J Kehr

Summary

Publications

  1. doi request reprint Ginkgo biloba leaf extract (EGb 761®) and its specific acylated flavonol constituents increase dopamine and acetylcholine levels in the rat medial prefrontal cortex: possible implications for the cognitive enhancing properties of EGb 761®
    J Kehr
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Int Psychogeriatr 24:S25-34. 2012
  2. pmc Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats
    J Kehr
    Department of Physiology and Pharmacology, Karolinska Institutet Science Park, Fogdevreten 2A, Stockholm, Sweden
    Br J Pharmacol 164:1949-58. 2011
  3. ncbi request reprint Intraseptal muscarinic ligands and galanin: influence on hippocampal acetylcholine and cognition
    E Elvander
    Department of Neuroscience, Division of Behavioral Neuroscience, Karolinska Institutet, Retzius vag 8, SE 171 77 Stockholm, Sweden
    Neuroscience 126:541-57. 2004
  4. pmc The Ginkgo biloba extract EGb 761(R) and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex
    T Yoshitake
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Br J Pharmacol 159:659-68. 2010
  5. ncbi request reprint Modulation of acetylcholine and serotonin transmission by galanin. Relationship to spatial and aversive learning
    S O Ogren
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Ann N Y Acad Sci 863:342-63. 1998
  6. doi request reprint Galanin differentially regulates acetylcholine release in ventral and dorsal hippocampus: a microdialysis study in awake rat
    T Yoshitake
    Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, 17177 Stockholm, Sweden
    Neuroscience 197:172-80. 2011
  7. ncbi request reprint Galanin and learning
    S O Ogren
    Division of Cellular and Molecular Neurochemistry, Department of Neuroscience, Karolinska Institute, SE 171 77, Stockholm, Sweden
    Brain Res 848:174-82. 1999
  8. ncbi request reprint Activation of 5-HT(1A) autoreceptors enhances the inhibitory effect of galanin on hippocampal 5-HT release in vivo
    T Yoshitake
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Neuropharmacology 44:206-13. 2003
  9. doi request reprint Determination of histamine in microdialysis samples from Guinea pig skin by high-performance liquid chromatography with fluorescence detection
    T Yoshitake
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden takashi yoshitake ki se
    Skin Pharmacol Physiol 25:65-72. 2012
  10. ncbi request reprint Derivatization chemistries for determination of serotonin, norepinephrine and dopamine in brain microdialysis samples by liquid chromatography with fluorescence detection
    T Yoshitake
    Department of Physiology and Pharmacology, Nanna Svartz vag 2, Karolinska Institutet, Stockholm, Sweden
    Biomed Chromatogr 20:267-81. 2006

