- Functional pancreatic beta-cell mass: involvement in type 2 diabetes and therapeutic interventionM Karaca
Universite Paris Diderot, 75205 Paris Cedex 13, France
Diabetes Metab 35:77-84. 2009..The development of drugs regulating this parameter will be the major challenge of the next few years in the management of type 2 diabetes...
- Exploring functional beta-cell heterogeneity in vivo using PSA-NCAM as a specific markerMelis Karaca
Laboratoire de Physiopathologie de la Nutrition, Universite Paris Diderot, CNRS UMR 7059, Paris, France
PLoS ONE 4:e5555. 2009..Here we characterized two functionally distinct groups of beta-cells and investigated their physiological relevance in increased insulin demand conditions in rats...
- In vivo functional heterogeneity among β-cellsMelis Karaca
CNRS EAC, Universite Denis Diderot, Paris, France
Islets 2:124-6. 2010..Here we summarize our main results on β(high) and β(low)-cell populations and discuss some of the open remaining questions...