Interferon-alpha2b induction treatment with or without ribavirin in chronic hepatitis C: a multicenter, randomized, controlled trialHakan Senturk
Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University, Istanbul, Turkey
Dig Dis Sci 48:1124-9. 2003
..005.) In conclusion, IFN induction treatment in combination with ribavirin is superior to IFN induction treatment alone in genotype 1 patients, and the SVR rate of 39% is encouraging...
Alpha interferon and ribavirin combination therapy of chronic hepatitis DSabahattin Kaymakoglu
Department of Gastroenterohepatology, Istanbul Medical Faculty, Istanbul University, Capa, 34390, Istanbul, Turkey
Antimicrob Agents Chemother 49:1135-8. 2005
....
Pneumatic balloon dilatation in primary achalasia: the long-term follow-up resultsGungor Boztas
Department of Internal Medicine, Gastroenterology Division, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Hepatogastroenterology 52:475-80. 2005
..Pneumatic dilatation is a safe and most effective treatment for achalasia. We analyzed the long-term results of pneumatic dilatation in primary achalasia by objective and subjective findings...
Long-term results of interferon alpha monotherapy in patients with HBeAg-negative chronic hepatitis BSabahattin Kaymakoglu
Department of Gastroenterohepatology, Istanbul Medical Faculty, Istanbul University, Capa 34390, Istanbul, Turkey
Dig Dis Sci 52:727-31. 2007
..Nearly half of the patients with HBeAg-negative chronic hepatitis B responds to IFN-alpha at the end of therapy. Despite the high recurrence rates, response continues in about one third of patients after a mean of 59.5 months...
Pegylated interferon Alfa-2b monotherapy and pegylated interferon Alfa-2b plus lamivudine combination therapy for patients with hepatitis B virus E antigen-negative chronic hepatitis BSabahattin Kaymakoglu
Istanbul University, Department of Gastroenterohepatology, Istanbul Medical Faculty, Capa, Istanbul, Turkey
Antimicrob Agents Chemother 51:3020-2. 2007
..At the end of follow-up, virological response rates (HBV DNA levels of <400 copies/ml) were similar in the monotherapy (24%) and combination therapy (26%) groups...
Lamivudine monotherapy and lamivudine plus interferon alpha combination therapy in HBeAg negative chronic hepatitis B not responding to previous interferon alpha monotherapyFiliz Akyuz
1 Department of Gastroenterohepatology, Istanbul University, Istanbul Medical Faculty
Acta Gastroenterol Belg 70:20-4. 2007
....
Prevalence and clinical significance of SEN-H virus in chronic hepatitis B, C and delta infections in TurkeyYilmaz Cakaloglu
Department of Gastroenterohepatology, Istanbul Medical Faculty, Istanbul, Turkey
Turk J Gastroenterol 19:104-8. 2008
..We aimed to determine the prevalence and clinical significance of SEN viruses- H in patients with chronic hepatitis C, B and delta in Turkey...
Intestinal metaplasia in portal hypertensive gastropathy: a frequent pathologyDuygu Ibrisim
Department of Gastroenterohepatology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Eur J Gastroenterol Hepatol 20:874-80. 2008
..To compare the frequency of intestinal metaplasia (IM) in patients with portal hypertensive gastropathy (PHG) to the control group with functional dyspepsia...
What is the reason of elevated alanine aminotransferase level in HBeAg negative patients with low viremia: NAFLD or chronic hepatitis?Kadir Demir
Department of Gastroenterohepatology, Istanbul University, Turkey
Ann Hepatol 6:92-6. 2007
..We aimed to evaluate the causes of elevated ALT levels in patients who are negative for hepatitis B e antigen (HBeAg) and HBV DNA (by hybridization) for at least 6 months...
Are acquired hepatocerebral degeneration and hepatic myelopathy reversible?Binnur Pinarbasi
Department of Gastroenterohepatology, Medical Faculty, Istanbul University, Istanbul, Turkey
J Clin Gastroenterol 43:176-81. 2009
..Acquired hepatocerebral degeneration (AHD) and hepatic myelopathy (HM) are rare complications of chronic liver disease and are usually resistant to medical therapy...
Prevalence and virological features of occult hepatitis B virus infection in female sex workers who work uncontrolled in TurkeyBinnur Pinarbasi
Department of Gastroenterohepatology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Liver Int 29:227-30. 2009
..There is little information about the prevalence of occult hepatitis B virus infection (OHBVI). We have investigated the prevalence and virological features of OHBVI among female sex workers (FSWs) in Istanbul...
