Josef Jiricny

Summary

Publications

  1. pmc Postreplicative mismatch repair
    Josef Jiricny
    Institute of Molecular Cancer Research, University of Zurich and ETH Zurich, 8057 Zurich, Switzerland
    Cold Spring Harb Perspect Biol 5:a012633. 2013
  2. doi request reprint DNA repair: how MutM finds the needle in a haystack
    Josef Jiricny
    Institute of Molecular Cancer Research, University of Zurich and ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Biol 20:R145-7. 2010
  3. doi request reprint DNA Cytosine demethylation: are we getting close?
    Josef Jiricny
    Department of Biology, Swiss Federal Institutes of Technology ETH, 8057 Zurich, Switzerland
    Cell 135:1167-9. 2008
  4. ncbi request reprint Defective DNA mismatch repair determines a characteristic transcriptional profile in proximal colon cancers
    Massimiliano Di Pietro
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Gastroenterology 129:1047-59. 2005
  5. ncbi request reprint Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2
    Elda Cannavo
    Institute of Molecular Cancer Research, University of Zurich, Switzerland
    J Biol Chem 282:2976-86. 2007
  6. ncbi request reprint Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair
    Elda Cannavo
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Cancer Res 65:10759-66. 2005
  7. ncbi request reprint Mismatch repair and DNA damage signalling
    Lovorka Stojic
    Institute of Molecular Cancer Research, University of Zurich, August Forel Strasse 7, 8008 Zurich, Switzerland
    DNA Repair (Amst) 3:1091-101. 2004
  8. ncbi request reprint Mismatch repair-dependent transcriptome changes in human cells treated with the methylating agent N-methyl-n'-nitro-N-nitrosoguanidine
    Massimiliano Di Pietro
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Cancer Res 63:8158-66. 2003
  9. doi request reprint DNA mismatch repair and colon cancer
    Giancarlo Marra
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Adv Exp Med Biol 570:85-123. 2005
  10. pmc Interplay of DNA repair pathways controls methylation damage toxicity in Saccharomyces cerevisiae
    Petr Cejka
    Institute of Molecular Cancer Research, University of Zurich, CH 8057 Zurich, Switzerland
    Genetics 179:1835-44. 2008

