Runs of homozygosity implicate autozygosity as a schizophrenia risk factorMatthew C Keller
Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado, United States of America
PLoS Genet 8:e1002656. 2012
..Such a bias towards recessivity suggests that alleles that increase the risk of schizophrenia have been selected against over evolutionary time...
Is low mood an adaptation? Evidence for subtypes with symptoms that match precipitantsMatthew C Keller
Center for Society and Genetics UCLA, Box 951405, 1339 Murphy Hall, Los Angeles, CA, 90095, USA
J Affect Disord 86:27-35. 2005
..To test this hypothesis, we examined how symptoms of low mood differ depending upon the precipitating situation, and whether these differences match expectations of symptoms useful in each kind of situation...
- Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data
Matthew C Keller
Department of Psychology and Neuroscience, Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
Genetics 189:237-49. 2011
..However, large samples (e.g., 12,000-65,000) will be required to detect inbreeding depression for likely effect sizes, and so studies using Froh to date have probably been underpowered...
- Are extended twin family designs worth the trouble? A comparison of the bias, precision, and accuracy of parameters estimated in four twin family models
Matthew C Keller
Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA
Behav Genet 40:377-93. 2010
..We conclude that researchers interested in characterizing the environment or the makeup of genetic variation should use ETFDs when possible...
Modeling extended twin family data I: description of the Cascade modelMatthew C Keller
Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309, United States of America
Twin Res Hum Genet 12:8-18. 2009
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- Association of different adverse life events with distinct patterns of depressive symptoms
Matthew C Keller
Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, VA 23219, USA
Am J Psychiatry 164:1521-9; quiz 1622. 2007
..The authors sought to determine whether, in a general population sample, different categories of adverse life events were associated with different patterns of depressive symptoms...
- Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best?
Matthew C Keller
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219
Behav Brain Sci 29:385-404; discussion 405-52. 2006
..This evolutionary genetic framework for mental disorders has wide-ranging implications for psychology, psychiatry, behavior genetics, molecular genetics, and evolutionary approaches to studying human behavior...
- The evolutionary significance of depressive symptoms: different adverse situations lead to different depressive symptom patterns
Matthew C Keller
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219, USA
J Pers Soc Psychol 91:316-30. 2006
..These significant differences were replicated in an experiment in which 113 students were randomly assigned to visualize a major failure or the death of a loved one...
- Quantifying and addressing parameter indeterminacy in the classical twin design
Matthew C Keller
Center for Society and Genetics, University of California Los Angeles, 1339 Murphy Hall, Los Angeles, CA 90095 1405, USA
Twin Res Hum Genet 8:201-13. 2005
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- Widespread evidence for non-additive genetic variation in Cloninger's and Eysenck's personality dimensions using a twin plus sibling design
Matthew C Keller
Center for Society and Genetics UCLA, University of California, 1339 Murphy Hall, Los Angeles, CA 90095 1405, USA
Behav Genet 35:707-21. 2005
..Our results illustrate the increased sensitivity afforded by extending the classical twin design to include siblings, and may provide clues to the evolutionary origins of genetic variation underlying personality...
- Flexible Mx specification of various extended twin kinship designs
Hermine H Maes
Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0003, United States of America
Twin Res Hum Genet 12:26-34. 2009
..Results indicate that biases in the estimation of variance components depend both on the types of relative available for analysis, and on the underlying genetic and environmental architecture of the phenotype of interest...
- Endophenotypes in the genetic analyses of mental disorders
Tyrone D Cannon
Department of Psychology, University of California, Los Angeles, California 90095, USA
Annu Rev Clin Psychol 2:267-90. 2006
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- Detecting autozygosity through runs of homozygosity: a comparison of three autozygosity detection algorithms
Daniel P Howrigan
Department of Psychology, University of Colorado at Boulder, 1416 Broadway, Boulder, CO 80301, USA
BMC Genomics 12:460. 2011
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- Modeling extended twin family data II: power associated with different family structures
Sarah E Medland
Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, United States of America
Twin Res Hum Genet 12:19-25. 2009
..These results demonstrate that the Cascade model has sufficient power to detect parameters of interest in existing datasets. Mx scripts are available from www.vipbg.vcu.edu/~sarahme/cascade...
- Mutational load analysis of unrelated individuals
Daniel P Howrigan
Institute for Behavioral Genetics, University of Colorado at Boulder, 1480 30th Street, Boulder, CO 80303, USA
BMC Proc 5:S55. 2011
..Overall, we did not find clear support for mutational load burden on affection status; however, these results are ultimately dependent on and limited by the nature of the Genetic Analysis Workshop 17 simulation...
- A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry
Laramie E Duncan
Harvard School of Public Health, Massachusetts General Hospital, McLean Hospital, Harvard Medical School, Belmont, USA
Am J Psychiatry 168:1041-9. 2011
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- Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease risk
Matthew A Simonson
Department of Psychology, University of Colorado Boulder, USA
BMC Med Genet 12:146. 2011
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- A warm heart and a clear head. The contingent effects of weather on mood and cognition
Matthew C Keller
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA 23219, USA
Psychol Sci 16:724-31. 2005
..These results are consistent with findings on seasonal affective disorder, and suggest that pleasant weather improves mood and broadens cognition in the spring because people have been deprived of such weather during the winter...
- Mental exercising through simple socializing: social interaction promotes general cognitive functioning
Oscar Ybarra
Department of Psychology, Research Center for Group Dynamics, University of Michigan, Ann Arbor, MI 48109 1109, USA
Pers Soc Psychol Bull 34:248-59. 2008
..The findings are discussed in the context of the benefits social relationships have for so many aspects of people's lives...
- The Genetic Correlation between Height and IQ: Shared Genes or Assortative Mating?
Matthew C Keller
Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, United States of America Institute for Behavioral Genetics, University of Colorado Boulder, Boulder, Colorado, United States of America
PLoS Genet 9:e1003451. 2013
..Model fits indicate that both pleiotropy and assortative mating contribute significantly and about equally to this genetic correlation...
- Increased sensitivity in neuroimaging analyses using robust regression
Tor D Wager
Department of Psychology, Columbia University, New York, NY 10027, USA
Neuroimage 26:99-113. 2005
..We show that IRLS can have substantial benefits in analysis of group data and in estimating hemodynamic response shapes from time series data. We provide software to implement IRLS in group neuroimaging analyses...
- Estimating the extent of parameter bias in the classical twin design: a comparison of parameter estimates from extended twin-family and classical twin designs
William L Coventry
Queensland Institute of Medical Research, Brisbane, Australia
Twin Res Hum Genet 8:214-23. 2005
..These results suggest that CTD estimates can be misleading when interpreted literally, but useful, albeit coarse, when interpreted properly...