Etiological factors of duodenal and gastric ulcersAhmet Uyanikoglu
Istanbul University, Faculty of Medicine, Department of Gastroenterohepatology, Istanbul, Turkey
Turk J Gastroenterol 23:99-103. 2012
..We aimed to determine the etiology of patients with duodenal and gastric ulcers...
Terlipressin and albumin combination treatment in hepatorenal syndromeAhmet Danalioglu
Istanbul University, Istanbul Medical Faculty, Gastroenterohepatology Department, Turkey
Hepatogastroenterology 50:ccciii-cccv. 2003
..Parameters associated with response to terlipressin+albumin and increased survival should be defined better in a large cohort of cirrhotic patients with HRS...
The effects of rosiglitazone, metformin, and diet with exercise in nonalcoholic fatty liver diseaseFiliz Akyuz
Department of Gastroenterohepatology Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey
Dig Dis Sci 52:2359-67. 2007
..Diet with exercise seems to be superior to metformin and rosiglitazone. Decreasing treatment response at month 12 compared to month 6 may be due to fluctuations of ALT levels. Treatment response should be evaluated histologically...
Electron microscopic findings in non-alcoholic fatty liver disease: is there a difference between hepatosteatosis and steatohepatitis?Emel Ahishali
Department of Gastroenterohepatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
J Gastroenterol Hepatol 25:619-26. 2010
..This study was designed to comparatively evaluate electron microscopic features of non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH)...
Intrahepatic and peripheral T-cell responses in genotype 1b hepatitis C virus-infected patients with persistently normal and elevated aminotransferase levelsFiliz Akyuz
Department of Gastroenterohepatology, Istanbul University, Istanbul, Turkey
World J Gastroenterol 11:7188-91. 2005
..To evaluate whether the cytokine responses in liver and serum differ in chronic hepatitis C patients with normal and high alanine aminotransferase (ALT) levels...
Risk factors for the transmission of hepatitis C virus infection in the Turkish populationCetin Karaca
Department of Gastroenterohepatology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Dig Dis Sci 51:365-9. 2006
..2%) patients, however, in 8 (1.6%) patients no risk factors could be found. In Turkey, the most common risk factor for the transmission of HCV infection is surgery, which can be preventable...
Cyclosporin for severe ulcerative colitis attacksAhmet Danalioglu
Istanbul University, Istanbul School of Medicine, Gastroenterohepatology Department, Turkey
Hepatogastroenterology 50:ccxcviii-ccc. 2003
..CONCLUSION: Cyclosporin-A therapy in severe ulcerative colitis that is refractory to steroids, provides initial remission in 80% of patients and allows 40% to retain their colon for 1 year...
The role of thrombopoietin and spleen volume in thrombocytopenia of patients with noncirrhotic and cirrhotic portal hypertensionFiliz Akyuz
Departments of Gastroenterohepatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul
Turk J Gastroenterol 18:95-9. 2007
..To determine the role of thrombopoietin and spleen volume in thrombocytopenia diagnosed in cirrhotic and noncirrhotic portal hypertensive patients...
Anticoagulant therapy and Budd-Chiari syndrome: is it successful?Filiz Akyuz
Department of Gastroenterohepatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
Hepatogastroenterology 58:900-3. 2011
..Anticoagulant therapy is an accepted treatment for Budd-Chiari syndrome (BCS). However, the natural course of untreated patients is unclear. We aimed to evaluate the efficacy of anticoagulant therapy on survival in BCS...
Liver abscess as a rare complication of Crohn's disease: a case reportCetin Karaca
Department of Gastroenterohepatology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Turk J Gastroenterol 15:45-8. 2004
..The radiological methods are very useful in diagnosis and treatment of liver abscess. In this paper, we present a patient with pyogenic liver abscess which developed in the course of Crohn's disease...
Effect of proton pump inhibitor (PPI) treatment in obstructive sleep apnea syndrome: an esophageal impedance-pHmetry studyFatih Ermis
Department of Gastroenterology, Istanbul University, Istanbul, Turkey
Hepatogastroenterology 58:1566-73. 2011
..We first evaluated the role of reflux in OSAS with simultaneous polysomnography and impedance-pHmetry and then investigated whether the effect of proton pump inhibitor (PPI) treatment changes in these parameters...