Collaborators

Detail Information

Publications21

  1. doi request reprint Ginkgo biloba leaf extract (EGb 761®) and its specific acylated flavonol constituents increase dopamine and acetylcholine levels in the rat medial prefrontal cortex: possible implications for the cognitive enhancing properties of EGb 761®
    J Kehr
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Int Psychogeriatr 24:S25-34. 2012
    ....
  2. pmc Mephedrone, compared with MDMA (ecstasy) and amphetamine, rapidly increases both dopamine and 5-HT levels in nucleus accumbens of awake rats
    J Kehr
    Department of Physiology and Pharmacology, Karolinska Institutet Science Park, Fogdevreten 2A, Stockholm, Sweden
    Br J Pharmacol 164:1949-58. 2011
    ....
  3. ncbi request reprint Intraseptal muscarinic ligands and galanin: influence on hippocampal acetylcholine and cognition
    E Elvander
    Department of Neuroscience, Division of Behavioral Neuroscience, Karolinska Institutet, Retzius vag 8, SE 171 77 Stockholm, Sweden
    Neuroscience 126:541-57. 2004
    ..In summary, a limited range of cholinergic muscarinic transmission may contribute to optimal hippocampal function, a finding that has important implications for therapeutic approaches in the treatment of disorders of memory function...
  4. pmc The Ginkgo biloba extract EGb 761(R) and its main constituent flavonoids and ginkgolides increase extracellular dopamine levels in the rat prefrontal cortex
    T Yoshitake
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Br J Pharmacol 159:659-68. 2010
    ....
  5. ncbi request reprint Modulation of acetylcholine and serotonin transmission by galanin. Relationship to spatial and aversive learning
    S O Ogren
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Ann N Y Acad Sci 863:342-63. 1998
    ..The implications of these findings are discussed in relation to the role of acetylcholine in cognitive functions in the forebrain and the role of the raphe 5-HT neurons in affective disorders...
  6. doi request reprint Galanin differentially regulates acetylcholine release in ventral and dorsal hippocampus: a microdialysis study in awake rat
    T Yoshitake
    Department of Physiology and Pharmacology, Karolinska Institutet, Nanna Svartz vag 2, 17177 Stockholm, Sweden
    Neuroscience 197:172-80. 2011
    ....
  7. ncbi request reprint Galanin and learning
    S O Ogren
    Division of Cellular and Molecular Neurochemistry, Department of Neuroscience, Karolinska Institute, SE 171 77, Stockholm, Sweden
    Brain Res 848:174-82. 1999
    ..GAL is also a potent inhibitor of mesencephalic 5-HT neurotransmission in vivo. These findings are discussed in relation to the role of acetylcholine and serotonin in cognition...
  8. ncbi request reprint Activation of 5-HT(1A) autoreceptors enhances the inhibitory effect of galanin on hippocampal 5-HT release in vivo
    T Yoshitake
    Department of Neuroscience, Karolinska Institutet, Retzius vag 8, 171 77 Stockholm, Sweden
    Neuropharmacology 44:206-13. 2003
    ..Thus, the enhanced galanin receptor-mediated inhibition of 5-HT neurotransmission may contribute to the pathophysiology of depression or to the reduced and delayed efficacy of antidepressant therapies...
  9. doi request reprint Determination of histamine in microdialysis samples from Guinea pig skin by high-performance liquid chromatography with fluorescence detection
    T Yoshitake
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden takashi yoshitake ki se
    Skin Pharmacol Physiol 25:65-72. 2012
    ....
  10. ncbi request reprint Derivatization chemistries for determination of serotonin, norepinephrine and dopamine in brain microdialysis samples by liquid chromatography with fluorescence detection
    T Yoshitake
    Department of Physiology and Pharmacology, Nanna Svartz vag 2, Karolinska Institutet, Stockholm, Sweden
    Biomed Chromatogr 20:267-81. 2006
    ..These techniques play an important role in drug discovery and clinical investigation of psychiatric and neurological diseases such as depression, schizophrenia and Parkinson's disease...
  11. ncbi request reprint Intracerebral infusion of H-dopamine and H-mannitol in the striatum of halothane-anaesthetized male rats. A dual-probe microdialysis study of long-distance diffusion
    M Höistad
    Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Eur J Neurosci 12:2505-14. 2000
    ..In conclusion, the dual-probe microdialysis approach proved to be a valid method to study in vivo diffusion and migration in the brain, and the intracerebral spread of compounds highly depends on the nature of the compound infused...
  12. pmc Bidirectional regulation of emotional memory by 5-HT1B receptors involves hippocampal p11
    T M Eriksson
    1 Translational Neuropharmacology, Center of Molecular Medicine, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden 2 Behavioral Neuroscience, Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Mol Psychiatry 18:1096-105. 2013
    ..These results emphasize the importance of using relevant disease models when evaluating the role of serotonin neurotransmission in cognitive deficits related to psychiatric disorders...
  13. doi request reprint Diffusion and clearance of superparamagnetic iron oxide nanoparticles infused into the rat striatum studied by MRI and histochemical techniques
    F H Wang
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Nanotechnology 22:015103. 2011
    ....
  14. ncbi request reprint Effects of isoflurane on prefrontal acetylcholine release and hypothalamic Fos response in young adult and aged rats
    A Jansson
    Center for Surgical Sciences, Karolinska Institutet, Karolinska University Hospital, Huddinge, 141 86 Stockholm, Sweden
    Exp Neurol 190:535-43. 2004
    ..This may have implications for understanding the development of postoperative delirium in aged patients...
  15. ncbi request reprint Adenosine A2A and group I metabotropic glutamate receptors synergistically modulate the binding characteristics of dopamine D2 receptors in the rat striatum
    S Ferre
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    Neuropharmacology 38:129-40. 1999
    ....
  16. ncbi request reprint Striatal dopamine and glutamate release: effects of intranigral injections of substance P
    M S Reid
    Department of Pharmacology, Karolinska Institutet, Stockholm, Sweden
    Acta Physiol Scand 140:527-37. 1990
    ..These findings suggest that striatonigral substance P provides a stimulatory regulation of ipsilateral striatal glutamate release. Furthermore, it is indicated that striatal glutamate release can also be regulated by dopamine terminals...
  17. ncbi request reprint Simultaneous determination of acetylcholine, choline and physostigmine in microdialysis samples from rat hippocampus by microbore liquid chromatography/electrochemistry on peroxidase redox polymer coated electrodes
    J Kehr
    Department of Neuroscience, Karolinska Institute, Stockholm, Sweden
    J Neurosci Methods 83:143-50. 1998
    ..Additionally, other endogenous cholines such as butyrylcholine or synthetic choline derivatives could be detected by the present method...
  18. doi request reprint Impaired social interaction and enhanced sensitivity to phencyclidine-induced deficits in novel object recognition in rats with cortical cholinergic denervation
    S Savage
    Department of Neuroscience, Retzius Laboratory, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Neuroscience 195:60-9. 2011
    ....
  19. ncbi request reprint MitoPark mice mirror the slow progression of key symptoms and L-DOPA response in Parkinson's disease
    D Galter
    Department of Neuroscience, Retzius vag 8, B2 4, Karolinska Institutet, 171 77 Stockholm, Sweden
    Genes Brain Behav 9:173-81. 2010
    ..In contrast, the ratio decreased over time in cortex, revealing important differences between DA cells in substantia nigra and the ventral tegmental area...
  20. ncbi request reprint Microdialysis in freely moving mice: determination of acetylcholine, serotonin and noradrenaline release in galanin transgenic mice
    J Kehr
    Department of Neuroscience, Karolinska Institutet, 171 77, Stockholm, Sweden
    J Neurosci Methods 109:71-80. 2001
    ..Furthermore, modulation by galanin and by behavioral activation, of NA and 5-HT neurotransmission in galanin over-expressing mice indicates its possible role in the aetiology of mood disorders...
  21. ncbi request reprint Continuous delivery of rotigotine decreases extracellular dopamine suggesting continuous receptor stimulation
    J Kehr
    Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden
    J Neural Transm 114:1027-31. 2007
    ..This suggests that the sustained administration of rotigotine provides stable extracellular drug levels in the striatum resulting in continuous stimulation of dopamine receptors...