Darpan Kaushik

Summary

Publications

  1. pmc QSAR studies of benzofuran/benzothiophene biphenyl derivatives as inhibitors of PTPase-1B
    D Kaushik
    F O Pharmacy, Rajendra Institute of Technology and Sciences, Sirsa 125055, India
    J Pharm Bioallied Sci 2:27-31. 2010
  2. ncbi request reprint Synthesis and antimicrobial screening of N-[2-(2/4-substituted phenyl)-1-(5/6 substituted 1H- benzimidazol-2-yl)vinyl]benzamides
    Darpan Kaushik
    Medicinal Chemistry Division, F O Pharmacy, Jamia Hamdard, New Delhi 1 1062, India
    Acta Pol Pharm 69:629-36. 2012
  3. doi request reprint N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides: synthesis and anticonvulsant activity
    Darpan Kaushik
    Medicinal Chemistry Division, F O Pharmacy, Jamia Hamdard, New Delhi 125055, India
    Eur J Med Chem 45:3943-9. 2010
  4. doi request reprint Design & synthesis of 2-(substituted aryloxy)-5-(substituted benzylidene)-3-phenyl-2,5-dihydro-1H-[1,2,4] triazin-6-one as potential anticonvulsant agents
    Darpan Kaushik
    Medicinal Chemistry Division, F O Pharmacy, Jamia Hamdard, New Delhi 125055, India
    Eur J Med Chem 45:3960-9. 2010
  5. doi request reprint Ceftaroline: a comprehensive update
    Darpan Kaushik
    Department of Pharmaceutical Chemistry, Rajendra Institute of Technology and Sciences, 4th Mile Stone, Hisar Road, Sirsa 125055, Haryana, India
    Int J Antimicrob Agents 37:389-95. 2011
  6. doi request reprint Design, synthesis and screening of quinoline-incorporated thiadiazole as a potential anticonvulsant
    Suresh Kumar
    Medicinal Chemistry Division, F O Pharmacy, Jamia Hamdard, New Delhi, India
    Chem Biol Drug Des 79:104-11. 2012
  7. ncbi request reprint Synthesis of hydrazones derivatives of quinoxalinone--prospective antimicrobial and antiinflammatory agents
    Suroor A Khan
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard Hamdard University Hamdard Nagar, New Delhi 110062, India
    Acta Pol Pharm 66:169-72. 2009
  8. doi request reprint Synthesis and in-vitro antimicrobial activity of secondary and tertiary amines containing 2-chloro-6-methylquinoline moiety
    Suresh Kumar
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard Hamdard University, New Delhi, India
    Arch Pharm (Weinheim) 344:474-80. 2011
  9. doi request reprint Synthesis, antibacterial evaluation and QSAR studies of 7-[4-(5-aryl-1,3,4-oxadiazole-2-yl)piperazinyl] quinolone derivatives
    Rajnish Kumar
    Rajendra Institute of Technology and Sciences, 4th Milestone Hisar Road, Sirsa 125055, India
    Eur J Med Chem 46:3543-50. 2011
  10. ncbi request reprint Synthesis of 1,2,4-triazine derivatives as potential anti-anxiety and anti-inflammatory agents
    Pooja Mullick
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard Hamdard University Hamdard Nagar, New Delhi 1 10062, India
    Acta Pol Pharm 66:379-85. 2009

