Onset of pain relief with rofecoxib in chronic low back pain: results of two four-week, randomized, placebo-controlled trialsNathaniel Katz
Harvard Medical School, Boston, Massachusetts 02464, USA
Curr Med Res Opin 20:651-8. 2004
..The objectives of this report are to present data regarding the onset of efficacy of rofecoxib from these trials and propose methods for reporting onset...
- Methodological issues in clinical trials of opioids for chronic pain
Nathaniel Katz
Tufts University School of Medicine, Boston, MA, USA
Neurology 65:S32-49. 2005
..Opioid analgesics should be studied in a manner that is clinically relevant, and that supports internal validity. More systematic attention is needed to clinical research methodology...
- A 12-week, randomized, placebo-controlled trial assessing the safety and efficacy of oxymorphone extended release for opioid-naive patients with chronic low back pain
Nathaniel Katz
Tufts University School of Medicine, Boston, MA, USA
Curr Med Res Opin 23:117-28. 2007
..Determine the efficacy and tolerability of oxymorphone extended release (OPANA ER) in opioid-naive patients with moderate to severe chronic low back pain (CLBP)...
- Preliminary development of a responder index for chronic low back pain
Lee S Simon
Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02465, USA
J Rheumatol 34:1386-91. 2007
..The aim of the OMERACT Special Interest Group was to discuss the development and validation of a preliminary responder index in CLBP...
- Role of urine toxicology testing in the management of chronic opioid therapy
Nathaniel Katz
Pain Trials Center, Brigham and Women s Hospital, Boston, Massachusetts, USA
Clin J Pain 18:S76-82. 2002
..The authors conclude that, although further research is urgently needed, at this time it is appropriate to conduct routine urine toxicology testing in patients with chronic pain treated with opioids...
- Efficacy and safety of rofecoxib in patients with chronic low back pain: results from two 4-week, randomized, placebo-controlled, parallel-group, double-blind trials
Nathaniel Katz
Pain Trials Center, Brigham and Women s Hospital, Boston, Massachusetts, USA
Spine (Phila Pa 1976) 28:851-8; discussion 859. 2003
..Two replicate, 4-week, randomized, double-blind, placebo-controlled, trials of rofecoxib 25 and 50 mg versus placebo for chronic low back pain...
- Opioids for neuropathic pain
Nathaniel Katz
Inflexxion, Inc, 320 Needham Street, Suite 100, Newton, MA 02464, USA
Curr Pain Headache Rep 9:153-60. 2005
..Opioids have an important role in the treatment of neuropathic pain; however, skillful opioid use balances the benefits with management of side effects and prevention and treatment of abuse and addiction...
Measuring attractiveness for abuse of prescription opioidsStephen F Butler
Inflexxion, Inc, Newton, Massachusetts, USA
Pain Med 11:67-80. 2010
....
- Morphine sulfate and naltrexone hydrochloride extended release capsules in patients with chronic osteoarthritis pain
Nathaniel Katz
Tufts University School of Medicine, Boston, MA, USA
Postgrad Med 122:112-28. 2010
....
- Update on prescription monitoring in clinical practice: a survey study of prescription monitoring program administrators
Nathaniel Katz
Inflexxion, Inc, Newton, Massachusetts 02464, USA
Pain Med 9:587-94. 2008
..The purpose of this study was to provide a benchmark of the current status of PMPs for healthcare providers upon which to engage PMP administrators...
- Estimating attractiveness for abuse of a not-yet-marketed "abuse-deterrent" prescription opioid formulation
Stephen F Butler
Inflexxion, Inc, Newton, Massachusetts 02464, USA
Pain Med 11:81-91. 2010
..A second online sample rated the extent to which these features applied to particular products they had actually used/abused. These data were used to model the abusers' overall preference for prescription opioids they had used/abused...
- Development of a budget-impact model to quantify potential cost savings from prescription opioids designed to deter abuse or ease of extraction
Alan G White
Analysis Group, Inc, Boston, Massachusetts, USA
Appl Health Econ Health Policy 7:61-70. 2009
..As well as public health and safety benefits, use of an abuse-deterrent/resistant RxO (ADO) that may deter abuse, dependence and misuse could also generate cost savings...
- ALO-01 (morphine sulfate and naltrexone hydrochloride) extended-release capsules in the treatment of chronic pain of osteoarthritis of the hip or knee: pharmacokinetics, efficacy, and safety
Nathaniel Katz
Tufts University School of Medicine, Boston, Massachusetts Analgesic Research, Needham, MA 02494, USA
J Pain 11:303-11. 2010
..Results highlight the potential for morphine in ALO-01 to manage moderate-to-severe osteoarthritis pain, while the sequestered naltrexone does not interfere with efficacy...
Development and validation of the Current Opioid Misuse MeasureStephen F Butler
Inflexxion, Inc, Newton, MA 02464, USA
Pain 130:144-56. 2007
..The COMM was found to have promise as a brief, self-report measure of current aberrant drug-related behavior. Further cross-validation and replication of these preliminary results is pending...
- Internet surveillance: content analysis and monitoring of product-specific internet prescription opioid abuse-related postings
Stephen F Butler
Inflexxion, Inc, Newton, MA 02464, USA
Clin J Pain 23:619-28. 2007
..This study describes the development of a systematic approach to the analysis of Internet chatter as a means of monitoring potentially abusable opioid analgesics...
