- Primary support cultures of hippocampal and substantia nigra neurons
Oncology Research Unit, The Children s Hospital at Westmead, Sydney, Westmead, New South Wales 2145, Australia
Nat Protoc 4:78-85. 2009
..This method has been adopted for neurons from the substantia nigra (E16.5), with support from a ring of striatal neurons...
- Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons
Janet van Eersel
Laboratory for Translational Neurodegeneration, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
PLoS ONE 6:e22850. 2011
..Taken together, our data suggests a role for the proteasome in subcellular localization of TDP-43, and possibly in disease...
- Phosphorylation of soluble tau differs in Pick's disease and Alzheimer's disease brains
Janet van Eersel
Discipline of Pathology, The University of Sydney, Sydney, NSW, 2006, Australia
J Neural Transm 116:1243-51. 2009
..Such differences in solubility and phosphorylation may contribute, at least in part, to the formation of distinct tau deposits, but may also have implications for the clinical differences between AD and PiD...
- Experimental diabetes mellitus exacerbates tau pathology in a transgenic mouse model of Alzheimer's disease
Yazi D Ke
Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, Australia
PLoS ONE 4:e7917. 2009
..Hence, DM can accelerate onset and increase severity of disease in individuals with a predisposition to developing tau pathology...
- Neuronal microRNA deregulation in response to Alzheimer's disease amyloid-beta
Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, New South Wales, Australia
PLoS ONE 5:e11070. 2010
..Taken together, our findings suggest that neuronal miRNA deregulation in response to an insult by Abeta may be an important factor contributing to the cascade of events leading to AD...
- Phosphorylated Tau interacts with c-Jun N-terminal kinase-interacting protein 1 (JIP1) in Alzheimer disease
Lars M Ittner
Alzheimer s and Parkinson s Disease Laboratory, Brain and Mind Research Institute, University of Sydney, Sydney, Camperdown, New South Wales 2050, Australia
J Biol Chem 284:20909-16. 2009
..Because JIP1 is involved in regulating cargo binding to kinesin motors, our findings may, at least in part, explain how hyperphosphorylated Tau mediates impaired axonal transport in AD and frontotemporal dementia...