David E Kemp

Summary

Publications

  1. ncbi request reprint Clinical correlates of patients with rapid-cycling bipolar disorder and a recent history of substance use disorder: a subtype comparison from baseline data of 2 randomized, placebo-controlled trials
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at the Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 69:1057-63. 2008
  2. doi request reprint Treatment-emergent mania/hypomania during antidepressant monotherapy in patients with rapid cycling bipolar disorder
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, 10524 Euclid Avenue, Cleveland, OH 44106, USA
    Bipolar Disord 10:907-15. 2008
  3. ncbi request reprint PPAR-γ Agonism as a Modulator of Mood: Proof-of-Concept for Pioglitazone in Bipolar Depression
    David E Kemp
    University Hospitals Case Medical Center, Case Western Reserve University, 10524 Euclid Ave, 12th Floor, Cleveland, OH, 44106, USA
    CNS Drugs 28:571-81. 2014
  4. ncbi request reprint Weight change and metabolic effects of asenapine in patients with schizophrenia and bipolar disorder
    David E Kemp
    10524 Euclid Ave, 12th Floor, Cleveland, OH 44106
    J Clin Psychiatry 75:238-45. 2014
  5. doi request reprint Investigation into the long-term metabolic effects of aripiprazole adjunctive to lithium, valproate, or lamotrigine
    David E Kemp
    University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA
    J Affect Disord 148:84-91. 2013
  6. pmc Lamotrigine as add-on treatment to lithium and divalproex: lessons learned from a double-blind, placebo-controlled trial in rapid-cycling bipolar disorder
    David E Kemp
    Department of Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Bipolar Disord 14:780-9. 2012
  7. pmc Use of insulin sensitizers for the treatment of major depressive disorder: a pilot study of pioglitazone for major depression accompanied by abdominal obesity
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Department of Psychiatry, Cleveland, OH 44106, USA
    J Affect Disord 136:1164-73. 2012
  8. ncbi request reprint Predictive value of early improvement in bipolar depression trials: a post-hoc pooled analysis of two 8-week aripiprazole studies
    D E Kemp
    Case Western Reserve University, Cleveland, OH, USA
    Psychopharmacol Bull 43:5-27. 2010
  9. pmc Ziprasidone with adjunctive mood stabilizer in the maintenance treatment of bipolar I disorder: long-term changes in weight and metabolic profiles
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA
    Eur Neuropsychopharmacol 22:123-31. 2012
  10. doi request reprint Clinical utility of early improvement to predict response or remission in acute mania: focus on olanzapine and risperidone
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    J Clin Psychiatry 72:1236-41. 2011

Detail Information

Publications43

  1. ncbi request reprint Clinical correlates of patients with rapid-cycling bipolar disorder and a recent history of substance use disorder: a subtype comparison from baseline data of 2 randomized, placebo-controlled trials
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at the Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    J Clin Psychiatry 69:1057-63. 2008
    ..To compare clinical variables in patients with rapid-cycling bipolar I or II disorder and a recent history of substance use disorder (SUD)...
  2. doi request reprint Treatment-emergent mania/hypomania during antidepressant monotherapy in patients with rapid cycling bipolar disorder
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, 10524 Euclid Avenue, Cleveland, OH 44106, USA
    Bipolar Disord 10:907-15. 2008
    ..To study treatment-emergent mania/hypomania (TEM) associated with second-generation antidepressant monotherapy in patients with rapid cycling bipolar disorder (RCBD)...
  3. ncbi request reprint PPAR-γ Agonism as a Modulator of Mood: Proof-of-Concept for Pioglitazone in Bipolar Depression
    David E Kemp
    University Hospitals Case Medical Center, Case Western Reserve University, 10524 Euclid Ave, 12th Floor, Cleveland, OH, 44106, USA
    CNS Drugs 28:571-81. 2014
    ..A secondary objective was to determine whether levels of highly sensitive C-reactive protein and interleukin (IL)-6 predicted treatment outcome...
