Treatment of type 2 diabetes with a combination regimen of repaglinide plus pioglitazoneLois Jovanovic
Sansum Medical Research Institute, 2219 Bath Street, Santa Barbara, CA 93105, USA
Diabetes Res Clin Pract 63:127-34. 2004
..In summary, for patients who had previously failed oral antidiabetic monotherapy, the combination repaglinide/pioglitazone had acceptable safety, with greater reductions of glycemic parameters than therapy using either agent alone...
Zone model predictive control: a strategy to minimize hyper- and hypoglycemic eventsBenyamin Grosman
Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, California 93106 5080, USA
J Diabetes Sci Technol 4:961-75. 2010
....
- Experimental evaluation of a recursive model identification technique for type 1 diabetes
Daniel A Finan
Department of Chemical Engineering, University of California, Santa Barbara, California, USA
J Diabetes Sci Technol 3:1192-202. 2009
..Such an adaptive strategy will ensure that the most accurate model is used for the current conditions, and thus the most accurate model predictions are used in model-based control calculations...
- A novel adaptive basal therapy based on the value and rate of change of blood glucose
Youqing Wang
Department of Chemical Engineering, University of California, Santa Barbara, California, USA
J Diabetes Sci Technol 3:1099-108. 2009
..New insulin pumps could receive a direct feed of glucose values from a continuous glucose monitoring (CGM) system and could enable dynamic basal adaptation to improve glycemic control...
- Clinical update on optimal prandial insulin dosing using a refined run-to-run control algorithm
Howard Zisser
Sansum Diabetes Research Institute, Santa Barbara, California, USA
J Diabetes Sci Technol 3:487-91. 2009
..The objective was to use a refined run-to-run algorithm to calculate prandial insulin-to-carbohydrate ratios (I:CHO) for meals of variable carbohydrate content in subjects with type 1 diabetes (T1DM)...
- Clinically relevant hypoglycemia prediction metrics for event mitigation
Rebecca A Harvey
Sansum Diabetes Research Institute, Santa Barbara, CA 93106, USA
Diabetes Technol Ther 14:719-27. 2012
....
- Enhanced 911/global position system wizard: a telemedicine application for the prevention of severe hypoglycemia--monitor, alert, and locate
Eyal Dassau
Department of Chemical Engineering, University of California at Santa Barbara, Santa Barbara, California 93106 5080, USA
J Diabetes Sci Technol 3:1501-6. 2009
..In addition to providing a safety layer to a future artificial pancreas, this system also can be easily implemented in current continuous glucose monitors to help provide information and alerts to people with diabetes...
- Calculating the insulin to carbohydrate ratio using the hyperinsulinaemic-euglycaemic clamp-a novel use for a proven technique
Wendy C Bevier
Sansum Diabetes Research Institute, Santa Barbara, CA 93105, USA
Diabetes Metab Res Rev 23:472-8. 2007
..We are presenting data for a novel use of the hyperinsulinaemic-euglycaemic clamp (HEC) in patients with type 1 diabetes that minimizes the impact of these variables and can be used to determine the I : C...
Automatic bolus and adaptive basal algorithm for the artificial pancreatic β-cellYouqing Wang
Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106, USA
Diabetes Technol Ther 12:879-87. 2010
..To conquer these challenges, an automatic bolus and adaptive basal (ABAB) therapy is proposed to regulate glucose levels for people with type 1 diabetes mellitus...
- Modeling the effects of subcutaneous insulin administration and carbohydrate consumption on blood glucose
Matthew W Percival
Department of Chemical Engineering, University of California, Santa Barbara, CA 93106 5080, USA
J Diabetes Sci Technol 4:1214-28. 2010
..The goal of this study was to quantify these effects in people with T1DM using a novel protocol...
- Safety constraints in an artificial pancreatic beta cell: an implementation of model predictive control with insulin on board
Christian Ellingsen
Department of Chemical Engineering, University of California at Santa Barbara, Santa Barbara, CA 93106 5080, USA
J Diabetes Sci Technol 3:536-44. 2009
..The core of such a system is a control algorithm that calculates the insulin dose based on automated glucose measurements...
- Real-Time hypoglycemia prediction suite using continuous glucose monitoring: a safety net for the artificial pancreas
Eyal Dassau
Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, California, USA
Diabetes Care 33:1249-54. 2010
..This approach can provide a solution to the problem of nocturnal hypoglycemia, a major concern of patients with diabetes...
- Bolus calculator: a review of four "smart" insulin pumps
Howard Zisser
Sansum Diabetes Research Institute, Santa Barbara, California 93105, USA
Diabetes Technol Ther 10:441-4. 2008
..It will also include an in silico simulation of a meal followed by a snack using multiple insulin decay curves...
