Brain death in Canadian PICUs: demographics, timing, and irreversibilityAri R Joffe
Stollery Children s Hospital, John Dossetor Health Ethics Center, University of Alberta, Edmonton, Alberta, Canada
Pediatr Crit Care Med 14:1-9. 2013
..To determine any discordance between first and second brain death examinations and investigate the quality of brain death determination in Canadian PICUs...
- Pediatric outcomes after extracorporeal membrane oxygenation for cardiac disease and for cardiac arrest: a review
Ari R Joffe
Stollery Children s Hospital, Edmonton, Alberta, Canada
ASAIO J 58:297-310. 2012
..Survival outcomes of most cardiac subgroups were similar, except for concerning mortality in cavopulmonary connection patients. Priority areas for study include identification of potentially modifiable predictors of long-term outcomes...
Multicentre validation of the bedside paediatric early warning system score: a severity of illness score to detect evolving critical illness in hospitalised childrenChristopher S Parshuram
Department of Critical Care Medicine, Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
Crit Care 15:R184. 2011
..The objective of this study was to validate the Bedside PEWS score in a large patient population at multiple hospitals...
- A survey of American neurologists about brain death: understanding the conceptual basis and diagnostic tests for brain death
Ari R Joffe
Stollery Children s Hospital and University of Alberta, Edmonton, Alberta, Canada
Ann Intensive Care 2:4. 2012
..abstract:..
- Donation after cardiocirculatory death: a call for a moratorium pending full public disclosure and fully informed consent
Ari R Joffe
Department of Pediatrics, University of Alberta, Stollery Children s Hospital, Edmonton Clinic Health Academy 11405 87 Avenue, Edmonton, Alberta, T6G 1C9, Canada
Philos Ethics Humanit Med 6:17. 2011
..These are tall orders, and require open public debate. Until this debate occurs, we call for a moratorium on the practice of DCD...
- Reduction in hospital mortality over time in a hospital without a pediatric medical emergency team: limitations of before-and-after study designs
Ari R Joffe
Division of Pediatric Intensive Care, Department of Pediatrics, 8440 112th St, Edmonton, Alberta, Canada
Arch Pediatr Adolesc Med 165:419-23. 2011
..To determine whether hospital mortality has decreased over time in a hospital that has not introduced a pediatric medical emergency team (PMET)...
- Outcomes after heart transplantation in children under six years of age
Ari R Joffe
Department of Pediatrics, School of Public Health, John Dossetor Health Ethics Center, University of Alberta, and Stollery Children s Hospital, Edmonton, Alberta, Canada
Ann Thorac Surg 92:174-82. 2011
..Survival after heart transplant has improved and more attention is focused on developmental outcomes. We aimed to determine the survival, morbidity, and developmental outcomes of young children after heart transplant...
- The apnea test: rationale, confounders, and criticism
Ari R Joffe
University of Alberta and Stollery Children s Hospital, Edmonton, Alberta, Canada
J Child Neurol 25:1435-43. 2010
..Hyperoxia during the apnea test can further suppress the function of medullary respiratory rhythm centers. Finally, the philosophical rationale for the need to show lack of spontaneous breathing in brain death is lacking...
- Variability in the pediatric intensivists' threshold for withdrawal/limitation of life support as perceived by bedside nurses: a multicenter survey study
Colleen S Gresiuk
University of Alberta, Stollery Children s Hospital, 8440 112 Street, Edmonton, Alberta, T6G 2B7, Canada
Ann Intensive Care 1:31. 2011
..abstract:..
- Two-year survival, mental, and motor outcomes after cardiac extracorporeal life support at less than five years of age
Laurance Lequier
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
J Thorac Cardiovasc Surg 136:976-983.e3. 2008
..Comprehensive outcome assessment of children receiving cardiac extracorporeal life support...
