Nasiara Karim

Summary

Publications

  1. doi request reprint 3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes
    Nasiara Karim
    University of Sydney, Sydney NSW, 2006, Australia
    Biochem Pharmacol 82:1971-83. 2011
  2. doi request reprint Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors
    Nasiara Karim
    Faculty of Pharmacy, Department of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia
    Biochem Pharmacol 84:549-57. 2012
  3. doi request reprint Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review
    Nasiara Karim
    Faculty of Pharmacy A15, University of Sydney, Sydney, NSW, 2006, Australia
    Amino Acids 44:1139-49. 2013
  4. pmc Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed
    Nathan L Absalom
    From the Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia
    J Biol Chem 288:26521-32. 2013
  5. pmc 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors
    Nasiara Karim
    Faculty of Pharmacy A15, University of Sydney, Sydney, NSW, Australia
    Br J Pharmacol 165:880-96. 2012
  6. pmc α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)
    Nathan Absalom
    Faculty of Pharmacy A15, University of Sydney, Sydney, New South Wales 2006, Australia
    Proc Natl Acad Sci U S A 109:13404-9. 2012
  7. pmc Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors
    Sebastian P Fernandez
    Department of Pharmacology Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia
    Br J Pharmacol 165:965-77. 2012

Collaborators

Detail Information

Publications7

  1. doi request reprint 3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes
    Nasiara Karim
    University of Sydney, Sydney NSW, 2006, Australia
    Biochem Pharmacol 82:1971-83. 2011
    ....
  2. doi request reprint Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors
    Nasiara Karim
    Faculty of Pharmacy, Department of Pharmacology, University of Sydney, Sydney, NSW 2006, Australia
    Biochem Pharmacol 84:549-57. 2012
    ..Taken together, GABA may have different binding modes for extrasynaptic δ-containing GABA(A) receptors compared to their synaptic counterparts...
  3. doi request reprint Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review
    Nasiara Karim
    Faculty of Pharmacy A15, University of Sydney, Sydney, NSW, 2006, Australia
    Amino Acids 44:1139-49. 2013
    ..At α4β2δ, GABA had low micromolar activity...
  4. pmc Covalent trapping of methyllycaconitine at the α4-α4 interface of the α4β2 nicotinic acetylcholine receptor: antagonist binding site and mode of receptor inhibition revealed
    Nathan L Absalom
    From the Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia
    J Biol Chem 288:26521-32. 2013
    ..Consistent with other studies, we propose that the α4-α4 interface is a structural target for potential therapeutics that modulate (α4)3(β2)2 nAChRs. ..
  5. pmc 2'-Methoxy-6-methylflavone: a novel anxiolytic and sedative with subtype selective activating and modulating actions at GABA(A) receptors
    Nasiara Karim
    Faculty of Pharmacy A15, University of Sydney, Sydney, NSW, Australia
    Br J Pharmacol 165:880-96. 2012
    ..Flavonoids are known to have anxiolytic and sedative effects mediated via actions on ionotropic GABA receptors. We sought to investigate this further...
  6. pmc α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB)
    Nathan Absalom
    Faculty of Pharmacy A15, University of Sydney, Sydney, New South Wales 2006, Australia
    Proc Natl Acad Sci U S A 109:13404-9. 2012
    ..This finding will aid in elucidating the molecular mechanisms behind the proposed function of GHB as a neurotransmitter and its unique therapeutic effects in narcolepsy and alcoholism...
  7. pmc Flavan-3-ol esters: new agents for exploring modulatory sites on GABA(A) receptors
    Sebastian P Fernandez
    Department of Pharmacology Faculty of Pharmacy, The University of Sydney, Sydney, New South Wales, Australia
    Br J Pharmacol 165:965-77. 2012
    ..In this study we further investigated the interactions between these agents...