J Jernvall

Summary

Publications

  1. ncbi The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot
    J Jernvall
    Institute of Biotechnology, University of Helsinki, Finland
    Development 125:161-9. 1998
  2. ncbi Common mammals drive the evolutionary increase of hypsodonty in the Neogene
    Jukka Jernvall
    Developmental Biology Programme, Institute of Biotechnology, PO Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Nature 417:538-40. 2002
  3. pmc Evolutionary modification of development in mammalian teeth: quantifying gene expression patterns and topography
    J Jernvall
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Post Office Box 56 Viikinkaariq, FIN 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 97:14444-8. 2000
  4. pmc Linking development with generation of novelty in mammalian teeth
    J Jernvall
    Institute of Biotechnology, Viikki Biocenter, P O Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Proc Natl Acad Sci U S A 97:2641-5. 2000
  5. ncbi Gene expression patterns associated with suppression of odontogenesis in mouse and vole diastema regions
    S V Keränen
    Developmental Biology Program, Institute of Biotechnology, Biocenter 1, University of Helsinki, P O Box 56, Helsinki, FIN 00014, Finland
    Dev Genes Evol 209:495-506. 1999
  6. ncbi The enamel knot as a signaling center in the developing mouse tooth
    A Vaahtokari
    Institute of Dentistry, University of Helsinki, Finland
    Mech Dev 54:39-43. 1996
  7. ncbi Association of developmental regulatory genes with the development of different molar tooth shapes in two species of rodents
    S V Keränen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocentre, P O Box 56, University of Helsinki, FIN 00014, Finland
    Dev Genes Evol 208:477-86. 1998
  8. ncbi Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF
    J Pispa
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Biol 216:521-34. 1999
  9. ncbi Enamel knots as signaling centers linking tooth morphogenesis and odontoblast differentiation
    I Thesleff
    Developmental Biology Program, Institute of Biotechnology, Vlikki Biocenter, 00014 University of Helsinki, Finland
    Adv Dent Res 15:14-8. 2001
  10. ncbi Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene
    J Jernvall
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Int J Dev Biol 38:463-9. 1994

Collaborators

Detail Information

Publications11

  1. ncbi The life history of an embryonic signaling center: BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot
    J Jernvall
    Institute of Biotechnology, University of Helsinki, Finland
    Development 125:161-9. 1998
    ..These results show that the life history of the enamel knot is intimately linked to the initiation of tooth shape development and support the role of the enamel knot as an embryonic signaling center...
  2. ncbi Common mammals drive the evolutionary increase of hypsodonty in the Neogene
    Jukka Jernvall
    Developmental Biology Programme, Institute of Biotechnology, PO Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Nature 417:538-40. 2002
    ..These results suggest that the relatively small number of species known from multiple localities are palaeoecologically informative by themselves, irrespective of the rest of the known species...
  3. pmc Evolutionary modification of development in mammalian teeth: quantifying gene expression patterns and topography
    J Jernvall
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Post Office Box 56 Viikinkaariq, FIN 00014, Helsinki, Finland
    Proc Natl Acad Sci U S A 97:14444-8. 2000
    ..The diversity of mammalian molar patterns may largely result from the heterotopic and iterative processes...
  4. pmc Linking development with generation of novelty in mammalian teeth
    J Jernvall
    Institute of Biotechnology, Viikki Biocenter, P O Box 56, FIN 00014, University of Helsinki, Helsinki, Finland
    Proc Natl Acad Sci U S A 97:2641-5. 2000
    ..In phylogenetic studies, small cusps may be unreliable as phylogenetic signals. Population level variation can be a powerful tool in testing and generating hypotheses in developmental evolution studies...
  5. ncbi Gene expression patterns associated with suppression of odontogenesis in mouse and vole diastema regions
    S V Keränen
    Developmental Biology Program, Institute of Biotechnology, Biocenter 1, University of Helsinki, P O Box 56, Helsinki, FIN 00014, Finland
    Dev Genes Evol 209:495-506. 1999
    ..However, based on earlier tissue recombination experiments it is conceivable that the developmental arrest is determined by the early oral epithelium...
  6. ncbi The enamel knot as a signaling center in the developing mouse tooth
    A Vaahtokari
    Institute of Dentistry, University of Helsinki, Finland
    Mech Dev 54:39-43. 1996
    ..We suggest that the enamel knot acts as a signaling or organizing center, which provides positional information for tooth morphogenesis and regulates the growth of tooth cusps...
  7. ncbi Association of developmental regulatory genes with the development of different molar tooth shapes in two species of rodents
    S V Keränen
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocentre, P O Box 56, University of Helsinki, FIN 00014, Finland
    Dev Genes Evol 208:477-86. 1998
    ....
  8. ncbi Cusp patterning defect in Tabby mouse teeth and its partial rescue by FGF
    J Pispa
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, Finland
    Dev Biol 216:521-34. 1999
    ..Instead FGF-10 partially restored morphogenesis and stimulated the development of additional tooth cusps in cultured Tabby molars...
  9. ncbi Enamel knots as signaling centers linking tooth morphogenesis and odontoblast differentiation
    I Thesleff
    Developmental Biology Program, Institute of Biotechnology, Vlikki Biocenter, 00014 University of Helsinki, Finland
    Adv Dent Res 15:14-8. 2001
    ..We suggest that the enamel knots are central regulators of tooth development, since they link cell differentiation to morphogenesis...
  10. ncbi Evidence for the role of the enamel knot as a control center in mammalian tooth cusp formation: non-dividing cells express growth stimulating Fgf-4 gene
    J Jernvall
    Department of Pedodontics and Orthodontics, University of Helsinki, Finland
    Int J Dev Biol 38:463-9. 1994
    ..Based on these results, we suggest that the enamel knot may control tooth morphogenesis by concurrently stimulating cusp growth (via FGF-4 synthesis) and by directing folding of cusp slopes (by not proliferating itself)...
  11. ncbi Reiterative signaling and patterning during mammalian tooth morphogenesis
    J Jernvall
    Developmental Biology Program, Institute of Biotechnology, Viikki Biocenter, P O Box 56, 00014, University of Helsinki, Helsinki, Finland
    Mech Dev 92:19-29. 2000
    ..Spatiotemporal induction of the secondary enamel knots determines the cusp patterns of individual teeth and is likely to involve repeated activation and inhibition of signaling as suggested for patterning of other epithelial organs...