- Association of hemoglobin and transfusion with outcome after operations for hypoplastic left heart
Jaime Blackwood
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Ann Thorac Surg 89:1378-84.e1-2. 2010
..Some studies suggest transfusion might contribute to adverse outcomes. This study investigated the association between hemoglobin concentration and transfusion with outcome in cyanotic neonates undergoing Norwood operations...
- Quality of life 4 years after complex heart surgery in infancy
Gonzalo Garcia Guerra
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
J Thorac Cardiovasc Surg 145:482-488.e2. 2013
..To determine the health-related quality of life at 4 years of age in children who had undergone cardiac surgery for congenital heart disease in early infancy...
- Two-year survival and mental and psychomotor outcomes after the Norwood procedure: an analysis of the modified Blalock-Taussig shunt and right ventricle-to-pulmonary artery shunt surgical eras
Joseph Atallah
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Circulation 118:1410-8. 2008
..In our institution, surgical practice changed from use of the MBTS to use of the RVPA shunt in 2002. We analyzed survival and mental and psychomotor outcomes of the 2 consecutive surgical eras...
- Neurodevelopmental outcome following exposure to sedative and analgesic drugs for complex cardiac surgery in infancy
Gonzalo Garcia Guerra
Department of Pediatrics, University of Alberta, Edmonton, AB, Canada
Paediatr Anaesth 21:932-41. 2011
..OBJECTIVES/AIM: To determine whether sedation/analgesia drugs used before, during, and after infant cardiac surgery are associated with neurodevelopmental outcome...
- Bilateral sensory permanent hearing loss after palliative hypoplastic left heart syndrome operation
Charlene M T Robertson
Department of Pediatrics, University of Alberta and Stollery Children s Hospital, Edmonton, Canada
Ann Thorac Surg 93:1248-53. 2012
....
- Two-year neurodevelopmental outcomes of infants undergoing neonatal cardiac surgery for interrupted aortic arch: a descriptive analysis
Chloe A Joynt
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
J Thorac Cardiovasc Surg 138:924-32. 2009
..This study determined neurodevelopmental outcomes of survivors of neonatal cardiac surgery for interrupted aortic arch through an interprovincial program and explored preoperative, intraoperative, and postoperative outcome predictors...
- Two-year survival and neurodevelopmental outcomes after cardiopulmonary resuscitation in neonatal patients after complex cardiac surgery
Gregory Hansen
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
Resuscitation 82:313-8. 2011
..To examine survival and neurodevelopmental outcomes in neonates having post-operative cardiopulmonary resuscitation (CPR)...
Two-year general and neurodevelopmental outcome after neonatal complex cardiac surgery in patients with deletion 22q11.2: a comparative studyJoseph Atallah
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
J Thorac Cardiovasc Surg 134:772-9. 2007
..Neonatal complex cardiac surgery carries a significant risk for adverse neurodevelopmental outcome. We hypothesized this risk to be higher in patients with deletion 22q11.2...
- Intermediate-term outcomes of the arterial switch operation for transposition of great arteries in neonates: alive but well?
Darren H Freed
Department of Surgery, University of Alberta, Edmonton, Alberta, Canada
J Thorac Cardiovasc Surg 132:845-52. 2006
..Predictors of outcome are explored...
- Early childhood health, growth, and neurodevelopmental outcomes after complete repair of total anomalous pulmonary venous connection at 6 weeks or younger
Gwen Y Alton
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
J Thorac Cardiovasc Surg 133:905-11. 2007
....
- Mortality after neonatal cardiac surgery: Prediction from mean arterial pressure after rewarming in the operating room
Ari R Joffe
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
J Thorac Cardiovasc Surg 134:311-8. 2007
..To examine the predictive contribution of mean arterial pressure after rewarming to > or =34 degrees C in the operating room to mortality after cardiac surgery in infants < or =6 weeks old...
- The registry and follow-up of complex pediatric therapies program of Western Canada: a mechanism for service, audit, and research after life-saving therapies for young children
Charlene M T Robertson
Department of Pediatrics, University of Alberta, Edmonton, AB, Canada T6G 2R3
Cardiol Res Pract 2011:965740. 2011
..Through this mechanism, consistently high (96%) follow-up over two years is maintained...