Collaborators

Detail Information

Publications10

  1. pmc QSAR studies of benzofuran/benzothiophene biphenyl derivatives as inhibitors of PTPase-1B
    D Kaushik
    F O Pharmacy, Rajendra Institute of Technology and Sciences, Sirsa 125055, India
    J Pharm Bioallied Sci 2:27-31. 2010
    ..The PTPase enzyme dephosphorylates the active form of the insulin receptor and thus attenuates its tyrosine kinase activity, therefore, the need for a potent PTPase inhibitor exists, with the intention of which the QSAR was performed...
  2. ncbi request reprint Synthesis and antimicrobial screening of N-[2-(2/4-substituted phenyl)-1-(5/6 substituted 1H- benzimidazol-2-yl)vinyl]benzamides
    Darpan Kaushik
    Medicinal Chemistry Division, F O Pharmacy, Jamia Hamdard, New Delhi 1 1062, India
    Acta Pol Pharm 69:629-36. 2012
    ..Thereby, it was found that only nitro substituted benzimidazoles exhibited good to moderate antibacterial activity, while other derivatives were devoid of any antimicrobial effect...
  3. doi request reprint N'-[(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)methylene] 2/4-substituted hydrazides: synthesis and anticonvulsant activity
    Darpan Kaushik
    Medicinal Chemistry Division, F O Pharmacy, Jamia Hamdard, New Delhi 125055, India
    Eur J Med Chem 45:3943-9. 2010
    ..Among the compound tested, all except 5 g showed protection from seizures in both the animal models. Some titled compounds exhibited lesser CNS depression and neurotoxicity compared to phenytoin...
  4. doi request reprint Design & synthesis of 2-(substituted aryloxy)-5-(substituted benzylidene)-3-phenyl-2,5-dihydro-1H-[1,2,4] triazin-6-one as potential anticonvulsant agents
    Darpan Kaushik
    Medicinal Chemistry Division, F O Pharmacy, Jamia Hamdard, New Delhi 125055, India
    Eur J Med Chem 45:3960-9. 2010
    ..Some titled compounds exhibited lesser CNS depression and neurotoxicity compared to clinically effective drug...
  5. doi request reprint Ceftaroline: a comprehensive update
    Darpan Kaushik
    Department of Pharmaceutical Chemistry, Rajendra Institute of Technology and Sciences, 4th Mile Stone, Hisar Road, Sirsa 125055, Haryana, India
    Int J Antimicrob Agents 37:389-95. 2011
    ..Thus, it would be a promising drug to fight multidrug-resistant superbugs such as S. aureus and Streptococcus pneumoniae for the treatment of cSSSIs and CAP...
  6. doi request reprint Design, synthesis and screening of quinoline-incorporated thiadiazole as a potential anticonvulsant
    Suresh Kumar
    Medicinal Chemistry Division, F O Pharmacy, Jamia Hamdard, New Delhi, India
    Chem Biol Drug Des 79:104-11. 2012
    ..These compounds exhibited lesser CNS depression and neurotoxicity compared with clinically effective drug...
  7. ncbi request reprint Synthesis of hydrazones derivatives of quinoxalinone--prospective antimicrobial and antiinflammatory agents
    Suroor A Khan
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard Hamdard University Hamdard Nagar, New Delhi 110062, India
    Acta Pol Pharm 66:169-72. 2009
    ..These hydrazones derivatives were characterized by FT-IR and 1H-NMR data. All the synthesized compounds were evaluated for their antimicrobial and antiinflammatory activity...
  8. doi request reprint Synthesis and in-vitro antimicrobial activity of secondary and tertiary amines containing 2-chloro-6-methylquinoline moiety
    Suresh Kumar
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard Hamdard University, New Delhi, India
    Arch Pharm (Weinheim) 344:474-80. 2011
    ..Results of the preliminary screening revealed that some of the compounds mainly those with electron withdrawing groups in the phenyl ring showed promising antifungal activity...
  9. doi request reprint Synthesis, antibacterial evaluation and QSAR studies of 7-[4-(5-aryl-1,3,4-oxadiazole-2-yl)piperazinyl] quinolone derivatives
    Rajnish Kumar
    Rajendra Institute of Technology and Sciences, 4th Milestone Hisar Road, Sirsa 125055, India
    Eur J Med Chem 46:3543-50. 2011
    ..Further, the developed models were cross validated using LOO method for their predictive nature...
  10. ncbi request reprint Synthesis of 1,2,4-triazine derivatives as potential anti-anxiety and anti-inflammatory agents
    Pooja Mullick
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard Hamdard University Hamdard Nagar, New Delhi 1 10062, India
    Acta Pol Pharm 66:379-85. 2009
    ..Many of the triazine compounds were found to possess good activity. Especially, compounds bearing the sulfur atom showed better activity than those bearing the oxygen atom...