Sergiusz Jozwiak

Summary

Publications

  1. ncbi [Application and comparison of NDT-Bobath and Vojta methods in treatment of selected pathologies of the nervous system in children]
    Sergiusz Jozwiak
    Klinika Neurologii i Epileptologii Instytutu, Pomnik Centrum Zdrowia Dziecka w Warszawie
    Przegl Lek 67:64-6. 2010
  2. ncbi Dietary treatment of epilepsy: rebirth of an ancient treatment
    Sergiusz Jozwiak
    Department of Neurology and Epileptology of the Children s Memorial Health Institute, Warsaw, Poland
    Neurol Neurochir Pol 45:370-8. 2011
  3. doi Management of subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC): Clinical recommendations
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 17:348-52. 2013
  4. doi Everolimus (RAD001): first systemic treatment for subependymal giant cell astrocytoma associated with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, 04 730, Warsaw, Poland
    Future Oncol 8:1515-23. 2012
  5. doi Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 15:424-31. 2011
  6. doi Cerebral tuber count and its impact on mental outcome of patients with tuberous sclerosis complex
    Magdalena Kaczorowska
    Department of Neurology Radiology, MR Unit Pediatric Rehabilitation Psychology, The Children s Memorial Health Institute, Warsaw, Poland
    Epilepsia 52:22-7. 2011
  7. ncbi Clinical and genotype studies of cardiac tumors in 154 patients with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, Children s Memorial Health Institute, Aleja Dzieci Polskich 20, 04 730 Warsaw, Poland
    Pediatrics 118:e1146-51. 2006
  8. ncbi Expression of tuberin and hamartin in tuberous sclerosis complex-associated and sporadic cortical dysplasia of Taylor's balloon cell type
    Wiesława Grajkowska
    Department of Pathology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 46:43-8. 2008
  9. doi Tuberous sclerosis complex: tumors and tumorigenesis
    Julita Borkowska
    Department of Child Neurology, Children s Memorial Health Institute, Warsaw, Poland
    Int J Dermatol 50:13-20. 2011
  10. ncbi Brain tumor formation in tuberous sclerosis depends on Erk activation
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, and Department of Pathology, The Children s Memorial Health Institute, Warsaw, Poland
    Neuromolecular Med 9:117-27. 2007

