Terje Johansen

Summary

Publications

  1. pmc Transforming growth factor-β-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs
    Endalkachew A Alemu
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromso, Tromsö 9037, Norway
    Cell Mol Life Sci 68:1953-68. 2011
  2. pmc FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport
    Serhiy Pankiv
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Cell Biol 188:253-69. 2010
  3. pmc Aggrephagy: selective disposal of protein aggregates by macroautophagy
    Trond Lamark
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    Int J Cell Biol 2012:736905. 2012
  4. pmc Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62
    Henning Kleine
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrase 30, Aachen, 52074, Germany
    Cell Commun Signal 10:28. 2012
  5. pmc Selective autophagy mediated by autophagic adapter proteins
    Terje Johansen
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    Autophagy 7:279-96. 2011
  6. pmc p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    Geir Bjørkøy
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Cell Biol 171:603-14. 2005
  7. pmc Pax6 represses androgen receptor-mediated transactivation by inhibiting recruitment of the coactivator SPBP
    Julianne Elvenes
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    PLoS ONE 6:e24659. 2011
  8. ncbi request reprint p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    Serhiy Pankiv
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Biol Chem 282:24131-45. 2007
  9. pmc p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
    Ashish Jain
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Biol Chem 285:22576-91. 2010
  10. ncbi request reprint p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy
    Terje Høyvarde Clausen
    Molecular Cancer Research Group, Department of Medical Biology, University of Tromsø, Tromsø, Norway
    Autophagy 6:330-44. 2010

Collaborators

  • Vladimir Kirkin
  • Ashish Jain
  • Harald Stenmark
  • Kirsten Krause
  • Espen Michaelsen
  • John D Hayes
  • Michael McMahon
  • Tom Egil Hansen
  • Trond Lamark
  • Geir Bjørkøy
  • Serhiy Pankiv
  • Eva Sjøttem
  • Aud Øvervatn
  • Julianne Elvenes
  • Andreas Brech
  • Sagar Darvekar
  • Steingrim Svenning
  • Jack Ansgar Bruun
  • Kenneth Bowitz Larsen
  • Heidi Outzen
  • Endalkachew A Alemu
  • Sylvia Sagen Johnsen
  • Terje Høyvarde Clausen
  • Turid Holm
  • Sagar Ramesh Darvekar
  • Asa Birna Birgisdottir
  • Henning Kleine
  • Endalkachew Ashenafi Alemu
  • Cecilie Rekdal
  • Ernst Ivan Simon Thomassen
  • Aud Overvatn
  • Maria Perander
  • Kurt Kristiansen
  • Hanne Britt Brenne
  • Knut Martin Torgersen
  • Aasa Birna Birgisdottir
  • Juliane Lüscher-Firzlaff
  • Alexandra H Forst
  • Andreas Herrmann
  • Hallvard Olsvik
  • Barbara Lippok
  • Agnete Bratsberg Eriksen
  • Gerhard Muller-Newen
  • Elisabeth Kremmer
  • Nicolas Herzog
  • Karla Lh Feijs
  • Bernhard Luscher
  • Patricia Verheugd
  • Kenneth B Larsen
  • Katrine Kaino
  • Anne Simonsen
  • Kim Finley
  • Pauline Isakson
  • Ingvill Harneshaug
  • Ivan Dikic
  • Gunbjørg Svineng
  • Helle Klenow
  • Rebecca Dale Uglehus
  • Ingvild Mikkola
  • Garth Tylden