Decreased prohepcidin levels in patients with HBV-related liver disease: relation with ferritin levelsOya Yonal
Department of Gastroenterohepatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
Dig Dis Sci 55:3548-51. 2010
..We investigated whether serum prohepcidin is related to iron overload and perenchymal dysfuction in HBV-related liver disease...
Is portal hypertensive enteropathy an important additional cause of blood loss in portal hypertensive patients?Filiz Akyuz
Istanbul Medical Faculty, Department of Gastroenterology, Capa Istanbul, Turkey
Scand J Gastroenterol 45:1497-502. 2010
..However, the clinical impact of these changes is unknown. In this study, we aimed to determine the additional cause of blood loss in portal hypertensive patients...
A new agent for tumour necrosis factor-alpha inhibition: In vitro effects of dipyridamole in Crohn's diseaseSule Poturoglu
Department of Internal Medicine, Division of Gastroenterohepatology Istanbul University, Istanbul, Turkey
Scand J Clin Lab Invest 69:696-702. 2009
..Our study aims to investigate the in vitro effects of dipyridamole (DP) on the TNF-alpha and interleukin-10 (IL-10) production in the intestinal mononuclear cells of CD patients...
HFE gene mutation, chronic liver disease, and iron overload In TurkeyOya Yonal
Department of Gastroenterohepatology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Dig Dis Sci 52:3298-302. 2007
..004). We conclude that C282Y mutation is very rare in Turkey. Iron overload is not related to H63D mutation but is positively correlated with biochemical activity and Child-Pugh score in chronic liver diseases...
Occult HBV infection and YMDD variants in hemodialysis patients with chronic HCV infectionFatih Besisik
Department of Internal Medicine, Hepatology Division, Istanbul University, Istanbul Medical Faculty, Capa, 34390 Istanbul, Turkey
J Hepatol 38:506-10. 2003
....
Second-line levofloxacin-based triple therapy's efficiency for Helicobacter pylori eradication in patients with peptic ulcerFatih Ermis
Department of Gastroenterology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
South Med J 104:579-83. 2011
..pylori eradication therapy in a country with a high rate of infection...
Sexual transmission of HCV between spousesVeysel Tahan
Marmara University School of Medicine, Department of Gastroenterology Altunizade, Istanbul, Turkey
Am J Gastroenterol 100:821-4. 2005
..However, the seroprevalence rate of the spouses was still within the upper limit of our country population...
A rare cause of hemosuccus pancreaticus: primary splenic artery aneurysm ruptured into pancreatic serous cystadenomaBinnur Pinarbasi
Department of Internal Medicine, Division of Gastroenterohepatology, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
Turk J Gastroenterol 19:57-63. 2008
..This is an interesting case diagnosed with multidisciplinary approaches...
Ulcerative colitis: analyses of 116 cases (do extraintestinal manifestations effect the time to catch remission?)Sadakat Ozdil
Istanbul University, Istanbul Medical Faculty, Department of Gastroenterohepatology, Turkey
Hepatogastroenterology 51:768-70. 2004
..Evaluation of clinical, demographic and epidemiologic features of ulcerative colitis and therapy response of these patients...
Hepatopulmonary syndrome in noncirrhotic portal hypertensive patientsSabahattin Kaymakoglu
Division of Gastroenterology, Istanbul Medical Faculty, Istanbul University, Istanbul, Turkey
Dig Dis Sci 48:556-60. 2003
..8 mm Hg). These findings show that hepatopulmonary syndrome may occur in both liver cirrhosis and noncirrhotic portal hypertension and that portal hypertension is the predominant etiopathogenic factor related to hepatopulmonary syndrome...
Congenital portal vein aneurysm associated with peliosis hepatis and intestinal lymphangiectasiaZeynel Mungan
Department of Gastroenterohepatology, Istanbul Medical Faculty, Istanbul University, Millet Cad 34390 Capa, Istanbul, Turkey
Gastroenterol Res Pract 2009:479264. 2009
..Best of our knowledge, there is no such a case reported previously with the association of PVA, PH and IL. Therefore, we propose PVAPHIL syndrome to define this novel association...
