Li Jin

Summary

Publications

  1. pmc The evolutionary relationship between microbial rhodopsins and metazoan rhodopsins
    Libing Shen
    State Key Laboratory of Genetic Engineering, Ministry of Education, School of Life Sciences, Fudan University, Shanghai 200433, China
    ScientificWorldJournal 2013:435651. 2013
  2. pmc Genome amplification of single sperm using multiple displacement amplification
    Zhengwen Jiang
    Department of Environmental Health, Center for Genome Information, University of Cincinnati College of Medicine 3223 Eden Ave, Cincinnati, OH 45267, USA
    Nucleic Acids Res 33:e91. 2005
  3. pmc Mitochondrial DNA evidence for a diversified origin of workers building First Emperor of China
    Zhi Xu
    Ministry of Education MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    PLoS ONE 3:e3275. 2008
  4. pmc Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population
    Xiao yun Cai
    State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    PLoS ONE 4:e6423. 2009
  5. pmc Rationales, design and recruitment of the Taizhou Longitudinal Study
    Xiaofeng Wang
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, PR China
    BMC Public Health 9:223. 2009
  6. pmc Investigation gene and microRNA expression in glioblastoma
    Hua Dong
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China
    BMC Genomics 11:S16. 2010
  7. pmc Genetic evidence supports linguistic affinity of Mlabri--a hunter-gatherer group in Thailand
    Shuhua Xu
    Chinese Academy of Sciences and Max Planck Society CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    BMC Genet 11:18. 2010
  8. pmc Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study
    Yun Bai
    Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    BMC Cancer 7:81. 2007
  9. pmc Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations
    Hong Shi
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Centre, Chinese Academy of Sciences, Kunming, PR China
    BMC Biol 6:45. 2008
  10. pmc Evidence that a West-East admixed population lived in the Tarim Basin as early as the early Bronze Age
    Chunxiang Li
    Ancient DNA Laboratory, Research Center for Chinese Frontier Archaeology, Jilin University, Changchun 130012, PR China
    BMC Biol 8:15. 2010

Collaborators

  • Wei Huang
  • Yi Wang
  • Hui Li
  • Jiucun Wang
  • Momiao Xiong
  • Feng Zhang
  • Haifeng Wang
  • Ji Qian
  • Daru Lu
  • Qingyi Wei
  • Hongliang Liu
  • Weiwei Fan
  • Hongxia Ma
  • Hongbing Shen
  • Zhibin Hu
  • Wenting Wu
  • Yanhong Liu
  • Rong Lin
  • Xiao Feng Wang
  • Jing He
  • Rui Li
  • Weiwei Sun
  • Guangfu Jin
  • Shuhua Xu
  • Dan Chen
  • Ming Lu
  • Xueying Zhao
  • Hongyan Chen
  • Shaohua Gu
  • Xiaofeng Wang
  • Wenqing Fu
  • Yu An
  • Ya jun Yang
  • Yajun Yang
  • Qihan Wu
  • Dandan Zhang
  • Baohui Han
  • Zhengwen Jiang
  • Yin Yao Shugart
  • Shuyu Zhang
  • Hao Wen
  • Ruifen Miao
  • Ruifeng Miao
  • Minhua Shao
  • Ting Yan Shi
  • Mei ling Zhu
  • Meng yun Wang
  • Jin Li
  • Qing Yi Wei
  • Meng Hong Sun
  • Ranjan Deka
  • Xiao Yan Zhou
  • Wenfei Jin
  • Xiaoming Tan
  • Chunhong Shao
  • Yifeng Li
  • Ranajit Chakraborty
  • Yu lan Qiu
  • Zhao lin Xia
  • Chunxiang Li
  • Shou Min Zhu
  • Keke Zhou
  • Lucia F Jorge-Nebert
  • Zhi Xu
  • Shilin Li
  • Ren Yong Lin
  • Feng Wang
  • Wentao Yuan
  • Jun Zhang
  • Daniel W Nebert
  • Bo Wen
  • Qing Sang
  • Zhenhong Zhao
  • Qiaoxin Li
  • Xue Yan Yang
  • Libing Shen
  • Erli Wang
  • Mengyun Wang
  • Xiaoyan Zhou
  • Lixin Yang
  • Li Xin Qiu
  • Haichuan Hu
  • Zhiqiang Gao
  • Hongxiang Zheng
  • Wei Wang
  • Wei Zhang
  • Fen Wu
  • Yuan Yang
  • Yun Zhou
  • Hua Dong

Detail Information

Publications69

  1. pmc The evolutionary relationship between microbial rhodopsins and metazoan rhodopsins
    Libing Shen
    State Key Laboratory of Genetic Engineering, Ministry of Education, School of Life Sciences, Fudan University, Shanghai 200433, China
    ScientificWorldJournal 2013:435651. 2013
    ....
