- Studies of four new human myeloma cell lines
Department of Haematology, Cambridge University Clinical School, MRC Centre, UK
Leuk Lymphoma 46:101-12. 2005
..FISH analysis revealed cryptic translocations affecting the IGH locus in 14q32 of 2 of these cell lines. Using R- and G-banding numerous other chromosomal abnormalities were recorded and illustrated in each of the 4 cell lines...
- A human myeloma cell line suitable for the generation of human monoclonal antibodies
Department of Hematology, Cambridge University, Medical Research Council Centre, Hills Road, Cambridge CB2 2QH, United Kingdom
Proc Natl Acad Sci U S A 98:1799-804. 2001
..The availability of this cell line should enable the in vitro immortalization of human antibody-producing B cells that are formed in vivo. The monoclonal antibodies produced may have advantages in immunotherapy...
- Human retroviruses in leukaemia and AIDS: reflections on their discovery, biology and epidemiology
Department of Haematology, University of Cambridge Clinical School, MRC Centre, Hills Road, Cambridge CB2 2QH, UK
Biol Rev Camb Philos Soc 79:911-33. 2004
..The isolation of HIV enabled screening tests to be developed for contaminated blood. However, due to the peculiar biology of HIV infection, unfortunately all efforts to develop an effective vaccine have so far failed...
- Effects of passive immunization in patients with the acquired immunodeficiency syndrome-related complex and acquired immunodeficiency syndrome
Department of Hematological Medicine, Cambridge University Clinical School, United Kingdom
Proc Natl Acad Sci U S A 85:9234-7. 1988
..Circulating CD4+ cell counts were unchanged after 2 months. By the third month none of these patients remained in hospital. As this treatment was of minimal toxicity, it merits wider evaluation in ARC and AIDS patients...
- Molecular characterization of human monoclonal antibodies derived from fusions of tonsil lymphocytes with a human myeloma cell line
Department of Haematology, University of Cambridge, Hills Road, Cambridge CB2 2QH, United Kingdom
Hybrid Hybridomics 20:287-92. 2001
- Polymerase chain reaction evidence for human immunodeficiency virus 1 neutralization by passive immunization in patients with AIDS and AIDS-related complex
Department of Haematology, Cambridge University Clinical School, United Kingdom
Proc Natl Acad Sci U S A 87:7613-7. 1990
..It reduces HIV-1 viremia to levels undetectable even by PCR. To advanced/terminal patients, the benefit is of limited duration, while to ARC patients it may be long-term. Therefore, passive immunization should start early in the disease...
- GPC5 is a possible target for the 13q31-q32 amplification detected in lymphoma cell lines
Department of Molecular Cytogenetics, Medical Research Institute, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo ku, Tokyo 113 8510, Japan
J Hum Genet 48:331-5. 2003
..Our findings suggest that GPC5 is a likely target for amplification, and that over-expression of this gene may contribute to development and/or progression of lymphomas and other tumors...
- Identification and characterization of a novel gene, C13orf25, as a target for 13q31-q32 amplification in malignant lymphoma
Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
Cancer Res 64:3087-95. 2004
..Transcript-B also contained seven mature microRNAs in its untranslated region. These results suggest that the C13orf25 gene is the most likely candidate gene for the 13q31-q32 amplicon found in hematopoietic malignancies...