Matthew C Keller

Summary

Publications

  1. pmc Gene × environment interaction studies have not properly controlled for potential confounders: the problem and the (simple) solution
    Matthew C Keller
    Department of Psychology and Neuroscience, and the Institute for Behavioral Genetics, University of Colorado at Boulder, Colorado Electronic address
    Biol Psychiatry 75:18-24. 2014
  2. pmc The genetic correlation between height and IQ: shared genes or assortative mating?
    Matthew C Keller
    Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, United States of America
    PLoS Genet 9:e1003451. 2013
  3. pmc Runs of homozygosity implicate autozygosity as a schizophrenia risk factor
    Matthew C Keller
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado, United States of America
    PLoS Genet 8:e1002656. 2012
  4. ncbi request reprint Is low mood an adaptation? Evidence for subtypes with symptoms that match precipitants
    Matthew C Keller
    Center for Society and Genetics UCLA, Box 951405, 1339 Murphy Hall, Los Angeles, CA, 90095, USA
    J Affect Disord 86:27-35. 2005
  5. pmc Modeling extended twin family data I: description of the Cascade model
    Matthew C Keller
    Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309, United States of America
    Twin Res Hum Genet 12:8-18. 2009
  6. pmc Are extended twin family designs worth the trouble? A comparison of the bias, precision, and accuracy of parameters estimated in four twin family models
    Matthew C Keller
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA
    Behav Genet 40:377-93. 2010
  7. ncbi request reprint Association of different adverse life events with distinct patterns of depressive symptoms
    Matthew C Keller
    Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, VA 23219, USA
    Am J Psychiatry 164:1521-9; quiz 1622. 2007
  8. pmc Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data
    Matthew C Keller
    Department of Psychology and Neuroscience, Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Genetics 189:237-49. 2011
  9. ncbi request reprint Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best?
    Matthew C Keller
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219
    Behav Brain Sci 29:385-404; discussion 405-52. 2006
  10. ncbi request reprint The evolutionary significance of depressive symptoms: different adverse situations lead to different depressive symptom patterns
    Matthew C Keller
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219, USA
    J Pers Soc Psychol 91:316-30. 2006