  2. pmc Genome amplification of single sperm using multiple displacement amplification
    Zhengwen Jiang
    Department of Environmental Health, Center for Genome Information, University of Cincinnati College of Medicine 3223 Eden Ave, Cincinnati, OH 45267, USA
    Nucleic Acids Res 33:e91. 2005
    ..The use of MDA in single sperm amplification may open a new era for studies on local recombination rates...
  3. pmc Mitochondrial DNA evidence for a diversified origin of workers building First Emperor of China
    Zhi Xu
    Ministry of Education MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    PLoS ONE 3:e3275. 2008
    ..Our results showed that mausoleum-building workers may be derived from very diverse sources of origin...
  4. pmc Association of mitochondrial DNA haplogroups with exceptional longevity in a Chinese population
    Xiao yun Cai
    State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    PLoS ONE 4:e6423. 2009
    ..Longevity is a multifactorial trait with a genetic contribution, and mitochondrial DNA (mtDNA) polymorphisms were found to be involved in the phenomenon of longevity...
  5. pmc Rationales, design and recruitment of the Taizhou Longitudinal Study
    Xiaofeng Wang
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, 200433, PR China
    BMC Public Health 9:223. 2009
    ..The burdens of non-communicable diseases, such as cardiovascular diseases, diabetes and cancer, have also increased substantially...
  6. pmc Investigation gene and microRNA expression in glioblastoma
    Hua Dong
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China
    BMC Genomics 11:S16. 2010
    ..Glioblastoma is the most common primary brain tumor in adults. Though a lot of research has been focused on this disease, the causes and pathogenesis of glioblastoma have not been indentified clearly...
  7. pmc Genetic evidence supports linguistic affinity of Mlabri--a hunter-gatherer group in Thailand
    Shuhua Xu
    Chinese Academy of Sciences and Max Planck Society CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    BMC Genet 11:18. 2010
    ..This study aims to examine whether the genetic affinity of the Mlabri is consistent with this linguistic relationship, and to further explore the origins of this enigmatic population...
  8. pmc Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study
    Yun Bai
    Institute of Occupational Medicine and Ministry of Education Key Lab for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, PR China
    BMC Cancer 7:81. 2007
    ..Because mutations in XPC cause a high risk of cancer in XP patients, we hypothesized that inherited sequence variations in XPC may alter DNA repair and thus susceptibility to cancer...
  9. pmc Y chromosome evidence of earliest modern human settlement in East Asia and multiple origins of Tibetan and Japanese populations
    Hong Shi
    State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Centre, Chinese Academy of Sciences, Kunming, PR China
    BMC Biol 6:45. 2008
    ..However, the fragmented distribution of one East Asian specific Y chromosome lineage (D-M174), which is found at high frequencies only in Tibet, Japan and the Andaman Islands, is inconsistent with this scenario...
  10. pmc Evidence that a West-East admixed population lived in the Tarim Basin as early as the early Bronze Age
    Chunxiang Li
    Ancient DNA Laboratory, Research Center for Chinese Frontier Archaeology, Jilin University, Changchun 130012, PR China
    BMC Biol 8:15. 2010
    ....
