Vladimir A Karginov

Summary

Publications

  1. pmc Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design
    Vladimir A Karginov
    Innovative Biologics, Inc, 10900 University Boulevard, Manassas, VA 20110, USA
    Proc Natl Acad Sci U S A 102:15075-80. 2005
  2. pmc Cyclodextrin derivatives as anti-infectives
    Vladimir A Karginov
    Innovative Biologics, Inc, 13455 Sunrise Valley Drive, Suite 200, Herndon, VA 20171, USA Electronic address
    Curr Opin Pharmacol 13:717-25. 2013
  3. ncbi request reprint Beta-cyclodextrin derivatives that inhibit anthrax lethal toxin
    Vladimir A Karginov
    Innovative Biologics, Inc, 10900 University Blvd, Manassas, VA 20110, USA
    Bioorg Med Chem 14:33-40. 2006
  4. pmc Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities
    Vladimir A Karginov
    Innovative Biologics, Inc, 10900 University Blvd, MSN 1A8, Manassas, VA 20110, USA
    Antimicrob Agents Chemother 50:3740-53. 2006
  5. pmc Inhibition of S. aureus alpha-hemolysin and B. anthracis lethal toxin by beta-cyclodextrin derivatives
    Vladimir A Karginov
    Innovative Biologics, Inc, 10900 University Blvd, MSN 1A8, Manassas, VA 20110, USA
    Bioorg Med Chem 15:5424-31. 2007
  6. ncbi request reprint Treatment of anthrax infection with combination of ciprofloxacin and antibodies to protective antigen of Bacillus anthracis
    Vladimir A Karginov
    Advanced Biosystems, Inc, 10900 University Blvd, Manassas, VA 20110, USA
    FEMS Immunol Med Microbiol 40:71-4. 2004
  7. pmc Inhibition of anthrax protective antigen outside and inside the cell
    Marina V Backer
    SibTech, Inc, 705 North Mountain Road, Newington, CT 06111, USA
    Antimicrob Agents Chemother 51:245-51. 2007
  8. pmc Symmetry requirements for effective blocking of pore-forming toxins: comparative study with alpha-, beta-, and gamma-cyclodextrin derivatives
    Konstantina Yannakopoulou
    Institute of Physical Chemistry, National Center for Scientific Research Demokritos, Aghia Paraskevi 15310, Athens, Greece
    Antimicrob Agents Chemother 55:3594-7. 2011
  9. pmc In vivo efficacy of beta-cyclodextrin derivatives against anthrax lethal toxin
    Mahtab Moayeri
    Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Antimicrob Agents Chemother 52:2239-41. 2008

Research Grants

  1. Small Molecule Blockers of B. anthracis Toxin
    VLADIMIR KARGINOV; Fiscal Year: 2005
  2. Small Molecule Inhibitors of C. perfringens Epsilon-Toxin
    VLADIMIR KARGINOV; Fiscal Year: 2007

Collaborators

Detail Information

Publications9

  1. pmc Blocking anthrax lethal toxin at the protective antigen channel by using structure-inspired drug design
    Vladimir A Karginov
    Innovative Biologics, Inc, 10900 University Boulevard, Manassas, VA 20110, USA
    Proc Natl Acad Sci U S A 102:15075-80. 2005
    ..We anticipate that this approach will serve as the basis for a structure-directed drug discovery program to find new and effective treatments for anthrax...
  2. pmc Cyclodextrin derivatives as anti-infectives
    Vladimir A Karginov
    Innovative Biologics, Inc, 13455 Sunrise Valley Drive, Suite 200, Herndon, VA 20171, USA Electronic address
    Curr Opin Pharmacol 13:717-25. 2013
    ..It was demonstrated that multi-targeted inhibitors can be found using this approach and could be utilized for the development of broad-spectrum drugs against various pathogens. ..
  3. ncbi request reprint Beta-cyclodextrin derivatives that inhibit anthrax lethal toxin
    Vladimir A Karginov
    Innovative Biologics, Inc, 10900 University Blvd, Manassas, VA 20110, USA
    Bioorg Med Chem 14:33-40. 2006
    ..These results provide the basis for a structure-based drug discovery program, with the goal of identifying new drug candidates for anthrax treatment...
  4. pmc Search for cyclodextrin-based inhibitors of anthrax toxins: synthesis, structural features, and relative activities
    Vladimir A Karginov
    Innovative Biologics, Inc, 10900 University Blvd, MSN 1A8, Manassas, VA 20110, USA
    Antimicrob Agents Chemother 50:3740-53. 2006
    ..It is hoped that these results will help to identify a new class of drugs for anthrax treatment, i.e., drugs that block the pathway for toxin translocation into the cytosol, the PA channel...
  5. pmc Inhibition of S. aureus alpha-hemolysin and B. anthracis lethal toxin by beta-cyclodextrin derivatives
    Vladimir A Karginov
    Innovative Biologics, Inc, 10900 University Blvd, MSN 1A8, Manassas, VA 20110, USA
    Bioorg Med Chem 15:5424-31. 2007
    ..We anticipate that this approach can serve as the basis for a structure-directed drug discovery program to find new and effective therapeutics against various pathogens that utilize pore-forming proteins as virulence factors...
  6. ncbi request reprint Treatment of anthrax infection with combination of ciprofloxacin and antibodies to protective antigen of Bacillus anthracis
    Vladimir A Karginov
    Advanced Biosystems, Inc, 10900 University Blvd, Manassas, VA 20110, USA
    FEMS Immunol Med Microbiol 40:71-4. 2004
    ..These data indicate that a combination of antibiotic/immunoglobulin therapy is more effective than antibiotic treatment alone in a rodent anthrax model...
  7. pmc Inhibition of anthrax protective antigen outside and inside the cell
    Marina V Backer
    SibTech, Inc, 705 North Mountain Road, Newington, CT 06111, USA
    Antimicrob Agents Chemother 51:245-51. 2007
    ..These data suggest the potential for the use of beta-cyclodextrins in combination with LFn-Lip loaded with antianthrax drugs against intracellular targets...
  8. pmc Symmetry requirements for effective blocking of pore-forming toxins: comparative study with alpha-, beta-, and gamma-cyclodextrin derivatives
    Konstantina Yannakopoulou
    Institute of Physical Chemistry, National Center for Scientific Research Demokritos, Aghia Paraskevi 15310, Athens, Greece
    Antimicrob Agents Chemother 55:3594-7. 2011
    ..In contrast, α-hemolysin was selectively blocked only by β-cyclodextrin derivatives, demonstrating that both symmetry and size of the inhibitor and the pore are important...
  9. pmc In vivo efficacy of beta-cyclodextrin derivatives against anthrax lethal toxin
    Mahtab Moayeri
    Bacterial Toxins and Therapeutics Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Antimicrob Agents Chemother 52:2239-41. 2008
    ..These compounds were at least 15-fold more potent than previously described beta-cyclodextrins in protecting against anthrax lethal toxin in a rat model. One of the drugs was shown to protect mice from bacterial infection...

Research Grants3

  1. Small Molecule Blockers of B. anthracis Toxin
    VLADIMIR KARGINOV; Fiscal Year: 2005
    ..Long term goals include subsequent preclinical and clinical studies that will lead to the development of a new anti-anthrax treatment. ..
  2. Small Molecule Inhibitors of C. perfringens Epsilon-Toxin
    VLADIMIR KARGINOV; Fiscal Year: 2007
    ..Currently, there is no effective treatment for the epsilon -toxin-mediated intoxication; therefore, a great need exists for the development of therapeutics against this biodefense toxin. ..