Detail Information

Publications30

  1. pmc Transforming growth factor-β-inducible early response gene 1 is a novel substrate for atypical protein kinase Cs
    Endalkachew A Alemu
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromso, Tromsö 9037, Norway
    Cell Mol Life Sci 68:1953-68. 2011
    ..Interestingly, the aPKC-mediated phosphorylation of TIEG1 affected its DNA-binding activity, subnuclear localization and transactivation potential...
  2. pmc FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport
    Serhiy Pankiv
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Cell Biol 188:253-69. 2010
    ..We also propose a mechanism for selective autophagosomal membrane recruitment of FYCO1...
  3. pmc Aggrephagy: selective disposal of protein aggregates by macroautophagy
    Trond Lamark
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    Int J Cell Biol 2012:736905. 2012
    ..Here we review the processes of aggregate formation, recognition, transport, and sequestration into autophagosomes by autophagy receptors and the role of aggrephagy in different protein aggregation diseases...
  4. pmc Dynamic subcellular localization of the mono-ADP-ribosyltransferase ARTD10 and interaction with the ubiquitin receptor p62
    Henning Kleine
    Institute of Biochemistry and Molecular Biology, Medical School, RWTH Aachen University, Pauwelsstrase 30, Aachen, 52074, Germany
    Cell Commun Signal 10:28. 2012
    ..abstract:..
  5. pmc Selective autophagy mediated by autophagic adapter proteins
    Terje Johansen
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    Autophagy 7:279-96. 2011
    ..The emerging picture of selective autophagy affecting the regulation of cell signaling with consequences for oxidative stress responses, tumorigenesis and innate immunity is also addressed...
  6. pmc p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    Geir Bjørkøy
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Cell Biol 171:603-14. 2005
    ..We suggest that p62 may, via LC3, be involved in linking polyubiquitinated protein aggregates to the autophagy machinery...
  7. pmc Pax6 represses androgen receptor-mediated transactivation by inhibiting recruitment of the coactivator SPBP
    Julianne Elvenes
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    PLoS ONE 6:e24659. 2011
    ..Understanding the mechanism for inhibition of AR coactivators can give rise to molecular targeted drugs for treatment of prostate cancer...
  8. ncbi request reprint p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
    Serhiy Pankiv
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Biol Chem 282:24131-45. 2007
    ..In fact, p62 bodies and these structures are indistinguishable. Taken together, our results clearly suggest that p62 is required both for the formation and the degradation of polyubiquitin-containing bodies by autophagy...
  9. pmc p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription
    Ashish Jain
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Biol Chem 285:22576-91. 2010
    ..Our data explain how p62 contributes to activation of NRF2 target genes in response to oxidative stress through creating a positive feedback loop...
  10. ncbi request reprint p62/SQSTM1 and ALFY interact to facilitate the formation of p62 bodies/ALIS and their degradation by autophagy
    Terje Høyvarde Clausen
    Molecular Cancer Research Group, Department of Medical Biology, University of Tromsø, Tromsø, Norway
    Autophagy 6:330-44. 2010
    ..We conclude that p62 and ALFY interact to organize misfolded, ubiquitinated proteins into protein bodies that become degraded by autophagy...
  11. pmc ATG8 family proteins act as scaffolds for assembly of the ULK complex: sequence requirements for LC3-interacting region (LIR) motifs
    Endalkachew Ashenafi Alemu
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Biol Chem 287:39275-90. 2012
    ..Importantly, the LIR motif is required for starvation-induced association of ULK1 with autophagosomes. Our data suggest that ATG8 proteins act as scaffolds for assembly of the ULK complex at the phagophore...
  12. pmc Plant NBR1 is a selective autophagy substrate and a functional hybrid of the mammalian autophagic adapters NBR1 and p62/SQSTM1
    Steingrim Svenning
    Molecular Cancer Research Group, Department of Medical Biology, University of Tromsø, Tromsø, Norway
    Autophagy 7:993-1010. 2011
    ..This strategy allowed us to show that AtNBR1 is an autophagy substrate degraded in the vacuole dependent on the polymerization property of the PB1 domain and of expression of AtATG7. A functional LIR was required for vacuolar import...
  13. pmc Nucleocytoplasmic shuttling of p62/SQSTM1 and its role in recruitment of nuclear polyubiquitinated proteins to promyelocytic leukemia bodies
    Serhiy Pankiv
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Biol Chem 285:5941-53. 2010
    ..Furthermore, p62 contributed to the assembly of proteasome-containing degradative compartments in the vicinity of nuclear aggregates containing polyglutamine-expanded Ataxin1Q84 and to the degradation of Ataxin1Q84...
  14. ncbi request reprint A reporter cell system to monitor autophagy based on p62/SQSTM1
    Kenneth Bowitz Larsen
    Bioimaging Core Facility, Medical Faculty, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    Autophagy 6:784-93. 2010
    ..Inducers of autophagy can be identified using rich medium whereas inhibitors are identified under starvation conditions...
  15. pmc The ePHD protein SPBP interacts with TopBP1 and together they co-operate to stimulate Ets1-mediated transcription
    Eva Sjøttem
    Biochemistry Department and Department of Molecular Biotechnology, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    Nucleic Acids Res 35:6648-62. 2007
    ..Taken together, our results show that TopBP1 and SPBP interact physically and functionally to co-operate as co-activators of Ets1...
  16. doi request reprint Pax6 localizes to chromatin-rich territories and displays a slow nuclear mobility altered by disease mutations
