Treatment of episodes of hereditary angioedema with C1 inhibitor: serial assessment of observed abnormalities of the plasma bradykinin-forming pathway and fibrinolysisKusumam Joseph
Division of Rheumatology and Clinical Immunology, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Ann Allergy Asthma Immunol 104:50-4. 2010
..The production of factor XII fragment on in vitro activation of plasma with HAE has also been observed...
Interaction of high molecular weight kininogen binding proteins on endothelial cellsKusumam Joseph
Medical University of South Carolina, Department of Medicine, Division of Pulmonary Critical Care, Allergy and Clinical Immunology, 96 Jonathan Lucas Street, P O Box 250623, Charleston, South Carolina 29425, USA
Thromb Haemost 91:61-70. 2004
..Our data suggest that formation of HK (and Factor XII) binding sites along endothelial cell membranes consists of bimolecular com-plexes of gC1qR-cytokeratin 1 and u-PAR-cytokeratin 1, with gC1qR binding being favored...
- Inhibition of contact activation by a kininogen peptide (HKH20) derived from domain 5
Yoshitaka Nakazawa
Konishi-MUSC Institute for Inflammation Research, Division of Pulmonary and Critical Care Medicine and Allergy and Clinical Immunology, Department of Medicine, The Medical University of South Carolina, Charleston, SC 29425, USA
Int Immunopharmacol 2:1875-85. 2002
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- High molecular weight kininogen and factor XII binding to endothelial cells and astrocytes
Lawrence P Fernando
Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology, Medical University of South Carolina, P O Box 250623, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
Thromb Haemost 90:787-95. 2003
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- Studies of the mechanisms of bradykinin generation in hereditary angioedema plasma
Kusumam Joseph
Department of Medicine, Division of Rheumatology and Clinical Immunology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
Ann Allergy Asthma Immunol 101:279-86. 2008
..Factor XII-dependent bradykinin formation is thought to be responsible for the swelling associated with the various forms of C1 inhibitor deficiency, and complement activation is augmented during attacks of swelling...
Novel mechanisms in the regulation of G protein-coupled receptor trafficking to the plasma membraneBaby G Tholanikunnel
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
J Biol Chem 285:33816-25. 2010
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- The 3'-untranslated region length and AU-rich RNA location modulate RNA-protein interaction and translational control of β2-adrenergic receptor mRNA
Kothandharaman Subramaniam
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC 29425, USA
Mol Cell Biochem 352:125-41. 2011
..Further, the importance of 3'-UTR length and ARE location in TIAR and HuR association with mRNA and translational suppression was demonstrated using a chimeric luciferase reporter gene...
- Factor XII-independent cleavage of high-molecular-weight kininogen by prekallikrein and inhibition by C1 inhibitor
Kusumam Joseph
Department of Medicine, Division of Rheumatology and Immunology, Medical University of South Carolina, 171 Ashley Ave, Charleston, SC 29425, USA
J Allergy Clin Immunol 124:143-9. 2009
..Nonenzymatic cell-derived initiators, such as heat shock protein 90, can activate the HK-PK complex to generate kallikrein, bradykinin, and cleaved HK, even in the absence of Factor XII...
- Activation of the bradykinin-forming cascade on endothelial cells: a role for heat shock protein 90
Kusumam Joseph
Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and Konishi-MUSC, Institute for Inflammation Research, 96 Jonathan Lucas Street, P.O. Box 250623, Charleston, SC 29425, USA
Int Immunopharmacol 2:1851-9. 2002
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- The bradykinin-forming cascade and its role in hereditary angioedema
Allen P Kaplan
Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA
Ann Allergy Asthma Immunol 104:193-204. 2010
..To review the mechanisms by which bradykinin is generated in hereditary angioedema (HAE) (C1 inhibitor deficiency), including the role of human plasma proteins and endothelial cells...
- Translational control of beta2-adrenergic receptor mRNA by T-cell-restricted intracellular antigen-related protein
Karthikeyan Kandasamy
Department of Medicine and Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina 29425-2221, USA
J Biol Chem 280:1931-43. 2005
..Taken together, our results provide the first evidence for translational control of beta(2)-AR mRNA by TIAR...
- Treatment of chronic autoimmune urticaria with omalizumab
Allen P Kaplan
National Allergy, Asthma, and Urticaria Centers of Charleston, Charleston, SC, USA
J Allergy Clin Immunol 122:569-73. 2008
..If this occurs in CAU, cross-linking of IgE receptors by autoantibody would be less likely, reducing cell activation and urticaria/angioedema...
- Formation of bradykinin: a major contributor to the innate inflammatory response
Kusumam Joseph
Division of Pulmonary/Critical Care Medicine and Allergy/Clinical Immunology, Medical University of South Carolina, Charleston, SC 29425, USA
Adv Immunol 86:159-208. 2005
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- Regulatory mechanism of G protein-coupled receptor trafficking to the plasma membrane: a role for mRNA localization
Kusumam Joseph
Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, South Carolina, USA
Methods Enzymol 521:131-50. 2013
..Thus, a new paradigm is emerging in GPCR trafficking that suggests a fundamental role for mRNA partitioning to specific cytoplasmic regions for efficient plasma membrane localization of the receptors...
- Functional assessment of pathogenic IgG subclasses in chronic autoimmune urticaria
Sridharan Soundararajan
Department of Medicine, Division of Pulmonary/Critical Care, Allergy and Clinical Immunology, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
J Allergy Clin Immunol 115:815-21. 2005
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- Pathways for bradykinin formation and inflammatory disease
Allen P Kaplan
Department of Medicine, Medical University of South Carolina, 29425, USA
J Allergy Clin Immunol 109:195-209. 2002
..Activation of the plasma cascade occurs as a result of heparin release and endothelial-cell activation and as a secondary event caused by other pathways of inflammation...
- Alterations in eotaxin, monocyte chemoattractant protein-4, interleukin-5, and interleukin-13 after systemic steroid treatment for nasal polyps
Bradford A Woodworth
Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, SC 29425, USA
Otolaryngol Head Neck Surg 131:585-9. 2004
..SIGNIFICANCE: Novel approaches to block inflammatory mediators, particularly Th2 chemokines, may lead to better control of nasal polyposis in the future...
- The 3'-untranslated region of the beta2-adrenergic receptor mRNA regulates receptor synthesis
Kothandharaman Subramaniam
Department of Medicine and the Division of Nephrology, Medical University of South Carolina, Charleston, South Carolina 29425-2221, USA
J Biol Chem 279:27108-15. 2004
..Taken together, our results provide the first evidence for translational control of beta(2)-AR expression by 3'-UTR sequences. Presumably, this occurs by affecting the receptor mRNA localization...
- Heat shock protein 90 catalyzes activation of the prekallikrein-kininogen complex in the absence of factor XII
Kusumam Joseph
Department of Medicine, Division of Pulmonary and Critical Care, Allergy and Clinical Immunology and Konishi Medical University of South Carolina, Institute for Inflammation Research, 96 Jonathan Lucas Street, Charleston, SC 29425, USA
Proc Natl Acad Sci U S A 99:896-900. 2002
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