CAS/CSE 1 stimulates E-cadhrin-dependent cell polarity in HT-29 human colon epithelial cellsMing Chung Jiang
Institute of Zoology, Academia Sinica, Taipei 11529, Taiwan, ROC
Biochem Biophys Res Commun 294:900-5. 2002
..CAS-mediated HT-29 cell polarity is also inhibited by antisense E-cadherin DNA expression. Our results indicate that CAS cooperates with E-cadherin and plays a role in the establishment of epithelial cell polarity...
CSE1L/CAS, the cellular apoptosis susceptibility protein, enhances invasion and metastasis but not proliferation of cancer cellsChing Fong Liao
Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan, PR China
J Exp Clin Cancer Res 27:15. 2008
..We studied whether increased CAS expression can increase cancer cell proliferation and whether CAS regulates the invasion of cancer cells...
- CSE1L/CAS, a microtubule-associated protein, inhibits taxol (paclitaxel)-induced apoptosis but enhances cancer cell apoptosis induced by various chemotherapeutic drugs
Ching Fong Liao
Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan, ROC
BMB Rep 41:210-6. 2008
..Our results indicate that CAS may play an important role in regulating the cytotoxicities of chemotherapeutic drugs used in cancer chemotherapy against cancer cells...
- A modified mutation detection method for large-scale cloning of the possible single nucleotide polymorphism sequences
Ming Chung Jiang
Institute of Zoology, Academia Sinica, Taipei, Taiwan ROC
J Biochem Mol Biol 38:191-7. 2005
..Experimental validations of the presence and location of sequence variations in the isolated clones by PCR and DNA sequencing support the capability of this method in identifying sequence differences between tumor cells and normal cells...
- Presence of secretory cellular apoptosis susceptibility protein in cerebrospinal fluids of patients with intracerebral hemorrhage caused by stroke and neurotrauma
Jai Nien Tung
Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan, Taiwan
Neuro Endocrinol Lett 31:390-8. 2010
..The cellular apoptosis susceptibility (CSE1L/CAS) protein has been shown to regulate MMP-2 secretion...
- CSE1L, a novel microvesicle membrane protein, mediates Ras-triggered microvesicle generation and metastasis of tumor cells
Ching Fong Liao
Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
Mol Med 18:1269-80. 2012
..Furthermore, the novel microvesicle membrane protein, CSE1L, may have clinical utility in cancer diagnosis and targeted cancer therapy...
- CAS Enhances Chemotherapeutic Drug-Induced p53 Accumulation and Apoptosis: Use of CAS for High-Sensitivity Anticancer Drug Screening
Ching Fong Liao
Institute of Cellular and Organismic Biology, Academia Sinica, Taipei, Taiwan
Toxicol Mech Methods 18:771-6. 2008
..Thus, anticancer compounds could be identified more sensitively. Our study indicates that CAS is an important p53 and apoptosis regulator and may be used for high-throughput anticancer drug screening as well as cytotoxic toxin assays...
- Clinical-pathological correlation of K-Ras mutation and ERK phosphorylation in colorectal cancer
Cheng Jeng Tai
Department of Pathology, Changhua Christian Hospital, Changhua, Taiwan
Pol J Pathol 63:93-100. 2012
..Moreover, although colorectal cancer with K-Ras mutations has a more aggressive phenotype; the mutation rate is not very high. Phospho-ERK may be a useful marker in combination with K-Ras for improving the prognosis of colorectal cancer...
