Ari R Joffe

Summary

Publications

  1. doi request reprint Brain death in Canadian PICUs: demographics, timing, and irreversibility
    Ari R Joffe
    Stollery Children s Hospital, John Dossetor Health Ethics Center, University of Alberta, Edmonton, Alberta, Canada
    Pediatr Crit Care Med 14:1-9. 2013
  2. doi request reprint Pediatric outcomes after extracorporeal membrane oxygenation for cardiac disease and for cardiac arrest: a review
    Ari R Joffe
    Stollery Children s Hospital, Edmonton, Alberta, Canada
    ASAIO J 58:297-310. 2012
  3. pmc Multicentre validation of the bedside paediatric early warning system score: a severity of illness score to detect evolving critical illness in hospitalised children
    Christopher S Parshuram
    Department of Critical Care Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Crit Care 15:R184. 2011
  4. pmc A survey of American neurologists about brain death: understanding the conceptual basis and diagnostic tests for brain death
    Ari R Joffe
    Stollery Children s Hospital and University of Alberta, Edmonton, Alberta, Canada
    Ann Intensive Care 2:4. 2012
  5. pmc Donation after cardiocirculatory death: a call for a moratorium pending full public disclosure and fully informed consent
    Ari R Joffe
    Department of Pediatrics, University of Alberta, Stollery Children s Hospital, Edmonton Clinic Health Academy 11405 87 Avenue, Edmonton, Alberta, T6G 1C9, Canada
    Philos Ethics Humanit Med 6:17. 2011
  6. doi request reprint The apnea test: rationale, confounders, and criticism
    Ari R Joffe
    University of Alberta and Stollery Children s Hospital, Edmonton, Alberta, Canada
    J Child Neurol 25:1435-43. 2010
  7. pmc Variability in the pediatric intensivists' threshold for withdrawal/limitation of life support as perceived by bedside nurses: a multicenter survey study
    Colleen S Gresiuk
    University of Alberta, Stollery Children s Hospital, 8440 112 Street, Edmonton, Alberta, T6G 2B7, Canada
    Ann Intensive Care 1:31. 2011
  8. doi request reprint Reduction in hospital mortality over time in a hospital without a pediatric medical emergency team: limitations of before-and-after study designs
    Ari R Joffe
    Division of Pediatric Intensive Care, Department of Pediatrics, 8440 112th St, Edmonton, Alberta, Canada
    Arch Pediatr Adolesc Med 165:419-23. 2011
  9. doi request reprint Outcomes after heart transplantation in children under six years of age
    Ari R Joffe
    Department of Pediatrics, School of Public Health, John Dossetor Health Ethics Center, University of Alberta, and Stollery Children s Hospital, Edmonton, Alberta, Canada
    Ann Thorac Surg 92:174-82. 2011
  10. doi request reprint Two-year survival, mental, and motor outcomes after cardiac extracorporeal life support at less than five years of age
    Laurance Lequier
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Thorac Cardiovasc Surg 136:976-983.e3. 2008

Collaborators

Detail Information

Publications49

  1. doi request reprint Brain death in Canadian PICUs: demographics, timing, and irreversibility
    Ari R Joffe
    Stollery Children s Hospital, John Dossetor Health Ethics Center, University of Alberta, Edmonton, Alberta, Canada
    Pediatr Crit Care Med 14:1-9. 2013
    ..To determine any discordance between first and second brain death examinations and investigate the quality of brain death determination in Canadian PICUs...
  2. doi request reprint Pediatric outcomes after extracorporeal membrane oxygenation for cardiac disease and for cardiac arrest: a review
    Ari R Joffe
    Stollery Children s Hospital, Edmonton, Alberta, Canada
    ASAIO J 58:297-310. 2012
    ..Survival outcomes of most cardiac subgroups were similar, except for concerning mortality in cavopulmonary connection patients. Priority areas for study include identification of potentially modifiable predictors of long-term outcomes...
  3. pmc Multicentre validation of the bedside paediatric early warning system score: a severity of illness score to detect evolving critical illness in hospitalised children
    Christopher S Parshuram
    Department of Critical Care Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
    Crit Care 15:R184. 2011
    ..The objective of this study was to validate the Bedside PEWS score in a large patient population at multiple hospitals...
  4. pmc A survey of American neurologists about brain death: understanding the conceptual basis and diagnostic tests for brain death
    Ari R Joffe
    Stollery Children s Hospital and University of Alberta, Edmonton, Alberta, Canada
    Ann Intensive Care 2:4. 2012
    ..abstract:..
