Marc G Jeschke

Summary

Publications

  1. ncbi request reprint Possibilities of non-viral gene transfer to improve cutaneous wound healing
    M G Jeschke
    Klinik und Poliklinik für Chirurgie, Klinikum der Universitat Regensburg, Eranz Joseph Strauss Allee 11, 93053 Regensburg, Germany
    Curr Gene Ther 1:267-78. 2001
  2. ncbi request reprint The effect of growth hormone on gut mucosal homeostasis and cellular mediators after severe trauma
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, University Texas Medical Branch, Galveston, Texas 77550, USA
    J Surg Res 127:183-9. 2005
  3. pmc Insulin attenuates the systemic inflammatory response to thermal trauma
    Marc G Jeschke
    Klinik und Poliklinik für Chirurgie Klinikum der Universität Regensburg, Germany
    Mol Med 8:443-50. 2002
  4. ncbi request reprint [Intensive insulin therapy in sepsis. Improvement of survival chances?]
    M G Jeschke
    Abteilung für Plastische und Handchirurgie, Friedrich Alexander Universität Erlangen, Erlangen
    Anaesthesist 52:S20-3. 2003
  5. ncbi request reprint Development of new reconstructive techniques: use of Integra in combination with fibrin glue and negative-pressure therapy for reconstruction of acute and chronic wounds
    Marc G Jeschke
    Department of General Surgery, University of Regensburg, Germany
    Plast Reconstr Surg 113:525-30. 2004
  6. pmc Insulin treatment improves the systemic inflammatory reaction to severe trauma
    Marc G Jeschke
    Klinik und Poliklinik für Chirurgie, Klinikum der Universitat Regensburg, Germany
    Ann Surg 239:553-60. 2004
  7. ncbi request reprint Exogenous liposomal IGF-I cDNA gene transfer leads to endogenous cellular and physiological responses in an acute wound
    Marc G Jeschke
    Klinik fur Chirurgie, Abteilung für Plastische und Handchirurgie, Friedrich Alexander University Erlangen, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Am J Physiol Regul Integr Comp Physiol 286:R958-66. 2004
  8. ncbi request reprint Insulin attenuates the systemic inflammatory response in endotoxemic rats
    Marc G Jeschke
    Department of Surgery, Friedrich Alexander University of Erlangen, Erlangen, Germany
    Endocrinology 145:4084-93. 2004
  9. ncbi request reprint Extended hypermetabolic response of the liver in severely burned pediatric patients
    Marc G Jeschke
    Department of Plastic and Hand Surgery, Friedrich Alexander University of Erlangen, Erlangen, Germany
    Arch Surg 139:641-7. 2004
  10. ncbi request reprint The effect of hepatocyte growth factor on gut mucosal apoptosis and proliferation, and cellular mediators after severe trauma
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, Galveston, TX 77550, USA
    Surgery 138:482-9. 2005

Detail Information

Publications131 found, 100 shown here

  1. ncbi request reprint Possibilities of non-viral gene transfer to improve cutaneous wound healing
    M G Jeschke
    Klinik und Poliklinik für Chirurgie, Klinikum der Universitat Regensburg, Eranz Joseph Strauss Allee 11, 93053 Regensburg, Germany
    Curr Gene Ther 1:267-78. 2001
    ..This review discusses the success, potential and limitations of non-viral gene transfer to improve regeneration of dermal and epidermal structures...
  2. ncbi request reprint The effect of growth hormone on gut mucosal homeostasis and cellular mediators after severe trauma
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, University Texas Medical Branch, Galveston, Texas 77550, USA
    J Surg Res 127:183-9. 2005
    ..The purpose of this study was to determine whether growth hormone can improve small bowel homeostasis after injury and by which cellular mechanisms these changes occur...
  3. pmc Insulin attenuates the systemic inflammatory response to thermal trauma
    Marc G Jeschke
    Klinik und Poliklinik für Chirurgie Klinikum der Universität Regensburg, Germany
    Mol Med 8:443-50. 2002
    ..The purpose of the present study was to determine the effect of insulin therapy on the systemic inflammatory response. In vivo we determined the effect of insulin therapy on the inflammatory cascade, which was induced by thermal injury...
  4. ncbi request reprint [Intensive insulin therapy in sepsis. Improvement of survival chances?]
    M G Jeschke
    Abteilung für Plastische und Handchirurgie, Friedrich Alexander Universität Erlangen, Erlangen
    Anaesthesist 52:S20-3. 2003
  5. ncbi request reprint Development of new reconstructive techniques: use of Integra in combination with fibrin glue and negative-pressure therapy for reconstruction of acute and chronic wounds
    Marc G Jeschke
    Department of General Surgery, University of Regensburg, Germany
    Plast Reconstr Surg 113:525-30. 2004
    ..Therefore, it is suggested that Integra be used in combination with fibrin glue and negative-pressure therapy to improve clinical outcomes and shorten hospital stays, with decreased risks of accompanying complications...
  6. pmc Insulin treatment improves the systemic inflammatory reaction to severe trauma
    Marc G Jeschke
    Klinik und Poliklinik für Chirurgie, Klinikum der Universitat Regensburg, Germany
    Ann Surg 239:553-60. 2004
    ..Determine the effect of insulin on the systemic inflammatory response, pro- and anti-inflammatory cytokines and hepatic acute-phase-response in severely burned pediatric patients...
