Franklin Johnson

Summary

Publications

  1. ncbi request reprint The relative bioavailability of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA®) and an extended release morphine sulfate capsule formulation (KADIAN®) in healthy adults under fasting conditions
    Franklin K Johnson
    ClinPharm PK Consulting LLC, 625 Talamini Road, Bridgewater, NJ 08807, USA
    Am J Ther 18:2-8. 2011
  2. doi request reprint Effects of alcohol on the pharmacokinetics of morphine sulfate and naltrexone hydrochloride extended release capsules
    Franklin K Johnson
    King Pharmaceuticals, Inc, Bridgewater, NJ, USA
    J Clin Pharmacol 52:747-56. 2012
  3. doi request reprint Relative oral bioavailability of morphine and naltrexone derived from crushed morphine sulfate and naltrexone hydrochloride extended-release capsules versus intact product and versus naltrexone solution: a single-dose, randomized-sequence, open-label, thr
    Franklin K Johnson
    Alpharma Pharmaceuticals LLC, a wholly owned subsidiary of King Pharmaceuticals, Inc, Bridgewater, New Jersey, USA
    Clin Ther 32:1149-64. 2010
  4. doi request reprint Food effects on the pharmacokinetics of morphine sulfate and naltrexone hydrochloride extended release capsules
    Franklin Johnson
    ClinPharm PK Consulting LLC, Bridgewater, NJ 08807, USA
    Adv Ther 27:846-58. 2010
  5. ncbi request reprint Morphine sulfate and naltrexone hydrochloride extended-release capsules: naltrexone release, pharmacodynamics, and tolerability
    Franklin Johnson
    ClinPharm PK Consulting LLC, 625 Talamini Road, Bridgewater, NJ 08807, USA
    Pain Physician 14:391-406. 2011
  6. doi request reprint Subjective effects and safety of whole and tampered morphine sulfate and naltrexone hydrochloride (ALO-01) extended-release capsules versus morphine solution and placebo in experienced non-dependent opioid users: a randomized, double-blind, placebo-contro
    Joseph Stauffer
    Alpharma Pharmaceuticals LLC, a wholly owned subsidiary of King Pharmaceuticals, Inc, Bridgewater, New Jersey, USA
    Clin Drug Investig 29:777-90. 2009
  7. doi request reprint Effect of concomitant ingestion of alcohol on the in vivo pharmacokinetics of KADIAN (morphine sulfate extended-release) capsules
    Franklin Johnson
    Clinical Pharmacology, Alpharma Pharmaceuticals LLC, Piscataway, New Jersey 08854, USA
    J Pain 9:330-6. 2008

Collaborators

Detail Information

Publications7

  1. ncbi request reprint The relative bioavailability of morphine sulfate and naltrexone hydrochloride extended release capsules (EMBEDA®) and an extended release morphine sulfate capsule formulation (KADIAN®) in healthy adults under fasting conditions
    Franklin K Johnson
    ClinPharm PK Consulting LLC, 625 Talamini Road, Bridgewater, NJ 08807, USA
    Am J Ther 18:2-8. 2011
    ..When subjects who vomited during the 12-hour dosing interval were excluded, the confidence interval for AUC0-t and AUCinf fell within the 80%-125% range, but the lower limit for Cmax was 76.9%...
  2. doi request reprint Effects of alcohol on the pharmacokinetics of morphine sulfate and naltrexone hydrochloride extended release capsules
    Franklin K Johnson
    King Pharmaceuticals, Inc, Bridgewater, NJ, USA
    J Clin Pharmacol 52:747-56. 2012
    ..Naltrexone sequestering was successful in all treatment arms and not affected by coadministration with alcohol over the dose range tested...
  3. doi request reprint Relative oral bioavailability of morphine and naltrexone derived from crushed morphine sulfate and naltrexone hydrochloride extended-release capsules versus intact product and versus naltrexone solution: a single-dose, randomized-sequence, open-label, thr
    Franklin K Johnson
    Alpharma Pharmaceuticals LLC, a wholly owned subsidiary of King Pharmaceuticals, Inc, Bridgewater, New Jersey, USA
    Clin Ther 32:1149-64. 2010
    ..MS-sNT was designed so that if the product is tampered with by crushing, the naltrexone becomes bioavailable to mitigate morphine-induced subjective effects, rendering the product less attractive for tampering...
  4. doi request reprint Food effects on the pharmacokinetics of morphine sulfate and naltrexone hydrochloride extended release capsules
    Franklin Johnson
    ClinPharm PK Consulting LLC, Bridgewater, NJ 08807, USA
    Adv Ther 27:846-58. 2010
    ....
  5. ncbi request reprint Morphine sulfate and naltrexone hydrochloride extended-release capsules: naltrexone release, pharmacodynamics, and tolerability
    Franklin Johnson
    ClinPharm PK Consulting LLC, 625 Talamini Road, Bridgewater, NJ 08807, USA
    Pain Physician 14:391-406. 2011
    ..While it is necessary to establish that formulations intended to reduce attractiveness for abuse are successful in doing so, it is also necessary to demonstrate that product therapeutic integrity is maintained for patients...
  6. doi request reprint Subjective effects and safety of whole and tampered morphine sulfate and naltrexone hydrochloride (ALO-01) extended-release capsules versus morphine solution and placebo in experienced non-dependent opioid users: a randomized, double-blind, placebo-contro
    Joseph Stauffer
    Alpharma Pharmaceuticals LLC, a wholly owned subsidiary of King Pharmaceuticals, Inc, Bridgewater, New Jersey, USA
    Clin Drug Investig 29:777-90. 2009
    ..The purpose of this study was to assess the pharmacodynamic effects (including drug-liking and euphoria) of whole and crushed ALO-01 versus morphine sulfate solution (MSS) and placebo...
  7. doi request reprint Effect of concomitant ingestion of alcohol on the in vivo pharmacokinetics of KADIAN (morphine sulfate extended-release) capsules
    Franklin Johnson
    Clinical Pharmacology, Alpharma Pharmaceuticals LLC, Piscataway, New Jersey 08854, USA
    J Pain 9:330-6. 2008
    ..There were no serious adverse events or deaths reported during the study...