  5. pmc Donation after cardiocirculatory death: a call for a moratorium pending full public disclosure and fully informed consent
    Ari R Joffe
    Department of Pediatrics, University of Alberta, Stollery Children s Hospital, Edmonton Clinic Health Academy 11405 87 Avenue, Edmonton, Alberta, T6G 1C9, Canada
    Philos Ethics Humanit Med 6:17. 2011
    ..These are tall orders, and require open public debate. Until this debate occurs, we call for a moratorium on the practice of DCD...
  6. doi request reprint The apnea test: rationale, confounders, and criticism
    Ari R Joffe
    University of Alberta and Stollery Children s Hospital, Edmonton, Alberta, Canada
    J Child Neurol 25:1435-43. 2010
    ..Hyperoxia during the apnea test can further suppress the function of medullary respiratory rhythm centers. Finally, the philosophical rationale for the need to show lack of spontaneous breathing in brain death is lacking...
  7. pmc Variability in the pediatric intensivists' threshold for withdrawal/limitation of life support as perceived by bedside nurses: a multicenter survey study
    Colleen S Gresiuk
    University of Alberta, Stollery Children s Hospital, 8440 112 Street, Edmonton, Alberta, T6G 2B7, Canada
    Ann Intensive Care 1:31. 2011
    ..abstract:..
  8. doi request reprint Reduction in hospital mortality over time in a hospital without a pediatric medical emergency team: limitations of before-and-after study designs
    Ari R Joffe
    Division of Pediatric Intensive Care, Department of Pediatrics, 8440 112th St, Edmonton, Alberta, Canada
    Arch Pediatr Adolesc Med 165:419-23. 2011
    ..To determine whether hospital mortality has decreased over time in a hospital that has not introduced a pediatric medical emergency team (PMET)...
  9. doi request reprint Outcomes after heart transplantation in children under six years of age
    Ari R Joffe
    Department of Pediatrics, School of Public Health, John Dossetor Health Ethics Center, University of Alberta, and Stollery Children s Hospital, Edmonton, Alberta, Canada
    Ann Thorac Surg 92:174-82. 2011
    ..Survival after heart transplant has improved and more attention is focused on developmental outcomes. We aimed to determine the survival, morbidity, and developmental outcomes of young children after heart transplant...
  10. doi request reprint Two-year survival, mental, and motor outcomes after cardiac extracorporeal life support at less than five years of age
    Laurance Lequier
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Thorac Cardiovasc Surg 136:976-983.e3. 2008
    ..Comprehensive outcome assessment of children receiving cardiac extracorporeal life support...
  11. doi request reprint Clinical outcome score predicts the need for neurodevelopmental intervention after infant heart surgery
    Andrew S Mackie
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Thorac Cardiovasc Surg 145:1248-1254.e2. 2013
    ..Our goal was to determine if a clinical outcome score derived from early postoperative events is associated with 18- to 24-month Psychomotor Developmental Index (PDI) score among infants undergoing cardiopulmonary bypass surgery...
  12. doi request reprint Association of hemoglobin and transfusion with outcome after operations for hypoplastic left heart
    Jaime Blackwood
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Ann Thorac Surg 89:1378-84.e1-2. 2010
    ..Some studies suggest transfusion might contribute to adverse outcomes. This study investigated the association between hemoglobin concentration and transfusion with outcome in cyanotic neonates undergoing Norwood operations...
  13. doi request reprint Quality of life 4 years after complex heart surgery in infancy
    Gonzalo Garcia Guerra
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Thorac Cardiovasc Surg 145:482-488.e2. 2013
    ..To determine the health-related quality of life at 4 years of age in children who had undergone cardiac surgery for congenital heart disease in early infancy...
  14. doi request reprint Two-year survival and mental and psychomotor outcomes after the Norwood procedure: an analysis of the modified Blalock-Taussig shunt and right ventricle-to-pulmonary artery shunt surgical eras
    Joseph Atallah
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Circulation 118:1410-8. 2008
    ..In our institution, surgical practice changed from use of the MBTS to use of the RVPA shunt in 2002. We analyzed survival and mental and psychomotor outcomes of the 2 consecutive surgical eras...
  15. doi request reprint Neurodevelopmental outcome following exposure to sedative and analgesic drugs for complex cardiac surgery in infancy
    Gonzalo Garcia Guerra
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    Paediatr Anaesth 21:932-41. 2011
    ..OBJECTIVES/AIM: To determine whether sedation/analgesia drugs used before, during, and after infant cardiac surgery are associated with neurodevelopmental outcome...