  7. ncbi request reprint Exogenous liposomal IGF-I cDNA gene transfer leads to endogenous cellular and physiological responses in an acute wound
    Marc G Jeschke
    Klinik fur Chirurgie, Abteilung für Plastische und Handchirurgie, Friedrich Alexander University Erlangen, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Am J Physiol Regul Integr Comp Physiol 286:R958-66. 2004
    ..Liposomal IGF-I gene transfer further leads to improved dermal and epidermal regeneration by interacting with other growth factors...
  8. ncbi request reprint Insulin attenuates the systemic inflammatory response in endotoxemic rats
    Marc G Jeschke
    Department of Surgery, Friedrich Alexander University of Erlangen, Erlangen, Germany
    Endocrinology 145:4084-93. 2004
    ....
  9. ncbi request reprint Extended hypermetabolic response of the liver in severely burned pediatric patients
    Marc G Jeschke
    Department of Plastic and Hand Surgery, Friedrich Alexander University of Erlangen, Erlangen, Germany
    Arch Surg 139:641-7. 2004
    ..We hypothesize that the proinflammatory hepatic acute phase response perseveres for an extended time and enhances hypermetabolism longer than previously believed...
  10. ncbi request reprint The effect of hepatocyte growth factor on gut mucosal apoptosis and proliferation, and cellular mediators after severe trauma
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, Galveston, TX 77550, USA
    Surgery 138:482-9. 2005
    ..The purpose of this study was to determine whether HGF can improve small-bowel homeostasis after injury and the cellular mechanisms by which these changes occur...
  11. ncbi request reprint Insulin prevents liver damage and preserves liver function in lipopolysaccharide-induced endotoxemic rats
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, The University Texas Medical Branch, Galveston Burns Unit, 815 Market Street, Galveston, TX 77550, USA
    J Hepatol 42:870-9. 2005
    ..The aim of the present study was to determine whether insulin exerts positive effects on hepatic homeostasis and function during endotoxemia...
  12. ncbi request reprint Interaction of exogenous liposomal insulin-like growth factor-I cDNA gene transfer with growth factors on collagen expression in acute wounds
    Marc G Jeschke
    Shriners Hospital for Children, University Texas Medical Branch, Galveston, Texas 77550, USA
    Wound Repair Regen 13:269-77. 2005
    ..We conclude that liposomal IGF-I gene transfer can accelerate wound healing without causing an increase in types I and III collagen expression...
  13. ncbi request reprint Effect of oxidized regenerated cellulose/collagen matrix on dermal and epidermal healing and growth factors in an acute wound
    Marc G Jeschke
    Department of Surgery, University of Regensburg, Germany
    Wound Repair Regen 13:324-31. 2005
    ..Increased reepithelization was associated with decreased skin cell apoptosis. Based on our data we hypothesize that the ORC/collagen matrix may also have beneficial effects on acute wounds in a clinical setting...
  14. pmc IGF-I/IGFBP-3 equilibrates ratios of pro- to anti-inflammatory cytokines, which are predictors for organ function in severely burned pediatric patients
    Marc G Jeschke
    University of Regensburg, Department of Surgery, Regensburg, Germany
    Mol Med 8:238-46. 2002
    ..Furthermore, insulin-like growth factor-I (IGF-I) in combination with its principle binding protein (IGFBP-3) equilibrates pro- to anti-inflammatory cytokine ratios and improves homeostasis of severely burned pediatric patients...
  15. ncbi request reprint Nutritional intervention high in vitamins, protein, amino acids, and omega3 fatty acids improves protein metabolism during the hypermetabolic state after thermal injury
    M G Jeschke
    Klinik und Poliklinik für Chirurgie, Klinikum der Universitat Regensburg, Franz Joseph Strauss Allee 11, 93053 Regensburg, Germany
    Arch Surg 136:1301-6. 2001
    ..The purpose of this study was to determine the effect of enriched nutritional support during the postburn hypermetabolic state on protein metabolism in serum, liver, muscle, and skin...
  16. ncbi request reprint Effect of growth factors as therapeutic drugs on hepatic metabolism during the systemic inflammatory response syndrome
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, University Texas Medical Branch, Galveston, Texas 77550, USA
    Curr Drug Metab 5:399-413. 2004
    ....
  17. ncbi request reprint Biodistribution and feasibility of non-viral IGF-I gene transfers in thermally injured skin
    M G Jeschke
    Shriners Hospital for Children, and the Department of Surgery, University of Texas Medical Branch, Galveston, USA
    Lab Invest 80:151-8. 2000
    ..Liposomes containing the cDNA coding for IGF-I present an effective approach to gene therapy in the skin...
  18. pmc Intensive insulin therapy in severely burned pediatric patients: a prospective randomized trial
    Marc G Jeschke
    Shriners Hospitals for Children, Galveston, TX 77550, USA
    Am J Respir Crit Care Med 182:351-9. 2010
    ..However, to date no prospective randomized study exists that determines whether intensive insulin therapy is associated with improved post-burn morbidity and mortality...
  19. doi request reprint Age differences in inflammatory and hypermetabolic postburn responses
    Marc G Jeschke
    Galveston Burns Unit, Shriners Hospitals for Children, 815 Market St, Galveston, TX 77550, USA
    Pediatrics 121:497-507. 2008
    ..The aim of this study was to identify contributors to morbidity and death in severely burned patients <4 years of age...