    Julianne Elvenes
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromso, Norway
    Cell Mol Life Sci 67:4079-94. 2010
    ..Hence, our results support the conclusion that disease mutations result in proteins with impaired function because of altered DNA- and protein-interaction capabilities...
  17. pmc The third helix of the homeodomain of paired class homeodomain proteins acts as a recognition helix both for DNA and protein interactions
    Jack Ansgar Bruun
    Biochemistry Department, Institute of Medical Biology, University of Tromsø 9037 Tromsø, Norway
    Nucleic Acids Res 33:2661-75. 2005
    ..These findings suggest a critical role for the recognition helix and N-terminal arm of the paired class homeodomain in protein-protein interactions...
  18. ncbi request reprint Interaction codes within the family of mammalian Phox and Bem1p domain-containing proteins
    Trond Lamark
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Biol Chem 278:34568-81. 2003
    ..An interaction between the cell polarity scaffold protein Par6 and MEK5 was found. Furthermore, p62 interacts both with MEK5 and NBR1 in addition to the aPKCs. Evidence for involvement of p62 in MEK5-ERK5 signaling is presented...
  19. ncbi request reprint p62/SQSTM1: a missing link between protein aggregates and the autophagy machinery
    Geir Bjørkøy
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    Autophagy 2:138-9. 2006
    ..It can also recruit the autophagosomal protein LC3 and co-localizes with many types of polyubiquitinated protein aggregates.(1) Here we discuss possible implications of these findings and raise some questions for further investigation...
  20. doi request reprint Monitoring autophagic degradation of p62/SQSTM1
    Geir Bjørkøy
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, Norway
    Methods Enzymol 452:181-97. 2009
    ..We also present data on species-specificity and map the epitopes recognized by several commercially available anti-p62 antibodies...
  21. doi request reprint Identification of two independent nucleosome-binding domains in the transcriptional co-activator SPBP
    Sagar Darvekar
    Molecular Cancer Research Group, Department of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    Biochem J 442:65-75. 2012
    ....
  22. doi request reprint Autophagy: links with the proteasome
    Trond Lamark
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    Curr Opin Cell Biol 22:192-8. 2010
    ..We will here discuss recent findings that shed some light on the cellular processes deciding when and how misfolded proteins are specifically selected for autophagic degradation in favor of proteasomal degradation...
  23. doi request reprint FYCO1: linking autophagosomes to microtubule plus end-directing molecular motors
    Serhiy Pankiv
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    Autophagy 6:550-2. 2010
    ..FYCO1 is likely selectively recruited to autophagosomal membranes via a mechanism involving a conformational change upon LC3-LIR interaction to expose the FYVE domain for PtdIns(3)P binding...
  24. ncbi request reprint NBR1 and p62 as cargo receptors for selective autophagy of ubiquitinated targets
    Trond Lamark
    Biochemistry Department, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    Cell Cycle 8:1986-90. 2009
    ..Here we discuss the role of p62 and NBR1 in degradation of ubiquitinated cargoes and the putative role of LIR as a general motif for docking of proteins to ATG8 family proteins...
  25. ncbi request reprint The LIR motif - crucial for selective autophagy
    Asa Birna Birgisdottir
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    J Cell Sci 126:3237-47. 2013
    ..Here, we comment on these new insights and focus on the interactions of LIR-containing proteins with members of the ATG8 protein family. ..
  26. pmc A phylogenetic study of SPBP and RAI1: evolutionary conservation of chromatin binding modules
    Sagar Darvekar
    Molecular Cancer Research Group, Department of Medical Biology, University of Tromsø, Tromsø, Norway
    PLoS ONE 8:e78907. 2013
    ..However, an adjacent conserved AT-hook motif as identified in SPBP is not present in RAI1, and deletion of the novel nucleosome binding region of RAI1 did not significantly affect its nuclear localisation. ..
  27. doi request reprint Selective autophagy
    Steingrim Svenning
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    Essays Biochem 55:79-92. 2013
    ..In the present chapter, we discuss these autophagy receptors, their binding to ATG8/LC3 proteins and how they act in ubiquitin-mediated selective autophagy of intracellular bacteria (xenophagy) and protein aggregates (aggrephagy). ..
  28. pmc Following autophagy step by step
    Tom Egil Hansen
    Molecular Cancer Research Group, Institute of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
    BMC Biol 9:39. 2011
    ..Hundeshagen and colleagues describe this month in BMC Biology a screening assay based on flow cytometry that makes it possible to track distinct steps in the autophagic process and thereby identify novel modulators of autophagy...
  29. pmc SPBP is a sulforaphane induced transcriptional coactivator of NRF2 regulating expression of the autophagy receptor p62/SQSTM1
    Sagar Ramesh Darvekar
    Molecular Cancer Research Group, Department of Medical Biology, University of Tromsø, Tromsø, Norway
    PLoS ONE 9:e85262. 2014
    ..Collectively, these results suggest that SPBP is a coactivator of NRF2, and hence may be important for securing enhanced and sustained expression of NRF2 induced genes such as proteins involved in selective autophagy. ..
  30. ncbi request reprint Selective autophagy goes exclusive
    Terje Johansen
    Department of Medical Biology, Faculty of Health Sciences, University of Tromsø The Arctic University of Norway, NO 9037, Tromsø, Norway
    Nat Cell Biol 16:395-7. 2014
    ..The results have important mechanistic implications for selective macroautophagy, scaffold formation and spatio-temporal organization of the lipidation process during autophagosome formation. ..