Karahalil B, Orhan G, Ak F. The impact of detoxifying and repair gene polymorphisms and the levels of serum ROS in the susceptibility to multiple sclerosis. Clin Neurol Neurosurg. 2015;139:288-94 pubmed publisher
..Smoking is also a pivotal confounding factor for subjects with mutant genotypes of XRCC1 Arg399Gln. Further studies are needed to reaffirm our results. ..
Orhan G, Elkama A, Mungan S, Eruyar E, Karahalil B. The impact of detoxifying and repair gene polymorphisms on oxidative stress in ischemic stroke. Neurol Sci. 2016;37:955-61 pubmed publisher
..Our data showed that OGG1 Ser326Cys and XRCC1 Arg399Gln gene polymorphisms had impacts on the development of stroke. ..
Orhan G, Eruyar E, Mungan S, Ak F, Karahalil B. The association of IL-18 gene promoter polymorphisms and the levels of serum IL-18 on the risk of multiple sclerosis. Clin Neurol Neurosurg. 2016;146:96-101 pubmed publisher
..In conclusion, we suggest that IL-18 -607C/A gene promoter polymorphism is a major genetic factor for determining individual susceptibility to MS, where smoking status also increases the risk of MS. ..
Karahalil B, Coskun E, Emerce E. ADRA2A polymorphism and smoking in a Turkish population. Toxicol Ind Health. 2008;24:171-6 pubmed publisher
..There is a need for expanding genotype and haplotype studies because of its importance in various physiological disorders and to confirm the association of this polymorphism with smoking. ..
Karahalil B, Emerce E, Kocer B, Han S, Alkis N, Karakaya A. The association of OGG1 Ser326Cys polymorphism and urinary 8-OHdG levels with lung cancer susceptibility: a hospital-based case-control study in Turkey. Arh Hig Rada Toksikol. 2008;59:241-50 pubmed publisher
..Larger association studies are needed to validate our findings, and mechanistic studies are needed to elucidate the underlying molecular mechanisms of this association. ..