Collaborators

Detail Information

Publications40

  1. pmc Postreplicative mismatch repair
    Josef Jiricny
    Institute of Molecular Cancer Research, University of Zurich and ETH Zurich, 8057 Zurich, Switzerland
    Cold Spring Harb Perspect Biol 5:a012633. 2013
    ..This article reviews the progress in our understanding of the mechanism of replication error repair made during the past decade...
  2. doi request reprint DNA repair: how MutM finds the needle in a haystack
    Josef Jiricny
    Institute of Molecular Cancer Research, University of Zurich and ETH Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Biol 20:R145-7. 2010
    ..High-resolution crystal structures of DNA complexes with the bacterial MutM protein show how the enzyme feels its way around the double helix in search of an oxidized guanine before flipping it out into its active site and excising it...
  3. doi request reprint DNA Cytosine demethylation: are we getting close?
    Josef Jiricny
    Department of Biology, Swiss Federal Institutes of Technology ETH, 8057 Zurich, Switzerland
    Cell 135:1167-9. 2008
    ..Rai et al. (2008) now report that cytosine demethylation can be accomplished in a one-cell zebrafish embryo by the combined action of a cytidine deaminase and a thymine DNA glycosylase...
  4. ncbi request reprint Defective DNA mismatch repair determines a characteristic transcriptional profile in proximal colon cancers
    Massimiliano Di Pietro
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Gastroenterology 129:1047-59. 2005
    ..Our aim was to characterize the transcriptional profile of this colon cancer subset...
  5. ncbi request reprint Characterization of the interactome of the human MutL homologues MLH1, PMS1, and PMS2
    Elda Cannavo
    Institute of Molecular Cancer Research, University of Zurich, Switzerland
    J Biol Chem 282:2976-86. 2007
    ....
  6. ncbi request reprint Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair
    Elda Cannavo
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Cancer Res 65:10759-66. 2005
    ..If hMLH3 participates in MMR in vivo, its partial redundancy with hPMS2, coupled with the fluctuating expression levels of hMLH3, may help explain the low penetrance of hPMS2 mutations in hereditary nonpolyposis colon cancer families...
  7. ncbi request reprint Mismatch repair and DNA damage signalling
    Lovorka Stojic
    Institute of Molecular Cancer Research, University of Zurich, August Forel Strasse 7, 8008 Zurich, Switzerland
    DNA Repair (Amst) 3:1091-101. 2004
    ..The scope of this article is to provide a brief overview of the recent literature on this subject and to raise questions that could be addressed in future studies...
  8. ncbi request reprint Mismatch repair-dependent transcriptome changes in human cells treated with the methylating agent N-methyl-n'-nitro-N-nitrosoguanidine
    Massimiliano Di Pietro
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Cancer Res 63:8158-66. 2003
    ..Moreover, once DNA methylation damage has been processed by the MMR system, tumor cells might be committed to die, although one or more of their signaling pathways are impaired...
  9. doi request reprint DNA mismatch repair and colon cancer
    Giancarlo Marra
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Adv Exp Med Biol 570:85-123. 2005
  10. pmc Interplay of DNA repair pathways controls methylation damage toxicity in Saccharomyces cerevisiae
    Petr Cejka
    Institute of Molecular Cancer Research, University of Zurich, CH 8057 Zurich, Switzerland
    Genetics 179:1835-44. 2008
    ..Notably, DNA damage signaling proteins played a protective rather than sensitizing role in the MNNG response. Taken together, this evidence demonstrates that (Me)G-containing lesions in yeast must be processed to be cytotoxic...
  11. pmc Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair
    Medini Manohar Ghodgaonkar
    Institute of Molecular Cancer Research of the University of Zurich and ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Mol Cell 50:323-32. 2013
    ..We therefore propose that ribonucleotides misincoporated during DNA replication serve as physiological markers of the nascent DNA strand...
  12. ncbi request reprint Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae
    Petr Cejka
    Institute of Molecular Cancer Research, University of Zurich, August Forel Strasse 7, Ch 8008 Zurich, Switzerland
    Curr Biol 15:1395-400. 2005
    ..cerevisiae MMR system...
  13. pmc Interplay between mismatch repair and chromatin assembly
    Barbara Schöpf
    Institute of Molecular Cancer Research, University of Zurich, Winterthurerstasse 190, CH 8057 Zurich, Switzerland
    Proc Natl Acad Sci U S A 109:1895-900. 2012
    ..In vivo this interaction increases during S-phase and may be controlled by the phosphorylation status of the p150 subunit of CAF-1...
  14. pmc Mismatch repair-dependent processing of methylation damage gives rise to persistent single-stranded gaps in newly replicated DNA
