Roger L Kaspar

Summary

Publications

  1. doi request reprint Use of self-delivery siRNAs to inhibit gene expression in an organotypic pachyonychia congenita model
    Robyn P Hickerson
    TransDerm Inc, Santa Cruz, California, USA
    J Invest Dermatol 131:1037-44. 2011
  2. doi request reprint Development of quantitative molecular clinical end points for siRNA clinical trials
    Robyn P Hickerson
    TransDerm, Santa Cruz, California 95060, USA
    J Invest Dermatol 131:1029-36. 2011
  3. ncbi request reprint Single-nucleotide-specific siRNA targeting in a dominant-negative skin model
    Robyn P Hickerson
    TransDerm Inc, Santa Cruz, California, USA
    J Invest Dermatol 128:594-605. 2008
  4. pmc Stability study of unmodified siRNA and relevance to clinical use
    Robyn P Hickerson
    TransDerm Inc, Santa Cruz, California, USA
    Oligonucleotides 18:345-54. 2008
  5. pmc Inhibition of CD44 gene expression in human skin models, using self-delivery short interfering RNA administered by dissolvable microneedle arrays
    Maria Fernanda Lara
    TransDerm, Santa Cruz, CA 95060, USA
    Hum Gene Ther 23:816-23. 2012
  6. pmc Intravital fluorescence imaging of small interfering RNA-mediated gene repression in a dual reporter melanoma xenograft model
    Robyn P Hickerson
    TransDerm Inc, Santa Cruz, California, USA
    Nucleic Acid Ther 22:438-43. 2012
  7. ncbi request reprint shRNAs targeting hepatitis C: effects of sequence and structural features, and comparision with siRNA
    Alexander V Vlassov
    SomaGenics, Inc, Santa Cruz, CA 95060, USA
    Oligonucleotides 17:223-36. 2007
  8. ncbi request reprint Delivery and inhibition of reporter genes by small interfering RNAs in a mouse skin model
    Qian Wang
    Molecular Imaging Program at Stanford, and Department of Radiology, Stanford University School of Medicine, Stanford, California, USA
    J Invest Dermatol 127:2577-84. 2007
  9. pmc Silencing of reporter gene expression in skin using siRNAs and expression of plasmid DNA delivered by a soluble protrusion array device (PAD)
    Emilio Gonzalez-Gonzalez
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
    Mol Ther 18:1667-74. 2010
  10. doi request reprint Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients
    Robyn P Hickerson
    TransDerm, Inc, Santa Cruz, CA, USA
    J Dermatol Sci 56:82-8. 2009

