Buprenorphine: how to use it rightRolley E Johnson
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 70:S59-77. 2003
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- Use of buprenorphine in pregnancy: patient management and effects on the neonate
Rolley E Johnson
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Drug Alcohol Depend 70:S87-101. 2003
..From a review of the literature, buprenorphine appears to be safe and effective in both mother and infant with an NAS that may differ from methadone both qualitatively and quantitatively...
Methadone, cocaine, opiates, and metabolite disposition in umbilical cord and correlations to maternal methadone dose and neonatal outcomesAna de Castro
Chemical and Drug Metabolism Section, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland, USA
Ther Drug Monit 33:443-52. 2011
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- Umbilical cord monitoring of in utero drug exposure to buprenorphine and correlation with maternal dose and neonatal outcomes
Marta Concheiro
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland 21224, USA
J Anal Toxicol 34:498-505. 2010
..Buprenorphine provided a controlled drug administration model for evaluating drug disposition in the maternal-fetal dyad...
- Transferring methadone-stabilized pregnant patients to buprenorphine using an immediate release morphine transition: an open-label exploratory study
Hendree E Jones
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
Am J Addict 15:61-70. 2006
..Withdrawal symptoms appeared during buprenorphine induction; however, these data suggest that the intensity of withdrawal symptoms may be lessened by the dose and frequency of buprenorphine administration...
- Buprenorphine versus methadone in the treatment of pregnant opioid-dependent patients: effects on the neonatal abstinence syndrome
Hendree E Jones
The Department of Psychiatry and Behavioral Sciences, Johns Hopkins Bayview Medical Campus, Johns Hopkins University School of Medicine, D 3 East, 4940 Eastern Avenue, Baltimore, MD 21224, USA
Drug Alcohol Depend 79:1-10. 2005
..25). Results suggest that buprenorphine is not inferior to methadone on outcome measures assessing NAS and maternal and neonatal safety when administered starting in the second trimester of pregnancy...
- Concurrent validation of the Clinical Opiate Withdrawal Scale (COWS) and single-item indices against the Clinical Institute Narcotic Assessment (CINA) opioid withdrawal instrument
D Andrew Tompkins
Johns Hopkins University School of Medicine, Department of Psychiatry and Behavioral Sciences, Behavioral Pharmacology Research Unit, 5510 Nathan Shock Drive, Baltimore, MD 21224, USA
Drug Alcohol Depend 105:154-9. 2009
..Though commonly used in clinical practice, it has not been systematically validated. The present study validated the COWS in comparison to the validated Clinical Institute Narcotic Assessment (CINA) scale...
- Predictors of outcome in LAAM, buprenorphine, and methadone treatment for opioid dependence
Lisa A Marsch
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Exp Clin Psychopharmacol 13:293-302. 2005
..We did not find any factors that would strongly guide selection of one medication over others...
- Maternal buprenorphine dose, placenta buprenorphine, and metabolite concentrations and neonatal outcomes
Marta Concheiro
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD, USA
Ther Drug Monit 32:206-15. 2010
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Maternal methadone dose, placental methadone concentrations, and neonatal outcomesAna de Castro
Chemistry and Drug Metabolism, National Institute on Drug Abuse, NIH, Baltimore, MD 21224, USA
Clin Chem 57:449-58. 2011
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- Buprenorphine and norbuprenorphine in hair of pregnant women and their infants after controlled buprenorphine administration
Robert S Goodwin
Chemistry and Drug Metabolism Section, National Institute on Drug Abuse Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA
Clin Chem 53:2136-43. 2007
..We hypothesized that there would be a relationship between the cumulative maternal dose of buprenorphine during pregnancy and the concentration of buprenorphine and norbuprenorphine in maternal and infant hair...
- Urinary excretion of buprenorphine, norbuprenorphine, buprenorphine-glucuronide, and norbuprenorphine-glucuronide in pregnant women receiving buprenorphine maintenance treatment
Sherri L Kacinko
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, NIH, Baltimore, MD, USA
Clin Chem 55:1177-87. 2009
..We investigated BUP and metabolite disposition in urine from women maintained on BUP during the second and third trimesters of pregnancy and postpartum...