Collaborators

Detail Information

Publications34

  1. ncbi [Application and comparison of NDT-Bobath and Vojta methods in treatment of selected pathologies of the nervous system in children]
    Sergiusz Jozwiak
    Klinika Neurologii i Epileptologii Instytutu, Pomnik Centrum Zdrowia Dziecka w Warszawie
    Przegl Lek 67:64-6. 2010
    ..The existing literature is supplemented by own clinical experience of the authors. The paper forms the opinion on the constant debates on the superiority of one method over another...
  2. ncbi Dietary treatment of epilepsy: rebirth of an ancient treatment
    Sergiusz Jozwiak
    Department of Neurology and Epileptology of the Children s Memorial Health Institute, Warsaw, Poland
    Neurol Neurochir Pol 45:370-8. 2011
    ..This dietary treatment for epilepsy has undergone a rebirth. Its widespread use in Poland and Europe is a welcome additional treatment for those with drug-resistant epilepsy...
  3. doi Management of subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis complex (TSC): Clinical recommendations
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 17:348-52. 2013
    ..This report summarizes the clinical recommendations for the management of SEGA made by a panel of European experts in March 2012. Current treatment options and outstanding questions are outlined...
  4. doi Everolimus (RAD001): first systemic treatment for subependymal giant cell astrocytoma associated with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, 04 730, Warsaw, Poland
    Future Oncol 8:1515-23. 2012
    ..The most common adverse events in clinical trials were stomatitis/mouth ulceration and upper respiratory tract infections, and most adverse events were grade 1 or 2; grade 4 events were rare...
  5. doi Antiepileptic treatment before the onset of seizures reduces epilepsy severity and risk of mental retardation in infants with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 15:424-31. 2011
    ..Clinical epileptic seizures are preceded by deterioration of EEG recording thus infants with high risk of epilepsy can be identified...
  6. doi Cerebral tuber count and its impact on mental outcome of patients with tuberous sclerosis complex
    Magdalena Kaczorowska
    Department of Neurology Radiology, MR Unit Pediatric Rehabilitation Psychology, The Children s Memorial Health Institute, Warsaw, Poland
    Epilepsia 52:22-7. 2011
    ..The aim of the study was to reveal the relationships between the tuber count of the brain found in patients with tuberous sclerosis complex (TSC) and their cognitive outcome...
  7. ncbi Clinical and genotype studies of cardiac tumors in 154 patients with tuberous sclerosis complex
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, Children s Memorial Health Institute, Aleja Dzieci Polskich 20, 04 730 Warsaw, Poland
    Pediatrics 118:e1146-51. 2006
    ..Our aim for this study was to characterize the incidence, progression, and clinical consequences of tuberous sclerosis complex-associated rhabdomyomas in a large cohort of patients with TSC1 and TSC2 genotypes...
  8. ncbi Expression of tuberin and hamartin in tuberous sclerosis complex-associated and sporadic cortical dysplasia of Taylor's balloon cell type
    Wiesława Grajkowska
    Department of Pathology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 46:43-8. 2008
    ..In conclusion, loss of TSC1 and TSC2 products expression in balloon cells of both cortical dysplasia type IIB in TSC-related and sporadic patients suggests that FCD type IIB may represent the focal form of TSC...
  9. doi Tuberous sclerosis complex: tumors and tumorigenesis
    Julita Borkowska
    Department of Child Neurology, Children s Memorial Health Institute, Warsaw, Poland
    Int J Dermatol 50:13-20. 2011
    ..The authors elucidate the variety of neoplasms seen in TSC patients, along with their clinical significance, and suggest suitable evaluation and management strategies...
  10. ncbi Brain tumor formation in tuberous sclerosis depends on Erk activation
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, and Department of Pathology, The Children s Memorial Health Institute, Warsaw, Poland
    Neuromolecular Med 9:117-27. 2007
    ..Importantly, Erk inhibition leads to the decrease of proliferation potential of such lines. These results show that Erk is specifically implicated in the pathogenesis of hamartomas...
  11. ncbi Cardiac rhabdomyomas in tuberous sclerosis complex show apoptosis regulation and mTOR pathway abnormalities
    Katarzyna Kotulska
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Pediatr Dev Pathol 12:89-95. 2009
