Remy Kachadourian

Summary

Publications

  1. ncbi Casiopeína IIgly-induced oxidative stress and mitochondrial dysfunction in human lung cancer A549 and H157 cells
    Remy Kachadourian
    Department of Medicine, National Jewish Health, Denver, CO 80206, USA
    Toxicology 268:176-83. 2010
  2. ncbi Selected flavonoids potentiate the toxicity of cisplatin in human lung adenocarcinoma cells: a role for glutathione depletion
    Remy Kachadourian
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Int J Oncol 31:161-8. 2007
  3. ncbi A synthetic chalcone as a potent inducer of glutathione biosynthesis
    Remy Kachadourian
    Department of Medicine, National Jewish Health, Denver, Colorado 80206, United States
    J Med Chem 55:1382-8. 2012
  4. ncbi Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: the role of glutathione
    Heather M Brechbuhl
    Pediatrics, National Jewish Health, Denver, Colorado, USA
    Toxicol Appl Pharmacol 258:1-9. 2012
  5. ncbi Flavonoid-induced glutathione depletion: potential implications for cancer treatment
    Remy Kachadourian
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Free Radic Biol Med 41:65-76. 2006
  6. ncbi Harnessing drug resistance: using ABC transporter proteins to target cancer cells
    Heather M Leitner
    Department of Pharmaceutical Sciences, University of Colorado, Health Sciences Center, Denver, CO, USA
    Biochem Pharmacol 74:1677-85. 2007
  7. ncbi 2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways
    Remy Kachadourian
    Department of Medicine, National Jewish Health, Denver, CO 80206, USA
    Free Radic Biol Med 51:1146-54. 2011
  8. ncbi Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice
    Leonard W Velsor
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Science Center, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 35:579-86. 2006

Collaborators

Detail Information

Publications8

  1. ncbi Casiopeína IIgly-induced oxidative stress and mitochondrial dysfunction in human lung cancer A549 and H157 cells
    Remy Kachadourian
    Department of Medicine, National Jewish Health, Denver, CO 80206, USA
    Toxicology 268:176-83. 2010
    ..These results suggest that Cas IIgly initiates multiple possible sources of ROS over-production leading to mitochondrial dysfunction and cell death...
  2. ncbi Selected flavonoids potentiate the toxicity of cisplatin in human lung adenocarcinoma cells: a role for glutathione depletion
    Remy Kachadourian
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Int J Oncol 31:161-8. 2007
    ....
  3. ncbi A synthetic chalcone as a potent inducer of glutathione biosynthesis
    Remy Kachadourian
    Department of Medicine, National Jewish Health, Denver, Colorado 80206, United States
    J Med Chem 55:1382-8. 2012
    ....
  4. ncbi Chrysin enhances doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: the role of glutathione
    Heather M Brechbuhl
    Pediatrics, National Jewish Health, Denver, Colorado, USA
    Toxicol Appl Pharmacol 258:1-9. 2012
    ..Chrysin worked synergistically with DOX to induce cancer cell death. This approach could allow for use of lower concentrations and/or sensitize cancer cells to drugs that are typically resistant to therapy...
  5. ncbi Flavonoid-induced glutathione depletion: potential implications for cancer treatment
    Remy Kachadourian
    Department of Medicine, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Free Radic Biol Med 41:65-76. 2006
    ..Assessments of mitochondrial GSH levels mitochondrial membrane potential and cytochrome c release showed that the potentiation effects induced by 2',5'-DHC and chrysin involve mitochondrial dysfunction...
  6. ncbi Harnessing drug resistance: using ABC transporter proteins to target cancer cells
    Heather M Leitner
    Department of Pharmaceutical Sciences, University of Colorado, Health Sciences Center, Denver, CO, USA
    Biochem Pharmacol 74:1677-85. 2007
    ..This review will emphasize MRP-mediated modulation of intracellular GSH levels as a potential alternative and adjunctive approach for cancer therapy...
  7. ncbi 2',5'-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways
    Remy Kachadourian
    Department of Medicine, National Jewish Health, Denver, CO 80206, USA
    Free Radic Biol Med 51:1146-54. 2011
    ..These findings suggest that the 2',5'-DHC-induced increase in GSH levels results from a combination of ROS-dependent and ROS-independent pathways...
  8. ncbi Mitochondrial oxidative stress in the lungs of cystic fibrosis transmembrane conductance regulator protein mutant mice
    Leonard W Velsor
    Department of Medicine, National Jewish Medical and Research Center, University of Colorado Health Science Center, Denver, Colorado, USA
    Am J Respir Cell Mol Biol 35:579-86. 2006
    ..Further studies are needed to determine how CFTR deficiency contributes to mitochondrial oxidative stress and the role this plays in CFTR-mediated lung pathophysiology...