Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritisPei Jin
Receptor BioLogix, Inc, Palo Alto, CA 94303, USA
Arthritis Res Ther 10:R73. 2008
..The objective of the present study was to identify alternative splice variants (ASV) from cell surface receptor genes, and to determine whether the novel proteins encoded exert therapeutic activity in an in vivo model of arthritis...
Serine 171, a conserved residue in the gamma-aminobutyric acid type A (GABAA) receptor gamma2 subunit, mediates subunit interaction and cell surface localizationPei Jin
Incyte Corporation, Palo Alto, California 94304, USA
J Biol Chem 279:14179-83. 2004
..Mutation of serine 171 in the gamma2 subunit could therefore result in alteration of the structure of the subunit interaction site, preventing correct subunit assembly...
- PCR isolation and cloning of novel splice variant mRNAs from known drug target genes
Pei Jin
Incyte Corporation, 3160 Porter Drive, Palo Alto, CA 94304, USA
Genomics 83:566-71. 2004
..Our findings demonstrate the existence of many novel alternatively spliced mRNA transcripts and suggest that many more genes undergo functionally significant alternative splicing than previously thought...
- A pan-HER approach for cancer therapy: background, current status and future development
Zhongdong Huang
Receptor BioLogix, Inc, Palo Alto, CA 94303, USA
Expert Opin Biol Ther 9:97-110. 2009
..The human EGF receptor (EGFR or HER) family and its cognate ligands contribute significantly to the aggressiveness of many human malignancies, and are therefore therapeutic targets with great clinical potential...
Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenograftsJay Sarup
Receptor BioLogix, Inc, 3350 West Bayshore Road, Suite 150, Palo Alto, CA 94303, USA
Mol Cancer Ther 7:3223-36. 2008
..Taken together, the data reveal that RB200 has the potential to sequester multiple HER ligands and interfere with signaling by HER-1, HER-2, and HER-3...
- Cloning and characterization of a GABAA receptor gamma2 subunit variant
Pei Jin
Incyte Corporation, Palo Alto, California 94304, USA
J Biol Chem 279:1408-14. 2004
..Together, our results indicate that Ser171 and Tyr172 in the gamma2 subunit constitute a critical motif. When this motif is disrupted by insertion of the alternative exon, access of the gamma2 subunit to the cell surface is prevented...