  11. doi request reprint Common variants of four bilirubin metabolism genes and their association with serum bilirubin and coronary artery disease in Chinese Han population
    Rong Lin
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Institute of Biomedical Sciences, Fudan University, and Ruijin Hospital, Shanghai, China
    Pharmacogenet Genomics 19:310-8. 2009
    ....
  12. ncbi request reprint Methyl-CpG binding domain 1 gene polymorphisms and lung cancer risk in a Chinese population
    Hongliang Liu
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China
    Biomarkers 13:607-17. 2008
    ..0041). Our results suggested that MBD1 polymorphisms might be involved in the development of lung cancer. Validation of these findings in larger studies of other populations is needed...
  13. doi request reprint Polymorphisms of LIG4 and XRCC4 involved in the NHEJ pathway interact to modify risk of glioma
    Yanhong Liu
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China
    Hum Mutat 29:381-9. 2008
    ..Further dendrogram and graph analysis indicated a more-than-additive effect among these three loci. These results suggested that these variants may contribute to glioma susceptibility...
  14. doi request reprint Genetic variations of mTORC1 genes and risk of gastric cancer in an Eastern Chinese population
    Jing He
    Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    Mol Carcinog 52:E70-9. 2013
    ..These data support the hypothesis that functional polymorphisms of mTOR may contribute to gastric cancer risk. Clearly, our results require validation in larger studies with different ethnic populations...
  15. ncbi request reprint Association between polymorphisms in the GSTA4 gene and risk of lung cancer: a case-control study in a Southeastern Chinese population
    Ji Qian
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China
    Mol Carcinog 48:253-9. 2009
    ..37; 95% CI, 0.23-0.61; P < 0.0001), especially for those smokers who smoked </=25 pack-years (P < 0.000001). These results need to be confirmed in larger studies with different ethnic groups...
  16. doi request reprint Association of a BLVRA common polymorphism with essential hypertension and blood pressure in Kazaks
    Rong Lin
    Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai, China
    Clin Exp Hypertens 33:294-8. 2011
    ..3 mmHg, 95.1 mmHg) (p = 0.005 and 0.009, respectively). These findings provide the first genetic evidence for the role of BLVRA on the susceptibility to human essential hypertension and blood pressure...
  17. doi request reprint Association of human aryl hydrocarbon receptor gene polymorphisms with risk of lung cancer among cigarette smokers in a Chinese population
    Dan Chen
    State Key Laboratory of Genetic Engineering and Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
    Pharmacogenet Genomics 19:25-34. 2009
    ..We hypothesized that genetic variations in AHR might confer individual susceptibility to lung cancer...
  18. doi request reprint Lack of association of functional variants in alpha-ENaC gene and essential hypertension in two ethnic groups in China
    Xiao Feng Wang
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Kidney Blood Press Res 31:268-73. 2008
    ..To further test this hypothesis, we observed the role of three functional variants G2139A, A334T and A663T in the alpha-ENaC gene on essential hypertension in two Chinese minority groups, the Kazaks and Uyghurs...
  19. doi request reprint Association of polymorphisms in four bilirubin metabolism genes with serum bilirubin in three Asian populations
    Rong Lin
    Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Hum Mutat 30:609-15. 2009
    ..Finally, we observed that significant differences of TBIL levels existed among the three populations; however, this could not be completely explained by the differences at the (TA)n repeat polymorphism and SNP rs4148323:G>A...
  20. doi request reprint Common genetic variations of the cytochrome P450 1A1 gene and risk of hepatocellular carcinoma in a Chinese population
    Rui Li
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, 220 Handan Rd, Shanghai 200433, PR China
    Eur J Cancer 45:1239-47. 2009
    ..However, our findings need to be validated in at least one independent study of Han Chinese population...
  21. pmc Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population
    Meng yun Wang
    Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China
    PLoS ONE 8:e74041. 2013
    ..However, few studies have evaluated associations between functional single nucleotide polymorphisms (SNPs) in the 3' untranslational region (UTR) of CASP7 and risk of gastric cancer...