- Postoperative lactate concentrations predict the outcome of infants aged 6 weeks or less after intracardiac surgery: a cohort follow-up to 18 months
Po Yin Cheung
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
J Thorac Cardiovasc Surg 130:837-43. 2005
..An observational cohort study was conducted in infants less than 6 weeks of age undergoing intracardiac surgery to examine the predictive value of serial postoperative lactate determination on survival and early childhood neurodevelopment...
- Risk factors for and outcomes of acute kidney injury in neonates undergoing complex cardiac surgery
Catherine J Morgan
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
J Pediatr 162:120-7.e1. 2013
..To characterize the epidemiology of and identify risk factors for neonatal cardiac surgery-associated acute kidney injury (CS-AKI) and determine its impact on clinical outcomes...
- The approach to delayed resuscitation in paediatric cardiac arrest: A survey of paediatric intensivists in Canada
Ari R Joffe
Department of Paediatrics, Division of Paediatric Intensive Care, University of Alberta, 8440 112 Street, Edmonton, Alberta, Canada T6G 2B7
Resuscitation 80:318-23. 2009
..To determine how long a period of having had no cardiopulmonary-resuscitation (CPR) (delay time) is considered to result in subsequent futile efforts at resuscitation...
- Five-year neurocognitive and health outcomes after the neonatal arterial switch operation
Ruth E Neufeld
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada
J Thorac Cardiovasc Surg 136:1413-21, 1421.e1-1421.e2. 2008
..We sought to assess the 5-year neurocognition and health of an interprovincial inception cohort undergoing the arterial switch operation for transposition of the great arteries...
- Donation after cardiac death: a survey of university student opinions on death and donation
Ari R Joffe
Department of Pediatrics, 3A3 Stollery Children s Hospital, University of Alberta, 8440 112 Street, Edmonton, AB, T6G 2B7, Canada
Intensive Care Med 35:240-7. 2009
..To determine if university students consider the donation after cardiac death donor as dead...
- Survey of pediatricians' opinions on donation after cardiac death: are the donors dead?
Ari R Joffe
Department of Pediatrics, University of Alberta and Stollery Children s Hospital, Edmonton, Alberta, Canada
Pediatrics 122:e967-74. 2008
..We set out to determine whether pediatricians consider the donation-after-cardiac-death donor as dead...
- Critical illness in children with influenza A/pH1N1 2009 infection in Canada
Philippe Jouvet
Department of Pediatrics, University of Montreal, Montreal, Quebec, Canada
Pediatr Crit Care Med 11:603-9. 2010
..To describe characteristics, treatment, and outcomes of critically ill children with influenza A/pandemic influenza A virus (pH1N1) infection in Canada...
- Autoresuscitation after pediatric cardiac arrest: is hyperventilation a cause?
Jonathan P Duff
Department of Pediatrics, University of Alberta and Stollery Children s Hospital, Edmonton, Alberta, Canada
Pediatr Emerg Care 27:208-9. 2011
..There are no published reports of this phenomenon in children. We report 2 pediatric cases of the Lazarus phenomenon, likely caused by unintentional hyperventilation during resuscitation...
- A survey to determine the understanding of the conceptual basis and diagnostic tests used for brain death by neurosurgeons in Canada
Ari R Joffe
Department of Pediatrics, Division of Pediatric Intensive Care, University of Alberta, Edmonton, Canada
Neurosurgery 61:1039-45; discussion 1046-7. 2007
..To determine the understanding of the conceptual basis and diagnostic tests used for brain death (BD) by neurosurgeons in Canada...
- Brain death: understanding of the conceptual basis by pediatric intensivists in Canada
Ari R Joffe
Division of Pediatric Intensive Care, Department of Pediatrics, University of Alberta, Edmonton, Canada
Arch Pediatr Adolesc Med 160:747-52. 2006
..To determine whether pediatric intensivists in Canada are aware of the controversies regarding the concept of brain death (BD)...
