Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trialJuan J Jimenez
Intensive Care Department, Hospital Universitario de Canarias, Ofra s n La Cuesta, La Laguna, 38320, Spain
Crit Care 11:R117. 2007
..Tranexamic acid (TA) reduces fibrinolysis and blood loss after cardiopulmonary bypass (CPB). However, its effects on IR and vasoplegic shock (VS) are not well known and elucidating these effects was the main objective of this study...
Safety and effectiveness of two treatment regimes with tranexamic acid to minimize inflammatory response in elective cardiopulmonary bypass patients: a randomized double-blind, dose-dependent, phase IV clinical trialJuan J Jimenez
Critical Care Department, Hospital Universitario de Canarias, Ofra s n, La Cuesta, 38320 La Laguna, Espana
J Cardiothorac Surg 6:138. 2011
..We aimed to determine whether an additional postoperative dose of antifibrinolytic tranexamic acid (TA) reduced CPB-mediated inflammatory response (IR)...
Postoperative bleeding in cardiac surgery: the role of tranexamic acid in patients homozygous for the 5G polymorphism of the plasminogen activator inhibitor-1 geneJose L Iribarren
Intensive Care Department, University Hospital of the Canary Islands, University of La Laguna, Tenerife, Spain
Anesthesiology 108:596-602. 2008
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Lower incidence of catheter-related bloodstream infection in cubital than in femoral artery accessLeonardo Lorente
Department of Intensive Care, Hospital Universitario de Canarias, Santa Cruz de Tenerife, Spain
Scand J Infect Dis 43:814-7. 2011
..However the development of randomized controlled trials is necessary before this conclusion can be definitively established. In addition, it is necessary to consider other potential mechanical complications when decision-making...
Relative adrenal insufficiency and hemodynamic status in cardiopulmonary bypass surgery patients. A prospective cohort studyJose L Iribarren
Critical Care Department, Hospital Universitario de Canarias, Ofra s n, La Cuesta, 38320 La Laguna, Tenerife, Espana
J Cardiothorac Surg 5:26. 2010
..The objectives of this study were to determine the risk factors for relative adrenal insufficiency in cardiopulmonary bypass patients and the impact on postoperative vasopressor requirements...
Lower arterial catheter-related infection in brachial than in femoral accessLeonardo Lorente
Department of Intensive Care, Hospital Universitario de Canarias, Ofra s n, La Laguna, Santa Cruz de Tenerife, Spain
Am J Infect Control 38:e40-2. 2010
..08 vs 0 per 1000 catheter-days, respectively; odds ratio, 6.18; 95% confidence interval: 1.11-infinite; P = .02). Thus, arterial brachial access should be used in preference to femoral access...
Left atrial dysfunction and new-onset atrial fibrillation after cardiac surgeryJose L Iribarren
Servicio de Medicina Intensiva Hospital Universitario de Canarias La Laguna Santa Cruz España
Rev Esp Cardiol 62:774-80. 2009
..The aim of this study was to determine whether preoperative left atrial contractile dysfunction, as assessed by tissue Doppler echocardiography, is associated with the development of postoperative new-onset atrial fibrillation (PAF)...
Coagulopathy after cardiac surgeryJuan J Jimenez
Anesth Analg 105:1514; author reply 1514-5. 2007