- Insulin pumps in pregnancy: using technology to achieve normoglycemia in women with diabetes
Kristin Castorino
Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA 93105, USA
Curr Diab Rep 12:53-9. 2012
..In this review of the literature we focus on the use of insulin pumps in the management of diabetes in pregnancy...
- Continuous glucose monitoring during pregnancy
Lironn Chitayat
Sansum Diabetes Research Institute, University of California Santa Barbara, Santa Barbara, California 93105, USA
Diabetes Technol Ther 11:S105-11. 2009
..Demarcation of the normal glucose profile that is present during gestation better defines the therapeutic goals for women with diabetes and ultimately promotes success in pregnancy...
- Insulin pumps and their use in pregnancy
Adrienne D Wollitzer
Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA 93105, USA
Diabetes Technol Ther 12:S33-6. 2010
..Although only a small percentage of pregnant women with diabetes in the United States currently use insulin pumps, we believe that insulin pumps may represent a superior mode of insulin delivery for many women with diabetes in pregnancy...
- In silico evaluation platform for artificial pancreatic beta-cell development--a dynamic simulator for closed-loop control with hardware-in-the-loop
Eyal Dassau
Department of Chemical Engineering, Univ of California at Santa Barbara, California Biomolecular Science and Engineering Program, Univ of California at Santa Barbara, California Sansum Diabetes Research Institute, Santa Barbara, California, USA
Diabetes Technol Ther 11:187-94. 2009
..Computer simulations usually involve only the controller software, leaving untested the hardware elements, including the critical communication interface between the controller and the glucose sensor and insulin pump...
- Practical issues in the identification of empirical models from simulated type 1 diabetes data
Daniel A Finan
Department of Chemical Engineering, University of California, Santa Barbara, CA 93106 5080, USA
Diabetes Technol Ther 9:438-50. 2007
..Thus, the identification of simple, accurate models plays an important role in the development of an artificial beta-cell...
- Siphon effects on continuous subcutaneous insulin infusion pump delivery performance
Howard C Zisser
Sansum Diabetes Research Institute, Santa Barbara, California 93105, USA
J Diabetes Sci Technol 4:98-103. 2010
..The objective was to quantify hydrostatic effects on continuous subcutaneous insulin infusion (CSII) pumps during basal and bolus insulin delivery...
- Prandial insulin dosing using run-to-run control: application of clinical data and medical expertise to define a suitable performance metric
Cesar C Palerm
Department of Chemical Engineering, University of California Santa Barbara, Santa Barbara, CA 93106 5080, USA
Diabetes Care 30:1131-6. 2007
..The dose is adjusted on the basis of a performance measure for the same meal on the previous day. We determine the best performance measure and tune the algorithm to match the recommendations of experienced physicians...
- New modalities in the treatment of pregnancies complicated by diabetes: drugs and devices
Lironn Chitayat
Sansum Diabetes Research Institute, Santa Barbara, CA 93105, USA
Semin Fetal Neonatal Med 14:72-6. 2009
..Oral anti-diabetic agents are not recommended for use during pregnancy. Better control may be achieved with the incorporation of real-time glucose sensors and new insulin pumps with hopes of improving pregnancy outcome...
- Efficacy comparison between preprandial and postprandial insulin aspart administration with dose adjustment for unpredictable meal size
Lois Jovanovic
Sansum Diabetes Research Institute, Santa Barbara, California 93105, USA
Clin Ther 26:1492-7. 2004
....
- Distribution of capillary glycated hemoglobin among adolescents of high school age
David J Pettitt
Sansum Diabetes Research Institute, Santa Barbara, CA 93105, USA
Endocr Pract 14:529-34. 2008
..To report the distribution of glycated hemoglobin (hemoglobin A1c or A1C) in whole blood collected from a cohort of high school students with use of a capillary method...
- Definition, size of the problem, screening and diagnostic criteria: who should be screened, cost-effectiveness, and feasibility of screening
Lois Jovanovic
Sansum Diabetes Research Institute, Santa Barbara, California 93105, USA
Int J Gynaecol Obstet 104:S17-9. 2009
....
- Restoring euglycemia in the basal state using continuous glucose monitoring in subjects with type 1 diabetes mellitus
Howard C Zisser
Sansum Diabetes Research Institute, Santa Barbara, California 93105, USA
Diabetes Technol Ther 9:509-15. 2007
..Our objective was to use continuous glucose monitoring to derive the optimal basal insulin infusion rates in adults with type 1 diabetes and using continuous subcutaneous insulin infusion (CSII) pumps...