  16. doi request reprint Bilateral sensory permanent hearing loss after palliative hypoplastic left heart syndrome operation
    Charlene M T Robertson
    Department of Pediatrics, University of Alberta and Stollery Children s Hospital, Edmonton, Canada
    Ann Thorac Surg 93:1248-53. 2012
    ....
  17. doi request reprint Two-year survival and neurodevelopmental outcomes after cardiopulmonary resuscitation in neonatal patients after complex cardiac surgery
    Gregory Hansen
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    Resuscitation 82:313-8. 2011
    ..To examine survival and neurodevelopmental outcomes in neonates having post-operative cardiopulmonary resuscitation (CPR)...
  18. doi request reprint Two-year neurodevelopmental outcomes of infants undergoing neonatal cardiac surgery for interrupted aortic arch: a descriptive analysis
    Chloe A Joynt
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Thorac Cardiovasc Surg 138:924-32. 2009
    ..This study determined neurodevelopmental outcomes of survivors of neonatal cardiac surgery for interrupted aortic arch through an interprovincial program and explored preoperative, intraoperative, and postoperative outcome predictors...
  19. doi request reprint Neurotoxicity of sedative and analgesia drugs in young infants with congenital heart disease: 4-year follow-up
    Gonzalo Garcia Guerra
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
    Paediatr Anaesth 24:257-65. 2014
    ..To determine whether sedation/analgesia drugs used before, during, and after infant cardiac surgery are associated with neurocognitive and functional outcomes...
  20. ncbi request reprint Two-year general and neurodevelopmental outcome after neonatal complex cardiac surgery in patients with deletion 22q11.2: a comparative study
    Joseph Atallah
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Thorac Cardiovasc Surg 134:772-9. 2007
    ..Neonatal complex cardiac surgery carries a significant risk for adverse neurodevelopmental outcome. We hypothesized this risk to be higher in patients with deletion 22q11.2...
  21. ncbi request reprint Intermediate-term outcomes of the arterial switch operation for transposition of great arteries in neonates: alive but well?
    Darren H Freed
    Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
    J Thorac Cardiovasc Surg 132:845-52. 2006
    ..Predictors of outcome are explored...
  22. ncbi request reprint Early childhood health, growth, and neurodevelopmental outcomes after complete repair of total anomalous pulmonary venous connection at 6 weeks or younger
    Gwen Y Alton
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Thorac Cardiovasc Surg 133:905-11. 2007
    ....
  23. ncbi request reprint Postoperative lactate concentrations predict the outcome of infants aged 6 weeks or less after intracardiac surgery: a cohort follow-up to 18 months
    Po Yin Cheung
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Thorac Cardiovasc Surg 130:837-43. 2005
    ..An observational cohort study was conducted in infants less than 6 weeks of age undergoing intracardiac surgery to examine the predictive value of serial postoperative lactate determination on survival and early childhood neurodevelopment...
  24. ncbi request reprint Mortality after neonatal cardiac surgery: Prediction from mean arterial pressure after rewarming in the operating room
    Ari R Joffe
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Thorac Cardiovasc Surg 134:311-8. 2007
    ..To examine the predictive contribution of mean arterial pressure after rewarming to > or =34 degrees C in the operating room to mortality after cardiac surgery in infants < or =6 weeks old...
  25. pmc The registry and follow-up of complex pediatric therapies program of Western Canada: a mechanism for service, audit, and research after life-saving therapies for young children
    Charlene M T Robertson
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada T6G 2R3
    Cardiol Res Pract 2011:965740. 2011
    ..Through this mechanism, consistently high (96%) follow-up over two years is maintained...
  26. doi request reprint Incidence of milrinone blood levels outside the therapeutic range and their relevance in children after cardiac surgery for congenital heart disease
    Gonzalo Garcia Guerra
    Department of Pediatrics, University of Alberta, Stollery Children s Hospital, Edmonton, AB, Canada
    Intensive Care Med 39:951-7. 2013
    ..To evaluate whether variability in milrinone blood levels (MBL) occurs during administration to critically ill children after surgical repair of congenital heart disease, and the clinical relevance of this variability...
  27. doi request reprint Low energy intakes are associated with adverse outcomes in infants after open heart surgery
    Bodil M K Larsen
    Nutrition Services, University of Alberta, Edmonton, Alberta, Canada
    JPEN J Parenter Enteral Nutr 37:254-60. 2013
    ..The purpose of this study was to determine the relationship between energy intake and hospital outcomes during the first 10 days following neonatal open heart surgery...
  28. doi request reprint Risk factors for and outcomes of acute kidney injury in neonates undergoing complex cardiac surgery
    Catherine J Morgan
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Pediatr 162:120-7.e1. 2013
    ..To characterize the epidemiology of and identify risk factors for neonatal cardiac surgery-associated acute kidney injury (CS-AKI) and determine its impact on clinical outcomes...