  20. doi request reprint Gender differences in pediatric burn patients: does it make a difference?
    Marc G Jeschke
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Ann Surg 248:126-36. 2008
    ..The aim of the present study was to compare hospital course and physiologic markers between severely burned pediatric females and males...
  21. ncbi request reprint Gut mucosal homeostasis and cellular mediators after severe thermal trauma and the effect of insulin-like growth factor-I in combination with insulin-like growth factor binding protein-3
    Marc G Jeschke
    Shriners Hospitals for Children, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    Endocrinology 148:354-62. 2007
    ..IGF-I/IGFBP-3 decreases small bowel epithelial cell apoptosis through down-regulation of the Fas pathway, which improves gut mucosal integrity after a severe thermal injury...
  22. pmc Randomized controlled trial to determine the efficacy of long-term growth hormone treatment in severely burned children
    Ludwik K Branski
    Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, USA
    Ann Surg 250:514-23. 2009
    ....
  23. ncbi request reprint Sex differences in the long-term outcome after a severe thermal injury
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 27:461-5. 2007
    ..Data indicate that girls have a reduced REE associated with changes in bone content and endogenous anabolic hormones...
  24. pmc The effect of ketoconazole on post-burn inflammation, hypermetabolism and clinical outcomes
    Marc G Jeschke
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 7:e35465. 2012
    ..Ketoconazole, an anti-fungal agent, inhibits cortisol synthesis. We, therefore, studied the effect of ketoconazole on post-burn cortisol levels and the hyper-catabolic response in a prospective randomized trial (block randomization 2:1)...
  25. pmc Insulin increases resistance to burn wound infection-associated sepsis
    Gerd G Gauglitz
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, USA
    Crit Care Med 38:202-8. 2010
    ..This study was designed to determine the ability of insulin to improve outcome following a Pseudomonas aeruginosa wound infection in a rodent model of severe burn injury...
  26. pmc Starvation-induced proximal gut mucosal atrophy diminished with aging
    Juquan Song
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    JPEN J Parenter Enteral Nutr 33:411-6. 2009
    ..Starvation induces small bowel atrophy with increased intestinal epithelial apoptosis and decreased proliferation. The authors examined these parameters after starvation in aged animals...
  27. pmc Survivors versus nonsurvivors postburn: differences in inflammatory and hypermetabolic trajectories
    Marc G Jeschke
    Shriners Hospitals for Children Department of Surgery, University of Texas Medical Branch Institute for Translational Science and Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, TX Department of Dermatology and Allergy, Ludwig Maximilians University, Munich, Germany Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre and Sunnybrook Research Institute, Departments of Surgery and Immunology, Division of Plastic Surgery, University of Toronto, Ontario, Canada
    Ann Surg 259:814-23. 2014
    ..To evaluate whether a panel of common biomedical markers can be utilized as trajectories to determine survival in pediatric burn patients...
  28. pmc Thermal injury activates the eEF2K-dependent eEF2 pathway in pediatric patients
    Juquan Song
    Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    JPEN J Parenter Enteral Nutr 36:596-602. 2012
    ..The aim of this study was to determine the expression of eEF2 and the upstream eEF2-inactivating kinase, eEF2K, in severely burned pediatric patients...
  29. pmc Abnormal insulin sensitivity persists up to three years in pediatric patients post-burn
    Gerd G Gauglitz
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    J Clin Endocrinol Metab 94:1656-64. 2009
    ..The acute hypermetabolic response post-burn is associated with insulin resistance and hyperglycemia, significantly contributing to adverse outcome of these patients...
  30. pmc The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn
    Marc G Jeschke
    Shriners Hospital for Children, and Department of Surgery, University Texas Medical Branch, Galveston, Texas, USA
    Ann Surg 246:351-60; discussion 360-2. 2007
    ..The effects of oxandrolone on clinical outcome, body composition, endocrine system, and inflammation during the acute phase postburn in a large prospective randomized single-center trial have not been studied...
  31. doi request reprint Combination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children
    Marc G Jeschke
    Shriners Hospitals for Children and the Department of Surgery, University Texas Medical Branch, Galveston, TX, USA
    Pediatr Crit Care Med 9:209-16. 2008
    ..The aim of the present study was to determine whether rhGH plus propranolol improves hypermetabolism and the inflammatory and acute phase response after severe burn without causing adverse side effects...
  32. ncbi request reprint Benchmarking outcomes in the critically injured burn patient
    Matthew B Klein
    Department of Surgery, University of Washington School of Medicine and Harborview Medical Center, Seattle, WA Department of Surgery, Harvard Medical School and Massachusetts General Hospital, Boston, MA Department of Medicine, Massachusetts General Hospital, Boston, MA Department of Surgery, Massachusetts General Hospital, Boston, MA Department of Surgery, Loyola University School of Medicine, Maywood, Il Department of Surgery, University of Texas Medical Branch, Galveston, TX Department of Surgery and Plastic Surgery, University of Toronto, Canada Department of Surgery, Parkland Memorial Hospital, University of Texas, Southwestern Medical Center, Dallas TX Stanford Genome Technology Center, Palo Alto, CA Department of Surgery, Harborview Medical Center, Seattle, WA Department of Medicine, Harvard Medical School and Massachusetts General Hospital, Boston, MA
    Ann Surg 259:833-41. 2014
    ..To determine and compare outcomes with accepted benchmarks in burn care at 6 academic burn centers...
