Pei Jin

Summary

Publications

  1. pmc Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis
    Pei Jin
    Receptor BioLogix, Inc, Palo Alto, CA 94303, USA
    Arthritis Res Ther 10:R73. 2008
  2. ncbi request reprint Serine 171, a conserved residue in the gamma-aminobutyric acid type A (GABAA) receptor gamma2 subunit, mediates subunit interaction and cell surface localization
    Pei Jin
    Incyte Corporation, Palo Alto, California 94304, USA
    J Biol Chem 279:14179-83. 2004
  3. ncbi request reprint PCR isolation and cloning of novel splice variant mRNAs from known drug target genes
    Pei Jin
    Incyte Corporation, 3160 Porter Drive, Palo Alto, CA 94304, USA
    Genomics 83:566-71. 2004
  4. ncbi request reprint A pan-HER approach for cancer therapy: background, current status and future development
    Zhongdong Huang
    Receptor BioLogix, Inc, Palo Alto, CA 94303, USA
    Expert Opin Biol Ther 9:97-110. 2009
  5. doi request reprint Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts
    Jay Sarup
    Receptor BioLogix, Inc, 3350 West Bayshore Road, Suite 150, Palo Alto, CA 94303, USA
    Mol Cancer Ther 7:3223-36. 2008
  6. ncbi request reprint Cloning and characterization of a GABAA receptor gamma2 subunit variant
    Pei Jin
    Incyte Corporation, Palo Alto, California 94304, USA
    J Biol Chem 279:1408-14. 2004

Collaborators

Detail Information

Publications6

  1. pmc Novel splice variants derived from the receptor tyrosine kinase superfamily are potential therapeutics for rheumatoid arthritis
    Pei Jin
    Receptor BioLogix, Inc, Palo Alto, CA 94303, USA
    Arthritis Res Ther 10:R73. 2008
    ..The objective of the present study was to identify alternative splice variants (ASV) from cell surface receptor genes, and to determine whether the novel proteins encoded exert therapeutic activity in an in vivo model of arthritis...
  2. ncbi request reprint Serine 171, a conserved residue in the gamma-aminobutyric acid type A (GABAA) receptor gamma2 subunit, mediates subunit interaction and cell surface localization
    Pei Jin
    Incyte Corporation, Palo Alto, California 94304, USA
    J Biol Chem 279:14179-83. 2004
    ..Mutation of serine 171 in the gamma2 subunit could therefore result in alteration of the structure of the subunit interaction site, preventing correct subunit assembly...
  3. ncbi request reprint PCR isolation and cloning of novel splice variant mRNAs from known drug target genes
    Pei Jin
    Incyte Corporation, 3160 Porter Drive, Palo Alto, CA 94304, USA
    Genomics 83:566-71. 2004
    ..Our findings demonstrate the existence of many novel alternatively spliced mRNA transcripts and suggest that many more genes undergo functionally significant alternative splicing than previously thought...
  4. ncbi request reprint A pan-HER approach for cancer therapy: background, current status and future development
    Zhongdong Huang
    Receptor BioLogix, Inc, Palo Alto, CA 94303, USA
    Expert Opin Biol Ther 9:97-110. 2009
    ..The human EGF receptor (EGFR or HER) family and its cognate ligands contribute significantly to the aggressiveness of many human malignancies, and are therefore therapeutic targets with great clinical potential...
  5. doi request reprint Human epidermal growth factor receptor (HER-1:HER-3) Fc-mediated heterodimer has broad antiproliferative activity in vitro and in human tumor xenografts
    Jay Sarup
    Receptor BioLogix, Inc, 3350 West Bayshore Road, Suite 150, Palo Alto, CA 94303, USA
    Mol Cancer Ther 7:3223-36. 2008
    ..Taken together, the data reveal that RB200 has the potential to sequester multiple HER ligands and interfere with signaling by HER-1, HER-2, and HER-3...
  6. ncbi request reprint Cloning and characterization of a GABAA receptor gamma2 subunit variant
    Pei Jin
    Incyte Corporation, Palo Alto, California 94304, USA
    J Biol Chem 279:1408-14. 2004
    ..Together, our results indicate that Ser171 and Tyr172 in the gamma2 subunit constitute a critical motif. When this motif is disrupted by insertion of the alternative exon, access of the gamma2 subunit to the cell surface is prevented...