Rajaiah Prabhu P, Moorthy S, Madhumathi J, Pradhan S, Perbandt M, Betzel C, et al
. Wucherria bancrofti glutathione S-Transferase: Insights into the 2.3 Å resolution X-ray structure and function, a therapeutic target for human lymphatic filariasis. Biochem Biophys Res Commun. 2018;505:979-984 pubmed publisher
..Further, the study also evaluates the inhibition of WbGST and its variants by antifilarial diethylcarbamazine through kinetic assays. ..
Anugraha G, Madhumathi J, Jeya Prita P, Kaliraj P. Biodegradable poly-l-lactide based microparticles as controlled release delivery system for filarial vaccine candidate antigens. Eur J Pharmacol. 2015;747:174-80 pubmed publisher
..Overall strong humoral and cellular responses were observed for PLA encapsulated antigens compared with single dose of alum adsorbed or protein alone. ..
Parasurama Jawaharlal J, Rajaiah Prabhu P, Gandhirajan A, Krishnan N, Perumal K. Immunoadjuvant effect of diethylcarbamazine in experimental filariasis. Int Immunopharmacol. 2015;24:458-462 pubmed publisher
..05) and hence it is concluded that the need of repeated drug administration can be controlled when there is a possibility of developing protective immunity in the host against mf by vaccination. ..
Arunkumar C, Pandiaraja P, Prince P, Kaliraj P. Immunological characterization of recombinant Wuchereria bancrofti cuticular collagen (COL-4) as putative vaccine candidate for human lymphatic filariasis. Asian Pac J Trop Med. 2014;7:505-12 pubmed publisher
..Our immunological findings in experimental host suggest Th2 mediated immune response. Hence, we propose that W. bancrofti COL-4 could be an efficacious vaccine candidate against lymphatic filariasis. ..
Sakthidevi M, Hoti S, Kaliraj P. Functional analysis of a highly conserved abundant larval transcript-2 (alt-2) intron 2 repeat region of lymphatic filarial parasites. Infect Genet Evol. 2014;24:177-82 pubmed publisher
..We therefore identify IR2 as a suppressor element that regulates L3 stage-specific expression of alt-2. ..
Immanuel C, Ramanathan A, Balasubramaniyan M, Khatri V, Amdare N, Rao D, et al
. Immunoprophylaxis of multi-antigen peptide (MAP) vaccine for human lymphatic filariasis. Immunol Res. 2017;65:729-738 pubmed publisher
..04% compared to control (8.5%). Multi-antigen peptide vaccine is one best approach to provide immunity against multiple antigens delivered by the complex filarial parasite. ..