Edor Kabashi

Summary

Publications

  1. pmc Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio
    Alexandra Vaccaro
    Université de Montréal Hospital Research Centre, Montreal, Quebec, Canada
    PLoS ONE 7:e42117. 2012
  2. pmc FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis
    Edor Kabashi
    Department of Pathology and Cell Biology and Groupe de Recherche sur le Système Nerveux Central, University of Montreal, Montreal, Canada
    PLoS Genet 7:e1002214. 2011
  3. doi request reprint Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo
    Edor Kabashi
    Centre of Excellence in Neuromics, Department of Medicine, Universite de Montre al, Montreal, Quebec, Canada
    Hum Mol Genet 19:671-83. 2010
  4. ncbi request reprint Tryptophan 32 potentiates aggregation and cytotoxicity of a copper/zinc superoxide dismutase mutant associated with familial amyotrophic lateral sclerosis
    David M Taylor
    Department of Neurology and Neurosurgery, Montreal Neurological Institute and Sheldon Biotechnology Centre, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 282:16329-35. 2007
  5. doi request reprint Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo
    Alexandra Vaccaro
    CRCHUM, Universite de Montreal, Montreal, QC, Canada
    Neurobiol Dis 55:64-75. 2013
  6. doi request reprint Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis
    Edor Kabashi
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurochem 105:2353-66. 2008
  7. doi request reprint Impaired proteasome function in sporadic amyotrophic lateral sclerosis
    Edor Kabashi
    Department of Neurology Neurosurgery and Montreal Neurological Institute, McGill University, Montreal, Canada
    Amyotroph Lateral Scler 13:367-71. 2012
  8. pmc Proteasome activity or expression is not altered by activation of the heat shock transcription factor Hsf1 in cultured fibroblasts or myoblasts
    David M Taylor
    Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Cell Stress Chaperones 10:230-41. 2005
  9. doi request reprint Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish
    Francois Gros-Louis
    Department of Medicine, Center for Excellence in Neuromics, CHUM Research Center, University of Montreal, Montreal, QC, Canada
    Hum Mol Genet 17:2691-702. 2008
  10. doi request reprint TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
    Edor Kabashi
    Center of Excellence in Neuromics, Centre Hospitalier de l Universite de Montreal, and Department of Medicine, University of Montreal, Montreal, Quebec H2L4MI, Canada
    Nat Genet 40:572-4. 2008