    Nina Mojas
    Institute of Molecular Cancer Research, University of Zurich, CH 8057 Zurich, Switzerland
    Genes Dev 21:3342-55. 2007
    ..During the subsequent S phase, these gaps cause replication fork collapse and elicit recombination and cell cycle arrest...
  15. doi request reprint Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents
    Katja Kratz
    Institute of Molecular Cancer Research, University of Zurich, ETH Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Cell 142:77-88. 2010
    ..The link of KIAA1018 to the FA pathway is further strengthened by its recruitment to DNA damage through interaction of its UBZ domain with monoubiquitylated FANCD2. We therefore propose to name KIAA1018 FANCD2-associated nuclease, FAN1...
  16. ncbi request reprint Characterization of the mismatch repair defect in the human lymphoblastoid MT1 cells
    Marta Szadkowski
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Cancer Res 65:4525-9. 2005
    ..The MMR defect in MT1 cells is thus the compound result of one mutation that inactivates the ATPase function of hMutS alpha and a second mutation that apparently destabilizes the Val(1260)Ile hMSH6 protein in human cells in vivo...
  17. pmc Preinvasive colorectal lesion transcriptomes correlate with endoscopic morphology (polypoid vs. nonpolypoid)
    Elisa Cattaneo
    Institute of Molecular Cancer Research, University of Zurich, Switzerland
    EMBO Mol Med 3:334-47. 2011
    ..We conclude that molecular dysregulation in slightly elevated, nonpolypoid, precancerous colorectal lesions may be somewhat less severe than that observed in classic adenomatous polyps...
  18. ncbi request reprint High doses of SN1 type methylating agents activate DNA damage signaling cascades that are largely independent of mismatch repair
    Lovorka Stojic
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Cell Cycle 4:473-7. 2005
    ..However, the MMR system still contributes towards cell killing, as MMR deficiency favors the long-term survival of the cells, albeit to a substantially smaller extent than when low MNNG concentrations are deployed...
  19. pmc Repair of cisplatin-induced DNA interstrand crosslinks by a replication-independent pathway involving transcription-coupled repair and translesion synthesis
    Milica Enoiu
    Institute of Molecular Cancer Research, University of Zurich, 8057 Zurich, Switzerland
    Nucleic Acids Res 40:8953-64. 2012
    ..We conclude that transcription- and replication-dependent pathways contribute to cellular survival following treatment with crosslinking agents...
  20. pmc The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis
    Mirco Menigatti
    Institute of Molecular Cancer Research, University of Zurich, Switzerland
    Mol Cancer 8:124. 2009
    ..These alterations result in significant, inheritable changes in gene expression that contribute to the selection of tumor cells with enhanced survival potential...
  21. ncbi request reprint Degradation of human exonuclease 1b upon DNA synthesis inhibition
    Mahmoud El-Shemerly
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Cancer Res 65:3604-9. 2005
    ..Our data support the evidence that control of exonuclease 1 activity may be critical for the maintenance of stalled replication forks...
  22. ncbi request reprint Immunohistochemical analysis reveals high frequency of PMS2 defects in colorectal cancer
    Kaspar Truninger
    Institute of Molecular Cancer Research, University of Zurich, Switzerland
    Gastroenterology 128:1160-71. 2005
    ..The protein encoded by PMS2 is also essential for MMR; however, alterations in this gene have been documented only in extremely rare cases. We addressed this unexpected finding by analyzing a large series of CRCs...
  23. doi request reprint Noncanonical mismatch repair as a source of genomic instability in human cells
    Javier Pena-Diaz
    Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Mol Cell 47:669-80. 2012
    ..Importantly, ncMMR is not limited to B cells but occurs also in other cell types. Moreover, it contributes to mutagenesis induced by alkylating agents. Activation of ncMMR may therefore play a role in genomic instability and cancer...
  24. ncbi request reprint Mismatch repair status and the response of human cells to cisplatin
    Elisabetta Pani
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Cell Cycle 6:1796-802. 2007
    ....
  25. ncbi request reprint Dependence of the cytotoxicity of DNA-damaging agents on the mismatch repair status of human cells
    Efterpi Papouli
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Cancer Res 64:3391-4. 2004
    ..We now report that MMR deficiency reproducibly desensitized cells solely to cisplatin...
  26. pmc Interference of mismatch and base excision repair during the processing of adjacent U/G mispairs may play a key role in somatic hypermutation
    Silvia Schanz
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Proc Natl Acad Sci U S A 106:5593-8. 2009