    ..Hamartin and tuberin expression was decreased in tumors versus normal heart tissues. This is the first study showing mTOR pathway dysregulation and an increased expression of proapoptotic Bax protein in CRs associated with TSC...
  12. doi Fibroblasts from normal skin of a tuberous sclerosis patient show upregulation of mTOR pathway
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland
    Am J Dermatopathol 31:68-70. 2009
    ..We found that even healthy skin fibroblasts show upregulation of S6 ribosomal protein...
  13. ncbi Subependymal giant cell astrocytomas with atypical histological features mimicking malignant gliomas
    Wiesława Grajkowska
    Department of Pathology, The Children s Memorial Health Institute, Warsaw, Poland
    Folia Neuropathol 49:39-46. 2011
    ..We suggest recognizing such cases of subependymal giant cell astrocytoma as atypical SEGAs...
  14. doi Long-term effect of everolimus on epilepsy and growth in children under 3 years of age treated for subependymal giant cell astrocytoma associated with tuberous sclerosis complex
    Katarzyna Kotulska
    Department of Science, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 17:479-85. 2013
    ..There are also some reports on the antiepileptic and antiepileptogenic potential of mTOR inhibitors in TSC. However, the data on everolimus efficacy and safety in young children are very limited...
  15. doi Effective everolimus treatment of inoperable, life-threatening subependymal giant cell astrocytoma and intractable epilepsy in a patient with tuberous sclerosis complex
    Marta Perek-Polnik
    Department of Oncology, The Children s Memorial Health Institute, Warsaw, Poland
    Eur J Paediatr Neurol 16:83-5. 2012
    ..Moreover, the therapy was well tolerated. These findings indicate that everolimus treatment should be considered as a therapeutic option alternative to surgery in patients with tuberous sclerosis complex...
  16. pmc Novel proteins regulated by mTOR in subependymal giant cell astrocytomas of patients with tuberous sclerosis complex and new therapeutic implications
    Magdalena Ewa Tyburczy
    The Nencki Institute of Experimental Biology, Warsaw, Poland
    Am J Pathol 176:1878-90. 2010
    ....
  17. ncbi Multiple cardiac rhabdomyomas as a sole symptom of tuberous sclerosis complex: case report with molecular confirmation
    Sergiusz Jozwiak
    Department of Neurology, The Children s Memorial Health Institute, Warsaw, Poland
    J Child Neurol 20:988-9. 2005
    ..We propose that all cases of multiple cardiac rhabdomyomas in an infant be given a tentative diagnosis of tuberous sclerosis complex...
  18. ncbi Upregulation of the WNT pathway in tuberous sclerosis-associated subependymal giant cell astrocytomas
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland
    Brain Dev 29:273-80. 2007
    ..At the same time, c-Myc and N-Myc proteins were detected in the same two samples. Thus, we show for the first time that aberrant WNT signaling may contribute to the pathogenesis of TS-associated SEGAs...
  19. ncbi Clinical symptoms of tuberous sclerosis complex in patients with an identical TSC2 mutation
    Paulina Rok
    Department of Child Neurology and Epileptology, The Children s Memorial Health Institute, Warsaw, Poland
    Med Sci Monit 11:CR230-234. 2005
    ..We tried to discover to what extent we may expect variability in the clinical set of symptoms in patients with identical mutation of TSC2 gene...
  20. ncbi Giant cells: contradiction to two-hit model of tuber formation?
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw ul, Chalubinskiego, Warsaw, Poland
    Cell Mol Neurobiol 27:251-61. 2007
    ..In this paper, we review literature covering origination of giant cells and present several hypotheses explaining why in spite of the presence of hamartin and tuberin, brain lesions form in TSC patients...
  21. doi Possible prevention of tuberous sclerosis complex lesions
    Katarzyna Kotulska
    Department of Science, The Children s Memorial Health Institute, Warsaw, Poland
    Pediatrics 132:e239-42. 2013
    ..This observation indicates that early mTOR inhibition in TSC patients may prevent the development of TSC lesions and alter the natural history of the disease. ..
  22. doi Possible mechanisms of disease development in tuberous sclerosis
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland
    Lancet Oncol 9:73-9. 2008
    ..We postulate that ERK activation consistently detected in different tuberous-sclerosis-associated tumours is a molecular trigger for the development of these neoplasms...
  23. ncbi Molecular activity of sirolimus and its possible application in tuberous sclerosis treatment
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, Warsaw, Poland
    Med Res Rev 26:160-80. 2006
