Kusumam Joseph

Summary

Publications

  1. doi request reprint Treatment of episodes of hereditary angioedema with C1 inhibitor: serial assessment of observed abnormalities of the plasma bradykinin-forming pathway and fibrinolysis
    Kusumam Joseph
    Division of Rheumatology and Clinical Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann Allergy Asthma Immunol 104:50-4. 2010
  2. ncbi request reprint Interaction of high molecular weight kininogen binding proteins on endothelial cells
    Kusumam Joseph
    Medical University of South Carolina, Department of Medicine, Division of Pulmonary Critical Care, Allergy and Clinical Immunology, 96 Jonathan Lucas Street, P O Box 250623, Charleston, South Carolina 29425, USA
    Thromb Haemost 91:61-70. 2004
  3. ncbi request reprint Inhibition of contact activation by a kininogen peptide (HKH20) derived from domain 5
    Yoshitaka Nakazawa
    Konishi MUSC Institute for Inflammation Research, Division of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, The Medical University of South Carolina, Charleston, SC 29425, USA
    Int Immunopharmacol 2:1875-85. 2002
  4. ncbi request reprint High molecular weight kininogen and factor XII binding to endothelial cells and astrocytes
    Lawrence P Fernando
    Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology, Medical University of South Carolina, P O Box 250623, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    Thromb Haemost 90:787-95. 2003
  5. doi request reprint Studies of the mechanisms of bradykinin generation in hereditary angioedema plasma
    Kusumam Joseph
    Department of Medicine, Division of Rheumatology and Clinical Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann Allergy Asthma Immunol 101:279-86. 2008
  6. doi request reprint Factor XII-independent activation of the bradykinin-forming cascade: Implications for the pathogenesis of hereditary angioedema types I and II
    Kusumam Joseph
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Allergy Clin Immunol 132:470-5. 2013
  7. pmc Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane
    Baby G Tholanikunnel
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 285:33816-25. 2010
  8. doi request reprint The 3'-untranslated region length and AU-rich RNA location modulate RNA-protein interaction and translational control of β2-adrenergic receptor mRNA
    Kothandharaman Subramaniam
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Mol Cell Biochem 352:125-41. 2011
  9. ncbi request reprint Factor XII-independent cleavage of high-molecular-weight kininogen by prekallikrein and inhibition by C1 inhibitor
    Kusumam Joseph
    Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425, USA
    J Allergy Clin Immunol 124:143-9. 2009
  10. ncbi request reprint Activation of the bradykinin-forming cascade on endothelial cells: a role for heat shock protein 90
    Kusumam Joseph
    Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and Konishi MUSC, Institute for Inflammation Research, 96 Jonathan Lucas Street, P O Box 250623, Charleston, SC 29425, USA
    Int Immunopharmacol 2:1851-9. 2002