  33. pmc Insulin decreases inflammatory signal transcription factor expression in primary human liver cells after LPS challenge
    Marc G Jeschke
    Shriners Hospitals for Children, Galveston Burns Unit, Galveston, TX 77550, USA
    Mol Med 14:11-9. 2008
    ..Based on our results, we suggest that primary hepatocyte cultures can be used to study the effect of LPS on the inflammatory cascade. Insulin decreases hepatic cytokine expression, which is associated with decreased STAT-5 expression...
  34. pmc Changes in cardiac physiology after severe burn injury
    Felicia N Williams
    Shriners Burn Hospital for Children, The University of Texas, Medical Branch, Galveston, Texas, USA
    J Burn Care Res 32:269-74. 2011
    ..Ejection fraction was within normal limits for 2 years. Cardiac stress persists for at least 2 years postburn, and the authors suggest that attenuation of these detrimental responses may improve long-term morbidity...
  35. pmc Burn size determines the inflammatory and hypermetabolic response
    Marc G Jeschke
    Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Crit Care 11:R90. 2007
    ..The purpose of the present study was to determine in a large prospective clinical trial whether different burn sizes are associated with differences in inflammation, body composition, protein synthesis, or organ function...
  36. pmc The use of exenatide in severely burned pediatric patients
    Gabriel A Mecott
    Department of Surgery, University of Texas Medical Branch, 301 University Blvd, Galveston, Texas 77555, USA
    Crit Care 14:R153. 2010
    ..We hypothesized that exenatide would decrease plasma glucose levels post-burn to levels similar to those achieved with IIT, and reduce the amount of exogenous insulin administered...
  37. pmc Extent and magnitude of catecholamine surge in pediatric burned patients
    Gabriela A Kulp
    Shriners Hospitals for Children, Department of Surgery, University Texas Medical Branch Galveston, Texas 77550, USA
    Shock 33:369-74. 2010
    ..Inflammatory cytokines show a similar profile during the study period. Our study gives clinicians a useful insight into the extent and magnitude of CA elevation to better design treatment strategies...
  38. pmc What, how, and how much should patients with burns be fed?
    Felicia N Williams
    Department of Surgery, Shriners Hospital for Children and University of Texas Medical Branch, 815 Market Street, Galveston, TX 77550, USA
    Surg Clin North Am 91:609-29. 2011
    ..This review focuses on the more recent advances in therapeutic strategies to attenuate the hypermetabolic response and its postburn-associated insulin resistance...
  39. doi request reprint Fibrin sealant improves graft adherence in a porcine full-thickness burn wound model
    Ludwik K Branski
    Shriners Hospital for Children and University of Texas Medical Branch, Galveston, TX, USA
    Burns 37:1360-6. 2011
    ..Slow-clotting fibrin sealant, applied with a spray-on device, has been shown to improve healing of skin grafts in large wounds. However, its use in burn wounds has not been studied so far...
  40. ncbi request reprint Body composition changes with time in pediatric burn patients
    Rene Przkora
    Department of Surgery, University of Texas Medical Branch, Texas, USA
    J Trauma 60:968-71; discussion 971. 2006
    ..Major trauma and burns are associated with whole body catabolism which can persist for 1 or more years after injury. This study investigates body composition in massively burned children for up to 2 years...
  41. ncbi request reprint Longitudinal assessment of Integra in primary burn management: a randomized pediatric clinical trial
    Ludwik K Branski
    Shriners Hospitals for Children, Galveston, TX, USA
    Crit Care Med 35:2615-23. 2007
    ..However, the suitability of its use in large burns (>50% total body surface area), its effects on postburn hypermetabolism, and the long-term cosmetic and functional results have not yet been evaluated...
  42. pmc Hyperglycemia exacerbates burn-induced liver inflammation via noncanonical nuclear factor-κB pathway activation
    Gabriela A Kulp
    Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, Texas, United States of America
    Mol Med 18:948-56. 2012
    ..Hyperglycemia is detrimental to burn outcome by augmenting inflammation mediated by hepatic noncanonical NF-κB pathway activation...
  43. pmc Long-term propranolol use in severely burned pediatric patients: a randomized controlled study
    David N Herndon
    Shriners Hospitals for Children Galveston, Galveston, TX 77550, USA
    Ann Surg 256:402-11. 2012
    ..To determine the safety and efficacy of propranolol given for 1 year on cardiac function, resting energy expenditure, and body composition in a prospective, randomized, single-center, controlled study in pediatric patients with large burns...
  44. pmc Insulin protects against hepatic damage postburn
    Marc G Jeschke
    Shriners Hospitals for Children, The University of Texas Medical Branch, Galveston, Texas, USA
    Mol Med 17:516-22. 2011
    ..These results support the use of insulin therapy after traumatic injury to improve patient outcomes...
  45. ncbi request reprint Differences in the hepatic signal transcription pathway and cytokine expression between thermal injury and sepsis
    Dagmar Klein
    Klinik und Poliklinik für Chirurgie, Klinikum der Universitat Regensburg, Germany
    Shock 20:536-43. 2003
    ....
  46. pmc Long-term persistance of the pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, United States of America
    PLoS ONE 6:e21245. 2011
    ....
