extended release) in the treatment of acute nonrefractory bipolar depression...
