Expression of vascular Notch ligands Delta-like 4 and Jagged-1 in glioblastomaAdrian M Jubb
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Oxford, UK
Histopathology 60:740-7. 2012
..The aims of this study were to characterize the expression of Dll4 and Jag1 in primary glioblastomas...
Vascular phenotypes in primary non-small cell lung carcinomas and matched brain metastasesA M Jubb
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, Level 4 Academic Block, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU, UK
Br J Cancer 104:1877-81. 2011
..The aim of this study was to evaluate these factors in a series of matched primary NSCLCs and brain metastases...
- Biomarkers to predict the clinical efficacy of bevacizumab in cancer
Adrian M Jubb
Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, UK
Lancet Oncol 11:1172-83. 2010
..Many questions relating to these and other surrogate biomarkers, however, remain unanswered and their clinical usefulness has yet to be proven...
Predicting benefit from anti-angiogenic agents in malignancyAdrian M Jubb
Academic Unit of Pathology, Leeds Institute for Molecular Medicine, University of Leeds, UK
Nat Rev Cancer 6:626-35. 2006
....
- Achaete-scute like 2 (ascl2) is a target of Wnt signalling and is upregulated in intestinal neoplasia
A M Jubb
Department of Pathology, Genentech Inc, South San Francisco, CA, USA
Oncogene 25:3445-57. 2006
..0008) and apcmin/+ tumours. Preliminary in vitro data suggest ascl2 may promote progression through the G2/M cell cycle checkpoint. In summary, ascl2 is a putative regulator of proliferation that is overexpressed in intestinal neoplasia...
- Impact of vascular endothelial growth factor-A expression, thrombospondin-2 expression, and microvessel density on the treatment effect of bevacizumab in metastatic colorectal cancer
Adrian M Jubb
Department of Pathology, Genentech Inc, South San Francisco, CA, USA
J Clin Oncol 24:217-27. 2006
..The aim of these retrospective subset analyses was to evaluate VEGF, thrombospondin-2 (THBS-2), and microvessel density (MVD) as prognostic factors and/or predictors of benefit from bevacizumab...
- EphB2 is a prognostic factor in colorectal cancer
Adrian M Jubb
Department of Pathology, Genentech, Inc, South San Francisco, California 94080, USA
Clin Cancer Res 11:5181-7. 2005
..18 to 0.95 (P = 0.035). In summary, EphB2 is expressed in normal crypts, colorectal adenomas, primary cancers, and metastases. High levels of EphB2 expression are associated with a longer mean duration of survival in colorectal cancer...
- Expression of vascular endothelial growth factor, hypoxia inducible factor 1alpha, and carbonic anhydrase IX in human tumours
A M Jubb
Department of Pathology, Genentech Inc, South San Francisco, CA94080, USA
J Clin Pathol 57:504-12. 2004
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- Quantitative analysis of colorectal tissue microarrays by immunofluorescence and in situ hybridization
A M Jubb
Department of Pathology, Genentech Inc, 1 DNA Way, South San Francisco, CA 94080, USA
J Pathol 200:577-88. 2003
..5-fold and the median VEGF-A expression was elevated 4-fold (p = 0.003) in this series of colorectal tumours. Laser imaging systems are therefore feasible for high-throughput, quantitative profiling of tissue microarrays...
- Expression of delta-like ligand 4 (Dll4) and markers of hypoxia in colon cancer
A M Jubb
Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
Br J Cancer 101:1749-57. 2009
..The aim of this study was to characterise the expression of Dll4 in colon cancer and to assess whether it is associated with markers of hypoxia and prognosis...
- Methylation and colorectal cancer
A M Jubb
Academic Unit of Pathology, Algernon Firth Building, University of Leeds, Leeds, LS2 9JT, UK
J Pathol 195:111-34. 2001
..Finally, the applications of epigenetics to molecular pathology and patient diagnosis and treatment are reviewed...
- Association of k-ras, b-raf, and p53 status with the treatment effect of bevacizumab
William L Ince
Department of Pathology, Genentech Inc, San Francisco, CA, USA
J Natl Cancer Inst 97:981-9. 2005
..CONCLUSIONS: We did not find a statistically significant relationship between mutations of k-ras, b-raf, or p53 and the increase in median survival associated with the addition of bevacizumab to IFL in metastatic colorectal cancer...
- Plasmalemmal vesicle-associated protein (PLVAP) is expressed by tumour endothelium and is upregulated by vascular endothelial growth factor-A (VEGF)
Laura A Strickland
Department of Pathology, Genentech Inc, South San Francisco, CA, USA
J Pathol 206:466-75. 2005
..We suggest that PLVAP is a downstream target of VEGF signalling. This work solidifies the association between VEGF and the appearance and maintenance of fenestrations by providing a potential mechanistic link...
- DNA methylation, a biomarker for colorectal cancer: implications for screening and pathological utility
Adrian M Jubb
Academic Unit of Pathology, Leeds University, Leeds, UK
Ann N Y Acad Sci 983:251-67. 2003
..In addition, the authors consider the pathological utility of epigenetic testing in refining tumor staging and predicting disease recurrence...
- Expression of vascular notch ligand delta-like 4 and inflammatory markers in breast cancer
Adrian M Jubb
Nuffield Department of Clinical Laboratory Sciences, Weatherall Institute ofMolecular Medicine, University of Oxford, Oxford, UK
Am J Pathol 176:2019-28. 2010
..002, respectively). In summary, Dll4 was expressed by endothelium associated with breast cancer cells. In these retrospective subset analyses, endothelial Dll4 expression was a statistically significant multivariate prognostic factor...
- Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for multiple cancers
Daniel Gray
Department of Molecular Biology, Pathology, and Bioinformatics, Genentech, Inc, South San Francisco, California 94080, USA
Cancer Res 65:9751-61. 2005
..Together, these results suggest that Melk may provide a growth advantage for neoplastic cells and, therefore, inactivation may be therapeutically beneficial...
- Quantitative in situ hybridization of tissue microarrays
Adrian M Jubb
Academic Unit of Pathology, University of Leeds, UK
Methods Mol Biol 326:255-64. 2006
..In addition, the method includes a protocol for the development of synthetic agarose cores to control for the specificity and sensitivity of hybridization...