  47. pmc The leading causes of death after burn injury in a single pediatric burn center
    Felicia N Williams
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555, USA
    Crit Care 13:R183. 2009
    ..Despite these advances, death still occurs. Our aim was to determine the predominant causes of death in burned pediatric patients in order to develop new treatment avenues and future trajectories associated with increased survival...
  48. pmc Insulin treatment improves hepatic morphology and function through modulation of hepatic signals after severe trauma
    Dagmar Klein
    Klinik und Poliklinik für Chirurgie, Klinikum der Universitat Regensburg, Germany
    Ann Surg 240:340-9. 2004
    ..The purpose of the present study was to determine the effect of insulin therapy on hepatic function, structure, and hepatic mRNA and protein cytokine expression during the hypermetabolic cascade post burn...
  49. pmc Burn size and survival probability in paediatric patients in modern burn care: a prospective observational cohort study
    Robert Kraft
    Shriners Hospitals for Children, Galveston, TX, USA
    Lancet 379:1013-21. 2012
    ..This study was designed to identify the burn size associated with significant increases in morbidity and mortality in paediatric patients...
  50. pmc Long-term oxandrolone treatment increases muscle protein net deposition via improving amino acid utilization in pediatric patients 6 months after burn injury
    Demidmaa Tuvdendorj
    Department of Surgery, University of Texas Medical Branch, Galveston, TX 77555 1220, USA
    Surgery 149:645-53. 2011
    ..In the current study, we evaluated whether oxandrolone treatment affects mechanisms of protein turnover in skeletal muscle and whole-body protein breakdown in pediatric burn patients 6 months postinjury...
  51. pmc Beneficial effects of extended growth hormone treatment after hospital discharge in pediatric burn patients
    Rene Przkora
    Department of Surgery, University of Texas Medical Branch and Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Ann Surg 243:796-801; discussion 801-3. 2006
    ..To study the efficacy of growth hormone given to severely burned children from discharge to 12 months after burn and for 12 months after the drug was discontinued...
  52. pmc Glucose control in severely thermally injured pediatric patients: what glucose range should be the target?
    Marc G Jeschke
    Shriners Hospitals for Children, Biochemistry and Molecular Biology, Galveston, TX, USA
    Ann Surg 252:521-7; discussion 527-8. 2010
    ..To determine which glucose levels are associated with improved morbidity and mortality in thermally injured patients...
  53. pmc Proximal gut mucosal epithelial homeostasis in aged IL-1 type I receptor knockout mice after starvation
    Juquan Song
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, USA
    J Surg Res 169:209-13. 2011
    ..In this experiment, we assessed whether starvation-induced atrophy of proximal gut mucosa is associated with the Interleukin-1 receptor (IL-1R) signaling pathway in aged mice...
  54. doi request reprint Characterization of the inflammatory response during acute and post-acute phases after severe burn
    Gerd G Gauglitz
    Shriners Hospital for Children, Galveston, Texas 77550, USA
    Shock 30:503-7. 2008
    ....
  55. doi request reprint Second hit post burn increased proximal gut mucosa epithelial cells damage
    Juquan Song
    Shriners Hospitals for Children and Department of Surgery, The University of Texas Medical Branch, Galveston, TX 77550, USA
    Shock 30:184-8. 2008
    ..05) and significantly increased small intestinal epithelial apoptosis and mucosal atrophy, even after the first event, indicating a second detrimental effect of endotoxemia after the initial injury...
  56. pmc Hypoglycemia is associated with increased postburn morbidity and mortality in pediatric patients
    Marc G Jeschke
    1Ross Tilley Burn Centre, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada 2Division of Plastic Surgery, Department of Surgery, University of Toronto, Toronto, ON, Canada 3Department of Immunology, University of Toronto, Toronto, ON, Canada 4TECC Program Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada 5Shriners Hospitals for Children and University of Texas Medical Branch, Galveston, TX 6Department of Surgery, University of Texas Medical Branch, Galveston, TX 7Sealy Center for Molecular Medicine and the Institute for Translational Sciences, University of Texas Medical Branch, Galveston, TX
    Crit Care Med 42:1221-31. 2014
    ..The objective of this study was to determine the prevalence of hypoglycemia after burn injury and whether hypoglycemia is associated with increased postburn morbidity and mortality...
  57. pmc Determination of burn patient outcome by large-scale quantitative discovery proteomics
    Celeste C Finnerty
    Department of Surgery, University of Texas Medical Branch, and Shriners Hospitals for Children, Galveston, TX, USA
    Crit Care Med 41:1421-34. 2013
    ....
  58. pmc Propranolol improves impaired hepatic phosphatidylinositol 3-kinase/akt signaling after burn injury
    Natasha C Brooks
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas, United States of America
    Mol Med 18:707-11. 2012
    ..We conclude that catecholamine release is responsible for the ER stress response and impaired insulin receptor signaling after burn injury...
  59. pmc Intensive insulin treatment increases donor site wound protein synthesis in burn patients
    Demidmaa Tuvdendorj
    Metabolism Unit, Shriners Hospital for Children, Galveston, TX 77550 1220, USA
    Surgery 149:512-8. 2011
    ..We investigated whether intensive insulin treatment increases fractional synthesis rate (FSR) of the donor site wound protein and decreases the length of hospitalization normalized for total body surface area burned (LOS/TBSA)...