  4. ncbi request reprint Weight change and metabolic effects of asenapine in patients with schizophrenia and bipolar disorder
    David E Kemp
    10524 Euclid Ave, 12th Floor, Cleveland, OH 44106
    J Clin Psychiatry 75:238-45. 2014
    ..To describe weight changes and metabolic effects of asenapine compared with placebo and olanzapine in adults...
  5. doi request reprint Investigation into the long-term metabolic effects of aripiprazole adjunctive to lithium, valproate, or lamotrigine
    David E Kemp
    University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, USA
    J Affect Disord 148:84-91. 2013
    ..Bipolar I disorder (BPD) patients are often overweight or obese, and likely to have metabolic syndrome. Several medications used to treat BPD are associated with increased body weight and/or worsening metabolic parameters...
  6. pmc Lamotrigine as add-on treatment to lithium and divalproex: lessons learned from a double-blind, placebo-controlled trial in rapid-cycling bipolar disorder
    David E Kemp
    Department of Psychiatry, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA
    Bipolar Disord 14:780-9. 2012
    ..This study assessed the antidepressant effects of lamotrigine as compared with placebo when used as add-on therapy for rapid-cycling bipolar depression non-responsive to the combination of lithium plus divalproex...
  7. pmc Use of insulin sensitizers for the treatment of major depressive disorder: a pilot study of pioglitazone for major depression accompanied by abdominal obesity
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Department of Psychiatry, Cleveland, OH 44106, USA
    J Affect Disord 136:1164-73. 2012
    ..This study was conducted to examine the safety and efficacy of pioglitazone, a thiazolidinedione insulin sensitizer, in adult outpatients with major depressive disorder...
  8. ncbi request reprint Predictive value of early improvement in bipolar depression trials: a post-hoc pooled analysis of two 8-week aripiprazole studies
    D E Kemp
    Case Western Reserve University, Cleveland, OH, USA
    Psychopharmacol Bull 43:5-27. 2010
    ..To evaluate the value of early improvement to predict treatment outcome in patients with bipolar depression...
  9. pmc Ziprasidone with adjunctive mood stabilizer in the maintenance treatment of bipolar I disorder: long-term changes in weight and metabolic profiles
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA
    Eur Neuropsychopharmacol 22:123-31. 2012
    ..Our findings suggest that MetS is highly prevalent in patients with bipolar disorder, may be associated with greater manic symptom severity, and may predict treatment outcomes...
  10. doi request reprint Clinical utility of early improvement to predict response or remission in acute mania: focus on olanzapine and risperidone
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    J Clin Psychiatry 72:1236-41. 2011
    ..To evaluate early improvement associated with atypical antipsychotic treatment as a predictor of later response or remission among patients experiencing an acute manic or mixed episode without psychotic features...
  11. pmc Medical and substance use comorbidity in bipolar disorder
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA
    J Affect Disord 116:64-9. 2009
    ....
  12. pmc A 6-month, double-blind, maintenance trial of lithium monotherapy versus the combination of lithium and divalproex for rapid-cycling bipolar disorder and Co-occurring substance abuse or dependence
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Clin Psychiatry 70:113-21. 2009
    ....
  13. pmc Medical comorbidity in bipolar disorder: relationship between illnesses of the endocrine/metabolic system and treatment outcome
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Bipolar Disord 12:404-13. 2010
    ..It was hypothesized that illnesses of the endocrine/metabolic system would be associated with greater psychiatric symptom burden and would impact the response to treatment with lithium and valproate...
  14. pmc Long-acting risperidone: a review of its role in the treatment of bipolar disorder
    David E Kemp
    Mood and Metabolic Clinic, Case Western Reserve University, University Hospitals Case Medical Center, 10524 Euclid Avenue, 12th Floor, Cleveland, OH 44106, USA
    Adv Ther 26:588-99. 2009
    ..The specific role of LAR in comparison to other atypical antipsychotics, and the limitations of available studies will be discussed from the perspectives of efficacy, tolerability, and sequential positioning in treatment guidelines...