- Approach to the patient with diabetes during pregnancy
Jennifer Hone
F A C E, Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, California 93105, USA
J Clin Endocrinol Metab 95:3578-85. 2010
..Euglycemia before, during, and after all pregnancies complicated by diabetes results in the best opportunity for optimal outcomes for mother and infant...
- Run-to-run control of meal-related insulin dosing
Howard Zisser
Sansum Diabetes Research Institute, University of California, Santa Barbara, California 93105, USA
Diabetes Technol Ther 7:48-57. 2005
..This study was designed to determine if it was feasible to use a run-to-run algorithm to improve postprandial glucose concentrations in individuals with type 1 diabetes mellitus (T1DM)...
- Using meal-based self-monitoring blood glucose (SMBG) data to guide dietary recommendations in patients with diabetes
Lois Jovanovic
Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA 93105, USA
Diabetes Educ 35:1023-30. 2009
..They provide immediate feedback to patients on the effect of foods and meals, thereby allowing appropriate food and medication adjustments to improve postprandial glycemic control...
- Management of type 2 diabetes and gestational diabetes in pregnancy
Tara Boinpally
Sansum Diabetes Research Institute, Santa Barbara, CA, USA
Mt Sinai J Med 76:269-80. 2009
..From preconception care before pregnancy to medical treatment postpartum, it is essential that immediate care be taken to help mediate the effects of diabetes in pregnancy...
- Design of the health monitoring system for the artificial pancreas: low glucose prediction module
Rebecca A Harvey
Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, CA 93106, USA
J Diabetes Sci Technol 6:1345-54. 2012
..Safe operation of the APDS is a critical task, where the safety system is engaged only as needed to ensure reliable operation without positive feedback to the controller...
- Continuous glucose monitoring: is it helpful in pregnancy?
Elizabeth Z Byrne
Sansum Diabetes Research Institute, Santa Barbara, California 93105, USA
Curr Diabetes Rev 4:223-6. 2008
..With the use of CGM, the complications of diabetic pregnancies first seen nearly two centuries ago will become a problem of the past...
- Treatment with insulin and its analogs in pregnancies complicated by diabetes
Lois Jovanovic
Sansum Diabetes Research Institute, Santa Barbara, California 93105, USA
Diabetes Care 30:S220-4. 2007
- Predicting subcutaneous glucose concentration using a latent-variable-based statistical method for type 1 diabetes mellitus
Chunhui Zhao
Department of Chemical Engineering, University of California, Santa Barbara, Santa Barbara, California 93106 5080, USA
J Diabetes Sci Technol 6:617-33. 2012
..The availability of frequent glucose measurements, insulin infusion rates, and meal carbohydrate estimates can be used to good advantage to capture important information concerning glucose dynamics...
- Achieving euglycaemia in women with gestational diabetes mellitus: current options for screening, diagnosis and treatment
Lois Jovanovic
Sansum Medical Research Institute, 2219 Bath Street, Santa Barbara, CA 93105, USA
Drugs 64:1401-17. 2004
..There is now some evidence that insulin lispro, other insulin analogues and oral antihyperglycaemic drugs may be beneficial in gestational diabetes, and more data on these agents are awaited with interest...
- Insulin analogues in the treatment of diabetes in pregnancy
Charanpal Singh
Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA 93105, USA
Obstet Gynecol Clin North Am 34:275-91, ix. 2007
..This article also reviews the literature on the insulin analog during pregnancy and presents the authors' opinion as to the safety and efficacy of insulin analog treatment for the pregnant diabetic woman...
- Pregnancy and diabetes management: advances and controversies
Kristin Castorino
Sansum Diabetes Research Institute, Santa Barbara, CA 93110, USA
Clin Chem 57:221-30. 2011
..Early and accurate diagnosis of diabetes in pregnancy is necessary for optimizing maternal and fetal outcomes...
- Glucose and insulin requirements during labor and delivery: the case for normoglycemia in pregnancies complicated by diabetes
Lois Jovanovic
Sansum Diabetes Research Institute, Santa Barbara, California, USA
Endocr Pract 10:40-5. 2004
..Thus, protocols for maintaining normoglycemia during labor and delivery are necessary to achieve optimal results...
- Glycohemoglobin (A1C) distribution in school children: results from a school-based screening program
David J Pettitt
Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA 93105, USA
Diabetes Res Clin Pract 65:45-9. 2004
..To establish the normal distribution for glycohemoglobin (A1C) in sixth and seventh grade children and to assess the practicality of a school-based fingerstick screening program...
