Jiahua Jiang

Summary

Publications

  1. doi Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202, USA
    Clin Exp Metastasis 29:165-78. 2012
  2. pmc Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e47873. 2012
  3. doi Suppression of proliferation and invasive behavior of human metastatic breast cancer cells by dietary supplement BreastDefend
    Jiahua Jiang
    Methodist Research Institute, Indianapolis, IN 46202, USA
    Integr Cancer Ther 10:192-200. 2011
  4. pmc BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202, USA
    Oncol Rep 28:1139-45. 2012
  5. pmc NAHA, a novel hydroxamic acid-derivative, inhibits growth and angiogenesis of breast cancer in vitro and in vivo
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e34283. 2012
  6. doi Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN, USA
    Biochem Biophys Res Commun 415:325-9. 2011
  7. doi Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling
    Andrej Jedinak
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Oncol 38:761-7. 2011
  8. ncbi Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Mol Med 21:577-84. 2008
  9. doi ProstaCaid inhibits tumor growth in a xenograft model of human prostate cancer
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN, USA
    Int J Oncol 40:1339-44. 2012
  10. ncbi Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Oncol 29:695-703. 2006

Collaborators

Detail Information

Publications21

  1. doi Gossypol inhibits growth, invasiveness, and angiogenesis in human prostate cancer cells by modulating NF-κB/AP-1 dependent- and independent-signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202, USA
    Clin Exp Metastasis 29:165-78. 2012
    ..In summary, our data suggest that gossypol could have potential therapeutic effect for the treatment of invasive prostate cancer...
  2. pmc Mushroom Ganoderma lucidum prevents colitis-associated carcinogenesis in mice
    Daniel Sliva
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e47873. 2012
    ..The aim of the present study was to evaluate whether GLT prevents colitis-associated carcinogenesis in mice...
  3. doi Suppression of proliferation and invasive behavior of human metastatic breast cancer cells by dietary supplement BreastDefend
    Jiahua Jiang
    Methodist Research Institute, Indianapolis, IN 46202, USA
    Integr Cancer Ther 10:192-200. 2011
    ..The study was to evaluate the effect of the dietary supplement BreastDefend (BD) on the proliferation and invasive behavior of highly metastatic human breast cancer cells in vitro...
  4. pmc BreastDefend™ prevents breast-to-lung cancer metastases in an orthotopic animal model of triple-negative human breast cancer
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN 46202, USA
    Oncol Rep 28:1139-45. 2012
    ..In conclusion, BD may be considered as a biological therapeutic agent against invasive breast cancers...
  5. pmc NAHA, a novel hydroxamic acid-derivative, inhibits growth and angiogenesis of breast cancer in vitro and in vivo
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, Indiana, United States of America
    PLoS ONE 7:e34283. 2012
    ..Here, we evaluate the anticancer activity of NAHA against highly invasive human breast cancer cells MDA-MB-231 in vitro and in vivo...
  6. doi Ganodermanontriol (GDNT) exerts its effect on growth and invasiveness of breast cancer cells through the down-regulation of CDC20 and uPA
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN, USA
    Biochem Biophys Res Commun 415:325-9. 2011
    ..In conclusion, mushroom GDNT is a natural agent that has potential as a therapy for invasive breast cancers...
  7. doi Ganodermanontriol, a lanostanoid triterpene from Ganoderma lucidum, suppresses growth of colon cancer cells through ß-catenin signaling
    Andrej Jedinak
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Oncol 38:761-7. 2011
    ..In conclusion, our data suggest that ganodermanontriol might be a potential chemotherapeutic agent for the treatment of cancer...
  8. ncbi Ganoderic acids suppress growth and invasive behavior of breast cancer cells by modulating AP-1 and NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Mol Med 21:577-84. 2008
    ..In conclusion, hydroxylated triterpenes from G. lucidum could be promising natural agents for the therapy of invasive breast cancers...
  9. doi ProstaCaid inhibits tumor growth in a xenograft model of human prostate cancer
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, Indianapolis, IN, USA
    Int J Oncol 40:1339-44. 2012
    ....