  22. doi request reprint Common polymorphisms in ITGA2, PON1 and THBS2 are associated with coronary atherosclerosis in a candidate gene association study of the Chinese Han population
    Ying Wang
    Ruijin Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
    J Hum Genet 55:490-4. 2010
    ..Our study has identified three SNPs within ITGA2, PON1 and THBS2 that are associated with coronary atherosclerosis...
  23. doi request reprint Genetic variants in peroxisome proliferator-activated receptor-gamma gene are associated with risk of lung cancer in a Chinese population
    Dan Chen
    The State Key Laboratory of Genetic Engineering and The MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China
    Carcinogenesis 29:342-50. 2008
    ..These findings need to be validated in larger, preferably population-based, studies including different ethnic groups...
  24. ncbi request reprint Polymorphisms in hMLH1 and risk of early-onset lung cancer in a southeast Chinese population
    Yu An
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Handan Road, Shanghai 200433, China
    Lung Cancer 59:164-70. 2008
    ..Larger association studies are warranted to validate our findings and mechanistic studies are needed to elucidate the underlying molecular mechanisms of the association...
  25. ncbi request reprint Association of CASP7 polymorphisms and survival of patients with non-small cell lung cancer with platinum-based chemotherapy treatment
    Ji Qian
    State Key Laboratory of Genetic Engineering, School of Life Sciences and Fudan Taizhou Institute of Health Sciences, Fudan University, Shanghai, China
    Chest 142:680-9. 2012
    ..We, therefore, explored whether single nucleotide polymorphisms (SNPs) of the CASP7 gene can modulate outcomes of patients with advanced non-small cell lung cancer (NSCLC) treated with first-line platinum-based chemotherapy...
  26. doi request reprint WNK4 polymorphisms and essential hypertension in the Uyghur population
    Ming Lu
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Clin Exp Hypertens 31:179-85. 2009
    ..Further study should be conducted to observe the role of this gene on hypertension in other populations...
  27. doi request reprint Genetic susceptibility of lung cancer associated with common variants in the 3' untranslated regions of the adenosine triphosphate-binding cassette B1 (ABCB1) and ABCC1 candidate transporter genes for carcinogen export
    Haijian Wang
    State Key Laboratory of Genetic Engineering, Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Cancer 115:595-607. 2009
    ..The objective of the current study was to test the hypothesis that these common variants are associated with lung cancer risk...
  28. ncbi request reprint Dissecting linkage disequilibrium in African-American genomes: roles of markers and individuals
    Shuhua Xu
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Mol Biol Evol 24:2049-58. 2007
    ....
  29. doi request reprint Genetic polymorphisms in DNA double-strand break repair genes XRCC5, XRCC6 and susceptibility to hepatocellular carcinoma
    Rui Li
    State Key Laboratory of Genetic Engineering, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, 220 Handan Road, Shanghai 200433 China
    Carcinogenesis 32:530-6. 2011
    ..In conclusion, XRCC5 variants may play a role in determining individual's HCC susceptibility, which warranted validation in larger studies...
  30. pmc Prevalence and persistence of chromosomal damage and susceptible genotypes of metabolic and DNA repair genes in Chinese vinyl chloride-exposed workers
    Fang Ji
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, China
    Carcinogenesis 31:648-53. 2010
    ..This study provides evidence that cumulative exposure dose of VC and common genetic variants in genes relevant to detoxification of carcinogens are the major factors that modulate CBMN induction in VC-exposed workers...
  31. doi request reprint Association of TNFAIP3 polymorphism with rheumatic heart disease in Chinese Han population
    Rong Hua
    Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
    Immunogenetics 61:739-44. 2009
    ..Further genetic and functional studies are required to identify the etiological variants in linkage disequilibrium with this polymorphism...
  32. pmc Paternal genetic affinity between Western Austronesians and Daic populations
    Hui Li
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes for Biomedical Sciences, Fudan University, Shanghai 200433, China
    BMC Evol Biol 8:146. 2008
    ....
