Luc Jasmin

Summary

Publications

  1. pmc Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus
    Giovanni Villa
    Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Mol Pain 6:89. 2010
  2. pmc Can satellite glial cells be therapeutic targets for pain control?
    Luc Jasmin
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Neuron Glia Biol 6:63-71. 2010
  3. pmc Evidence for a role of connexin 43 in trigeminal pain using RNA interference in vivo
    Peter T Ohara
    Department of Anatomy, University of California San Francisco, San Francisco, CA 95143 0452, USA
    J Neurophysiol 100:3064-73. 2008
  4. ncbi request reprint Dopaminergic input to GABAergic neurons in the rostral agranular insular cortex of the rat
    Peter T Ohara
    Departments of Anatomy and the W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94143, USA
    J Neurocytol 32:131-41. 2003
  5. ncbi request reprint The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception
    Jean Philippe Vit
    Department of Anatomy, University of California San Francisco, 94143 0452, USA
    Pain 120:188-201. 2006
  6. pmc Evidence for glutamate as a neuroglial transmitter within sensory ganglia
    Ling Hsuan Kung
    Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e68312. 2013
  7. ncbi request reprint Long-term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception
    Luc Jasmin
    Department of Neurological Surgery and the WM Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 460:38-55. 2003
  8. ncbi request reprint Noradrenaline is necessary for the hedonic properties of addictive drugs
    Luc Jasmin
    Department of Neurological Surgery and W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94143, USA
    Vascul Pharmacol 45:243-50. 2006
  9. pmc Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia
    Jean Philippe Vit
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Pain 5:42. 2009
  10. pmc Gliopathic pain: when satellite glial cells go bad
    Peter T Ohara
    Department of Anatomy, University of California, San Francisco, California 95143 0452, USA
    Neuroscientist 15:450-63. 2009

Research Grants

  1. CORTICAL MODULATION OF PAIN BEHAVIOR
    Luc Jasmin; Fiscal Year: 2002
  2. Gene Therapy for Nerve Injury
    Luc Jasmin; Fiscal Year: 2007