  10. ncbi Ganoderma lucidum inhibits proliferation of human breast cancer cells by down-regulation of estrogen receptor and NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Oncol 29:695-703. 2006
    ..lucidum as a suitable herb for chemoprevention and chemotherapy of breast cancer...
  11. ncbi Ganoderma lucidum suppresses growth of breast cancer cells through the inhibition of Akt/NF-kappaB signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Nutr Cancer 49:209-16. 2004
    ..Our results suggest that Ganoderma lucidum inhibits the growth of MDA-MB-231 breast cancer cells by modulating Akt/NF-kappaB signaling and could have potential therapeutic use for the treatment of breast cancer...
  12. ncbi Novel medicinal mushroom blend suppresses growth and invasiveness of human breast cancer cells
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Oncol 37:1529-36. 2010
    ..In conclusion, the MC dietary supplement could have potential therapeutic value in the treatment of invasive human breast cancer...
  13. ncbi Gossypol inhibits the growth of MAT-LyLu prostate cancer cells by modulation of TGFbeta/Akt signaling
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Clarian Health Partners Inc, Indianapolis, IN 46202, USA
    Int J Mol Med 24:69-75. 2009
    ....
  14. doi Triterpenes from Ganoderma Lucidum induce autophagy in colon cancer through the inhibition of p38 mitogen-activated kinase (p38 MAPK)
    Anita Thyagarajan
    Methodist Research Institute, Indianapolis, Indiana, USA
    Nutr Cancer 62:630-40. 2010
    ..Taken together, our data demonstrate a novel mechanism responsible for the inhibition of colon cancer cells by G. lucidum and suggest GLT as natural product for the treatment of colon cancer...
  15. doi Suppression of growth and invasive behavior of human prostate cancer cells by ProstaCaid™: mechanism of activity
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, Indiana University Health, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Int J Oncol 38:1675-82. 2011
    ..In conclusion, the dietary supplement PC is a promising natural complex with the potency to inhibit invasive human prostate cancer...
  16. doi Semisynthesis and biological evaluation of ganodermanontriol and its stereoisomeric triols
    Erin M Kennedy
    Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis, 402 N Blackford Street, Indianapolis, Indiana 46202, USA
    J Nat Prod 74:2332-7. 2011
    ..The effect of ganodermanontriol and its isomers on cell proliferation was assayed; IC50 values of 5.8 and 9.7 μM on breast cancer cell lines MCF-7 and MDA-MB-231, respectively, were found for ganodermanontriol...
  17. ncbi Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion
    Anita Thyagarajan
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Mol Med 18:657-64. 2006
    ..In summary, our results suggest that G. lucidum inhibits the oxidative stress-induced invasive behavior of breast cancer cells by modulating Erk1/2 signaling and can be potentially considered as an antioxidant in adjuvant cancer therapy...
  18. ncbi Ganoderma lucidum suppresses angiogenesis through the inhibition of secretion of VEGF and TGF-beta1 from prostate cancer cells
    Gwenaelle Stanley
    Cancer Research Laboratory, Methodist Research Institute, 1800 N Capitol Ave, E504, Indianapolis, IN 46202, USA
    Biochem Biophys Res Commun 330:46-52. 2005
    ..In summary, our results suggest that G. lucidum inhibits prostate cancer-dependent angiogenesis by modulating MAPK and Akt signaling and could have potential therapeutic use for the treatment of prostate cancer...
  19. ncbi Ganoderma lucidum inhibits proliferation and induces apoptosis in human prostate cancer cells PC-3
    Jiahua Jiang
    Cancer Research Laboratory, Methodist Research Institute, E504, Indianapolis, IN 46202, USA
    Int J Oncol 24:1093-9. 2004
    ..Thus, Ganoderma lucidum exerts its effect on cancer cells by multiple mechanisms and may have potential therapeutic use for the prevention and treatment of cancer...
  20. ncbi Pleurotus ostreatus inhibits colitis-related colon carcinogenesis in mice
    Andrej Jedinak
    Cancer Research Laboratory, Methodist Research Institute, Indianapolis, IN 46202, USA
    Int J Mol Med 26:643-50. 2010
    ....
  21. doi Synergistic and additive effects of modified citrus pectin with two polybotanical compounds, in the suppression of invasive behavior of human breast and prostate cancer cells
    Jiahua Jiang
    Indiana University Health, Indianapolis, IN, USA
    Integr Cancer Ther 12:145-52. 2013
    ....