Detail Information

Publications27

  1. pmc Gene × environment interaction studies have not properly controlled for potential confounders: the problem and the (simple) solution
    Matthew C Keller
    Department of Psychology and Neuroscience, and the Institute for Behavioral Genetics, University of Colorado at Boulder, Colorado Electronic address
    Biol Psychiatry 75:18-24. 2014
    ..Thus, many alternative explanations for G × E findings that investigators had thought were eliminated have not been. ..
  2. pmc The genetic correlation between height and IQ: shared genes or assortative mating?
    Matthew C Keller
    Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, Colorado, United States of America
    PLoS Genet 9:e1003451. 2013
    ..Model fits indicate that both pleiotropy and assortative mating contribute significantly and about equally to this genetic correlation...
  3. pmc Runs of homozygosity implicate autozygosity as a schizophrenia risk factor
    Matthew C Keller
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, Colorado, United States of America
    PLoS Genet 8:e1002656. 2012
    ..Such a bias towards recessivity suggests that alleles that increase the risk of schizophrenia have been selected against over evolutionary time...
  4. ncbi request reprint Is low mood an adaptation? Evidence for subtypes with symptoms that match precipitants
    Matthew C Keller
    Center for Society and Genetics UCLA, Box 951405, 1339 Murphy Hall, Los Angeles, CA, 90095, USA
    J Affect Disord 86:27-35. 2005
    ..To test this hypothesis, we examined how symptoms of low mood differ depending upon the precipitating situation, and whether these differences match expectations of symptoms useful in each kind of situation...
  5. pmc Modeling extended twin family data I: description of the Cascade model
    Matthew C Keller
    Department of Psychology, University of Colorado at Boulder, Boulder, CO 80309, United States of America
    Twin Res Hum Genet 12:8-18. 2009
    ....
  6. pmc Are extended twin family designs worth the trouble? A comparison of the bias, precision, and accuracy of parameters estimated in four twin family models
    Matthew C Keller
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO, USA
    Behav Genet 40:377-93. 2010
    ..We conclude that researchers interested in characterizing the environment or the makeup of genetic variation should use ETFDs when possible...
  7. ncbi request reprint Association of different adverse life events with distinct patterns of depressive symptoms
    Matthew C Keller
    Department of Psychiatry, Virginia Commonwealth University School of Medicine, Richmond, VA 23219, USA
    Am J Psychiatry 164:1521-9; quiz 1622. 2007
    ..The authors sought to determine whether, in a general population sample, different categories of adverse life events were associated with different patterns of depressive symptoms...
  8. pmc Quantification of inbreeding due to distant ancestors and its detection using dense single nucleotide polymorphism data
    Matthew C Keller
    Department of Psychology and Neuroscience, Institute for Behavioral Genetics, University of Colorado, Boulder, CO 80309, USA
    Genetics 189:237-49. 2011
    ..However, large samples (e.g., 12,000-65,000) will be required to detect inbreeding depression for likely effect sizes, and so studies using Froh to date have probably been underpowered...
  9. ncbi request reprint Resolving the paradox of common, harmful, heritable mental disorders: which evolutionary genetic models work best?
    Matthew C Keller
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219
    Behav Brain Sci 29:385-404; discussion 405-52. 2006
    ..This evolutionary genetic framework for mental disorders has wide-ranging implications for psychology, psychiatry, behavior genetics, molecular genetics, and evolutionary approaches to studying human behavior...
  10. ncbi request reprint The evolutionary significance of depressive symptoms: different adverse situations lead to different depressive symptom patterns
    Matthew C Keller
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23219, USA
    J Pers Soc Psychol 91:316-30. 2006
    ..These significant differences were replicated in an experiment in which 113 students were randomly assigned to visualize a major failure or the death of a loved one...
  11. ncbi request reprint Widespread evidence for non-additive genetic variation in Cloninger's and Eysenck's personality dimensions using a twin plus sibling design
    Matthew C Keller
    Center for Society and Genetics UCLA, University of California, 1339 Murphy Hall, Los Angeles, CA 90095 1405, USA
    Behav Genet 35:707-21. 2005
    ..Our results illustrate the increased sensitivity afforded by extending the classical twin design to include siblings, and may provide clues to the evolutionary origins of genetic variation underlying personality...
  12. ncbi request reprint Quantifying and addressing parameter indeterminacy in the classical twin design
    Matthew C Keller
    Center for Society and Genetics, University of California Los Angeles, 1339 Murphy Hall, Los Angeles, CA 90095 1405, USA
    Twin Res Hum Genet 8:201-13. 2005
    ....
  13. pmc Flexible Mx specification of various extended twin kinship designs
    Hermine H Maes
    Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298 0003, United States of America
    Twin Res Hum Genet 12:26-34. 2009
    ..Results indicate that biases in the estimation of variance components depend both on the types of relative available for analysis, and on the underlying genetic and environmental architecture of the phenotype of interest...
  14. ncbi request reprint Endophenotypes in the genetic analyses of mental disorders