Collaborators

Detail Information

Publications14

  1. pmc Methylene blue protects against TDP-43 and FUS neuronal toxicity in C. elegans and D. rerio
    Alexandra Vaccaro
    Université de Montréal Hospital Research Centre, Montreal, Quebec, Canada
    PLoS ONE 7:e42117. 2012
    ..Our results indicate that methylene blue can rescue toxic phenotypes associated with mutant TDP-43 and FUS including neuronal dysfunction and oxidative stress...
  2. pmc FUS and TARDBP but not SOD1 interact in genetic models of amyotrophic lateral sclerosis
    Edor Kabashi
    Department of Pathology and Cell Biology and Groupe de Recherche sur le Système Nerveux Central, University of Montreal, Montreal, Canada
    PLoS Genet 7:e1002214. 2011
    ..Finally, overexpression of mutant SOD1 exacerbated the motor phenotype caused by overexpression of mutant FUS. Together our results indicate that TARDBP and FUS act in a pathogenic pathway that is independent of SOD1...
  3. doi request reprint Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo
    Edor Kabashi
    Centre of Excellence in Neuromics, Department of Medicine, Universite de Montre al, Montreal, Quebec, Canada
    Hum Mol Genet 19:671-83. 2010
    ....
  4. ncbi request reprint Tryptophan 32 potentiates aggregation and cytotoxicity of a copper/zinc superoxide dismutase mutant associated with familial amyotrophic lateral sclerosis
    David M Taylor
    Department of Neurology and Neurosurgery, Montreal Neurological Institute and Sheldon Biotechnology Centre, McGill University, Montreal, Quebec H3A 2B4, Canada
    J Biol Chem 282:16329-35. 2007
    ....
  5. doi request reprint Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo
    Alexandra Vaccaro
    CRCHUM, Universite de Montreal, Montreal, QC, Canada
    Neurobiol Dis 55:64-75. 2013
    ..Our results indicate that protein-folding homeostasis in the ER is an important target for therapeutic development in ALS and other TDP-43-related neurodegenerative diseases...
  6. doi request reprint Proteasomes remain intact, but show early focal alteration in their composition in a mouse model of amyotrophic lateral sclerosis
    Edor Kabashi
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada
    J Neurochem 105:2353-66. 2008
    ..Increase in detergent-insoluble, ubiquitinated proteins at P75 provided further evidence of stress on mechanisms of protein quality control in multiple cell types prior to significant motor neuron death...
  7. doi request reprint Impaired proteasome function in sporadic amyotrophic lateral sclerosis
    Edor Kabashi
    Department of Neurology Neurosurgery and Montreal Neurological Institute, McGill University, Montreal, Canada
    Amyotroph Lateral Scler 13:367-71. 2012
    ..In conclusion, there are commonalities of findings in sporadic ALS patients and presymptomatic SOD1-G93A transgenic mice and these implicate inadequate proteasome function in the pathogenesis of both familial and sporadic ALS...
  8. pmc Proteasome activity or expression is not altered by activation of the heat shock transcription factor Hsf1 in cultured fibroblasts or myoblasts
    David M Taylor
    Montreal Neurological Institute, McGill University, Montreal, QC, Canada
    Cell Stress Chaperones 10:230-41. 2005
    ..Thus, stress-induced or pharmacological activation of Hsf1 in mammalian cells would upregulate Hsps but not directly affect expression or activity of proteasomes...
  9. doi request reprint Als2 mRNA splicing variants detected in KO mice rescue severe motor dysfunction phenotype in Als2 knock-down zebrafish
    Francois Gros-Louis
    Department of Medicine, Center for Excellence in Neuromics, CHUM Research Center, University of Montreal, Montreal, QC, Canada
    Hum Mol Genet 17:2691-702. 2008
    ..Thus, we speculate that the newly identified Als2 mRNA species prevent the Als2 KO mice from developing severe neurodegenerative disease and might also regulate the severity of the motor neurons phenotype observed in ALS2 patients...
  10. doi request reprint TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
    Edor Kabashi
    Center of Excellence in Neuromics, Centre Hospitalier de l Universite de Montreal, and Department of Medicine, University of Montreal, Montreal, Quebec H2L4MI, Canada
    Nat Genet 40:572-4. 2008
    ..These findings further corroborate that TDP-43 is involved in ALS pathogenesis...
  11. doi request reprint Zebrafish models for the functional genomics of neurogenetic disorders
    Edor Kabashi
    Department of Medicine, Universite de Montreal, Montreal, QC, Canada
    Biochim Biophys Acta 1812:335-45. 2011
    ..This article is part of a Special Issue entitled Zebrafish Models of Neurological Diseases...
  12. doi request reprint In the swim of things: recent insights to neurogenetic disorders from zebrafish
    Edor Kabashi
    Center for Excellence in Neuromics, Centre Hospitalier de l Université de Montréal CHUM Research Center and Department of Medicine, Universite de Montreal, Montreal, QC, Canada
    Trends Genet 26:373-81. 2010
    ....
  13. ncbi request reprint Oxidized/misfolded superoxide dismutase-1: the cause of all amyotrophic lateral sclerosis?
    Edor Kabashi
    Centre for Excellence in Neuromics, University of Montreal, the Centre Hospitalier de l Université de Montreal and Ste Justine Hospital, Montreal, Quebec, Canada
    Ann Neurol 62:553-9. 2007
    ....
  14. ncbi request reprint Focal dysfunction of the proteasome: a pathogenic factor in a mouse model of amyotrophic lateral sclerosis
    Edor Kabashi
    Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, Quebec, Canada H3A 2B4
    J Neurochem 89:1325-35. 2004
    ..It is concluded that impairment of the proteasome is an early event and contributes to ALS pathogenesis...