    ..Because polymerase-eta has a propensity to misinsertions opposite adenine residues, the above mechanism would help explain why SHM affects not only C/G, but also A/T base pairs...
  27. ncbi request reprint MutLalpha: at the cutting edge of mismatch repair
    Josef Jiricny
    Institute of Molecular Cancer Research, University of Zurich, CH 8006 Zurich, Switzerland
    Cell 126:239-41. 2006
    ..MutLalpha introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXOI to degrade the strand containing the mismatch...
  28. doi request reprint Transcriptome profile of human colorectal adenomas
    Jacob Sabates-Bellver
    Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland
    Mol Cancer Res 5:1263-75. 2007
    ....
  29. ncbi request reprint 5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems
    Franziska Fischer
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Gastroenterology 133:1858-68. 2007
    ..Surprisingly, although FU is incorporated also into DNA, little is known about its metabolism in this nucleic acid...
  30. pmc Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide
    Patrick L Garcia
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    EMBO J 23:2882-91. 2004
    ..This is the first demonstration of a DNA helicase with an intrinsic DNA strand-annealing function residing in a separate domain...
  31. pmc The versatile thymine DNA-glycosylase: a comparative characterization of the human, Drosophila and fission yeast orthologs
    Ulrike Hardeland
    Institute of Molecular Cancer Research, University of Zurich, August Forel Strasse 7, Ch 8008 Zurich, Switzerland
    Nucleic Acids Res 31:2261-71. 2003
    ....
  32. ncbi request reprint Characterization of the "mismatch repairosome" and its role in the processing of modified nucleosides in vitro
    Katja Baerenfaller
    Institute of Molecular Cancer Research, University of Zurich, Switzerland
    Methods Enzymol 408:285-303. 2006
    ....
  33. pmc Early insights into the function of KIAA1199, a markedly overexpressed protein in human colorectal tumors
    Amit Tiwari
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    PLoS ONE 8:e69473. 2013
    ..Our findings suggest it may negatively regulate the Wnt/CTNNB1 signaling, and its expression is associated with decreased cell proliferation and invasiveness. ..
  34. ncbi request reprint The multifaceted mismatch-repair system
    Josef Jiricny
    Institute of Molecular Cancer Research, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Nat Rev Mol Cell Biol 7:335-46. 2006
    ..This article reviews our current understanding of this multifaceted DNA-repair system in human cells...
  35. pmc Pa-AGOG, the founding member of a new family of archaeal 8-oxoguanine DNA-glycosylases
    Alessandro A Sartori
    Institute of Molecular Cancer Research, University of Zurich, August Forel Strasse 7, Ch 8008 Zurich, Switzerland
    Nucleic Acids Res 32:6531-9. 2004
    ..aerophilum ORF PAE2237. We now show that PAE2237 encodes AGOG (Archaeal GO-Glycosylase), the founding member of a new family of DNA glycosylases, which can remove GO from single- and double-stranded substrates with great efficiency...
  36. ncbi request reprint Unfaithful DNA polymerase caught in the act
    Josef Jiricny
    Institute of Molecular Cancer Research, University of Zurich, August Forel Strasse 7, Ch 8008 Zurich, Switzerland
    Mol Cell 13:768-9. 2004
    ..The 3D structures of all 12 mispairs formed in the active site of a DNA polymerase help explain their differential effects on polymerase stalling and on translocation of the primer terminus to the enzyme's proofreading site...
  37. ncbi request reprint Differential killing of mismatch repair-deficient and -proficient cells: towards the therapy of tumors with microsatellite instability
    Petr Cejka
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Cancer Res 63:8113-7. 2003
    ..This difference may be exploited in gene therapy of tumors with MSI, which represent a substantial proportion of cancers of many different tissues...
  38. ncbi request reprint DNA repair defects in colon cancer
    Josef Jiricny
    Institute of Molecular Cancer Research, University of Zurich, Switzerland
    Curr Opin Genet Dev 13:61-9. 2003
    ....
  39. ncbi request reprint The Bloom's syndrome helicase interacts directly with the human DNA mismatch repair protein hMSH6
    Graziella Pedrazzi
    Institute of Veterinary Biochemistry and Molecular Biology, University of Zurich, Winterthurerstr 190, CH 8057 Zurich, Switzerland
    Biol Chem 384:1155-64. 2003
    ....
  40. ncbi request reprint Enzymology of base excision repair in the hyperthermophilic archaeon Pyrobaculum aerophilum
    Alessandro A Sartori
    Institute of Molecular Cancer Research, University of Zurich, August Forel Strasse 7, Switzerland
    J Biol Chem 278:24563-76. 2003
    ..U mispair in an oligonucleotide substrate to a G.C pair. Interestingly, the efficiency of the in vitro repair reaction was stimulated by Pa-PCNA1, the processivity clamp of DNA polymerases...