    Tyrone D Cannon
    Department of Psychology, University of California, Los Angeles, California 90095, USA
    Annu Rev Clin Psychol 2:267-90. 2006
    ....
  15. pmc Detecting autozygosity through runs of homozygosity: a comparison of three autozygosity detection algorithms
    Daniel P Howrigan
    Department of Psychology, University of Colorado at Boulder, 1416 Broadway, Boulder, CO 80301, USA
    BMC Genomics 12:460. 2011
    ....
  16. doi request reprint The nature and nurture of high IQ: an extended sensitive period for intellectual development
    Angela M Brant
    Department of Psychology, The Pennsylvania State University, PA 16802 3106, USA
    Psychol Sci 24:1487-95. 2013
    ..The pattern held across a cross-sectional sample of almost 11,000 twin pairs and a longitudinal sample of twins, biological siblings, and adoptive siblings. ..
  17. pmc Additive genetic variation in schizophrenia risk is shared by populations of African and European descent
    Teresa R de Candia
    Department of Psychology and Neuroscience, University of Colorado, Boulder, CO 80302, USA
    Am J Hum Genet 93:463-70. 2013
    ..61 (SE = 0.21, p(SNP-rg = 0) = 0.0003, p(SNP-rg = 1) = 0.16). These results suggest that many schizophrenia risk alleles are shared across ethnic groups and predate African-European divergence. ..
  18. doi request reprint Modeling extended twin family data II: power associated with different family structures
    Sarah E Medland
    Virginia Institute of Psychiatric and Behavioral Genetics, Virginia Commonwealth University, United States of America
    Twin Res Hum Genet 12:19-25. 2009
    ..These results demonstrate that the Cascade model has sufficient power to detect parameters of interest in existing datasets. Mx scripts are available from www.vipbg.vcu.edu/~sarahme/cascade...
  19. pmc Mutational load analysis of unrelated individuals
    Daniel P Howrigan
    Institute for Behavioral Genetics, University of Colorado at Boulder, 1480 30th Street, Boulder, CO 80303, USA
    BMC Proc 5:S55. 2011
    ..Overall, we did not find clear support for mutational load burden on affection status; however, these results are ultimately dependent on and limited by the nature of the Genetic Analysis Workshop 17 simulation...
  20. pmc A critical review of the first 10 years of candidate gene-by-environment interaction research in psychiatry
    Laramie E Duncan
    Harvard School of Public Health, Massachusetts General Hospital, McLean Hospital, Harvard Medical School, Belmont, USA
    Am J Psychiatry 168:1041-9. 2011
    ....
  21. ncbi request reprint Estimating the sex-specific effects of genes on facial attractiveness and sexual dimorphism
    Dorian G Mitchem
    Department of Psychology and Neuroscience, University of Colorado Boulder, Boulder, CO, USA
    Behav Genet 44:270-81. 2014
    ..Additionally, genetic influences on attractiveness were shared across the sexes, suggesting that attractive fathers tend to have attractive daughters and attractive mothers tend to have attractive sons...
  22. pmc Recent methods for polygenic analysis of genome-wide data implicate an important effect of common variants on cardiovascular disease risk
    Matthew A Simonson
    Department of Psychology, University of Colorado Boulder, USA
    BMC Med Genet 12:146. 2011
    ....
  23. pmc Whole-genome pathway analysis on 132,497 individuals identifies novel gene-sets associated with body mass index
    Matthew A Simonson
    Department of Psychology and Neuroscience, Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, United States of America Mayo Clinic, Department of Health Sciences, Division of Biomedical Statistics and Informatics, Rochester, Minnesota, United States of America
    PLoS ONE 9:e78546. 2014
    ..We estimate that the SNPs located in examined pathways explain ∼20% of the heritability for BMI that is tagged by common SNPs (3.35% of the 16.93% total). ..
  24. doi request reprint Mental exercising through simple socializing: social interaction promotes general cognitive functioning
    Oscar Ybarra
    Department of Psychology, Research Center for Group Dynamics, University of Michigan, Ann Arbor, MI 48109 1109, USA
    Pers Soc Psychol Bull 34:248-59. 2008
    ..The findings are discussed in the context of the benefits social relationships have for so many aspects of people's lives...
  25. ncbi request reprint A warm heart and a clear head. The contingent effects of weather on mood and cognition
    Matthew C Keller
    Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Richmond, VA 23219, USA
    Psychol Sci 16:724-31. 2005
    ..These results are consistent with findings on seasonal affective disorder, and suggest that pleasant weather improves mood and broadens cognition in the spring because people have been deprived of such weather during the winter...
  26. ncbi request reprint Increased sensitivity in neuroimaging analyses using robust regression
    Tor D Wager
    Department of Psychology, Columbia University, New York, NY 10027, USA
    Neuroimage 26:99-113. 2005
    ..We show that IRLS can have substantial benefits in analysis of group data and in estimating hemodynamic response shapes from time series data. We provide software to implement IRLS in group neuroimaging analyses...
  27. ncbi request reprint Estimating the extent of parameter bias in the classical twin design: a comparison of parameter estimates from extended twin-family and classical twin designs
    William L Coventry
    Queensland Institute of Medical Research, Brisbane, Australia
    Twin Res Hum Genet 8:214-23. 2005
    ..These results suggest that CTD estimates can be misleading when interpreted literally, but useful, albeit coarse, when interpreted properly...