  60. pmc Impact of anesthesia, analgesia, and euthanasia technique on the inflammatory cytokine profile in a rodent model of severe burn injury
    Ahmed M Al-Mousawi
    University of Texas Medical Branch, Galveston, TX, USA
    Shock 34:261-8. 2010
    ..Standardization across all experiments that are compared and awareness of these findings are essential for those investigating the pathophysiology of inflammation in animal models...
  61. pmc The role of acute pancreatitis in pediatric burn patients
    Haidy G Rivero
    Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Burns 37:82-5. 2011
    ....
  62. pmc Calcium and ER stress mediate hepatic apoptosis after burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, TX 77550, USA
    J Cell Mol Med 13:1857-65. 2009
    ..Our results reveal that thermal injury leads to dramatic hepatic disturbances in calcium homeostasis and resultant ER stress leading to mitochondrial abnormalities contributing to hepatic dysfunction and apoptosis after burn injury...
  63. doi request reprint Acute propranolol infusion stimulates protein synthesis in rabbit skin wound
    Xiao Jun Zhang
    Shriners Hospital for Children, Galveston, TX, USA
    Surgery 145:558-67. 2009
    ..Propranolol administration has been demonstrated to improve cardiac work, decrease energy expenditure, and attenuate lipolysis in burned patients; however, its effect on wound healing has not been reported...
  64. pmc Pathophysiologic response to severe burn injury
    Marc G Jeschke
    Shriners Hospitals for Children, University Texas Medical Branch, Galveston, Texas 77550, USA
    Ann Surg 248:387-401. 2008
    ..To improve clinical outcome and to determine new treatment options, we studied the pathophysiologic response postburn in a large prospective, single center, clinical trial...
  65. pmc Measurement of hepatic protein fractional synthetic rate with stable isotope labeling technique in thapsigargin stressed HepG2 cells
    Juquan Song
    Department of Surgery, University of Texas Health Science Center, San Antonio, Texas 78299, USA
    Int J Biol Sci 8:265-71. 2012
    ..05, vs. control). TG-induced ER stress inhibited hepatic protein synthesis. The stable isotope tracer incorporation technique is a useful method for studying the effects of ER stress on hepatic protein synthesis...
  66. pmc Is there a difference in clinical outcomes, inflammation, and hypermetabolism between scald and flame burn?
    Robert Kraft
    Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Pediatr Crit Care Med 12:e275-81. 2011
    ..The aim of the present study was to determine whether there is a difference in degree of inflammation, hypermetabolism, endocrine and acute-phase response, and clinical outcome between pediatric patients with scald and flame burns...
  67. pmc A porcine model of full-thickness burn, excision and skin autografting
    Ludwik K Branski
    Shriners Hospital for Children and University of Texas Medical Branch, Galveston, TX, USA
    Burns 34:1119-27. 2008
    ..The use of this standardized model provides burn researchers with a valuable tool for the comparison of different topical drug treatments and dressing materials in a setting that closely mimics clinical reality...
  68. ncbi request reprint Effect of insulin on the inflammatory and acute phase response after burn injury
    Marc G Jeschke
    Shriners Hospital for Children, Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care Med 35:S519-23. 2007
    ....
  69. pmc Effects of exercise training on resting energy expenditure and lean mass during pediatric burn rehabilitation
    Ahmed M Al-Mousawi
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas 77550, USA
    J Burn Care Res 31:400-8. 2010
    ..Therefore, the use of exercise conditioning as a safe and effective component of pediatric burn rehabilitation is advocated...
  70. pmc Association between dietary fat content and outcomes in pediatric burn patients
    Jong O Lee
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas, USA
    J Surg Res 166:e83-90. 2011
    ..The aim of the study was to compare a low fat/high-carbohydrate diet and a high-fat diet on clinical outcomes by a retrospective cohort study...
  71. doi request reprint Measurement of body composition in burned children: is there a gold standard?
    Ludwik K Branski
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas, and Shriners Hospitals for Children, Galveston, Texas 77550, USA
    JPEN J Parenter Enteral Nutr 34:55-63. 2010
    ..The aim of this study was to compare 2 measurement methods for body composition, whole-body potassium counting (K count) and dual x-ray absorptiometry (DEXA), in a large prospective clinical trial in severely burned pediatric patients...
  72. doi request reprint Propranolol as a modulator of M2b monocytes in severely burned patients
    Makiko Kobayashi
    Department of Internal Medicine, The University of Texas Medical Branch, Galveston, Texas 77555 0435, USA
    J Leukoc Biol 89:797-803. 2011
    ..The increased susceptibility, to be associated with the appearance of M2b monocytes, of severely burned patients to opportunistic pathogens might be controlled by propranolol...
  73. pmc A review of gene and stem cell therapy in cutaneous wound healing
    Ludwik K Branski
    Department of Surgery, The University of Texas Medical Branch and Shriners Hospitals for Children, Galveston, TX 77550, United States
    Burns 35:171-80. 2009
    ..Recently, the combination of gene and stem cell therapy has emerged as a promising approach for treatment of chronic and acute wounds...
  74. ncbi request reprint Upper airway mucus deposition in lung tissue of burn trauma victims
    Robert A Cox
    Shriners Hospital for Children and the University of Texas Medical Branch, Galveston, Texas 77550, USA
    Shock 29:356-61. 2008
    ..Increased mucus synthesis and/or impaired mucociliary function may contribute to the pulmonary pathophysiology associated with burn injury...