  33. doi request reprint Confirmation of papillary thyroid cancer susceptibility loci identified by genome-wide association studies of chromosomes 14q13, 9q22, 2q35 and 8p12 in a Chinese population
    Yu long Wang
    Department of Head and Neck Surgery, Cancer Hospital, Fudan University, Shanghai, China
    J Med Genet 50:689-95. 2013
    ..33), rs944289 (14q13.3), rs116909374 (14q13.3), rs966423 (2q35) and rs2439302 (8p12). Only the first two SNPs have been validated in independent populations and none were replicated in Chinese populations...
  34. doi request reprint DNA repair gene polymorphisms and micronucleus frequencies in Chinese workers exposed to vinyl chloride monomer
    Yu lan Qiu
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China
    Int J Hyg Environ Health 214:225-30. 2011
    ..04 and P = 0.004, respectively). Our findings suggest that XPC PAT, XPD Lys751Gln, XPA A23G and XPF 5'-UTR T2063A contribute to the level of chromosome damage in occupational exposure to VCM in Chinese population...
  35. doi request reprint Genetic variants in GTF2H1 and risk of lung cancer: a case-control analysis in a Chinese population
    Wenting Wu
    The State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China
    Lung Cancer 63:180-6. 2009
    ..Taken together, these results suggest that GTF2H1 polymorphisms/haplotypes may contribute to genetic susceptibility to lung cancer...
  36. pmc Association between CASP8 and CASP10 polymorphisms and toxicity outcomes with platinum-based chemotherapy in Chinese patients with non-small cell lung cancer
    Ji Qian
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Handan Road, Shanghai 200433, China
    Oncologist 17:1551-61. 2012
    ..If validated, the findings will facilitate the genotype-based selection of platinum-based chemotherapy regimens...
  37. pmc Prediction of lung cancer risk in a Chinese population using a multifactorial genetic model
    Huan Li
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, Institute of Genetics, School of Life Sciences, Fudan University, Handan Rd, Shanghai 200433, China
    BMC Med Genet 13:118. 2012
    ..In this study, we investigated whether a genetic risk score combining multiple...
  38. doi request reprint Angiotensinogen polymorphisms and acquired atrial fibrillation in Chinese
    Qun Shan Wang
    Department of Cardiology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    J Electrocardiol 43:373-7. 2010
    ..04-3.46; P = .036). We provide evidence that polymorphism in AGT gene may confer predisposition to acquired atrial fibrillation in Chinese Hans...
  39. ncbi request reprint Genetic structure of Hmong-Mien speaking populations in East Asia as revealed by mtDNA lineages
    Bo Wen
    State Key Laboratory of Genetic Engineering and Center for Anthropological Studies, School of Life Sciences, Fudan University, Shanghai, China
    Mol Biol Evol 22:725-34. 2005
    ..Moreover, our data defined some new (sub-)haplogroups (A6, B4e, B4f, C5, F1a1, F1a1a, and R9c), which will direct further efforts to improve the phylogeny of East Asian mtDNAs...
  40. pmc Analysis of human CYP1A1 and CYP1A2 genes and their shared bidirectional promoter in eight world populations
    Lucia F Jorge-Nebert
    Department of Environmental Health, University of Cincinnati Medical Center, PO Box 670056, Cincinnati, OH 45267 0056, USA
    Hum Mutat 31:27-40. 2010
    ....
  41. doi request reprint Polymorphisms and haplotypes of DNA repair and xenobiotic metabolism genes and risk of DNA damage in Chinese vinyl chloride monomer (VCM)-exposed workers
    Shou Min Zhu
    Department of Occupational Health and Toxicology, School of Public Health, Fudan University, Shanghai, China
    Toxicol Lett 178:88-94. 2008
    ..06) than in controls. Overall, our data suggest that the genotypes of CYP2E1, XRCC1 194, and XPD 751 were associated with the level of DNA damage and may contribute to individual sensitivity to DNA damage induced by VCM in the workplace...