    ..Current studies with sirolimus performed in tuberous sclerosis animal models are presented. Possible application of sirolimus for treating tuberous sclerosis, disease caused by mutations of TSC proteins, is discussed...
  24. doi Successful antiepileptic drug withdrawal in infants with epilepsy and cytomegalovirus neuroinfection: longitudinal study
    Dorota Dunin-Wasowicz
    Neurology and Epileptology Department, The Children s Memorial Health Institute, Warsaw, Poland
    Epilepsia 51:1212-8. 2010
    ..A prospective study estimating antiepileptic and antiviral regimens administered to infants with symptomatic epilepsy and human cytomegalovirus (HCMV) neuroinfection followed for at least 4 years...
  25. doi Progeria caused by a rare LMNA mutation p.S143F associated with mild myopathy and atrial fibrillation
    Agnieszka Madej-Pilarczyk
    Neuromuscular Unit, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5, Warsaw, Poland
    Eur J Paediatr Neurol 12:427-30. 2008
    ..To our knowledge, this is the second case of such association described in the literature...
  26. ncbi The role of trkB receptor in the formation of post-traumatic neuroma
    Katarzyna Kotulska
    Department of Neurology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsaw, Poland
    Folia Neuropathol 44:221-7. 2006
    ..We also noticed many more mast cells accumulated at the surgery site in trkB-deficient than in wild-type animals. These results indicate the important role of BDNF receptor in post-traumatic neuroma formation...
  27. ncbi Encephalocraniocutaneous lipomatosis
    Julita Gawel
    Department of Neurology, Child s Health Center, Warsaw, Poland
    J Cutan Med Surg 7:61-5. 2003
    ....
  28. ncbi Giant intracranial aneurysm in a 9-year-old boy with tuberous sclerosis
    Elzbieta Jurkiewicz
    MR Unit, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730, Warsaw, Poland
    Pediatr Radiol 36:463. 2006
  29. ncbi Giant cells: contradiction to two-hit model of tuber formation?
    Jaroslaw Jozwiak
    Department of Histology and Embryology, Center for Biostructure Research, Medical University of Warsaw, and Department of Pediatric Neurology, Children s Memorial Hospital, Warsaw, Poland
    Cell Mol Neurobiol 25:795-805. 2005
    ..3. In the present paper we review literature covering origination of giant cells and present several hypotheses explaining why in spite of the presence of hamartin and tuberin, brain lesions form in TSC patients...
  30. ncbi Tuberin and hamartin expression is reduced in the majority of subependymal giant cell astrocytomas in tuberous sclerosis complex consistent with a two-hit model of pathogenesis
    Sergiusz Jozwiak
    Department of Neurology, Children s Memorial Health Institute, Warsaw, Poland
    J Child Neurol 19:102-6. 2004
    ....
  31. doi Gene table: monogenic determined neurocutaneous disorders
    Sergiusz Jozwiak
    Department of Neurology and Epileptology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 783 Warszawa, Poland
    Eur J Paediatr Neurol 14:449-51. 2010
    ..Recently, a great progress has been achieved in understanding the pathogenesis of many neurocutaneous disorders. This work presents very concise review of molecular background of monogenic determined neurocutaneous disorders...
  32. ncbi Cyst-like cortical tubers in patients with tuberous sclerosis complex: MR imaging with the FLAIR sequence
    Elzbieta Jurkiewicz
    MR Unit, The Children s Memorial Health Institute, Al Dzieci Polskich 20, Warsaw, Poland
    Pediatr Radiol 36:498-501. 2006
    ..Tuberous sclerosis complex (TSC) is an inherited disorder characterized by the presence of cortical tubers, the majority of which are solid and show high signal on FLAIR images. Low-signal tubers are less frequent...
  33. doi Pyridoxine-dependent seizures caused by alpha amino adipic semialdehyde dehydrogenase deficiency: the first polish case with confirmed biochemical and molecular pathology
    Magdalena Kaczorowska
    Department of Child Neurology, The Children s Memorial Health Institute, Warsaw, Poland
    J Child Neurol 23:1455-9. 2008
    ..Due to the availability of reliable laboratory testing, confirmation of the diagnosis was made without the life-threatening trial of pyridoxine withdrawal...
  34. ncbi Epidermal nevus syndrome and intraspinal hemorrhage
    Katarzyna Kotulska
    Department of Neurology, The Children s Memorial Health Institute, Al Dzieci Polskich 20, 04 730 Warsawa, Poland
    Brain Dev 28:541-3. 2006
    ..We report a case of a patient with diagnosed ENS without any primary CNS lesions, who developed paraplegia resulting from spinal cord hemorrhage. The patient presented many vascular and skeletal anomalies...