  29. doi request reprint The approach to delayed resuscitation in paediatric cardiac arrest: A survey of paediatric intensivists in Canada
    Ari R Joffe
    Department of Paediatrics, Division of Paediatric Intensive Care, University of Alberta, 8440 112 Street, Edmonton, Alberta, Canada T6G 2B7
    Resuscitation 80:318-23. 2009
    ..To determine how long a period of having had no cardiopulmonary-resuscitation (CPR) (delay time) is considered to result in subsequent futile efforts at resuscitation...
  30. doi request reprint Five-year neurocognitive and health outcomes after the neonatal arterial switch operation
    Ruth E Neufeld
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
    J Thorac Cardiovasc Surg 136:1413-21, 1421.e1-1421.e2. 2008
    ..We sought to assess the 5-year neurocognition and health of an interprovincial inception cohort undergoing the arterial switch operation for transposition of the great arteries...
  31. doi request reprint Neurocognitive outcomes at kindergarten entry after liver transplantation at <3 yr of age
    Charlene M T Robertson
    Department of Pediatrics, University of Alberta, Edmonton, AB, Canada Pediatric Rehabilitation Outcomes Unit, Glenrose Rehabilitation Hospital, Edmonton, AB, Canada
    Pediatr Transplant 17:621-30. 2013
    ..039. Changes in care addressing modifiable predictors, including reducing acute post-transplant illness, pretransplant encephalopathy, transplant warm ischemia times, and preserving renal function, may improve neurocognitive outcomes. ..
  32. doi request reprint Donation after cardiac death: a survey of university student opinions on death and donation
    Ari R Joffe
    Department of Pediatrics, 3A3 Stollery Children s Hospital, University of Alberta, 8440 112 Street, Edmonton, AB, T6G 2B7, Canada
    Intensive Care Med 35:240-7. 2009
    ..To determine if university students consider the donation after cardiac death donor as dead...
  33. doi request reprint Survey of pediatricians' opinions on donation after cardiac death: are the donors dead?
    Ari R Joffe
    Department of Pediatrics, University of Alberta and Stollery Children s Hospital, Edmonton, Alberta, Canada
    Pediatrics 122:e967-74. 2008
    ..We set out to determine whether pediatricians consider the donation-after-cardiac-death donor as dead...
  34. doi request reprint Peri-operative interventions, but not inflammatory mediators, increase risk of acute kidney injury after cardiac surgery: a prospective cohort study
    Catherine J Morgan
    Department of Pediatrics, University of Alberta, Edmonton, Canada
    Intensive Care Med 39:934-41. 2013
    ..We aimed to determine the role of inflammatory mediators in CS-AKI in children and the efficacy of commonly used peri-operative interventions to reduce CS-AKI risk...
  35. doi request reprint Critical illness in children with influenza A/pH1N1 2009 infection in Canada
    Philippe Jouvet
    Department of Pediatrics, University of Montreal, Montreal, Quebec, Canada
    Pediatr Crit Care Med 11:603-9. 2010
    ..To describe characteristics, treatment, and outcomes of critically ill children with influenza A/pandemic influenza A virus (pH1N1) infection in Canada...
  36. doi request reprint Autoresuscitation after pediatric cardiac arrest: is hyperventilation a cause?
    Jonathan P Duff
    Department of Pediatrics, University of Alberta and Stollery Children s Hospital, Edmonton, Alberta, Canada
    Pediatr Emerg Care 27:208-9. 2011
    ..There are no published reports of this phenomenon in children. We report 2 pediatric cases of the Lazarus phenomenon, likely caused by unintentional hyperventilation during resuscitation...
  37. ncbi request reprint A survey to determine the understanding of the conceptual basis and diagnostic tests used for brain death by neurosurgeons in Canada
    Ari R Joffe
    Department of Pediatrics, Division of Pediatric Intensive Care, University of Alberta, Edmonton, Canada
    Neurosurgery 61:1039-45; discussion 1046-7. 2007
    ..To determine the understanding of the conceptual basis and diagnostic tests used for brain death (BD) by neurosurgeons in Canada...
  38. ncbi request reprint Brain death: understanding of the conceptual basis by pediatric intensivists in Canada
    Ari R Joffe
    Division of Pediatric Intensive Care, Department of Pediatrics, University of Alberta, Edmonton, Canada
    Arch Pediatr Adolesc Med 160:747-52. 2006
    ..To determine whether pediatric intensivists in Canada are aware of the controversies regarding the concept of brain death (BD)...