- The fidgety fetus hypothesis: fetal activity is an additional variable in determining birth weight of offspring of women with diabetes
Howard Zisser
Sansum Diabetes Research Institute, Santa Barbara, California, USA
Diabetes Care 29:63-7. 2006
..Increased fetal activity may minimize the impact of hyperglycemia on subsequent birth weight. The inactive fetus appears to be at a higher risk for glucose-mediated macrosomia...
- Advances in diabetes for the millennium: diabetes in women
Lois Jovanovic
Sansum Research Foundation, Santa Barbara, California, USA
MedGenMed 6:3. 2004
..This review outlines the rationale of programs of normalized glycemia for diabetic women and suggests strategies to achieve success...
- Frequent monitoring of A1C during pregnancy as a treatment tool to guide therapy
Lois Jovanovic
Sansum Diabetes Research Institute, Santa Barbara, California, USA
Diabetes Care 34:53-4. 2011
..No guidelines for A1C measurement exist for women with gestational diabetes mellitus (GDM). The aim of this study was to document the rate of A1C decline in women with GDM...
- Nutrition and pregnancy: the link between dietary intake and diabetes
Lois Jovanovic
Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA 93105, USA
Curr Diab Rep 4:266-72. 2004
..The challenge for clinicians is to provide nutritional information based on scientific evidence that facilitates the normalization of fetal nutrition, and thus minimize the risk that the child will develop diabetes...
- Low birth weight as a risk factor for gestational diabetes, diabetes, and impaired glucose tolerance during pregnancy
David J Pettitt
Sansum Diabetes Research Institute, 2219 Bath St, Santa Barbara, CA 93105, USA
Diabetes Care 30:S147-9. 2007
- Decreasing the risk of diabetic retinopathy in a study of case management: the California Medi-Cal Type 2 Diabetes Study
David J Pettitt
Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA 93105, USA
Diabetes Care 28:2819-22. 2005
..The findings also emphasized the retinal disease burden in this population, with development and progression of retinopathy occurring in <2 years...
- The vicious cycle of diabetes and pregnancy
David J Pettitt
Sansum Diabetes Research Institute, 2219 Bath Street, Santa Barbara, CA 93105, USA
Curr Diab Rep 7:295-7. 2007
..Solutions need to be found to break this cycle by preventing diabetes or delaying its onset until later in life and by normalizing glucose regulation during pregnancy...
- Comparison of an insulin analog, insulin aspart, and regular human insulin with no insulin in gestational diabetes mellitus
David J Pettitt
Sansum Medical Research Institute, Santa Barbara, California Novo Nordisk Pharmaceuticals, Inc, Princeton, New Jersey, USA
Diabetes Care 26:183-6. 2003
..To assess the short-term efficacy of insulin aspart in comparison with regular human insulin in women with gestational diabetes mellitus (GDM) during standardized meal tests...
- Oral anti-CD3 monoclonal antibody delays diabetes in non-obese diabetic (NOD) mice: effects on pregnancy and offspring--a preliminary report
Wendy C Bevier
Sansum Diabetes Research Institute, Santa Barbara, CA 93105, USA
Diabetes Metab Res Rev 27:480-7. 2011
..The objective was to observe the effect of oral anti-CD3 monoclonal antibody (mAb) on non-obese diabetic mice, pregnancy, and offspring...
- Pregnancy hormones prevent diabetes and reduce lymphocytic infiltration of islets in the NOD mouse
Illani Atwater
Sansum Medical Research Institute, Santa Barbara, California 93105, USA
Ann Clin Lab Sci 32:87-92. 2002
..Prolactin alone had a partial protective effect. The results have implications for prevention of type 1 diabetes and for immune suppression in patients receiving islet cell transplantation...
- Improving outcomes in pregnant women with type 1 diabetes
Moshe Hod
Diabetes Care 30:e62. 2007
- Run-to-run control of blood glucose concentrations for people with Type 1 diabetes mellitus
Camelia Owens
Department of Chemical Engineering, University of Delaware, Newark 19716, USA
IEEE Trans Biomed Eng 53:996-1005. 2006
..Along with this, the insulin sensitivity of the virtual patient model is varied. The algorithm is robust for differences in insulin sensitivity less than +/- 50% of the nominal value...