Collaborators

Detail Information

Publications21

  1. doi request reprint Treatment of episodes of hereditary angioedema with C1 inhibitor: serial assessment of observed abnormalities of the plasma bradykinin-forming pathway and fibrinolysis
    Kusumam Joseph
    Division of Rheumatology and Clinical Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann Allergy Asthma Immunol 104:50-4. 2010
    ..The production of factor XII fragment on in vitro activation of plasma with HAE has also been observed...
  2. ncbi request reprint Interaction of high molecular weight kininogen binding proteins on endothelial cells
    Kusumam Joseph
    Medical University of South Carolina, Department of Medicine, Division of Pulmonary Critical Care, Allergy and Clinical Immunology, 96 Jonathan Lucas Street, P O Box 250623, Charleston, South Carolina 29425, USA
    Thromb Haemost 91:61-70. 2004
    ..Our data suggest that formation of HK (and Factor XII) binding sites along endothelial cell membranes consists of bimolecular com-plexes of gC1qR-cytokeratin 1 and u-PAR-cytokeratin 1, with gC1qR binding being favored...
  3. ncbi request reprint Inhibition of contact activation by a kininogen peptide (HKH20) derived from domain 5
    Yoshitaka Nakazawa
    Konishi MUSC Institute for Inflammation Research, Division of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, The Medical University of South Carolina, Charleston, SC 29425, USA
    Int Immunopharmacol 2:1875-85. 2002
    ....
  4. ncbi request reprint High molecular weight kininogen and factor XII binding to endothelial cells and astrocytes
    Lawrence P Fernando
    Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology, Medical University of South Carolina, P O Box 250623, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    Thromb Haemost 90:787-95. 2003
    ....
  5. doi request reprint Studies of the mechanisms of bradykinin generation in hereditary angioedema plasma
    Kusumam Joseph
    Department of Medicine, Division of Rheumatology and Clinical Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Ann Allergy Asthma Immunol 101:279-86. 2008
    ..Factor XII-dependent bradykinin formation is thought to be responsible for the swelling associated with the various forms of C1 inhibitor deficiency, and complement activation is augmented during attacks of swelling...
  6. doi request reprint Factor XII-independent activation of the bradykinin-forming cascade: Implications for the pathogenesis of hereditary angioedema types I and II
    Kusumam Joseph
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    J Allergy Clin Immunol 132:470-5. 2013
    ..The reaction is stoichiometric and inhibited by C1 inhibitor (C1-INH) or corn trypsin inhibitor. Addition of heat shock protein 90 leads to conversion of prekallikrein to kallikrein in a zinc-dependent reaction...
  7. pmc Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membrane
    Baby G Tholanikunnel
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 285:33816-25. 2010
    ....
  8. doi request reprint The 3'-untranslated region length and AU-rich RNA location modulate RNA-protein interaction and translational control of β2-adrenergic receptor mRNA
    Kothandharaman Subramaniam
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
    Mol Cell Biochem 352:125-41. 2011
    ..Further, the importance of 3'-UTR length and ARE location in TIAR and HuR association with mRNA and translational suppression was demonstrated using a chimeric luciferase reporter gene...
  9. ncbi request reprint Factor XII-independent cleavage of high-molecular-weight kininogen by prekallikrein and inhibition by C1 inhibitor
    Kusumam Joseph
    Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425, USA
    J Allergy Clin Immunol 124:143-9. 2009
    ..Nonenzymatic cell-derived initiators, such as heat shock protein 90, can activate the HK-PK complex to generate kallikrein, bradykinin, and cleaved HK, even in the absence of Factor XII...
  10. ncbi request reprint Activation of the bradykinin-forming cascade on endothelial cells: a role for heat shock protein 90
    Kusumam Joseph
    Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and Konishi MUSC, Institute for Inflammation Research, 96 Jonathan Lucas Street, P O Box 250623, Charleston, SC 29425, USA
    Int Immunopharmacol 2:1851-9. 2002
    ....
  11. doi request reprint The bradykinin-forming cascade and its role in hereditary angioedema
    Allen P Kaplan
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
    Ann Allergy Asthma Immunol 104:193-204. 2010
    ..To review the mechanisms by which bradykinin is generated in hereditary angioedema (HAE) (C1 inhibitor deficiency), including the role of human plasma proteins and endothelial cells...
  12. ncbi request reprint Pathogenic mechanisms of bradykinin mediated diseases: dysregulation of an innate inflammatory pathway
    Allen P Kaplan
    Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA Electronic address
    Adv Immunol 121:41-89. 2014
    ..In allergy (anaphylaxis; perhaps other mast cell-dependent reactions), the oversulfated proteoglycan of mast cells, liberated along with histamine, also catalyze factor XII autoactivation. ..
  13. doi request reprint Treatment of chronic autoimmune urticaria with omalizumab
    Allen P Kaplan
    National Allergy, Asthma, and Urticaria Centers of Charleston, Charleston, SC, USA
    J Allergy Clin Immunol 122:569-73. 2008
    ..If this occurs in CAU, cross-linking of IgE receptors by autoantibody would be less likely, reducing cell activation and urticaria/angioedema...
  14. ncbi request reprint Translational control of beta2-adrenergic receptor mRNA by T-cell-restricted intracellular antigen-related protein
    Karthikeyan Kandasamy
    Department of Medicine and Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina 29425 2221, USA
    J Biol Chem 280:1931-43. 2005
    ..Taken together, our results provide the first evidence for translational control of beta(2)-AR mRNA by TIAR...
  15. ncbi request reprint Formation of bradykinin: a major contributor to the innate inflammatory response
    Kusumam Joseph
    Division of Pulmonary Critical Care Medicine and Allergy Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
    Adv Immunol 86:159-208. 2005
    ....
  16. doi request reprint Regulatory mechanism of G protein-coupled receptor trafficking to the plasma membrane: a role for mRNA localization
    Kusumam Joseph
    Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA
    Methods Enzymol 521:131-50. 2013
    ..Thus, a new paradigm is emerging in GPCR trafficking that suggests a fundamental role for mRNA partitioning to specific cytoplasmic regions for efficient plasma membrane localization of the receptors...
  17. ncbi request reprint Functional assessment of pathogenic IgG subclasses in chronic autoimmune urticaria
    Sridharan Soundararajan
    Department of Medicine, Division of Pulmonary Critical Care, Allergy and Clinical Immunology, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    J Allergy Clin Immunol 115:815-21. 2005
    ..We considered the possibility that pathogenic antibody may be present within particular IgG subclasses, which might facilitate development of a binding method that can reliably screen patients...
  18. ncbi request reprint Pathways for bradykinin formation and inflammatory disease
    Allen P Kaplan
    Department of Medicine, Medical University of South Carolina, 29425, USA
    J Allergy Clin Immunol 109:195-209. 2002
    ..Activation of the plasma cascade occurs as a result of heparin release and endothelial-cell activation and as a secondary event caused by other pathways of inflammation...
  19. ncbi request reprint Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps
    Bradford A Woodworth
    Department of Otolaryngology Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
    Otolaryngol Head Neck Surg 131:585-9. 2004
    ..To determine alterations in Th2 chemokines eotaxin and monocyte chemoattractant protein-4 (MCP-4), and cytokines interleukin-5 (IL-5) and interleukin-13 (IL-13), in nasal polyps (NP) after steroid treatment...
  20. ncbi request reprint The 3'-untranslated region of the beta2-adrenergic receptor mRNA regulates receptor synthesis
    Kothandharaman Subramaniam
    Department of Medicine and the Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina 29425 2221, USA
    J Biol Chem 279:27108-15. 2004
    ..Taken together, our results provide the first evidence for translational control of beta(2)-AR expression by 3'-UTR sequences. Presumably, this occurs by affecting the receptor mRNA localization...
  21. pmc Heat shock protein 90 catalyzes activation of the prekallikrein-kininogen complex in the absence of factor XII
    Kusumam Joseph
    Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and Konishi Medical University of South Carolina, Institute for Inflammation Research, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
    Proc Natl Acad Sci U S A 99:896-900. 2002
    ....