  39. doi request reprint Infections in children receiving extracorporeal life support
    Alena Tse-Chang
    Department of Pediatrics and Stollery Children s Hospital, Edmonton, Alberta, Canada
    Infect Control Hosp Epidemiol 32:115-20. 2011
    ..To describe risk factors for and the outcome of infections in children receiving extracorporeal life support (ECLS) and to determine the need for removal of foreign bodies with bloodstream infections (BSIs) in children receiving ECLS...
  40. doi request reprint Comparison of two red-cell transfusion strategies after pediatric cardiac surgery: a subgroup analysis
    Ariane Willems
    Pediatric Intensive Care Unit, Department of Pediatrics, Universite de Montreal, Montreal, QC, Canada
    Crit Care Med 38:649-56. 2010
    ..a liberal transfusion strategy on new or progressive multiple organ dysfunction syndrome in children post cardiac surgery. The optimal transfusion threshold after cardiac surgery in children is unknown...
  41. doi request reprint A 10-month-old infant with reversible findings of brain death
    Ari R Joffe
    Department of Pediatrics, University of Alberta and Stollery Children s Hospital, Edmonton, Alberta, Canada
    Pediatr Neurol 41:378-82. 2009
    ..Together with previous reports, the present case calls into question the assumption that brain death as currently diagnosed is irreversible, and therefore equivalent to death of the patient...
  42. ncbi request reprint Specificity of radionuclide brain blood flow testing in brain death: case report and review
    Ari R Joffe
    Stollery Children s Hospital, University of Alberta, Edmonton, Alberta, Canada
    J Intensive Care Med 25:53-64. 2010
    ..Larger numbers of patients both with and without BD (but with severe brain injury) must be studied to determine the sensitivity and specificity of these tests..
  43. ncbi request reprint The safety and efficacy of sustained inflations as a lung recruitment maneuver in pediatric intensive care unit patients
    Jonathan P Duff
    Division of Critical Care Medicine, Stollery Children s Hospital, University of Alberta, 8440 112 Street, 3A3 19 WMC, T6G 2B7, Edmonton, Alberta, Canada
    Intensive Care Med 33:1778-86. 2007
    ..To assess the safety and efficacy of sustained inflations (SI) as lung recruitment maneuvers (RMs) in ventilated pediatric intensive care unit (PICU) patients...
  44. doi request reprint A Canadian Survey of Perceived Barriers to Initiation and Continuation of Enteral Feeding in PICUs
    Amanda Y Leong
    1Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, AB, Canada 2Department of Pediatrics, University of Alberta, Stollery Children s Hospital, Edmonton, AB, Canada 3Nutrition Services Alberta Health Services, Stollery Children s Hospital, Edmonton, AB, Canada
    Pediatr Crit Care Med 15:e49-55. 2014
    ..The aim of this national survey was to examine the knowledge and perceived barriers among clinicians which prevent enteral nutrition administration to PICU patients...
  45. ncbi request reprint Injury admissions to pediatric intensive care are predictable and preventable: a call to action
    Ari R Joffe
    Department of Pediatrics, Division of Pediatric Critical Care, Stollery Children s Hospital, University of Alberta, Edmonton, Alberta, Canada
    J Intensive Care Med 21:227-34. 2006
    ..Novel strategies to improve the public's perception of the cost of childhood injury are needed...
  46. ncbi request reprint Some questions about brain death: a case report
    Ari R Joffe
    Department of Pediatrics, University of Alberta and Stollery Children s Hospital, Edmonton, Alberta, Canada
    Pediatr Neurol 37:289-91. 2007
    ....
  47. doi request reprint The safety of targeted antibiotic therapy for ventilator-associated pneumonia: a multicenter observational study
    Ari R Joffe
    Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
    J Crit Care 23:82-90. 2008
    ..The aim of this study was to determine the safety of targeted antibiotic therapy (TT) in ventilator-associated pneumonia (VAP)...
  48. ncbi request reprint Brain death is not death: a critique of the concept, criterion, and tests of brain death
    Ari R Joffe
    University of Alberta, and Stollery Children s Hospital, Edmonton, AB, Canada
    Rev Neurosci 20:187-98. 2009
    ..I conclude that brain death, while a devastating neurological state with a dismal prognosis, is not death...
  49. ncbi request reprint Outcomes from an interprovincial program of newborn open heart surgery
    Charlene M T Robertson
    Departments of Pediatrics and Surgery, University of Alberta, Edmonton, Alberta, Canada
    J Pediatr 144:86-92. 2004
    ..Cumulative risk for adverse outcome was determined through univariate and multivariate analyses...