Edmund C Jenkins

Summary

Publications

  1. pmc Reduced telomere length in individuals with FMR1 premutations and full mutations
    Edmund C Jenkins
    Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Am J Med Genet A 158:1060-5. 2012
  2. pmc Does the cryogenic freezing process cause shorter telomeres?
    Edmund C Jenkins
    The Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities IBR, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Cryobiology 65:72-3. 2012
  3. pmc Shorter telomeres may indicate dementia status in older individuals with Down syndrome
    Edmund C Jenkins
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 31:765-71. 2010
  4. pmc Increased "absence" of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome
    Edmund C Jenkins
    Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road Staten Island, NY 10314, United States
    Neurosci Lett 440:340-3. 2008
  5. pmc Mild cognitive impairment identified in older individuals with Down syndrome by reduced telomere signal numbers and shorter telomeres measured in microns
    Edmund C Jenkins
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Am J Med Genet B Neuropsychiatr Genet 159:598-604. 2012
  6. pmc Reduced telomere length in older men with premutation alleles of the fragile X mental retardation 1 gene
    Edmund C Jenkins
    Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Am J Med Genet A 146:1543-6. 2008
  7. doi request reprint Successful aging in a 70-year-old man with down syndrome: a case study
    Sharon J Krinsky-McHale
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Intellect Dev Disabil 46:215-28. 2008
  8. pmc Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome
    Warren B Zigman
    Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    Neurosci Lett 416:279-84. 2007
  9. ncbi request reprint De-novo 2.15 Mb terminal Xq duplication involving MECP2 but not L1CAM gene in a male patient with mental retardation
    Milen Velinov
    Department of Human Genetics, NYS Institute for Basic Research, in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Clin Dysmorphol 18:9-12. 2009
  10. ncbi request reprint Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Neurosci Lett 390:93-7. 2005

Detail Information

Publications16

  1. pmc Reduced telomere length in individuals with FMR1 premutations and full mutations
    Edmund C Jenkins
    Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Am J Med Genet A 158:1060-5. 2012
    ..We have thus confirmed our hypothesis that reduced telomere length is associated with both premutation and full mutation-FMR1 alleles and have demonstrated that direct measurements of telomere length can reliably detect such reductions...
  2. pmc Does the cryogenic freezing process cause shorter telomeres?
    Edmund C Jenkins
    The Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities IBR, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Cryobiology 65:72-3. 2012
    ....
  3. pmc Shorter telomeres may indicate dementia status in older individuals with Down syndrome
    Edmund C Jenkins
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 31:765-71. 2010
    ..Our findings suggest that it may be feasible to use telomere shortening as a biomarker for accurately inferring dementia status...
  4. pmc Increased "absence" of telomeres may indicate Alzheimer's disease/dementia status in older individuals with Down syndrome
    Edmund C Jenkins
    Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road Staten Island, NY 10314, United States
    Neurosci Lett 440:340-3. 2008
    ....
  5. pmc Mild cognitive impairment identified in older individuals with Down syndrome by reduced telomere signal numbers and shorter telomeres measured in microns
    Edmund C Jenkins
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Am J Med Genet B Neuropsychiatr Genet 159:598-604. 2012
    ....
  6. pmc Reduced telomere length in older men with premutation alleles of the fragile X mental retardation 1 gene
    Edmund C Jenkins
    Department of Human Genetics, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York 10314, USA
    Am J Med Genet A 146:1543-6. 2008
    ..Thus, telomere shortening may serve as a biomarker for cellular dysregulation that may precede the development of the symptoms of FXTAS...
  7. doi request reprint Successful aging in a 70-year-old man with down syndrome: a case study
    Sharon J Krinsky-McHale
    New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    Intellect Dev Disabil 46:215-28. 2008
    ..The authors present potential explanations for the phenotypic variability observed in individuals with Down syndrome...
  8. pmc Cholesterol level, statin use and Alzheimer's disease in adults with Down syndrome
    Warren B Zigman
    Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, United States
    Neurosci Lett 416:279-84. 2007
    ..402, p=.095, 95% CI: .138, 1.173). If the protective effects of statins can be further validated, these findings suggest that their use may delay or prevent AD onset in vulnerable populations...
  9. ncbi request reprint De-novo 2.15 Mb terminal Xq duplication involving MECP2 but not L1CAM gene in a male patient with mental retardation
    Milen Velinov
    Department of Human Genetics, NYS Institute for Basic Research, in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Clin Dysmorphol 18:9-12. 2009
    ..Our patient's features are similar to previously reported MECP2 gene duplication cases, thus suggesting minor or no contribution of duplicated genes distal of MECP2 to the reported phenotype...
  10. ncbi request reprint Mortality is associated with apolipoprotein E epsilon4 in nondemented adults with Down syndrome
    Warren B Zigman
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314 6399, USA
    Neurosci Lett 390:93-7. 2005
    ..These results suggest that the apolipoprotein E epsilon4 allele has an independent and strong relation to early mortality...
  11. pmc Ophthalmic disorders in adults with down syndrome
    Sharon J Krinsky-McHale
    Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Curr Gerontol Geriatr Res 2012:974253. 2012
    ..The high prevalence of ophthalmic disorders highlights the need for periodic evaluations and individualized treatment plans for adults with Down syndrome, in general, but especially when concerns are identified...
  12. ncbi request reprint Repetition priming in adults with Williams syndrome: age-related dissociation between implicit and explicit memory
    Sharon J Krinsky-McHale
    Department of Psychology, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314 6399, USA
    Am J Ment Retard 110:482-96. 2005
    ..Results also suggest that Williams syndrome, similar to Down syndrome, may be associated with precocious aging, resulting in the loss of some cognitive abilities...
  13. ncbi request reprint Psychotic manifestations in a patient with mental retardation and a 6.2 megabase deletion at the distal short arm of chromosome 12
    Milen Velinov
    The Comprehensive Genetic Services, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY 10314, USA
    CNS Spectr 13:515-9. 2008
    ..To-date such a chromosomal abnormality has not been described in association with schizophrenia/psychosis. This case suggests that psychosis-associated gene(s) may be located in the terminal region of the short arm of chromosome 12...
  14. pmc Glyoxalase I polymorphism rs2736654 causing the Ala111Glu substitution modulates enzyme activity--implications for autism
    Madhabi Barua
    Department of Developmental Biochemistry, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, New York, NY 10314, USA
    Autism Res 4:262-70. 2011
    ..We suggest that accumulation of MG results in the formation of AGEs, which induce expression of the RAGE that during crucial neuronal development may be a factor in the pathology of autism...
  15. ncbi request reprint Telomere shortening in T lymphocytes of older individuals with Down syndrome and dementia
    Edmund C Jenkins
    New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA
    Neurobiol Aging 27:941-5. 2006
    ..From this initial study, we conclude that telomere shortening is associated with dementia in this high-risk population and suggest that additional research may show that telomere shortening may be a biological marker of dementia status...
  16. doi request reprint Chlorination byproducts induce gender specific autistic-like behaviors in CD-1 mice
    Sara Rose Guariglia
    New York State Institute for Basic Research in Developmental Disabilities, Department of Developmental Neurobiology, Staten Island, NY 10314, United States
    Neurotoxicology 32:545-53. 2011
    ..We believe development of such aberrant behaviors likely involves GABAergic system development...