- OmniPod Insulin Management System: patient perceptions, preference, and glycemic control
Howard Zisser
Diabetes Care 29:2175. 2006
- Point: yes, it is necessary to rely entirely on glycemic values for the insulin treatment of all gestational diabetic women
Lois Jovanovic
Diabetes Care 26:946-7. 2003
- Metformin in pregnancy: its time has not yet come
Florence M Brown
Diabetes Care 29:485-6. 2006
- Reduction in hematocrit level after pioglitazone treatment is correlated with decreased plasma free testosterone level, not hemodilution, in women with polycystic ovary syndrome
Rachele Berria
Division of Diabetes, Department of Medicine Department of Obstetrics and Gynecology, The University of Texas Health Science Center at San Antonio, San Antonio, TX 78229-3900, USA
Clin Pharmacol Ther 80:105-14. 2006
..Further studies are necessary to evaluate whether the same scenario is applicable to normoandrogenic women and individuals with type 2 diabetes mellitus...
- Successful pregnancy in women with type 1 diabetes: from preconception through postpartum care
Lois Jovanovic
Keck School of Medicine, University of Southern California at Los Angeles, Los Angeles, CA, USA
Endocrinol Metab Clin North Am 35:79-97, vi. 2006
- Relationship of fasting and hourly blood glucose levels to HbA1c values: safety, accuracy, and improvements in glucose profiles obtained using a 7-day continuous glucose sensor
Satish Garg
Barbara Davis Center for Childhood Diabetes, University of Colorado at Denver and Health Sciences Center, 1775 N Ursula St A140, Aurora, CO 80010, USA
Diabetes Care 29:2644-9. 2006
..In this study, we evaluated the safety and efficacy of 7-day transcutaneous, real-time, continuous glucose monitoring (CGM) in subjects with insulin-requiring diabetes...
- Continuous glucose monitoring for the evaluation of gravid women with type 1 diabetes mellitus
Yariv Yogev
Department of Obstetrics and Gynecology, Rabin Medical Center, Beilinson Campus, Petah Tiqva, Israel
Obstet Gynecol 101:633-8. 2003
..To compare the daily glycemic profile reflected by continuous and intermittent blood glucose monitoring in pregnant women with type 1 diabetes and to compare the treatment protocols based on the two monitoring methods...
- Weight gain and gestational diabetes mellitus is a sensitive issue
Wendy C Bevier
Diabetes Care 31:e1. 2008
- Elevated pregnancy losses at high and low extremes of maternal glucose in early normal and diabetic pregnancy: evidence for a protective adaptation in diabetes
Lois Jovanovic
University of Washington, 325 Ninth Ave, Box 359720, Seattle, WA 98104, USA
Diabetes Care 28:1113-7. 2005
..CONCLUSIONS: Pregnancy losses are increased at the extremes of glycemia in both normal and diabetic pregnancy but at higher levels in diabetic pregnancy. The data suggest defensive adaptations against hyperglycemia in diabetic pregnancy...
- Point: Oral hypoglycemic agents should not be used to treat diabetic pregnant women
Lois Jovanovic
Diabetes Care 30:2976-9. 2007
- An improved PID switching control strategy for type 1 diabetes
Gianni Marchetti
Department of Chemical Engineering Principles and Practice, , Padova, Italy
Conf Proc IEEE Eng Med Biol Soc 1:5041-4. 2006
....
- Proposal for the reconsideration of the definition of gestational diabetes
Yasue Omori
Diabetes Care 28:2592-3. 2005
- An improved PID switching control strategy for type 1 diabetes
Gianni Marchetti
Dipartimento di Principi e Impianti di Ingegneria Chimica, Universita di Padova, 35131 Padova, Italy
IEEE Trans Biomed Eng 55:857-65. 2008
....
- Improvement in glycemic excursions with a transcutaneous, real-time continuous glucose sensor: a randomized controlled trial
Satish Garg
Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, 1775 N Ursula St, A140, Aurora, Colorado 80010, USA
Diabetes Care 29:44-50. 2006
..In this study we evaluated the accuracy, safety, and clinical effectiveness of a continuous glucose-sensing device...
- Never say never in medicine: confessions of an old dog
Lois Jovanovic
Diabetes Care 27:610-2. 2004
- Serum 1,5-anhydroglucitol (GlycoMark ): a short-term glycemic marker
John B Buse
Divisions of Endocrinology and of General Medicine and Clinical Epidemiology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA
Diabetes Technol Ther 5:355-63. 2003
..The behavior of this analyte is different from all others used in the management of diabetes, creating potential opportunities for its use in clinical practice...
- A retrospective cohort study of diabetes mellitus and antipsychotic treatment in the United States
John B Buse
Diabetes Care Center and Division of General Medicine, University of North Carolina School of Medicine, 5039 Old Clinic Building, CB 7110, Chapel Hill, NC 27599 7110, USA
J Clin Epidemiol 56:164-70. 2003
..An increased risk of developing diabetes compared with the AdvancePCS general patient population was observed during treatment with conventional or atypical antipsychotics...