  42. doi request reprint XRCC3 haplotypes and risk of gliomas in a Chinese population: a hospital-based case-control study
    Keke Zhou
    Neurosurgery Department of Huashan Hospital, Fudan University, Shanghai, China
    Int J Cancer 124:2948-53. 2009
    ..35, 95% CI = 1.14-1.58, p = 0.000 and adjusted OR = 1.67, 95% CI = 1.11-2.52, p = 0.015, respectively). Our results suggest that common genetic variants in the XRCC3 gene may modulate glioma risk...
  43. doi request reprint OPRM1 gene is associated with BMI in Uyghur population
    Ling Xu
    1MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Obesity (Silver Spring) 17:121-5. 2009
    ..14-2.49, P = 0.009) for rs514980, and 1.80 (95% confidence interval 1.14-2.85, P = 0.012) for rs7773995, respectively. Our observations give the evidence that OPRM1 gene is involved in the prevalence of obesity in Uyghurs...
  44. ncbi request reprint Randomly distributed crossovers may generate block-like patterns of linkage disequilibrium: an act of genetic drift
    Kun Zhang
    Center for Genome Information, 130 Kettering, Department of Environmental Health, University of Cincinnati, OH 45215, Cincinnati, USA
    Hum Genet 113:51-9. 2003
    ..Our findings highlight the necessity of characterizing haplotype blocks in world-wide populations...
  45. ncbi request reprint Polymorphisms in excision repair cross-complementing group 4 (ERCC4) and susceptibility to primary lung cancer in a Chinese Han population
    Minhua Shao
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes for Biomedical Sciences, Fudan University, Shanghai 200433, China
    Lung Cancer 60:332-9. 2008
    ..Further functional studies on this locus and/or other genetic variants in highly linkage disequilibrium with it are warranted to elucidate the underlying molecular mechanisms of the association...
  46. doi request reprint Putatively functional PLCE1 variants and susceptibility to esophageal squamous cell carcinoma (ESCC): a case-control study in eastern Chinese populations
    Haichuan Hu
    Department of Thoracic Surgery, Fudan University Shanghai Cancer Center, Shanghai, China
    Ann Surg Oncol 19:2403-10. 2012
    ..In this study, we aimed to assess such an association in an eastern Chinese population and to address its possibly functional role in the etiology of ESCC...
  47. doi request reprint A common polymorphism is associated with body mass index in Uyghur population
    Jun Zhang
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai, China
    Diabetes Res Clin Pract 81:e11-3. 2008
    ..47 (95% CI 1.11-1.95, P=0.006) under a dominant model (CC+GC versus GG). The mean BMI of rs7566605 CC+GC was 0.59kg/m(2) higher than for GG genotype (P=0.024), regardless of sex and age...
  48. ncbi request reprint Prehistorical East-West admixture of maternal lineages in a 2,500-year-old population in Xinjiang
    Fan Zhang
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, 200433 Shanghai, China
    Am J Phys Anthropol 142:314-20. 2010
    ..This result indicates that the initial contact of the East and the West Eurasians occurred further east than Central Asia as early as 2,500 years ago...
  49. ncbi request reprint Polymorphisms of CAK genes and risk for lung cancer: a case-control study in Chinese population
    Yuanchun Li
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China
    Lung Cancer 58:171-83. 2007
    ..Our results suggested that genetic variants in CAK genes, Cdk7, cyclin H, MAT1, might modulate the risk of lung cancer in a gene-gene interaction mode, which consist to the biochemical interaction of corresponding proteins...
  50. doi request reprint Association of polymorphisms in one-carbon metabolizing genes and lung cancer risk: a case-control study in Chinese population
    Hongliang Liu
    State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China
    Lung Cancer 61:21-9. 2008
    ..08%, p<0.001). These findings suggest that genetic variants in one-carbon metabolizing genes might modulate the risk of lung cancer. Validation of these findings in larger studies is needed...