Collaborators

Detail Information

Publications18

  1. pmc Temporomandibular joint inflammation activates glial and immune cells in both the trigeminal ganglia and in the spinal trigeminal nucleus
    Giovanni Villa
    Department of Pharmacological Sciences, Universita degli Studi di Milano, Via Balzaretti 9, 20133 Milan, Italy
    Mol Pain 6:89. 2010
    ....
  2. pmc Can satellite glial cells be therapeutic targets for pain control?
    Luc Jasmin
    Department of Anatomy, University of California, San Francisco, CA 94143 0452, USA
    Neuron Glia Biol 6:63-71. 2010
    ..Taken together these data suggest that SGCs may play a role in the genesis or maintenance of pain and open a range of new possibilities for curing neuropathic pain...
  3. pmc Evidence for a role of connexin 43 in trigeminal pain using RNA interference in vivo
    Peter T Ohara
    Department of Anatomy, University of California San Francisco, San Francisco, CA 95143 0452, USA
    J Neurophysiol 100:3064-73. 2008
    ....
  4. ncbi request reprint Dopaminergic input to GABAergic neurons in the rostral agranular insular cortex of the rat
    Peter T Ohara
    Departments of Anatomy and the W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94143, USA
    J Neurocytol 32:131-41. 2003
    ..Through these connections, dopamine innervation of the RAIC is likely to affect the motivational and affective dimensions of pain...
  5. ncbi request reprint The analgesic effect of low dose focal irradiation in a mouse model of bone cancer is associated with spinal changes in neuro-mediators of nociception
    Jean Philippe Vit
    Department of Anatomy, University of California San Francisco, 94143 0452, USA
    Pain 120:188-201. 2006
    ..We conclude that the analgesic effect of low dose irradiation of bone cancer is associated with the alteration of nociceptive transmission in the central nervous system...
  6. pmc Evidence for glutamate as a neuroglial transmitter within sensory ganglia
    Ling Hsuan Kung
    Department of Anatomy, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e68312. 2013
    ..These findings, together with our previous gene knockdown data, suggest that glutamatergic transmission within the ganglion could impact nociceptive threshold. ..
  7. ncbi request reprint Long-term effects of decreased noradrenergic central nervous system innervation on pain behavior and opioid antinociception
    Luc Jasmin
    Department of Neurological Surgery and the WM Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 460:38-55. 2003
    ..Our results suggest that NA contributes only modestly to determining the nociceptive threshold and that its antinociceptive effects are closely linked to opioidergic and tachykinergic neurotransmission...
  8. ncbi request reprint Noradrenaline is necessary for the hedonic properties of addictive drugs
    Luc Jasmin
    Department of Neurological Surgery and W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, CA 94143, USA
    Vascul Pharmacol 45:243-50. 2006
    ..The reversibility of this phenomenon, by restoring NA, indicates that even when this behavioral deficit is genetically determined it can be reversed...
  9. pmc Adenovector GAD65 gene delivery into the rat trigeminal ganglion produces orofacial analgesia
    Jean Philippe Vit
    Department of Anatomy, University of California San Francisco, San Francisco, CA 94143, USA
    Mol Pain 5:42. 2009
    ..We postulated that GABA produced from the expression of GAD would reduce pain behavior by acting on GABA receptors on neurons within the ganglion...
  10. pmc Gliopathic pain: when satellite glial cells go bad
    Peter T Ohara
    Department of Anatomy, University of California, San Francisco, California 95143 0452, USA
    Neuroscientist 15:450-63. 2009
    ..We propose the term gliopathic pain to describe those conditions in which central or peripheral glia are thought to be the principal generators of principal pain generators...
  11. ncbi request reprint Is noradrenaline a significant factor in the analgesic effect of antidepressants?
    Luc Jasmin
    Department of Neurological Surgery, University of California San Francisco, Box 0112, 505 Parnassus Avenue, San Francisco, CA 94143, USA
    Pain 106:3-8. 2003
  12. ncbi request reprint Rostral agranular insular cortex and pain areas of the central nervous system: a tract-tracing study in the rat
    Luc Jasmin
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143, USA
    J Comp Neurol 468:425-40. 2004
    ....
  13. ncbi request reprint Analgesia and hyperalgesia from GABA-mediated modulation of the cerebral cortex
    Luc Jasmin
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0452, USA
    Nature 424:316-20. 2003
    ..Whereas most studies focus on the role of the cerebral cortex as the end point of nociceptive processing, we suggest that cerebral cortex activity can change the set-point of pain threshold in a top-down manner...
  14. ncbi request reprint Recurrent paraplegia after remyelination of the spinal cord
    Luc Jasmin
    Department of Neurological Surgery, University of California San Francisco, San Francisco, California 94143 0452, USA
    J Neurosci Res 77:277-84. 2004
    ..This model might therefore be useful in studying the long-term effects of spinal insult of the type associated with conditions such as postpolio syndrome...
  15. pmc Chronic constriction injury of the infraorbital nerve in the rat using modified syringe needle
    Melanie Kernisant
    Department of Anatomy, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, United States
    J Neurosci Methods 172:43-7. 2008
    ..Pain behavior testing together with immunostaining for markers of nerve injury in the spinal trigeminal nucleus show the suitability of this procedure as a model of orofacial pain...
  16. doi request reprint Orofacial pain models and behavior assessment
    Timothy K Y Kaan
    Department of Anatomy, University of California San Francisco, San Francisco, CA, USA
    Methods Mol Biol 851:159-70. 2012
    ..The use of a combination of different pain models and behavior assessments is needed to aid in understanding the mechanisms contributing to orofacial pain in humans for developing effective therapy...
  17. ncbi request reprint Vagal afferents are necessary for the establishment but not the maintenance of kainic acid-induced hyperalgesia in mice
    Duc Tien
    Department of Neurological Surgery, University of California San Francisco, 505 Parnassus, Box 0112, San Francisco, CA 94143, USA
    Pain 102:39-49. 2003
    ..These findings suggest that the mechanism underlying KA-induced hyperalgesia is a long-term dysfunction of CNS areas that are activated by vagal afferents and involved in descending control of spinal nociceptive neurons...
  18. ncbi request reprint Experimental neurogenic cystitis
    Luc Jasmin
    Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    Adv Exp Med Biol 539:319-35. 2003
    ..Gonadectomy prevented the bladder inflammation altogether in both males and females. These findings further validate our model of neurogenic cystitis to study the neurogenic component of IC...

Research Grants7

  1. CORTICAL MODULATION OF PAIN BEHAVIOR
    Luc Jasmin; Fiscal Year: 2002
    ..The clinical implications of loss of dopaminergic inhibition of the cerebral cortex include central pain syndromes such as those reported in Parkinson's disease and in patients treated with neuroleptic drugs. ..
  2. Gene Therapy for Nerve Injury
    Luc Jasmin; Fiscal Year: 2007
    ..Our project is a pre-clinical study of the analgesic effects of correcting trigeminal nerve dysfunction by adding a gene that codes for GABA, a natural neurotransmitter to trigeminal nerve neurons. ..