- Infant neurobehavior following prenatal exposure to methadone or buprenorphine: results from the neonatal intensive care unit network neurobehavioral scale
Hendree E Jones
Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21224, USA
Subst Use Misuse 45:2244-57. 2010
..Results suggest the NNNS may detect subtle differences over time between both neonates prenatally exposed to methadone or buprenorphine and neonates pharmacologically treated or untreated for NAS...
- Excretion of methadone in sweat of pregnant women throughout gestation after controlled methadone administration
Allan J Barnes
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Ther Drug Monit 32:497-503. 2010
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- Males and females differ in response to opioid agonist medications
Hendree E Jones
Department of Psychiatry and Behavioral Sciences, The Jhons Hopkins University School of Medicine, Baltimore, MD 21224, USA
Am J Addict 14:223-33. 2005
..Within-subject change results indicate that all three medications benefit both sexes. Clinical trials should be designed to examine the impact of sex on outcomes...
- Confirmatory analysis of buprenorphine, norbuprenorphine, and glucuronide metabolites in plasma by LCMSMS. Application to umbilical cord plasma from buprenorphine-maintained pregnant women
Marta Concheiro
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Biomedical Research Center BRC, 251 Bayview Boulevard, Suite 200, Room 05A721, Baltimore, MD 21224, USA
J Chromatogr B Analyt Technol Biomed Life Sci 878:13-20. 2010
..5+/-0.8ng/mL) and BUP (0.4+/-0.2ng/mL). Although BUP biomarkers can be quantified in umbilical cord plasma in low ng/mL concentrations, the significance of these data as predictors of neonatal outcomes is currently unknown...
- Safety and efficacy of L-tryptophan and behavioral incentives for treatment of cocaine dependence: a randomized clinical trial
Hendree E Jones
Behavioral Pharmacology Research Unit, Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Am J Addict 13:421-37. 2004
..This study also showed that contingent vouchers were effective in the novel experimental model of relapse prevention...
- Methadone and metabolites in hair of methadone-assisted pregnant women and their infants
Sarah K Himes
Chemistry and Drug Metabolism, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
Ther Drug Monit 34:337-44. 2012
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- Dosing adjustments in postpartum patients maintained on buprenorphine or methadone
Hendree E Jones
From the Departments of Psychiatry and Behavioral Sciences HEJ, REJ, MT, Medicine DRJ, and Obstetrics and Gynecology LM, Johns Hopkins University School of Medicine, Baltimore, MD Reckitt Benckiser Pharmaceuticals Inc REJ, Richmond, VA and the Department of Psychology KEO, University of Maryland, College Park, College Park, MD
J Addict Med 2:103-7. 2008
..Buprenorphine-maintained participants required dose changes postpartum only after they transferred to methadone. Regardless of type of medication, postpartum patients should be monitored for signs of overmedication...
- Randomized controlled study transitioning opioid-dependent pregnant women from short-acting morphine to buprenorphine or methadone
Hendree E Jones
The Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21224, USA
Drug Alcohol Depend 78:33-8. 2005
..Transitioning opioid-dependent pregnant women from IRM to methadone or buprenorphine during the second trimester of pregnancy can be conducted with similar comfort and safety...
- Buprenorphine: considerations for pain management
Rolley E Johnson
Department of Psychiatry and Behavioral Sciences, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
J Pain Symptom Manage 29:297-326. 2005
..However, withdrawal symptoms appear to be mild to moderate in intensity compared with those of full mu agonists. Overdoses have primarily involved buprenorphine taken in combination with other central nervous system depressants...
- Randomized trial of buprenorphine for treatment of concurrent opiate and cocaine dependence
Ivan D Montoya
Division of Treatment Research and Development and Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Department of Health and Human Services, Baltimore, MD 21224, USA
Clin Pharmacol Ther 75:34-48. 2004
..CONCLUSIONS: A sublingual buprenorphine solution at 16 mg daily is well tolerated and effective in reducing concomitant opiate and cocaine use. The therapeutic effect on cocaine use appears independent of that on opiate use...