  51. ncbi request reprint Search for an association between the human CYP1A2 genotype and CYP1A2 metabolic phenotype
    Zhengwen Jiang
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA
    Pharmacogenet Genomics 16:359-67. 2006
    ..We conclude that no SNP or haplotype in the CYP1A2 gene has yet been identified that can unequivocally be used to predict the metabolic phenotype in any individual patient...
  52. ncbi request reprint The effect of dopamine D2, D5 receptor and transporter (SLC6A3) polymorphisms on the cue-elicited heroin craving in Chinese
    Yifeng Li
    State Key Laboratory of Genetic Engineering and Center for Anthropological Studies, School of Life Sciences and Morgan Tan International Center for Life Sciences, Fudan University, Shanghai, China
    Am J Med Genet B Neuropsychiatr Genet 141:269-73. 2006
    ..The results of our study suggest that human dopamine pathway be involved in cue-induced heroin craving, and indicate a potential genetic risk factor for persistent heroin behavior and relapse...
  53. pmc Polymorphisms in ERCC1 and XPF genes and risk of gastric cancer in an eastern Chinese population
    Jing He
    Cancer Research Laboratory, Fudan University Shanghai Cancer Center, Shanghai, China
    PLoS ONE 7:e49308. 2012
    ..Inherited functional single nucleotide polymorphisms (SNPs) in DNA repair genes may alter DNA repair capacity and thus contribute to cancer risk...
  54. pmc Missing call bias in high-throughput genotyping
    Wenqing Fu
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, PR China
    BMC Genomics 10:106. 2009
    ..While the primary focus has been invested upon the improvement of reducing genotyping error, the problems associated with missing calls are largely overlooked...
  55. ncbi request reprint Significant association of 5p15.33 (TERT-CLPTM1L genes) with lung cancer in Chinese Han population
    Zhenhong Zhao
    State Key Laboratory of Genetic Engineering, School of Life Sciences and Fudan Taizhou Institute of Health Sciences, Fudan University, and Department of Cardiothoracic Surgery and Pneumology, Changhai Hospital of Shanghai, Shanghai, China
    Exp Lung Res 39:91-8. 2013
    ..24 in the combined population). The results provided the evidence of a cross-race susceptibility of the lung cancer locus...
  56. doi request reprint A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer
    Shuyu Zhang
    The State Key Laboratory of Genetic Engineering and The MOE Key Laboratory of Contemporary Anthropology, School of Life Science, Fudan University, Shanghai 200433, China
    Carcinogenesis 31:1251-8. 2010
    ..These results support our hypothesis that the CHEK2 rs2236141 variant modifies lung cancer susceptibility in the Chinese population by affecting CHEK2 expression...
  57. doi request reprint Identification of microRNAs in human follicular fluid: characterization of microRNAs that govern steroidogenesis in vitro and are associated with polycystic ovary syndrome in vivo
    Qing Sang
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China
    J Clin Endocrinol Metab 98:3068-79. 2013
    ..Deviations in these components are often associated with reproductive diseases. There has been no report of microRNAs (miRNAs) in human follicular fluids...
  58. pmc Genome-wide detection of natural selection in African Americans pre- and post-admixture
    Wenfei Jin
    Chinese Academy of Sciences Key Laboratory of Computational Biology, Chinese Academy of Sciences and Max Planck Society CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
    Genome Res 22:519-27. 2012
    ..We suggest that the new approach is reasonably powerful and can also be applied to other admixed populations such as Latinos and Uyghurs...
  59. doi request reprint Association of XPD polymorphisms with severe toxicity in non-small cell lung cancer patients in a Chinese population
    Wenting Wu
    State Key Laboratory of Genetic Engineering and Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, China
    Clin Cancer Res 15:3889-95. 2009
    ..This study aimed to investigate the association of three polymorphisms of XPD at codons 156, 312, and 711, with the occurrence of grade 3 or 4 toxicity in advanced non-small cell lung cancer patients...