  15. pmc Bipolar depression: trial-based insights to guide patient care
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Dialogues Clin Neurosci 10:181-92. 2008
    ..A pragmatic clinical approach is presented for management of the depressed phase of bipolar disorder...
  16. pmc Clinical value of early partial symptomatic improvement in the prediction of response and remission during short-term treatment trials in 3369 subjects with bipolar I or II depression
    David E Kemp
    Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, OH, USA
    J Affect Disord 130:171-9. 2011
    ..To evaluate the clinical value of early partial symptomatic improvement in predicting the probability of response during the short-term treatment of bipolar depression...
  17. pmc Metabolic syndrome in patients enrolled in a clinical trial of aripiprazole in the maintenance treatment of bipolar I disorder: a post hoc analysis of a randomized, double-blind, placebo-controlled trial
    David E Kemp
    Case Western Reserve University School of Medicine, 10524 Euclid Ave, 12th Floor, Cleveland, OH 44106, USA
    J Clin Psychiatry 71:1138-44. 2010
    ..To compare the effects of maintenance treatment with aripiprazole or placebo on the incidence of metabolic syndrome in bipolar disorder...
  18. pmc Screening for bipolar disorder in a county jail at the time of criminal arrest
    David E Kemp
    Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA
    J Psychiatr Res 42:778-86. 2008
    ..This study assessed the operating characteristics of the mood disorder questionnaire (MDQ) among offenders arrested and detained at a county jail...
  19. ncbi request reprint An association of intrusive, repetitive phrases with lamotrigine treatment in bipolar II disorder
    David E Kemp
    Bipolar Disorder Research Center, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA
    CNS Spectr 12:106-11. 2007
    ..Bipolar disorder is frequently associated with obsessional symptoms. However, no reports have identified a pattern of obsessionality that is associated with a specific mood stabilizer treatment...
  20. ncbi request reprint Aripiprazole augmentation in treatment-resistant bipolar depression: early response and development of akathisia
    David E Kemp
    University Hospitals Case Medical Center, Case Western Reserve University, USA
    Prog Neuropsychopharmacol Biol Psychiatry 31:574-7. 2007
    ..This report, though limited by its small sample size and naturalistic design, suggests that the usefulness of aripiprazole in the treatment of bipolar depression may be limited by akathisia...
  21. pmc Lamotrigine adjunctive therapy to lithium and divalproex in depressed patients with rapid cycling bipolar disorder and a recent substance use disorder: a 12-week, double-blind, placebo-controlled pilot study
    Zuowei Wang
    Department of Psychiatry, Case Western Reserve University School of Medicine, Cleveland, OH, USA
    Psychopharmacol Bull 43:5-21. 2010
    ..To pilot the efficacy and safety data of lamotrigine adjunctive therapy to lithium and divalproex in patients with rapid-cycling bipolar disorder (RCBD) and a recent substance use disorder (SUD)...
  22. ncbi request reprint A review of sensitivity and tolerability of antipsychotics in patients with bipolar disorder or schizophrenia: focus on somnolence
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, University Hospitals Case Medical Center Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
    J Clin Psychiatry 69:302-9. 2008
    ..This study compared the sensitivity and tolerability of antipsychotics in patients with bipolar disorder or schizophrenia...
  23. pmc Correlates of historical suicide attempt in rapid-cycling bipolar disorder: a cross-sectional assessment
    Keming Gao
    Department of Psychiatry, Case Western University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Clin Psychiatry 70:1032-40. 2009
    ..A rapid-cycling course in bipolar disorder has previously been identified as a risk factor for attempted suicide. This study investigated factors associated with suicide attempts in patients with rapid-cycling bipolar I or II disorder...
