Location: Toronto, 1
To enhance our understanding of regulatory mechanisms supporting cytolysis, and will aid in the implementation of activated and expanded CIK cells as a potentially efficacious form of cellular immunotherapy
Research Support. CAD$677,345
Canadian (CIHR) Operating Grant 74754 10/01/10-9/30/15 NKG2D-mediated “induced-self”
Tumor immunity and immune evasion. Role: Co-Applicant
1. Immunology Open University of Fellowship award ($16400) October 2008 Best Oral presentation
Award, Day in Transplantation, University health Network University of Toronto Canada ($250)
2. University of Toronto Open Fellowship Award ( $5000)
4. Travel Award American Association of Immunologists ($1200) AAi Annual Meeting. Boston USA
5. December 2005: Travel Award, American Society of Hematology, San Diego California
6. February 2004: Best Abstract Award: American Society of Bone Marrow Transplants ( 1200)
7. December 2004: Travel Award: American Society of Hematology (ASH) ($1000)
8. June 2000: Doctors without borders, in Ghazni Afghanistan: for developing basic medical
Health clinics in southern Afghanistan Ghazni
May 20001: World Health Organization (midwife training camp in southern Afghanistan) Every
year the (WHO) recognize, an individual with excellence leadership skills, who has worked in the
most remote region of a war torn country, and has provided the basic
1 Annelie E. Abrahamssona,1, Ifat Gerona,1, Jason Gotlibb, Kim-Hien T. Daoa, Charlene F.
Barrogaa, Isabel G. Newtona, Francis J. Gilesc, Jeffrey Durocherd, Remi S. Creusotb, Mobin
Karimi Carol Jonesb, James L. Zehnderb, Armand Keatinge, Robert S. Negrinb, Irving L.
Weissmanb, and Catriona H. M. Jamiesona,2 Glycogen synthase kinase 3_ missplicing contributes
to leukemia stem cell generation Proc Natl Acad Sci U S A. 2009 Feb 23.
2 R. Nishimura, J. Baker, A. Beilhack, R. Zeiser, JA.Olson, EI.Sega, Mobin Karimi and RS Negrin.
In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with
retention of antitumor activity. Blood. S112(6):2563-74, 2008
3 C.Peter, J.T Kielstein, R.C. Katzenberg, M.CAdams, M. Pitsiouni, N. Kambham, Mobin Karimi,
K.M Kengatharan and J. Cooke. A novel bioluminescent tumor model of human renal cancer cell
lines: an in vitro and in vivo characterization. J Urol. 177(6):2342 2007
4 J. K. Chan, C.A Hamilton, M.K Cheung, Mobin Karimi, J.Baker, J.M. Gall, S.Schulz, S.H.
Thorne, N.N Teng. C.H Contag, L.G. Lum, and R.S Negrin. Enhanced killing of primary overian
cancer by retargeting autologous cytokine-induced killer cells with biospecific antibodies; a
preclinical study Clinical Cancer Research Vol. 12, 1859-1867, 2006
Karimi CV – Page 6
5 Karimi M, Cao TM, Baker JA, Verneris MR, Soares L, Negrin RS. Silencing human NKG2D, DAP10, and
DAP12 reduces cytotoxicity of activated CD8+ T cells and NK cells. J Immunol. 175(12):7819-
6 M. R.Verneris, A.Arshi, M. Edinger, M.Kornacker, Y. Natkunam, Mobin Karami, Y.Cao, N.
Marina, C.H. Contag and R.S. Negrin. Low levels of her2/neu expressed by ewings family tumor
cell lines can redirect cytokine-induced killer cells. Clinical Cancer Research Vol. 11, 4561-4570,
7 M.R. Verneris, Mobin Karimi, J.Baker, A. Jayaswal, and RS. Negrin. Role of NKG2D signaling in
the cytotoxicity of activated and expanded CD8+ T cells. Blood, 103(8): 3065-72, 2004.
8 A. P. McCaffrey, L Meuse, Mobin Karimi, C.H Contag, and M.A Kay. Potent and specific
morpholino antisense inhibitor of hepatitis C translation in mice. Hepatology 38(2):503-8, 2003
GENE BANK REFERENCES
AUTHORS: Mobin Karimi, T.M Cao, M.H Bachmann, L Su and R.S Negrin.GenBank flat file:
LOCUS. DQ494172 606 bp DNA linear PRI 08-MAY-2006 DEFINITION. Homo sapiens NK
cell receptor D (KLRK1) gene, partial cds. ACCESSION DQ494172 VERSION DQ494172
1 M. Karimi what you need to know about cancer, a 120 page basic information about cancer (mini
book) for Afghan people (in Farsi and Pashtoo) published by Afghan Academic press, Kabul
2 Mobin Karimi, The background to the present crisis in Afghanistan
3 Mobin Karimi Afghanistan the land of Gold mines and Natural resources
4 Mobin Karimi, What shall the world do in Afghanistan, (A salvation)
5 Mobin Karimi Mujaheed Afghan, (a short story on how the Afghan people defended their home
lands against the Russian in invasion from 1979 till 1992) Sarak vol 9. 198-215, 2006
6 Mobin Karimi The Building of a Nation ( The map road for Afghan people, how to build their
country (in press
International Travel and Provided medical help
1 Provided fist medical response Dr. without the borders, Somalia, Sudan, Bangladish, Pakistan
- In vivo trafficking and survival of cytokine-induced killer cells resulting in minimal GVHD with retention of antitumor activityRyosei Nishimura
Department of Medicine, Division of Blood and Marrow Transplantation, Stanford University, CA 94305, USA
Blood 112:2563-74. 2008..Due to these properties, allogeneic CIK cells had reduced expansion and caused less tissue damage. We conclude that CIK cells have the potential to separate graft-versus-tumor effects from GVHD...
- A truncated human NKG2D splice isoform negatively regulates NKG2D-mediated functionMobin A Karimi
Immunology Research Group, Department of Veterinary and Animal Sciences, University of Massachusetts, Amherst, MA 01003 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
J Immunol 193:2764-71. 2014..Taken together, these data suggest that competitive interference of NKG2D/DAP10 complexes by NKG2D(TR) constitutes a novel mechanism for regulation of NKG2D-mediated function in human CD8(+) T cells and NK cells. ..