Collaborators

Detail Information

Publications13

  1. doi request reprint Use of self-delivery siRNAs to inhibit gene expression in an organotypic pachyonychia congenita model
    Robyn P Hickerson
    TransDerm Inc, Santa Cruz, California, USA
    J Invest Dermatol 131:1037-44. 2011
    ..These results indicate that chemical modification of siRNA may overcome certain limitations to transdermal delivery (specifically keratinocyte uptake) and may have clinical utility for inhibition of gene expression in the skin...
  2. doi request reprint Development of quantitative molecular clinical end points for siRNA clinical trials
    Robyn P Hickerson
    TransDerm, Santa Cruz, California 95060, USA
    J Invest Dermatol 131:1029-36. 2011
    ....
  3. ncbi request reprint Single-nucleotide-specific siRNA targeting in a dominant-negative skin model
    Robyn P Hickerson
    TransDerm Inc, Santa Cruz, California, USA
    J Invest Dermatol 128:594-605. 2008
    ..These results suggest that efficient delivery of these "designer siRNAs" may allow effective treatment of numerous genetic disorders including PC...
  4. pmc Stability study of unmodified siRNA and relevance to clinical use
    Robyn P Hickerson
    TransDerm Inc, Santa Cruz, California, USA
    Oligonucleotides 18:345-54. 2008
    ..Taken together, these data indicate that unmodified siRNAs are viable therapeutic candidates...
  5. pmc Inhibition of CD44 gene expression in human skin models, using self-delivery short interfering RNA administered by dissolvable microneedle arrays
    Maria Fernanda Lara
    TransDerm, Santa Cruz, CA 95060, USA
    Hum Gene Ther 23:816-23. 2012
    ..Taken together, these results demonstrate that sd-siRNA, delivered by microneedle arrays, can reduce expression of a targeted endogenous gene in a human skin xenograft model...
  6. pmc Intravital fluorescence imaging of small interfering RNA-mediated gene repression in a dual reporter melanoma xenograft model
    Robyn P Hickerson
    TransDerm Inc, Santa Cruz, California, USA
    Nucleic Acid Ther 22:438-43. 2012
    ..No effect was observed with nonspecific control siRNA treatment. This model provides a platform on which siRNA delivery technologies can be screened and optimized in vivo...
  7. ncbi request reprint shRNAs targeting hepatitis C: effects of sequence and structural features, and comparision with siRNA
    Alexander V Vlassov
    SomaGenics, Inc, Santa Cruz, CA 95060, USA
    Oligonucleotides 17:223-36. 2007
    ..The results indicate that shRNAs, which can be prepared by either transcription or chemical synthesis, may be effective agents for the control of HCV...
  8. ncbi request reprint Delivery and inhibition of reporter genes by small interfering RNAs in a mouse skin model
    Qian Wang
    Molecular Imaging Program at Stanford, and Department of Radiology, Stanford University School of Medicine, Stanford, California, USA
    J Invest Dermatol 127:2577-84. 2007
    ..These results indicate that small interfering RNA, delivered locally as RNA directly or expressed from viral or non-viral vectors, may be effective agents for treating skin disorders...
  9. pmc Silencing of reporter gene expression in skin using siRNAs and expression of plasmid DNA delivered by a soluble protrusion array device (PAD)
    Emilio Gonzalez-Gonzalez
    Department of Pediatrics, Stanford University School of Medicine, Stanford, California, USA
    Mol Ther 18:1667-74. 2010
    ..These results support the use of PADs for delivery of functional nucleic acids to cells in the skin with an efficiency that may support clinical translation...
  10. doi request reprint Rapamycin selectively inhibits expression of an inducible keratin (K6a) in human keratinocytes and improves symptoms in pachyonychia congenita patients
    Robyn P Hickerson
    TransDerm, Inc, Santa Cruz, CA, USA
    J Dermatol Sci 56:82-8. 2009
    ..Published sequence data suggest the 5' untranslated regions of K6a and K6b mRNAs contain 5' TOP motifs and therefore may be sensitive to rapamycin treatment...
  11. pmc Hairpin ribozyme-antisense RNA constructs can act as molecular Lassos
    Anne Dallas
    SomaGenics, Inc, Santa Cruz, CA 95060, USA
    Nucleic Acids Res 36:6752-66. 2008
    ..We also show in cell culture experiments that Lassos directed against Fas pre-mRNA were able to induce a change in alternative splicing patterns...
  12. ncbi request reprint SiRNA-mediated selective inhibition of mutant keratin mRNAs responsible for the skin disorder pachyonychia congenita
    Robyn P Hickerson
    TransDerm, Santa Cruz, California 95060, USA
    Ann N Y Acad Sci 1082:56-61. 2006
    ..These studies suggest that siRNAs can discriminate single nucleotide mutations and further suggest that "designer siRNAs" may allow effective treatment of a host of genetic disorders including PC...
  13. ncbi request reprint Inhibition of hepatitis C IRES-mediated gene expression by small hairpin RNAs in human hepatocytes and mice
    Heini Ilves
    SomaGenics, Inc, Santa Cruz, CA 95060, USA
    Ann N Y Acad Sci 1082:52-5. 2006
    ..The results indicate that shRNAs, delivered as naked RNA or expressed from vectors, may be effective agents for the control of HCV and related viruses...