  24. pmc Differential interactions between comorbid anxiety disorders and substance use disorder in rapid cycling bipolar I or II disorder
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    J Affect Disord 110:167-73. 2008
    ..Anxiety disorders (AD) and substance use disorders (SUD) commonly co-occur with bipolar disorder. This study was undertaken to assess AD-SUD-bipolar subtype interactions...
  25. pmc Predictors of non-stabilization during the combination therapy of lithium and divalproex in rapid cycling bipolar disorder: a post-hoc analysis of two studies
    Keming Gao
    Department of Psychiatry, Case Western Reserve University, Cleveland, OH, USA
    Psychopharmacol Bull 43:23-38. 2010
    ....
  26. pmc Independent predictors for lifetime and recent substance use disorders in patients with rapid-cycling bipolar disorder: focus on anxiety disorders
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Am J Addict 19:440-9. 2010
    ....
  27. pmc Number needed to treat to harm for discontinuation due to adverse events in the treatment of bipolar depression, major depressive disorder, and generalized anxiety disorder with atypical antipsychotics
    Keming Gao
    Department of Psychiatry, Mood and Anxiety Clinic in the Mood Disorders Program, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    J Clin Psychiatry 72:1063-71. 2011
    ....
  28. pmc Associations among obesity, acute weight gain, and response to treatment with olanzapine in adolescent schizophrenia
    David E Kemp
    1 Department of Psychiatry, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio
    J Child Adolesc Psychopharmacol 23:522-30. 2013
    ..The purpose of this study was to investigate associations between body weight and illness characteristics, including weight gain and therapeutic efficacy, in adolescents with schizophrenia...
  29. doi request reprint Acute efficacy of divalproex sodium versus placebo in mood stabilizer-naive bipolar I or II depression: a double-blind, randomized, placebo-controlled trial
    David J Muzina
    Department of Psychiatry and Psychology, Neurological Institute, Cleveland Clinic Foundation, Cleveland, Ohio, USA
    J Clin Psychiatry 72:813-9. 2011
    ..To conduct an exploratory evaluation of the acute efficacy of extended-release divalproex sodium compared to placebo in patients with bipolar I or II depression...
  30. doi request reprint Should an assessment of Axis I comorbidity be included in the initial diagnostic assessment of mood disorders? Role of QIDS-16-SR total score in predicting number of Axis I comorbidity
    Keming Gao
    Mood and Anxiety Clinic in the Mood Disorders Program of Department of Psychiatry, Case Western Reserve University School of Medicine University Hospitals Case Medical Center, 10524 Euclid Avenue, 12th Floor, Cleveland, OH 44016, USA
    J Affect Disord 148:256-64. 2013
    ....
  31. pmc Antipsychotic-induced extrapyramidal side effects in bipolar disorder and schizophrenia: a systematic review
    Keming Gao
    Department of Psychiatry, Bipolar Disorder Research Center at the Mood Disorders Program, University Hospitals Case Medical Center Case Western Reserve University, School of Medicine, Cleveland, OH, USA
    J Clin Psychopharmacol 28:203-9. 2008
    ..This review is to compare antipsychotic-induced EPS relative to placebo in bipolar disorder (BPD) and schizophrenia...
  32. ncbi request reprint Treatment-emergent mania in unipolar and bipolar depression: focus on repetitive transcranial magnetic stimulation
    Guohua Xia
    Department of Psychiatry, Case Western Reserve University, Cleveland, OH 44106, USA
    Int J Neuropsychopharmacol 11:119-30. 2008
    ..More systematic studies are needed to better understand TEM associated with rTMS. Special precautions and measures should be adopted to prevent, monitor, and manage TEM in research and practice...
  33. doi request reprint Safety and efficacy of olanzapine monotherapy in treatment-resistant bipolar mania: a 12-week open-label study
    Jun Chen
    Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China
    Hum Psychopharmacol 26:588-95. 2011
    ..To examine the safety and efficacy of olanzapine monotherapy in treatment-resistant bipolar mania...
