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..PLARCA offers detection of lower protein levels and increased dynamic ranges compared to ELISA. The PLARCA procedure may be adapted to routine instrumentation available in hospitals and research laboratories. ..
Blokzijl A, Nong R, Darmanis S, Hertz E, Landegren U, Kamali Moghaddam M. Protein biomarker validation via proximity ligation assays. Biochim Biophys Acta. 2014;1844:933-9 pubmed publisher
..This article is part of a Special Issue entitled: Biomarkers: A Proteomic Challenge. ..
Larssen P, Wik L, Czarnewski P, Eldh M, LÃ¶f L, Ronquist K, et al
. Tracing Cellular Origin of Human Exosomes Using Multiplex Proximity Extension Assays. Mol Cell Proteomics. 2017;16:502-511 pubmed publisher
..In conclusion, PEA provides a powerful protein screening tool in exosome research, for purposes of identifying the cell source of exosomes, or new biomarkers in diseases such as cancer and inflammation. ..
Löf L, Arngården L, Olsson Stromberg U, Siart B, Jansson M, Dahlin J, et al
. Flow Cytometric Measurement of Blood Cells with BCR-ABL1 Fusion Protein in Chronic Myeloid Leukemia. Sci Rep. 2017;7:623 pubmed publisher
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. Detection of post-translational modifications using solid-phase proximity ligation assay. N Biotechnol. 2018;45:51-59 pubmed publisher
..In summary, we have established the use of SP-PLA as an appropriate method for sensitive detection of PTMs in lysates and sera, which may provide a basis for future PTM-based diagnostic and prognostic biomarkers. ..