Jeffrey M Johnston

Summary

Publications

  1. doi request reprint A review of the clinical efficacy of linaclotide in irritable bowel syndrome with constipation
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, Cambridge, MA, USA
    Curr Med Res Opin 29:149-60. 2013
  2. doi request reprint Pilot study on the effect of linaclotide in patients with chronic constipation
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, 320 Bent Street, Cambridge, MA, USA
    Am J Gastroenterol 104:125-32. 2009
  3. doi request reprint Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, Cambridge, Massachusetts, USA
    Gastroenterology 139:1877-1886.e2. 2010
  4. ncbi request reprint Clarification of trial end points presented in a recent review of linaclotide
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, 301 Binney Street, Cambridge, MA 02142, USA
    Expert Rev Gastroenterol Hepatol 6:13-4. 2012
  5. doi request reprint Two randomized trials of linaclotide for chronic constipation
    Anthony J Lembo
    Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA
    N Engl J Med 365:527-36. 2011
  6. doi request reprint Efficacy of linaclotide for patients with chronic constipation
    Anthony J Lembo
    Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 138:886-95.e1. 2010

Collaborators

Detail Information

Publications6

  1. doi request reprint A review of the clinical efficacy of linaclotide in irritable bowel syndrome with constipation
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, Cambridge, MA, USA
    Curr Med Res Opin 29:149-60. 2013
    ....
  2. doi request reprint Pilot study on the effect of linaclotide in patients with chronic constipation
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, 320 Bent Street, Cambridge, MA, USA
    Am J Gastroenterol 104:125-32. 2009
    ..In Phase 1 studies in healthy human volunteers, linaclotide was well-tolerated, increased bowel movement frequency, and loosened stool consistency...
  3. doi request reprint Linaclotide improves abdominal pain and bowel habits in a phase IIb study of patients with irritable bowel syndrome with constipation
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, Cambridge, Massachusetts, USA
    Gastroenterology 139:1877-1886.e2. 2010
    ..We assessed the efficacy and safety of linaclotide at a daily dose range of 75-600 μg in IBS-C...
  4. ncbi request reprint Clarification of trial end points presented in a recent review of linaclotide
    Jeffrey M Johnston
    Ironwood Pharmaceuticals, Inc, 301 Binney Street, Cambridge, MA 02142, USA
    Expert Rev Gastroenterol Hepatol 6:13-4. 2012
    ..Response to: Roque MV, Camilleri M. Linaclotide, a synthetic guanylate cyclase C agonist, for the treatment of functional gastrointestinal disorders associated with constipation. Expert Rev. Gastroenterol. Hepatol. 5(3), 301-310 (2011)...
  5. doi request reprint Two randomized trials of linaclotide for chronic constipation
    Anthony J Lembo
    Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA
    N Engl J Med 365:527-36. 2011
    ..Linaclotide is a minimally absorbed peptide agonist of the guanylate cyclase C receptor. In two trials, we aimed to determine the efficacy and safety of linaclotide in patients with chronic constipation...
  6. doi request reprint Efficacy of linaclotide for patients with chronic constipation
    Anthony J Lembo
    Department of Medicine, Division of Gastroenterology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Gastroenterology 138:886-95.e1. 2010
    ..We assessed the safety and efficacy of a range of linaclotide doses in patients with chronic constipation...