  34. ncbi request reprint Acute treatment of mania: an update on new medications
    Prashant Gajwani
    Case School of Medicine, Mood Disorders Program, University Hospitals Case Medical Center, 11400 Euclid Avenue, Suite 200, Cleveland, OH 44106, USA
    Curr Psychiatry Rep 8:504-9. 2006
    ....
  35. doi request reprint Communication of potential benefits and harm to patients and payers in psychiatry: a review and commentary
    Renrong Wu
    Department of Psychiatry, Mood and Anxiety Clinic in Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA
    Clin Ther 33:B62-76. 2011
    ..Communicating potential benefits and harm to patients and payers is essential for high-quality care. However, there are no published guidelines or consensuses on how to communicate potential benefits and harm to patients and payers...
  36. pmc Predictors of bipolar disorder risk among patients currently treated for major depression
    Joseph R Calabrese
    Mood Disorders Program, Department of Psychiatry, Case Western Reserve University, University Hospitals of Cleveland, Cleveland, Ohio, USA
    MedGenMed 8:38. 2006
    ..The primary objective of this study was to assess the rate of bipolar disorder (BPD) risk among patients unsuccessfully treated for major depression and to identify predictors of bipolarity...
  37. ncbi request reprint Differentiating bipolar disorders from major depressive disorders: treatment implications
    David J Muzina
    Cleveland Clinic Neurological Institute, Psychiatry and Psychology, Cleveland, OH 44195, USA
    Ann Clin Psychiatry 19:305-12. 2007
    ..Bipolar disorder is a highly prevalent mood disorder, frequently misdiagnosed as unipolar major depressive disorder...
  38. doi request reprint Switching to hypomania and mania: differential neurochemical, neuropsychological, and pharmacologic triggers and their mechanisms
    Jun Chen
    Department of Psychiatry, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH 44106, USA
    Curr Psychiatry Rep 12:512-21. 2010
    ..Venlafaxine was shown to have an increased risk of TEM compared with bupropion and sertraline. The evolving literature continues to support the role of mood stabilizers in preventing future mood episodes of BPD...
  39. doi request reprint A double-blind, placebo-controlled pilot study of galantamine to improve cognitive dysfunction in minimally symptomatic bipolar disorder
    S Nassir Ghaemi
    Department of Psychiatry, Mood Disorders Program, Tufts Medical Center, Boston, MA, USA
    J Clin Psychopharmacol 29:291-5. 2009
    ..In addition, the effect of galantamine on clinical measures of functioning and psychopathology was assessed...
  40. ncbi request reprint Aripiprazole augmentation for treatment-resistant bipolar depression: sustained remission after 36 months
    David E Kemp
    J Clin Psychopharmacol 27:304-5. 2007
  41. ncbi request reprint Bipolar disorder and suicide: research synthesis and clinical translation
    Roger S McIntyre
    Department of Psychiatry and Pharmacology, University of Toronto, Mood Disorders Psychopharmacology Unit, University Health Network, 399 Bathurst Street, Toronto, Ontario M5T 2S8, Canada
    Curr Psychiatry Rep 10:66-72. 2008
    ..A nascent database suggests that adjunctive psychosocial interventions may further reduce suicide risk in bipolar individuals...
  42. ncbi request reprint Bipolar drug development: are we getting closer to the real world?
    Joseph R Calabrese
    Am J Psychiatry 165:1234-6. 2008
  43. ncbi request reprint Divalproex in the treatment of acute bipolar depression: a preliminary double-blind, randomized, placebo-controlled pilot study
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Department of Psychiatry and Behavioral Sciences, Emory University, Atlanta, GA, USA
    J Clin Psychiatry 68:1840-4. 2007
    ..To determine the efficacy of divalproex (extended release) in the treatment of acute nonrefractory bipolar depression...