A case of Aeromonas hydrophila enteritis in the course of ulcerative colitisEmel Ahishali
Istanbul Medical Faculty, Department of Gastroenterohepatology, Turkey
Eur J Intern Med 18:430-1. 2007
..Clinical improvement was observed upon oral ciprofloxacin treatment. No clinical or laboratory activation of ulcerative colitis was detected during this infection...
Efficacy and safety of Saccharomyces boulardii in prevention of antibiotic-associated diarrhoea due to Helicobacterpylori eradicationDeniz Güney Duman
Department of Gastroenterology, Marmara University, School of Medicine, Istanbul, Turkey
Eur J Gastroenterol Hepatol 17:1357-61. 2005
..We aimed to evaluate the efficacy and safety of Saccharomyces boulardii in preventing antibiotic-associated diarrhoea in patients receiving antibiotics for H. pylori eradication...
Eosinophilic esophagitis: case reportZeynel Mungan
Department of Internal Medicine, Division of Gastroenterohepatology, Istanbul University, Istanbul Medical Faculty, Istanbul
Turk J Gastroenterol 18:100-2. 2007
..The long-term prognosis of eosinophilic esophagitis is uncertain; however, data suggests a benign course. We herein present two eosinophilic esophagitis cases that were the first to be diagnosed in our clinic...
Postprandial platelet-poor plasma 5-hydroxytryptamine concentrations during diarrhea and constipation periods of alternatingtype irritable bowel syndrome patientsFatma Sen
Department of Internal Medicine, Istanbul University Faculty of Medicine, Istanbul, Turkey
Turk J Gastroenterol 22:270-8. 2011
..Results of the two periods were compared with each other as well as with the results of the controls...
Evaluation of malignancy risk and endoscopic follow up in achalasia: case reportFiliz Akyuz
Department of Gastroenterohepatology, Istanbul University, Istanbul Medical Faculty, Istanbul, Turkey
Turk J Gastroenterol 17:46-9. 2006
..Cancer risk continues after surgical operation in achalasia, like in this case. In conclusion, endoscopic follow up is necessary for these patients even after surgical treatment...
The clinical significance of JAK2V617F mutation for Philadelphia-negative chronic myeloproliferative neoplasms in patients with splanchnic vein thrombosisIpek Yonal
Division of Hematology, Department of Internal Medicine, Medical Faculty, Istanbul University, Istanbul, Turkey
J Thromb Thrombolysis 34:388-96. 2012
..Our results imply that JAK2V617F mutation screening should be an initial test for MPN in patients with SVT...
Somatostatin and propranolol to treat small-for-size syndrome that occurred despite splenic artery ligationIlgin Ozden
Department of General Surgery, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
Exp Clin Transplant 5:686-9. 2007
..To the best of our knowledge, this is the first report of the successful treatment of small-for-size syndrome by somatostatin and propranolol in the clinical setting...
Intestinal metaplasia of the gastric cardia: a study from TurkeyDinc Dincer
Department of Gastroenterohepatology, Istanbul Medical Faculty, Istanbul, Turkey
Hepatogastroenterology 49:1153-6. 2002
..We also re-evaluated the relation between intestinal metaplasia in the cardia and gastroesophageal reflux disease, smoking, alcohol history, H. pylori infection, Barrett's esophagus and intestinal metaplasia elsewhere in the stomach...
Vanishing bile duct and Stevens-Johnson syndrome associated with ciprofloxacin treated with tacrolimusGokhan Okan
Gastroenterohepatology Department, Acibadem Bakirkoy Hospital, Istanbul, Turkey
World J Gastroenterol 14:4697-700. 2008
..It is the first case of ciprofloxacin-induced VBDS successfully treated with tacrolimus. This case reminds physicians of the importance of drug reactions, their severity, techniques for diagnosis and methods of management...
Coexistence of homozygous factor V Leiden mutation and antiphospholipid antibodies in two patients presented with Budd-Chiari syndromeReyhan Diz-Kucukkaya
Department of Internal Medicine, Istanbul Medical Faculty, The University of Istanbul, Turkey
Haematologia (Budap) 32:73-7. 2002
..The interaction of antiphospholipid antibodies and factor V Leiden mutation in the pathogenesis of antiphospholipid syndrome and their contribution to Budd-Chiari syndrome are discussed...
Rare complication of interferon alpha therapy: retinal vein thrombosisFiliz Akyuz
Acta Gastroenterol Belg 68:394-5. 2005