  75. ncbi request reprint Cytokine expression profile over time in severely burned pediatric patients
    Celeste C Finnerty
    Galveston Burns Unit and Department of Surgery, Shriners Hospital for Children University of Texas Medical Branch, Galveston, TX 77550, USA
    Shock 26:13-9. 2006
    ..Furthermore, the elevation in most serum cytokine levels during the first week after burn may indicate a potential window of opportunity for therapeutic intervention...
  76. ncbi request reprint Modulation of types I and II acute phase reactants with insulin-like growth factor-1/binding protein-3 complex in severely burned children
    Marcus Spies
    Shriners Hospital for Children and Department of Surgery, The University Texas Medical Branch, Galveston 77550, USA
    Crit Care Med 30:83-8. 2002
    ..To determine whether 0.5 mg/kg insulin-like growth factor (IGF)-1/binding protein (IGFBP)-3, given intravenously, effectively alters the acute phase response in severely burned children...
  77. ncbi request reprint Non-viral liposomal keratinocyte growth factor (KGF) cDNA gene transfer improves dermal and epidermal regeneration through stimulation of epithelial and mesenchymal factors
    M G Jeschke
    Klinik und Poliklinik für Chirurgie, University of Regensburg, Germany
    Gene Ther 9:1065-74. 2002
    ..005. Liposomes containing the KGF cDNA gene constructs were effective in improving epidermal and dermal regeneration. KGF gene transfer to acute wounds may represent a new therapeutic strategy to enhance wound healing...
  78. ncbi request reprint Therapeutic success and efficacy of nonviral liposomal cDNA gene transfer to the skin in vivo is dose dependent
    M G Jeschke
    , University of Regensburg, Germany
    Gene Ther 8:1777-84. 2001
    ..Both concentrations below and above the optimal concentration of DNA:liposomal preparations did not yield the results observed at the optimal concentration...
  79. pmc Endogenous anabolic hormones and hypermetabolism: effect of trauma and gender differences
    Marc G Jeschke
    Shriners Hospital for Children and Department of Surgery, University Texas Medical Branch, Galveston, Texas 77550, USA
    Ann Surg 241:759-67; discussion 767-8. 2005
    ..The aims of the present study were to determine the pattern of anabolic hormones, resting energy expenditure and cytokines in severely thermally injured pediatric patients and to compare these parameters in female and male patients...
  80. ncbi request reprint Insulin attenuates the cytokine response in a burn wound infection model
    Rene Przkora
    Shriners Hospital for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX 77550, USA
    Shock 27:205-8. 2007
    ..05). We conclude, that insulin treatment selectively modulates specific cytokines in a burn wound infection model...
  81. ncbi request reprint Liposomal gene transfer of keratinocyte growth factor improves wound healing by altering growth factor and collagen expression
    Clifford T Pereira
    Shriners Hospitals for Children, University of Texas Medical Branch, Galveston, Texas 77550, USA
    J Surg Res 139:222-8. 2007
    ..In the present study, we thought to determine the interaction between keratinocyte growth factor (KGF) administered as liposomal cDNA with other dermal and epidermal growth factors and collagen synthesis in an acute wound...
  82. doi request reprint Hepatic gene expression during endotoxemia
    Roland S Croner
    Department of Surgery, University of Erlangen Nuremberg, Erlangen, Germany
    J Surg Res 154:126-34. 2009
    ..The interaction of the different hepatic cell types during these processes is not completely understood and may be clarified by microarray technology...
  83. ncbi request reprint Insulin attenuates apoptosis and exerts anti-inflammatory effects in endotoxemic human macrophages
    Mareike Leffler
    Department of Plastic and Hand Surgery, University Hospital Erlangen Nürnberg, Erlangen, Germany
    J Surg Res 143:398-406. 2007
    ..The aim of the present study was to determine the effects of insulin on cell survival, cell activity, apoptosis, and proinflammatory response in a human macrophage-like cell line (THP-1 cells) stressed with lipopolysaccharide (LPS)...
  84. ncbi request reprint Liposomal gene transfer of multiple genes is more effective than gene transfer of a single gene
    M G Jeschke
    Plastic and Hand Surgery, University of Erlangen, University Hospital, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Gene Ther 11:847-55. 2004
    ..Our findings demonstrate that gene therapy with multiple genes is feasible, and that the gene transfer of multiple genes can enhance and accelerate physiologic and biological effects...
  85. ncbi request reprint Gene therapy in wound healing: present status and future directions
    L K Branski
    Department of Surgery, The University of Texas Medical Branch, Shriners Hospitals for Children, Galveston, TX 77550, USA
    Gene Ther 14:1-10. 2007
    ..This article aims to review the research on gene therapy in wound healing and possible future directions in this exciting field...
  86. ncbi request reprint The structure and composition of liposomes can affect skin regeneration, morphology and growth factor expression in acute wounds
    M G Jeschke
    Galveston Burns Unit and Department of Surgery, Shriners Hospital for Children, University Texas Medical Branch, TX 77550, USA
    Gene Ther 12:1718-24. 2005
    ..For gene transfer in acute wounds, the administration of DOTAP/Chol liposomes appears to be beneficial...
  87. pmc The role of hyperglycemia in burned patients: evidence-based studies
    Gabriel A Mecott
    Department of Surgery, The University of Texas Medical Branch, Galveston, Texas, USA
    Shock 33:5-13. 2010
    ....