- Internet-based survey of nonmedical prescription opioid use in the United States
Nathaniel Katz
Inflexxion Inc, Newton, MA 02464, USA
Clin J Pain 24:528-35. 2008
..An Internet-based survey of nonmedical opioid users visiting informational drug websites was used to measure rates of nonmedical use and characterize users...
- Illustration of a statistical process control approach to regional prescription opioid abuse surveillance
James C Benneyan
Center for Health Organization Transformation, Northeastern University, Boston, MA, USA
J Addict Med 5:99-109. 2011
..To investigate and illustrate the use of statistical process control (SPC) for prospective monitoring and detection of regional changes in prescription opioid abuse rates...
- Coxibs: Evolving role in pain management
Nathaniel Katz
Department of Anesthesia, Harvard Medical School, Boston, MA, USA
Semin Arthritis Rheum 32:15-24. 2002
..Decreased GI and antiplatelet effects of coxibs compared to traditional NSAIDs provide the potential to incorporate coxibs into the pain management algorithm used to treat cancer pain...
- Usefulness of prescription monitoring programs for surveillance--analysis of Schedule II opioid prescription data in Massachusetts, 1996-2006
Nathaniel Katz
Tufts University School of Medicine, Boston, MA 02111, USA
Pharmacoepidemiol Drug Saf 19:115-23. 2010
..We analyze herein 11 years of Massachusetts PMP data to evaluate trends in opioid prescribing, dispensing, and usage...
- Enriched enrollment randomized withdrawal trial designs of analgesics: focus on methodology
Nathaniel Katz
Analgesic Research, Needham, MA, 02494, USA
Clin J Pain 25:797-807. 2009
..To systematically identify and critically assess clinical trials that use enriched enrollment randomized withdrawal (EERW) trial design as a methodology for assessing the effect of analgesics pain...
- National addictions vigilance intervention and prevention program (NAVIPPRO): a real-time, product-specific, public health surveillance system for monitoring prescription drug abuse
Stephen F Butler
Inflexxion, Inc, Newton, MA 02464 1594, USA
Pharmacoepidemiol Drug Saf 17:1142-54. 2008
....
- Tampering with prescription opioids: nature and extent of the problem, health consequences, and solutions
Nathaniel Katz
Analgesic Solutions, Natick, MA, USA
Am J Drug Alcohol Abuse 37:205-17. 2011
..Transdermal and solid oral prescription opioid (PO) formulations can be abused by ingesting (with or without tampering), snorting, or injection (both requiring tampering)...
- Ultrasound-enabled topical anesthesia for pain reduction of phlebotomy for whole blood donation
Christopher P Stowell
Department of Pathology, Blood Transfusion Service, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA
Transfusion 49:146-53. 2009
..Ultrasound-facilitated delivery of topical anesthetics has been used to achieve effective anesthesia within 5 minutes for venipuncture and the insertion of intravenous access devices, but has never been studied for blood donation...
- The impact of opioids on the endocrine system
Nathaniel Katz
Analgesic Research, Tufts University School of Medicine, Boston, MA, USA
Clin J Pain 25:170-5. 2009
..However, their negative effects on the endocrine system, which have been known for some times, are barely discussed in modern medicine. Therefore, we conducted a systematic review of the impact of opioids on the endocrine system...
- Direct costs of opioid abuse in an insured population in the United States
Alan G White
Analysis Group, Inc, 111 Huntington Ave, 10th Fl, Boston, MA 02199, USA
J Manag Care Pharm 11:469-79. 2005
..g., inpatient, outpatient, emergency room, drug, other) from the perspective of a private payer...
- The impact of pain management on quality of life
Nathaniel Katz
Pain Trials Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
J Pain Symptom Manage 24:S38-47. 2002
....
- Treatment of postherpetic neuralgia: a review of therapeutic options
Charles E Argoff
Cohn Pain Management Center, North Shore University Hospital, Cohn Pain Management Center, Bethpage, New York 11714, USA
J Pain Symptom Manage 28:396-411. 2004
..Well-designed, multicenter, controlled clinical trials are needed to develop a treatment algorithm that provides an evidence-based, rational approach to treating PHN...
- Relative analgesic potency of fentanyl and sufentanil during intermediate-term infusions in patients after long-term opioid treatment for chronic pain
Lowell Reynolds
Center for Pain Management, Loma Linda University School of Medicine, Loma Linda, CA, USA
Pain 110:182-8. 2004
..5; mean potency ratio was 7.44 (95% confidence interval 6.8-8.2). During titrated, intermediate-term infusions in patients previously treated with opioids for chronic pain, sufentanil is approximately 7.5 times as potent as fentanyl...
- Reporting of clinical trials of analgesia
Nathaniel Katz
J Thorac Cardiovasc Surg 127:605; author reply 606. 2004
- Opioids: after thousands of years, still getting to know you
Nathaniel Katz
Analgesic Research, Needham, MA 02494, USA
Clin J Pain 23:303-6. 2007
- Abuse-deterrent opioid formulations: are they a pipe dream?
Nathaniel Katz
Analgesic Research, 109 Highland Avenue, Suite B2, Needham, MA 02494, USA
Curr Rheumatol Rep 10:11-8. 2008
....