  60. pmc Polymorphisms in the mTOR gene and risk of sporadic prostate cancer in an Eastern Chinese population
    Qiaoxin Li
    Cancer Institute, Fudan University Shanghai Cancer Institute, Shanghai, China
    PLoS ONE 8:e71968. 2013
    ..Abnormally increased expression of mTOR was associated with carcinogenesis, and its functional single nucleotide polymorphisms (SNPs) may regulate the expression of mTOR and thus contribute to cancer risk...
  61. ncbi request reprint Statistical power of association using the extreme discordant phenotype design
    Ge Zhang
    Department of Environmental Health and Center for Environmental Genetics CEG, University of Cincinnati Medical Center, Cincinnati, OH, USA
    Pharmacogenet Genomics 16:401-13. 2006
    ..The advantage of EDP design is intuitive and it has been successfully used in a number of studies...
  62. ncbi request reprint Effect of mu-opioid receptor gene polymorphisms on heroin-induced subjective responses in a Chinese population
    Dandan Zhang
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, West Lafayette, Indiana, USA
    Biol Psychiatry 61:1244-51. 2007
    ..Genetic factors that influence subjective responses to drug use (such as euphoria) contribute to the risk of addiction. mu-opioid receptor is the molecular target of heroin mediating its effects in both pain relief and euphoria...
  63. pmc Association of two variants in SMAD7 with the risk of congenital heart disease in the Han Chinese population
    Erli Wang
    Chinese Academy of Sciences and Max Planck Society CAS MPG Partner Institute for Computational Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China The State Key Laboratory of Genetic Engineering and Ministry of Education MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, China
    PLoS ONE 8:e72423. 2013
    ..To our knowledge, this is the first report that genetic variants in SMAD7 influence susceptibility to CHD risk...
  64. ncbi request reprint Y chromosomes of prehistoric people along the Yangtze River
    Hui Li
    MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai 200433, China
    Hum Genet 122:383-8. 2007
    ..Noticeable genetic segregation was observed among the prehistoric cultures, demonstrating the genetic foundation of the multiple origins of the Chinese Civilization...
  65. doi request reprint A spatial analysis of genetic structure of human populations in China reveals distinct difference between maternal and paternal lineages
    Fuzhong Xue
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, China
    Eur J Hum Genet 16:705-17. 2008
    ..On the paternal side, however, no obvious genetic differentiation between northern and southern populations is revealed...
  66. ncbi request reprint Dopamine D4 receptor polymorphism modulates cue-elicited heroin craving in Chinese
    Chunhong Shao
    Huashan Hospital Affiliated to Fudan University, Shanghai, 200040, China
    Psychopharmacology (Berl) 186:185-90. 2006
    ..Dopamine pathway has been implicated in the mechanism underlying the cue-elicited craving for a variety of addictive substances...
  67. doi request reprint Association of CASP3 polymorphism with hematologic toxicity in patients with advanced non-small-cell lung carcinoma treated with platinum-based chemotherapy
    Shaohua Gu
    State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Institutes for Biomedical Sciences, Fudan University, Shanghai, China
    Cancer Sci 103:1451-9. 2012
    ..No other association was found. In conclusion, for the first time, our study suggests that CASP3 rs6948 might influence CASP3 expression and be associated with severe hematologic toxicity risk...
  68. ncbi request reprint Mitochondrial DNA diversity and population differentiation in southern East Asia
    Hui Li
    MOE Key Laboratory of Contemporary Anthropology and Center for Evolutionary Biology, School of Life Sciences and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China
    Am J Phys Anthropol 134:481-8. 2007
    ..MtDNA data of Daic, Austro-Asiatic and other populations in South China has therefore proven pivotal for studying the human history of East Asia...
  69. doi request reprint Mutations in the COPII vesicle component gene SEC24B are associated with human neural tube defects
    Xue Yan Yang
    The State Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, People s Republic of China
    Hum Mutat 34:1094-101. 2013
    ..Our study demonstrated that functional mutations in SEC24B might contribute to the etiology of a subset of human NTDs and further expanded our knowledge of the role of PCP pathway-related genes in the pathogenesis of human NTDs. ..