- Infections in children receiving extracorporeal life support
Alena Tse-Chang
Department of Pediatrics and Stollery Children s Hospital, Edmonton, Alberta, Canada
Infect Control Hosp Epidemiol 32:115-20. 2011
..To describe risk factors for and the outcome of infections in children receiving extracorporeal life support (ECLS) and to determine the need for removal of foreign bodies with bloodstream infections (BSIs) in children receiving ECLS...
- A 10-month-old infant with reversible findings of brain death
Ari R Joffe
Department of Pediatrics, University of Alberta and Stollery Children s Hospital, Edmonton, Alberta, Canada
Pediatr Neurol 41:378-82. 2009
..Together with previous reports, the present case calls into question the assumption that brain death as currently diagnosed is irreversible, and therefore equivalent to death of the patient...
- Comparison of two red-cell transfusion strategies after pediatric cardiac surgery: a subgroup analysis
Ariane Willems
Pediatric Intensive Care Unit, Department of Pediatrics, Universite de Montreal, Montreal, QC, Canada
Crit Care Med 38:649-56. 2010
..a liberal transfusion strategy on new or progressive multiple organ dysfunction syndrome in children post cardiac surgery. The optimal transfusion threshold after cardiac surgery in children is unknown...
- Specificity of radionuclide brain blood flow testing in brain death: case report and review
Ari R Joffe
Stollery Children s Hospital, University of Alberta, Edmonton, Alberta, Canada
J Intensive Care Med 25:53-64. 2010
..Larger numbers of patients both with and without BD (but with severe brain injury) must be studied to determine the sensitivity and specificity of these tests..
- The safety and efficacy of sustained inflations as a lung recruitment maneuver in pediatric intensive care unit patients
Jonathan P Duff
Division of Critical Care Medicine, Stollery Children s Hospital, University of Alberta, 8440 112 Street, 3A3 19 WMC, T6G 2B7, Edmonton, Alberta, Canada
Intensive Care Med 33:1778-86. 2007
..To assess the safety and efficacy of sustained inflations (SI) as lung recruitment maneuvers (RMs) in ventilated pediatric intensive care unit (PICU) patients...
- Injury admissions to pediatric intensive care are predictable and preventable: a call to action
Ari R Joffe
Department of Pediatrics, Division of Pediatric Critical Care, Stollery Children s Hospital, University of Alberta, Edmonton, Alberta, Canada
J Intensive Care Med 21:227-34. 2006
..Novel strategies to improve the public's perception of the cost of childhood injury are needed...
- Some questions about brain death: a case report
Ari R Joffe
Department of Pediatrics, University of Alberta and Stollery Children s Hospital, Edmonton, Alberta, Canada
Pediatr Neurol 37:289-91. 2007
....
- Outcomes from an interprovincial program of newborn open heart surgery
Charlene M T Robertson
Departments of Pediatrics and Surgery, University of Alberta, Edmonton, Alberta, Canada
J Pediatr 144:86-92. 2004
..Cumulative risk for adverse outcome was determined through univariate and multivariate analyses...
- The safety of targeted antibiotic therapy for ventilator-associated pneumonia: a multicenter observational study
Ari R Joffe
Department of Pediatrics, University of Alberta, Edmonton, Alberta, Canada T6G 2B7
J Crit Care 23:82-90. 2008
..The aim of this study was to determine the safety of targeted antibiotic therapy (TT) in ventilator-associated pneumonia (VAP)...
- Brain death is not death: a critique of the concept, criterion, and tests of brain death
Ari R Joffe
University of Alberta, and Stollery Children s Hospital, Edmonton, AB, Canada
Rev Neurosci 20:187-98. 2009
..I conclude that brain death, while a devastating neurological state with a dismal prognosis, is not death...