  88. ncbi request reprint Applied tissue engineering in the closure of severe burns and chronic wounds using cultured human autologous keratinocytes in a natural fibrin matrix
    Jurgen Kopp
    Department of Plastic and Hand Surgery, Friedrich Alexander University Erlangen Nurnberg, Krankenhausstr 12, D 91054 Erlangen, Germany
    Cell Tissue Bank 5:89-96. 2004
    ..Prospective controlled comparative studies should be designed to further assess the clinical efficacy of this technique...
  89. pmc Temporal cytokine profiles in severely burned patients: a comparison of adults and children
    Celeste C Finnerty
    Shriners Hospitals for Children, 815 Market Street, Galveston, TX 77550, USA
    Mol Med 14:553-60. 2008
    ....
  90. ncbi request reprint Pre-clinical evaluation of liposomal gene transfer to improve dermal and epidermal regeneration
    L K Branski
    Shriners Hospitals for Children and University of Texas Medical Branch, Galveston, TX 77550, USA
    Gene Ther 17:770-8. 2010
    ..These data indicate that liposomal gene transfer can be a new therapeutic approach to improve wound healing in humans...
  91. ncbi request reprint The combination of IGF-I and KGF cDNA improves dermal and epidermal regeneration by increased VEGF expression and neovascularization
    M G Jeschke
    Shriners Hospitals for Children and Department of Surgery, University Texas Medical Branch Galveston, TX 77550, USA
    Gene Ther 14:1235-42. 2007
    ..In conclusion, exogenous administration of liposomal IGF-I plus KGF cDNA enhanced dermal and epidermal regeneration which is due to increased neovascularization...
  92. ncbi request reprint IGF-I/BP-3 administration preserves hepatic homeostasis after thermal injury which is associated with increases in no and hepatic NF-kappa B
    M G Jeschke
    Shriners Hospital for Children and Department of Surgery, University Texas Medical Branch, Galveston, Texas, USA
    Shock 16:373-9. 2001
    ....
  93. pmc Tissue engineered fetal skin constructs for pediatric burns
    William B Norbury
    Department of Surgery, Shriners Hospitals for Children, Galveston, Texas, USA
    Crit Care 9:533-4. 2005
    ..The use of FSCs gives us an additional option in a range of possible treatments for this notoriously difficult-to-treat patient group...
  94. ncbi request reprint Acute bronchial obstruction in sheep: histopathology and gland cytokine expression
    Robert A Cox
    Department of Pathology, University of Texas Medical Branch, Galveston, Texas 77550, USA
    Exp Lung Res 31:819-37. 2005
    ..05...
  95. ncbi request reprint Identification of factors contributing to hepatomegaly in severely burned children
    Robert E Barrow
    Shriners Hospitals for Children, Galveston, Texas 77550, USA
    Shock 24:523-8. 2005
    ..Increases in extracellular protein, intracellular glycogen, and fluid accumulation may make a minor contribution to postburn hepatomegaly...
  96. pmc The hepatic response to thermal injury: is the liver important for postburn outcomes?
    Marc G Jeschke
    Shriners Hospitals for Children and Department of Surgery, University Texas Medical Branch, Galveston, Texas, USA
    Mol Med 15:337-51. 2009
    ..This review discusses these studies and delineates the pivotal role of the liver in patients following severe thermal injury...
  97. ncbi request reprint Heat stress modulates hepatocyte membrane proteins during endotoxemia
    Rene Przkora
    Shriners Hospital for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX 77550, USA
    Burns 33:628-33. 2007
    ..This study investigates the influence of HS on hepatocyte membrane proteins during endotoxemia using 2D gel electrophoresis...
  98. pmc Inhalation injury in severely burned children does not augment the systemic inflammatory response
    Celeste C Finnerty
    Shriners Hospitals for Children and Department of Surgery, University of Texas Medical Branch, Galveston, TX, USA
    Crit Care 11:R22. 2007
    ..The aim of the present study was to determine the effect of inhalation injury on cytokine expression in severely burned children...
  99. ncbi request reprint Treatment of second degree facial burns with allografts--preliminary results
    Raymund E Horch
    Department of Plastic and Hand Surgery, Medical School, Friedrich Alexander University, Erlangen Nürnberg 12, 91054 Erlangen, Freiburg, Germany
    Burns 31:597-602. 2005
    ..This is in concordance with other reports on scalds. It would be worthwhile to perform more clinical studies with a larger number of patients to further evaluate the effect and function of allogenic skin for facial burns...
  100. ncbi request reprint Serum cytokine differences in severely burned children with and without sepsis
    Celeste C Finnerty
    Shriners Hospitals for Children, Galveston, TX 77550, USA
    Shock 27:4-9. 2007
    ..In addition, serum IL-6, IL-12 p70, and TNF can be used to identify burned patients who are at high risk of death from sepsis...
  101. pmc Insulin resistance postburn: underlying mechanisms and current therapeutic strategies
    Gerd G Gauglitz
    Shriners Burns Hospital for Children, Galveston, Texas 77550, USA
    J Burn Care Res 29:683-94. 2008
    ..This review aims to discuss the mechanisms underlying insulin resistance induced hyperglycemia postburn and outlines current therapeutic strategies that are being used to modulate hyperglycemia after thermal trauma...